Research Journal of Chemistry and Environment最新文献_第6页

A Molecular Docking and Dynamic Simulation Study for the Inhibition of Porcine Coronavirus: Drug Repurposing Approach 抑制猪冠状病毒的分子对接和动态模拟研究：药物再利用方法

Research Journal of Chemistry and Environment Pub Date : 2023-11-05 DOI: 10.25303/2712rjce1380144

Anupama Tiwari, Shweta Mishra, G.N. Darwhekar, Suman Mukhopadhyay

{"title":"A Molecular Docking and Dynamic Simulation Study for the Inhibition of Porcine Coronavirus: Drug Repurposing Approach","authors":"Anupama Tiwari, Shweta Mishra, G.N. Darwhekar, Suman Mukhopadhyay","doi":"10.25303/2712rjce1380144","DOIUrl":"https://doi.org/10.25303/2712rjce1380144","url":null,"abstract":"Severe acute respiratory syndrome (SARS) coronavirus-2 was declared as world pandemic by WHO in 2019. It has been spreading very rapidly around the world and is responsible for various health issues. Different forms of corona viruses are capable of initiating infections in humans ranging from common cold to respiratory disorders including diarrhea. In this study, we have utilized the drug repurposing approach for identifying the therapeutic potential candidate for the inhibition of the nsp1 protein of a new porcine coronavirus 6lpa. 81 FDA approved antiviral agents were docked against this virus using discovery studio and PyRx software. Analysis of result reveals three compounds based on the best docking score: Abivertinib, Vazegepant and Elbasvir. Pharmacological and toxicological properties of the leads were also determined. Furthermore, molecular dynamics simulation studies were performed to determine the stability of complexes. RMSD of protein- ligand complex is showing excellent stability with all three drugs. Least conformational changes can be seen within Abivertinib complex which shows its stability during simulation process. These screened drugs obtained through drug repurposing approach can prove to be useful in treating the infections caused by porcine corona virus 6lpa after further studies.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139289264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of Microbial fuel cell as a post treatment unit of UASB reactor for distillery spent wash 微生物燃料电池作为酒厂废水 UASB 反应器后处理装置的性能

Research Journal of Chemistry and Environment Pub Date : 2023-11-05 DOI: 10.25303/2712rjce900105

A.B. Saner, A.K. Mungray

引用次数: 0

Characterization of Green synthesised Iron nanoparticles and application of synthesised Iron nanoparticles as an effective catalyst for the removal of Carcinogenic metals in aqueous solution 绿色合成纳米铁粒子的表征以及将合成纳米铁粒子用作去除水溶液中致癌金属的有效催化剂的应用

Research Journal of Chemistry and Environment Pub Date : 2023-11-05 DOI: 10.25303/2712rjce1150122

Chandana Narasimha Rao, M. Sujatha

{"title":"Characterization of Green synthesised Iron nanoparticles and application of synthesised Iron nanoparticles as an effective catalyst for the removal of Carcinogenic metals in aqueous solution","authors":"Chandana Narasimha Rao, M. Sujatha","doi":"10.25303/2712rjce1150122","DOIUrl":"https://doi.org/10.25303/2712rjce1150122","url":null,"abstract":"The heavy metals such as chromium (Cr), lead (Pb) and cadmium (Cd) are considered as serious toxicants and act as carcinogenic agents that cause serious cancers to humans. The use of these heavy metals drastically increased in various industrial applications and subsequently increased the risk of contamination of these heavy metals in soil, water etc. To minimize the negative effects of these heavy metals, there is a need to reduce these heavy metals concentrations in environment samples. Hence this study focused to fabricate iron nanoparticles using Diospyros chloroxylon (Roxb.) for the removal of carcinogenic metals in water. The crystal structure, size and morphology of the nanoaprticles were evaluated and it was found that the particles were of rod shape with smooth surface and rhombohedral phase structure with an average particle size of 24 nm that contains 71.91 % of elemental iron. The heavy metal sorption experiments was conducted using selected concentration of heavy metal solution at various pH ranges, time and agitation rate. The maximum adsorption removal was 95.36 %, 98.42 % and 92.80 % within 120 min equilibrium time for Cr, Pb and Cd respectively suggesting that the nanoparticles possess high adsorption efficiency. The adsorption process follows pseudo-first order reaction kinetics with correlation coefficient of 0.978, 0.994 and 0.994 with rate constant (K) of 0.140, 0.280 and 0.108 respectively for Cr, Pb and Cd. The results suggest that the synthesized iron nanoparticles were biocompatible, stable and reusable that can be effectively utilized as promising agents for the removal of carcinogenic heavy metals in polluted water.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139289097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Characterization and In vitro Antibacterial Activity of Novel Ligand and its Metal Complexes 新型配体及其金属配合物的合成、表征及体外抗菌活性研究

Research Journal of Chemistry and Environment Pub Date : 2023-10-15 DOI: 10.25303/2711rjce07012

Mohit Joshi, Sandip Patel, Harshadkumar Patel

引用次数: 0

Synthesis of β-Lactams (2-Azitidinones) by using Schiff base via conventional and microwave synthesis 希夫碱合成β-内酰胺(2-叠氮啶酮)的常规和微波合成方法

Research Journal of Chemistry and Environment Pub Date : 2023-10-15 DOI: 10.25303/2711rjce1100113

Kaushal Kumar, Neha Mishra, Mithun Kori, Ritu Yadav, Satya Prakash Shrivastava

引用次数: 0

Bacteriocins- Convincible component of antimicrobial film for food packaging: A Review 细菌素。食品包装用抗菌膜的可靠成分:综述

Research Journal of Chemistry and Environment Pub Date : 2023-10-15 DOI: 10.25303/2711rjce1420150

Aswin Sridhar, Janani Muthukumar, Akshay Thampi, Ramalingam Chidambaram

引用次数: 0

Evaluation of dyeing properties of Eclipta Alba L. on protein yarn and their chemical analysis 黄花对蛋白纱染色性能评价及化学分析

Research Journal of Chemistry and Environment Pub Date : 2023-10-15 DOI: 10.25303/2711rjce045050

Minti Gogoi, Bulbul Baruah, Pori Buragohain

引用次数: 0

Environmental-Friendly Extraction Methods to produce Bioactive Compounds in Seaweed 海藻中生物活性物质的环保型提取方法研究

Research Journal of Chemistry and Environment Pub Date : 2023-10-15 DOI: 10.25303/2711rjce1140121

Muhammad Maskur, Mohammad Sayuti, I Ketut Sumandiarsa, Rahmatang .

引用次数: 0

A comparative study on the removal and recovery of hexavalent chromium from tannery wastewater using an isolated strain Aspergillus proliferans LA and a known strain Aspergillus terreus 分离菌株增殖曲霉LA和已知菌株地曲霉去除和回收制革废水中六价铬的比较研究

Research Journal of Chemistry and Environment Pub Date : 2023-10-15 DOI: 10.25303/2711rjce0970109

Abhimati Shukla, Lalit Kumar Singh

{"title":"A comparative study on the removal and recovery of hexavalent chromium from tannery wastewater using an isolated strain Aspergillus proliferans LA and a known strain Aspergillus terreus","authors":"Abhimati Shukla, Lalit Kumar Singh","doi":"10.25303/2711rjce0970109","DOIUrl":"https://doi.org/10.25303/2711rjce0970109","url":null,"abstract":"Isolation of a potent microorganism from the soil near tanneries and a comparative analysis of the removal and recovery of different concentrations of hexavalent chromium using known strain Aspergillus terreus and isolated strain Aspergillis proliferansLA are done. The isolated fungal species from the chromium contaminated soil sites located in the industrial area of Kanpur, U.P. were tested for its potential for the removal of hexavalent chromium from wastewater streams. The experiments were conducted comparing the biosorption efficiency of the isolated species Aspergillus proliferansLA and Aspergillus terreus by varying the initial Cr (VI) concentration and media constituents. The highest removal efficiency of 99.19% was shown by the isolated species Aspergillus proliferansLA for an initial Cr (VI) concentration of 10ppm followed by increasing the concentration to 50ppm whereas Aspergillus terreus showed 78.43% removal of hexavalent chromium. This was then followed by desorption using 0.8M NaOH and 75.12% hexavalent chromium was desorbed from the cells. The isolated strain Aspergillus proliferansLA was seen to show better removal and recovery results than the known strain Aspergillus terreus.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135766203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Thermodynamic Parameters of Phenol Adsorption onto Sewage Sludge based Adsorbent by different Methods 不同吸附剂在污泥上吸附苯酚的热力学参数测定

Research Journal of Chemistry and Environment Pub Date : 2023-10-15 DOI: 10.25303/2711rjce01006

Salim Bousba, Nabil Bougdah, Nabil Messikh

{"title":"Determination of Thermodynamic Parameters of Phenol Adsorption onto Sewage Sludge based Adsorbent by different Methods","authors":"Salim Bousba, Nabil Bougdah, Nabil Messikh","doi":"10.25303/2711rjce01006","DOIUrl":"https://doi.org/10.25303/2711rjce01006","url":null,"abstract":"The aim of this study is the determination of thermodynamic parameters of the adsorption of phenol onto sewage sludge based adsorbent (SSBA) by different methods. Thermodynamic parameters are calculated from three equilibrium constants (Kc) that were derived from the isotherm constants of Langmuir (KL), the distribution coefficient (Kd) and Freundlich isotherm exponent (n). For this, removal of phenol from aqueous solutions by adsorption under batch equilibrium experimental conditions at 293, 303 and 328 K was investigated. All values obtained for ΔG° are negatives this indicated that the adsorption process of phenol on the SSBA is spontaneous and thermodynamically feasible process. We also note that as the temperature increases, the absolute value of ΔG° decreases, it shows that the adsorption is more spontaneous at low temperatures. All values of the standard enthalpy ΔH° are negative and less than 35 kJ.mol-1 which confirm that the process is an exothermic physisorption. The negative values of the standard entropy ΔS° clearly show that the arrangement of phenol molecules is more preferred on the surface of the adsorbent.","PeriodicalId":21012,"journal":{"name":"Research Journal of Chemistry and Environment","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135766329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0