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Bone marrow aspirate concentrate for the treatment of fifth metatarsal head stress fracture: a case report. 骨髓抽吸浓缩物治疗第五跖骨头应力性骨折：病例报告。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-11-01 Epub Date: 2024-11-26 DOI: 10.1080/17460751.2024.2422193
Hirotaka Nakagawa, Kristen Mitchell, Walter I Sussman
{"title":"Bone marrow aspirate concentrate for the treatment of fifth metatarsal head stress fracture: a case report.","authors":"Hirotaka Nakagawa, Kristen Mitchell, Walter I Sussman","doi":"10.1080/17460751.2024.2422193","DOIUrl":"10.1080/17460751.2024.2422193","url":null,"abstract":"<p><p>Metatarsal head stress fractures pose treatment challenges with no established consensus. In this article, we introduce a percutaneous treatment involving autologous bone marrow aspirate concentrate (BMAC) injection without surgical fixation in a 21-year-old basketball player with a stress fracture of the right fifth metatarsal head. He underwent this procedure following unsuccessful 8 months of conservative treatment. Twelve weeks after the procedure, a CT scan confirmed complete healing, facilitating his return to sports. This innovative method offers a promising alternative, avoiding the associated morbidity of surgical intervention. Further research, comparing refracture rates with surgical options, is warranted to inform treatment decisions for this uncommon injury and validate the efficacy of percutaneous BMAC injection.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"529-539"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in July 2024. 2024年7月来自干细胞研究和再生医学领域的行业更新。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-11-01 Epub Date: 2024-10-14 DOI: 10.1080/17460751.2024.2402645
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in July 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2402645","DOIUrl":"https://doi.org/10.1080/17460751.2024.2402645","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in July 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":"19 11","pages":"511-518"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in July 2024. 2024 年 7 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-10-14 DOI: 10.1080/17460751.2024.2402645
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in July 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2402645","DOIUrl":"https://doi.org/10.1080/17460751.2024.2402645","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in July 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-8"},"PeriodicalIF":2.4,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regeneration of full thickness common extensor tendon tear after percutaneous microfragmented adipose graft. 经皮微碎脂肪移植后全厚总伸肌腱撕裂的再生。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-10-10 DOI: 10.1080/17460751.2024.2393555
Imran J Siddiqui, Alyssa Ritner, Sanjay Mahadevan, Kyle J Dineen, Roosevelt Desronvilles
{"title":"Regeneration of full thickness common extensor tendon tear after percutaneous microfragmented adipose graft.","authors":"Imran J Siddiqui, Alyssa Ritner, Sanjay Mahadevan, Kyle J Dineen, Roosevelt Desronvilles","doi":"10.1080/17460751.2024.2393555","DOIUrl":"https://doi.org/10.1080/17460751.2024.2393555","url":null,"abstract":"<p><p>Tennis elbow, also commonly known as lateral epicondylitis or common extensor tendinosis, is a common musculoskeletal injury in the adult population. Currently, the standard treatment regimen prescribed for this injury involves a combination of rest, physical therapy, bracing and anti-inflammatory medications. If refractory to these conservative measures, platelet-rich plasma has been shown effective. However, in the case of full thickness tears, surgery has remained the only treatment option until now. We present a case report of a 56-year-old man with a diagnosis of a left large full thickness tear and rupture with retraction of his common extensor tendon (CET) following a corticosteroid injection. The patient was treated with microfragmented adipose transfer. He was re-evaluated around 7 weeks and again at 15 weeks post-treatment and demonstrated ultrasound evidence of complete bridging and remodeling of his prior full thickness CET tear and resolution of retraction. This case presents a promising option for patients with full thickness CET tears who would like to refrain from or are unable to have surgery. Further research and possible randomized controlled trials are needed to further assess the full efficacy of microfragmented adipose transfer in the treatment of full thickness CET tears.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards stem cell therapies for hearing loss: awareness and perspectives of Australian audiologists and their patients. 听力损失的干细胞疗法：澳大利亚听力学家及其患者的认识和观点。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-10-08 DOI: 10.1080/17460751.2024.2402650
Dysiphan Iem, Georgia Carney, Megan Munsie, Bryony A Nayagam
{"title":"Towards stem cell therapies for hearing loss: awareness and perspectives of Australian audiologists and their patients.","authors":"Dysiphan Iem, Georgia Carney, Megan Munsie, Bryony A Nayagam","doi":"10.1080/17460751.2024.2402650","DOIUrl":"10.1080/17460751.2024.2402650","url":null,"abstract":"<p><p><b>Aim:</b> Over the last two decades, numerous experimental studies have examined the feasibility of delivering stem cells into the cochlea to restore hearing. While these studies have spawned new cell therapy companies, there is little information on what patients understand or expect from these emerging therapies.<b>Methods:</b> This study sought to understand the awareness and perspectives of Australian audiologists and their adult patients toward stem cell therapies for treating hearing loss.<b>Results:</b> An anonymous survey indicated 91% of patients and 39% of audiologists were unaware of these therapies being developed. Thirty percent of audiologists reported being asked about stem cell therapies for hearing loss, but 70% were not confident answering patient queries about this and were unsure where to gather information. Primary concerns reported by patients were cost (45%) and safety of treatment (42%). Interestingly, 58% of patients were unsure of how this therapy would improve their hearing, yet 25% of these patients expected that their hearing would return to normal.<b>Conclusion:</b> There was strong support for development of educational materials for both patient and clinician. The increasingly important role of audiologists in providing patient counselling was reflected in overwhelming support (from both patient and clinician) for audiologists providing such information.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-14"},"PeriodicalIF":2.4,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in June 2024. 2024 年 6 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-09-17 DOI: 10.1080/17460751.2024.2393560
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in June 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2393560","DOIUrl":"10.1080/17460751.2024.2393560","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in June 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-7"},"PeriodicalIF":2.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induced pluripotent stem cell therapies in heart failure treatment: a meta-analysis and systematic review. 诱导多能干细胞疗法在心力衰竭治疗中的应用：荟萃分析和系统综述。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-09-12 DOI: 10.1080/17460751.2024.2393558
Duy Cao Phuong Le, Hoa The Bui, Yen Thi Hai Vu, Quan Duy Vo
{"title":"Induced pluripotent stem cell therapies in heart failure treatment: a meta-analysis and systematic review.","authors":"Duy Cao Phuong Le, Hoa The Bui, Yen Thi Hai Vu, Quan Duy Vo","doi":"10.1080/17460751.2024.2393558","DOIUrl":"10.1080/17460751.2024.2393558","url":null,"abstract":"<p><p><b>Background:</b> Heart failure (HF) causes over 266,400 deaths annually. Despite treatment advancements, HF mortality remains high. Induced pluripotent stem cells (iPSCs) offer promising new options. This review assesses iPSC-based treatments for HF.<b>Method:</b> the review included studies from PubMed, ScienceDirect and Web of Science.<b>Results:</b> Analysis of 25 studies with 553 animals showed a baseline ejection fraction (EF) of 39.2 ± 8.9%. iPSC treatment significantly improved EF (MD = 8.6, <i>p</i> < 0.001) and fractional shortening (MD = 6.38, <i>p</i> < 0.001), and reduced ventricular remodeling without increasing arrhythmia risk.<b>Conclusion:</b> iPSC-based therapy improves heart function and reduces ventricular volumes in HF animal models, aligning with promising early clinical trial outcomes.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-13"},"PeriodicalIF":2.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of bi-layer silk fibroin grafts for onlay urethroplasty in a rabbit model of urethral stricture disease. 在兔尿道狭窄疾病模型中评估双层丝纤维蛋白移植物用于尿道嵌顿成形术的效果。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-08-30 DOI: 10.1080/17460751.2024.2389753
Gokhan Gundogdu, Jay Budrewicz, Jodie Giordano, Raffaele Melidone, Chris Searcy, Vikas Agarwal, Carlos R Estrada, Joshua R Mauney
{"title":"Evaluation of bi-layer silk fibroin grafts for onlay urethroplasty in a rabbit model of urethral stricture disease.","authors":"Gokhan Gundogdu, Jay Budrewicz, Jodie Giordano, Raffaele Melidone, Chris Searcy, Vikas Agarwal, Carlos R Estrada, Joshua R Mauney","doi":"10.1080/17460751.2024.2389753","DOIUrl":"10.1080/17460751.2024.2389753","url":null,"abstract":"<p><p><b>Background:</b> Autologous tissues such as buccal mucosa (BM) are widely used for reconstruction of urethral strictures; however, limitations such as donor site morbidity and scarce tissue supply require the development of alternative biomaterials for urethral repair. The goals of this study were to determine the safety and efficacy of bi-layer silk fibroin (BLSF) matrices for urethral stricture repair and compare histological and functional outcomes to the standard approach, BM urethroplasty under good laboratory practices.<b>Material and methods:</b> A total of 13 rabbits exhibiting urethral stricture formation following electrocoagulation injury were treated with onlay urethroplasty with either acellular BLSF (N = 7) or autologous BM (N = 6) grafts for 3 months. Uninjured control rabbits were maintained in parallel (N = 4).<b>Results and conclusion:</b> Animals receiving BLSF implants were demonstrated to be functionally equivalent to BM grafts in their ability to restored strictured calibers, support micturition and promote tissue regeneration with minimal inflammation.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in May 2024. 2024 年 5 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-08-05 DOI: 10.1080/17460751.2024.2378634
Dusko Ilic, Mirjana Liovic
{"title":"Industry updates from the field of stem cell research and regenerative medicine in May 2024.","authors":"Dusko Ilic, Mirjana Liovic","doi":"10.1080/17460751.2024.2378634","DOIUrl":"10.1080/17460751.2024.2378634","url":null,"abstract":"<p><p>Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in May 2024.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in regenerative rehabilitation in the rehabilitation of musculoskeletal injuries. 再生康复在肌肉骨骼损伤康复方面的进展。
IF 2.4 4区 医学
Regenerative medicine Pub Date : 2024-06-02 Epub Date: 2024-06-10 DOI: 10.1080/17460751.2024.2357956
Zirui Zhang, Pengfei Yao, Shuai Fan
{"title":"Advances in regenerative rehabilitation in the rehabilitation of musculoskeletal injuries.","authors":"Zirui Zhang, Pengfei Yao, Shuai Fan","doi":"10.1080/17460751.2024.2357956","DOIUrl":"10.1080/17460751.2024.2357956","url":null,"abstract":"<p><p>In the rapidly advancing field of regenerative medicine, relying solely on cell transplantation alone may be insufficient for achieving functional recovery, and rehabilitation before and after transplantation is crucial. Regenerative rehabilitation functions by synergizing the therapeutic effects of regeneration and rehabilitation to maximize tissue regeneration and patient function. We used the keywords \"regenerative rehabilitation\" to search across the database for published works; this review discusses the development of regenerative rehabilitation for the treatment of musculoskeletal injuries. Rehabilitation has become a crucial component of regenerative medicine because it can enhance patients' functional activity and facilitate their early return to society. Experimental data increasingly demonstrates that rehabilitation interventions support the regeneration of transplanted tissues.</p>","PeriodicalId":21043,"journal":{"name":"Regenerative medicine","volume":" ","pages":"345-354"},"PeriodicalIF":2.4,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11346529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141301406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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