新型配体及其金属配合物的合成、表征及体外抗菌活性研究

Q4 Earth and Planetary Sciences

Research Journal of Chemistry and Environment Pub Date : 2023-10-15 DOI:10.25303/2711rjce07012

Mohit Joshi, Sandip Patel, Harshadkumar Patel

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引用次数: 0

摘要

1H-苯并咪唑与氯丙酮反应生成1-(1H-苯并[d]咪唑-1-基)丙烯-2- 1,1-(1H-苯并[d]咪唑-1-基)丙烯-2- 1，再与硫代氨基脲反应生成新型配体2-(1-(1H-苯并[d]咪唑-1-基)丙烯-2-乙基)肼碳硫酰胺(BITS)。以BITS为配体合成了Cu+2、Co+2、Ni+2、Mn+2和Zn+2金属配合物。通过元素分析、IR-NMR谱分析、金属配体比和金属配合物的磁性能表征。此外，还对配体BITS和全金属配合物进行了抗菌活性筛选。

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Synthesis, Characterization and In vitro Antibacterial Activity of Novel Ligand and its Metal Complexes

1H-benzimidazole reacting with chloroacetone yielded 1-(1H-Benzo[d]imidazol-1-yl) propan-2-one.1-(1H-Benzo[d]imidazol-1-yl) propan-2-one further reacts with thiosemicarbazone to form novel ligand,2-(1-(1H- benzo[d] imidazol-1-yl) propan-2-ylidene) hydrazine carbo thioamide (BITS). Cu+2, Co+2, Ni+2, Mn+2 and Zn+2 metal complexes of BITS were synthesised from ligand BITS. Elemental analysis, IR-NMR spectral analysis, metal: ligand ratio and magnetic properties of all the ligand BITS and all metal complexes were characterized. The ligand BITS and all metal complexes also were screened for antibacterial Activity.

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