Synthesis of β-Lactams (2-Azitidinones) by using Schiff base via conventional and microwave synthesis

Synthesis of β-Lactams (2-azitidinones) (βL-1 to βL-11) by Schiff base cyclization in presence of Et3N and chloroacetyl chloride was carried out through both the conventional as well as microwave methods. Microwave method gives very high yield in lesser time as compared to conventional one which takes few hours for completion. Product is obtained within few minutes when reaction takes place in microwave while in conventional method, it takes around 2-3 hrs and yield is meagre. β –Lactam is antibiotics of broad class which includes penicillin derivatives also. β- Lactam nucleus is present in these antibiotics in its molecular structure and attacks on bacteria by binding with enzyme inside bacterial cell wall. Lactams are the most prescribed group of antibiotics due to their tremendous efficacy in antimicrobial property.