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Industry updates from the field of stem cell research and regenerative medicine in June 2024. 2024 年 6 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-09-17 DOI: 10.1080/17460751.2024.2393560
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in June 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2393560","DOIUrl":"10.1080/17460751.2024.2393560","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in June 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-7"},"PeriodicalIF":2.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induced pluripotent stem cell therapies in heart failure treatment: a meta-analysis and systematic review. 诱导多能干细胞疗法在心力衰竭治疗中的应用：荟萃分析和系统综述。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-09-12 DOI: 10.1080/17460751.2024.2393558
Duy Cao Phuong Le, Hoa The Bui, Yen Thi Hai Vu, Quan Duy Vo
{"title":"Induced pluripotent stem cell therapies in heart failure treatment: a meta-analysis and systematic review.","authors":"Duy Cao Phuong Le, Hoa The Bui, Yen Thi Hai Vu, Quan Duy Vo","doi":"10.1080/17460751.2024.2393558","DOIUrl":"10.1080/17460751.2024.2393558","url":null,"abstract":"<p><p><b>Background:</b> Heart failure (HF) causes over 266,400 deaths annually. Despite treatment advancements, HF mortality remains high. Induced pluripotent stem cells (iPSCs) offer promising new options. This review assesses iPSC-based treatments for HF.<b>Method:</b> the review included studies from PubMed, ScienceDirect and Web of Science.<b>Results:</b> Analysis of 25 studies with 553 animals showed a baseline ejection fraction (EF) of 39.2 ± 8.9%. iPSC treatment significantly improved EF (MD = 8.6, <i>p</i> < 0.001) and fractional shortening (MD = 6.38, <i>p</i> < 0.001), and reduced ventricular remodeling without increasing arrhythmia risk.<b>Conclusion:</b> iPSC-based therapy improves heart function and reduces ventricular volumes in HF animal models, aligning with promising early clinical trial outcomes.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-13"},"PeriodicalIF":2.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of bi-layer silk fibroin grafts for onlay urethroplasty in a rabbit model of urethral stricture disease. 在兔尿道狭窄疾病模型中评估双层丝纤维蛋白移植物用于尿道嵌顿成形术的效果。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-08-30 DOI: 10.1080/17460751.2024.2389753
Gokhan Gundogdu, Jay Budrewicz, Jodie Giordano, Raffaele Melidone, Chris Searcy, Vikas Agarwal, Carlos R Estrada, Joshua R Mauney
{"title":"Evaluation of bi-layer silk fibroin grafts for onlay urethroplasty in a rabbit model of urethral stricture disease.","authors":"Gokhan Gundogdu, Jay Budrewicz, Jodie Giordano, Raffaele Melidone, Chris Searcy, Vikas Agarwal, Carlos R Estrada, Joshua R Mauney","doi":"10.1080/17460751.2024.2389753","DOIUrl":"10.1080/17460751.2024.2389753","url":null,"abstract":"<p><p><b>Background:</b> Autologous tissues such as buccal mucosa (BM) are widely used for reconstruction of urethral strictures; however, limitations such as donor site morbidity and scarce tissue supply require the development of alternative biomaterials for urethral repair. The goals of this study were to determine the safety and efficacy of bi-layer silk fibroin (BLSF) matrices for urethral stricture repair and compare histological and functional outcomes to the standard approach, BM urethroplasty under good laboratory practices.<b>Material and methods:</b> A total of 13 rabbits exhibiting urethral stricture formation following electrocoagulation injury were treated with onlay urethroplasty with either acellular BLSF (N = 7) or autologous BM (N = 6) grafts for 3 months. Uninjured control rabbits were maintained in parallel (N = 4).<b>Results and conclusion:</b> Animals receiving BLSF implants were demonstrated to be functionally equivalent to BM grafts in their ability to restored strictured calibers, support micturition and promote tissue regeneration with minimal inflammation.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in May 2024. 2024 年 5 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-08-05 DOI: 10.1080/17460751.2024.2378634
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in May 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2378634","DOIUrl":"10.1080/17460751.2024.2378634","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in May 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in regenerative rehabilitation in the rehabilitation of musculoskeletal injuries. 再生康复在肌肉骨骼损伤康复方面的进展。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-06-02 Epub Date: 2024-06-10 DOI: 10.1080/17460751.2024.2357956
Zirui Zhang, Pengfei Yao, Shuai Fan
{"title":"Advances in regenerative rehabilitation in the rehabilitation of musculoskeletal injuries.","authors":"Zirui Zhang, Pengfei Yao, Shuai Fan","doi":"10.1080/17460751.2024.2357956","DOIUrl":"10.1080/17460751.2024.2357956","url":null,"abstract":"<p><p>In the rapidly advancing field of regenerative medicine, relying solely on cell transplantation alone may be insufficient for achieving functional recovery, and rehabilitation before and after transplantation is crucial. Regenerative rehabilitation functions by synergizing the therapeutic effects of regeneration and rehabilitation to maximize tissue regeneration and patient function. We used the keywords \"regenerative rehabilitation\" to search across the database for published works; this review discusses the development of regenerative rehabilitation for the treatment of musculoskeletal injuries. Rehabilitation has become a crucial component of regenerative medicine because it can enhance patients' functional activity and facilitate their early return to society. Experimental data increasingly demonstrates that rehabilitation interventions support the regeneration of transplanted tissues.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"345-354"},"PeriodicalIF":2.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facilitating the ethical sourcing of donor hematopoietic stem cells for cell and gene therapy research and development. 为细胞和基因疗法的研究与开发提供符合道德标准的造血干细胞捐献来源。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-06-02 Epub Date: 2024-06-18 DOI: 10.1080/17460751.2024.2357930
Lina Hamad, Choon Key Chekar, Chloe Anthias, Laura Machin
{"title":"Facilitating the ethical sourcing of donor hematopoietic stem cells for cell and gene therapy research and development.","authors":"Lina Hamad, Choon Key Chekar, Chloe Anthias, Laura Machin","doi":"10.1080/17460751.2024.2357930","DOIUrl":"10.1080/17460751.2024.2357930","url":null,"abstract":"<p><p><b>Aim:</b> Unrelated stem cell donor registries (DRs) are increasingly engaging in the field of cell and gene therapy (CGT). This study aims to explore the values, concerns, needs and expectations of donors and members of the public on donating hematopoietic stem cells (HSCs) for CGT.<b>Methods:</b> Seven focus groups were conducted in 2019 with members of the public, prospective donors and donors on the Anthony Nolan DR in the UK.<b>Results:</b> Participants expressed concerns over increased frequency of donation and incidental findings and required more information on the type of research including the purpose and possible outcomes.<b>Conclusion:</b> Addressing donors' concerns, needs and expectations on donating cellular materials for CGT research and development is essential to maintaining the highest standards for donor care and safety within this rapidly emerging field.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"317-326"},"PeriodicalIF":2.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141420607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PXL01 alters macrophage response with no effect on axonal outgrowth or Schwann cell response after nerve repair in rats. PXL01 可改变巨噬细胞的反应，但对大鼠神经修复后的轴突生长或许旺细胞反应没有影响。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-06-02 Epub Date: 2024-07-03 DOI: 10.1080/17460751.2024.2361515
Derya Burcu Hazer Rosberg, Lena Stenberg, Margit Mahlapuu, Lars B Dahlin
{"title":"PXL01 alters macrophage response with no effect on axonal outgrowth or Schwann cell response after nerve repair in rats.","authors":"Derya Burcu Hazer Rosberg, Lena Stenberg, Margit Mahlapuu, Lars B Dahlin","doi":"10.1080/17460751.2024.2361515","DOIUrl":"10.1080/17460751.2024.2361515","url":null,"abstract":"<p><p><b>Background:</b> Adjunctive pharmacological treatment may improve nerve regeneration. We investigated nerve regeneration processes of PXL01 - a lactoferrin-derived peptide - after repair of the sciatic nerve in healthy Wistar rats.<b>Materials & methods:</b> PXL01, sodium hyaluronate (carrier) or sodium chloride was administered around the repair. After 6 days axonal outgrowth, Schwann cell response, pan- (CD68) and pro-healing (CD206) macrophages in sciatic nerve, sensory neuronal response in dorsal root ganglia (DRG) and expression of heat shock protein 27 (HSP27) in sciatic nerves and DRGs were analyzed.<b>Results:</b> Despite a lower number of pan-macrophages, other investigated variables in sciatic nerves or DRGs did not differ between the treatment groups.<b>Conclusion:</b> PLX01 applied locally inhibits inflammation through pan-macrophages in repaired sciatic nerves without any impact on nerve regeneration or pro-healing macrophages.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"327-343"},"PeriodicalIF":2.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in February 2024. 2024 年 2 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-06-02 Epub Date: 2024-04-30 DOI: 10.1080/17460751.2024.2340888
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in February 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2340888","DOIUrl":"https://doi.org/10.1080/17460751.2024.2340888","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in February 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"19 6","pages":"279-287"},"PeriodicalIF":2.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of allograft bone matrix in clinical orthopedics. 异体骨基质在临床骨科中的应用。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-05-03 Epub Date: 2024-07-19 DOI: 10.1080/17460751.2024.2353473
Shaan Manawar, Erica Myrick, Peter Awad, Victor Hung, Cassidy Hinton, Keith Kenter, Karen Bovid, Yong Li
{"title":"Use of allograft bone matrix in clinical orthopedics.","authors":"Shaan Manawar, Erica Myrick, Peter Awad, Victor Hung, Cassidy Hinton, Keith Kenter, Karen Bovid, Yong Li","doi":"10.1080/17460751.2024.2353473","DOIUrl":"10.1080/17460751.2024.2353473","url":null,"abstract":"<p><p>Clinical orthopedics continuously aims to improve methods for bone formation. Clinical applications where bone formation is necessary include critical long bone defects in orthopedic trauma or tumor patients. Though some biomaterials combined with autologous stem cells significantly improve bone repair, critical-size damages are still challenged with the suitable implantation of biomaterials and donor cell survival. Extracellular matrix (ECM) is the fundamental structure in tissues that can nest and nourish resident cells as well as support specific functions of the tissue type. ECM also plays a role in cell signaling to promote bone growth, healing and turnover. In the last decade, the use of bone-derived ECMs or ECM-similar biomaterials have been widely investigated, including decellularized and demineralized bone ECM. In this article, we reviewed the current productions and applications of decellularized and demineralized bone matrices. We also introduce the current study of whole limb decellularization and recellularization.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"247-256"},"PeriodicalIF":2.4,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in January 2024. 2024 年 1 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-05-03 Epub Date: 2024-03-13 DOI: 10.2217/rme-2024-0034
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in January 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.2217/rme-2024-0034","DOIUrl":"https://doi.org/10.2217/rme-2024-0034","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in January 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"19 5","pages":"209-219"},"PeriodicalIF":2.4,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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