Respiration physiology最新文献_第6页

Respiratory and circulatory compensation to hypoxia in crustaceans. 甲壳类动物对缺氧的呼吸和循环补偿。

Respiration physiology Pub Date : 2001-11-15 DOI: 10.1016/S0034-5687(01)00311-5

Brian R. McMahon

引用次数: 160

A modulatory role for oxygen in shaping rhythmic motor output patterns of neuronal networks 氧在形成神经网络节律性运动输出模式中的调节作用

Respiration physiology Pub Date : 2001-11-15 DOI: 10.1016/S0034-5687(01)00308-5

Stefan Clemens , Jean-Charles Massabuau , Pierre Meyrand , John Simmers

{"title":"A modulatory role for oxygen in shaping rhythmic motor output patterns of neuronal networks","authors":"Stefan Clemens , Jean-Charles Massabuau , Pierre Meyrand , John Simmers","doi":"10.1016/S0034-5687(01)00308-5","DOIUrl":"10.1016/S0034-5687(01)00308-5","url":null,"abstract":"<div>It is becoming increasingly evident that O2-uptake in animal tissue is not only devoted to energy production. Here we review recent findings on a novel role of tissue oxygenation, notably in controlling the operation of neuronal networks in the central nervous system. Electrophysiological recordings in vivo and in vitro from rhythmically-active motor pattern generating networks in the lobster stomatogastric ganglion (STG) have revealed that oxygen is able to act in a manner equivalent to a classical neuromodulator. Local PO2 variations within the low, but physiological range of 1–6 kPa are able to shape ongoing activity of these networks and therefore the motor behaviours in which they are involved. Oxygen's contribution to two of these, feeding and moulting, have been investigated. Importantly, the PO2 effects are not related to hypoxic depression but are highly specific in terms of the network, neuron and even the synapse targeted. Our results are discussed in terms of functional significance and new research directions for mammalian physiology.</div>","PeriodicalId":20976,"journal":{"name":"Respiration physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0034-5687(01)00308-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73962978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Developmental changes in the hypoxic ventilatory response in C57BL/6 mice C57BL/6小鼠缺氧通气反应的发育变化

Respiration physiology Pub Date : 2001-11-01 DOI: 10.1016/S0034-5687(01)00271-7

John M Bissonnette , Sharon J Knopp

{"title":"Developmental changes in the hypoxic ventilatory response in C57BL/6 mice","authors":"John M Bissonnette , Sharon J Knopp","doi":"10.1016/S0034-5687(01)00271-7","DOIUrl":"10.1016/S0034-5687(01)00271-7","url":null,"abstract":"<div>C57BL/6 mice are the strain into which most null mutations for neurotransmitters or their receptors are backcrossed. A number of these transgenic mice have recently been shown to have an abnormal respiratory phenotype; however, the postnatal development of the ventilatory response to hypoxia has not been characterized in C57BL/6 mice. The effect of 8% oxygen for 5 min was examined in mice at five periods from P1 to P30 using a body plyethysmograph. Neonatal and juvenile animals from P7 to P30 showed a biphasic pattern in hypoxia in which the increase in minute ventilation achieved in the first min declined towards baseline by the fifth minute and was decreased below baseline in the first minute of return to air breathing. In contrast P1–P3 C57BL/6 mice had a sustained increase in both respiratory frequency and tidal volume and their minute volume remained above baseline on return to air. The decline in oxygen consumption, measured in the fifth minute of hypoxia, was not different in P1–P3 mice compared to P8–P10. These results suggest that the earliest response to hypoxia of the respiratory system in this strain is not characterized by a time dependent depression as seen in older animals and in species whose motor systems are relatively more developed at birth.</div>","PeriodicalId":20976,"journal":{"name":"Respiration physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0034-5687(01)00271-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88580491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Ventilation, EELV and diaphragmatic activity in rats during the early phase of normobaric hypoxia 大鼠常压缺氧早期通气、EELV和膈肌活动

Respiration physiology Pub Date : 2001-11-01 DOI: 10.1016/S0034-5687(01)00285-7

Monique Bonora , Martin Vizek

{"title":"Ventilation, EELV and diaphragmatic activity in rats during the early phase of normobaric hypoxia","authors":"Monique Bonora , Martin Vizek","doi":"10.1016/S0034-5687(01)00285-7","DOIUrl":"10.1016/S0034-5687(01)00285-7","url":null,"abstract":"<div>We tested whether the enhancement of end-expiratory activity of the diaphragm (De) induced by acute hypoxia persists during long-lasting hypoxia and participates in the enlargement of end-expiratory lung volume (EELV). We thus measured these two parameters together with ventilation (<math><mtext>V</mtext><mtext>̇</mtext><mtext>E</mtext></math>) in 30 rats, either awake or anesthetized, exposed to (1) poikilocapnic hypoxia sustained for 2 or 3 h; or (2) chronic normobaric hypoxia for 7 days interrupted by short episodes of normoxia. Twelve control animals were also studied. (1) Sustained hypoxia induced a stable increase in De, Ve and EELV. (2) In awake rats, chronic hypoxia induced a transient increase in Ve after 1 day of hypoxia, and an increase persisting during acute normoxia throughout the exposure. De followed the same, although less pronounced, course as Ve. In anesthetized animals, only EELV was increased in both chronic hypoxia and acute normoxia, but its enlargement in normoxia was not associated with a concomitant increase in De. The transition from hypoxia to normoxia always induced a decrease in De and EELV. Therefore, (1) during hypoxia sustained for 2 or 3 h, the ventilatory and diaphragmatic responses were stable; (2) during chronic hypoxia lasting 1 week, a ventilatory acclimatization was expressed by a transient increase in hypoxic Ve and a hyperventilation continuing during acute normoxia; (3) EELV enlargement in chronic hypoxia was partly related to changes in De and partly due to another mechanism possibly involving morphological adaptations.</div>","PeriodicalId":20976,"journal":{"name":"Respiration physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0034-5687(01)00285-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85922370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The oxygen gain of diving insects 潜水昆虫获得的氧气

Respiration physiology Pub Date : 2001-11-01 DOI: 10.1016/S0034-5687(01)00287-0

José Guilherme Chaui-Berlinck , José Eduardo P.W. Bicudo , Luiz Henrique Alves Monteiro

引用次数: 15

The effect of anticipatory anxiety on breathing and metabolism in humans 预期性焦虑对人类呼吸和新陈代谢的影响

Respiration physiology Pub Date : 2001-11-01 DOI: 10.1016/S0034-5687(01)00278-X

Yuri Masaoka, Ikuo Homma

{"title":"The effect of anticipatory anxiety on breathing and metabolism in humans","authors":"Yuri Masaoka, Ikuo Homma","doi":"10.1016/S0034-5687(01)00278-X","DOIUrl":"10.1016/S0034-5687(01)00278-X","url":null,"abstract":"<div>Respiratory patterns are influenced by cortical and limbic factors and generated by a complex interaction between metabolic requirements and their behavioral effects. Our previous results showed that the temporal pole and the amygdala in the limbic system are related to anxiety and associated with an increase of respiratory frequency, especially in high trait anxiety subjects. The purpose of this study was to investigate the relationship between respiratory patterns and metabolic output during the production of anticipatory anxiety. In all subjects, fr increased without changes in <math><mtext>V</mtext><mtext>̇</mtext><msub><mi></mi><mn><mtext>O</mtext><msub><mi></mi><mn>2</mn></msub></mn></msub><mtext>,</mtext></math> <math><mtext>V</mtext><mtext>̇</mtext><msub><mi></mi><mn><mtext>CO</mtext><msub><mi></mi><mn>2</mn></msub></mn></msub></math> and HR; and PetCO2 decreased during anticipatory anxiety. In the subjects with high trait anxiety, the increase of fr and the decrease of Te were larger than those in the subjects with low trait anxiety. These results suggest that an increase in respiratory frequency is not related to metabolic factors and is consistent with a mechanism involving the limbic system modulating respiratory drive.</div>","PeriodicalId":20976,"journal":{"name":"Respiration physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0034-5687(01)00278-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82636049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 125

The role of endothelin-1 in strain-related susceptibility to develop hypoxic pulmonary hypertension in rats 内皮素-1在大鼠缺氧性肺动脉高压易感性中的作用

Respiration physiology Pub Date : 2001-11-01 DOI: 10.1016/S0034-5687(01)00255-9

M.R. Karamsetty , L. Pietras , J.R. Klinger , J.J. Lanzillo , J.C. Leiter , L.-C. Ou , N.S. Hill

引用次数: 5

Time of measurement influences the variability of tidal breathing parameters in healthy and sick infants 测量时间影响健康和患病婴儿潮汐呼吸参数的变异性

Respiration physiology Pub Date : 2001-11-01 DOI: 10.1016/S0034-5687(01)00277-8

Andreas Patzak , Bertram Foitzik , Ralf Mrowka , Gerd Schmalisch

{"title":"Time of measurement influences the variability of tidal breathing parameters in healthy and sick infants","authors":"Andreas Patzak , Bertram Foitzik , Ralf Mrowka , Gerd Schmalisch","doi":"10.1016/S0034-5687(01)00277-8","DOIUrl":"10.1016/S0034-5687(01)00277-8","url":null,"abstract":"<div>The aim of this study was to investigate the influence of the time, when measuring tidal breathing parameters 1 min (epoch 1) and 5 min (epoch 2) after application of the facemask in healthy infants and infants with bronchopulmonary dysplasia (BPD), using the dead space free flow-through technique. In both patient groups, there were no statistically significant differences between epoch 1 and 2, in most of the tidal breathing parameters, except an increased V̇e and increased correlation dimension of the respiratory signal in the BPD infants in epoch 1. However, in nearly all parameters the coefficient of variation (CV) was significantly higher in epoch 1 compared with epoch 2, and in some infants, we found very high CVs (>50%) in epoch 1, which disappeared in epoch 2. The study shows that after having applied the facemask, a sufficient amount of adaptation time is necessary in order to reduce the within-subject variability and improve the reproducibility and interpretation of tidal breathing measurements in infants.</div>","PeriodicalId":20976,"journal":{"name":"Respiration physiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0034-5687(01)00277-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86099586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Arousal response to hypoxia in newborn mice 新生小鼠对缺氧的觉醒反应

Respiration physiology Pub Date : 2001-11-01 DOI: 10.1016/S0034-5687(01)00303-6

Stéphane Dauger , Sophie Aizenfisz , Sylvain Renolleau , Estelle Durand , Guy Vardon , Claude Gaultier , Jorge Gallego

引用次数: 30

Braking of expiratory airflow in obese pigs during wakefulness and sleep 肥胖猪在清醒和睡眠时呼气气流的制动

Respiration physiology Pub Date : 2001-11-01 DOI: 10.1016/S0034-5687(01)00302-4

Stephanie A Tuck, Joseph C Dort, John E Remmers

引用次数: 15