新生小鼠对缺氧的觉醒反应

Stéphane Dauger , Sophie Aizenfisz , Sylvain Renolleau , Estelle Durand , Guy Vardon , Claude Gaultier , Jorge Gallego
{"title":"新生小鼠对缺氧的觉醒反应","authors":"Stéphane Dauger ,&nbsp;Sophie Aizenfisz ,&nbsp;Sylvain Renolleau ,&nbsp;Estelle Durand ,&nbsp;Guy Vardon ,&nbsp;Claude Gaultier ,&nbsp;Jorge Gallego","doi":"10.1016/S0034-5687(01)00303-6","DOIUrl":null,"url":null,"abstract":"<div><p>We examined the arousal response to 5% O<sub>2</sub> in newborn mice at several ages before and after peripheral chemoreceptor resetting, namely, at 3, 12, and 48 h (<em>n</em>=22 in each group). Breathing was measured by whole-body flow barometric plethysmography. Sleep and arousal were determined behaviourally. We found that: (1) the arousal response was present in all age groups; (2) the arousal response occurred during the hypoxic ventilatory decline in all age groups, showing that mechanoreceptor input was not sufficient to trigger arousal; and (3) arousal latency was shorter after than before chemoreceptor resetting, suggesting a contribution of chemoreceptors to arousal. We conclude that arousal may contribute to the hypoxic ventilatory response in the early postnatal period in mice and that it should be taken into consideration in studies of ventilatory control maturation in newborns.</p></div>","PeriodicalId":20976,"journal":{"name":"Respiration physiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2001-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0034-5687(01)00303-6","citationCount":"30","resultStr":"{\"title\":\"Arousal response to hypoxia in newborn mice\",\"authors\":\"Stéphane Dauger ,&nbsp;Sophie Aizenfisz ,&nbsp;Sylvain Renolleau ,&nbsp;Estelle Durand ,&nbsp;Guy Vardon ,&nbsp;Claude Gaultier ,&nbsp;Jorge Gallego\",\"doi\":\"10.1016/S0034-5687(01)00303-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>We examined the arousal response to 5% O<sub>2</sub> in newborn mice at several ages before and after peripheral chemoreceptor resetting, namely, at 3, 12, and 48 h (<em>n</em>=22 in each group). Breathing was measured by whole-body flow barometric plethysmography. Sleep and arousal were determined behaviourally. We found that: (1) the arousal response was present in all age groups; (2) the arousal response occurred during the hypoxic ventilatory decline in all age groups, showing that mechanoreceptor input was not sufficient to trigger arousal; and (3) arousal latency was shorter after than before chemoreceptor resetting, suggesting a contribution of chemoreceptors to arousal. We conclude that arousal may contribute to the hypoxic ventilatory response in the early postnatal period in mice and that it should be taken into consideration in studies of ventilatory control maturation in newborns.</p></div>\",\"PeriodicalId\":20976,\"journal\":{\"name\":\"Respiration physiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0034-5687(01)00303-6\",\"citationCount\":\"30\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Respiration physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0034568701003036\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Respiration physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0034568701003036","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 30

摘要

我们在不同年龄的新生小鼠周围化学感受器重置前后(即3、12和48小时)检测了5% O2的唤醒反应(每组n=22)。呼吸测量采用全身流量气压容积描记仪。睡眠和觉醒是由行为决定的。我们发现:(1)唤醒反应存在于所有年龄组;(2)各年龄组缺氧通气下降时均出现唤醒反应,表明机械感受器输入不足以触发唤醒;(3)重置化学感受器后唤醒潜伏期比重置前短,提示化学感受器对唤醒有贡献。我们得出的结论是,唤醒可能有助于小鼠出生后早期的缺氧通气反应,并且在新生儿通气控制成熟的研究中应该考虑到这一点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Arousal response to hypoxia in newborn mice

We examined the arousal response to 5% O2 in newborn mice at several ages before and after peripheral chemoreceptor resetting, namely, at 3, 12, and 48 h (n=22 in each group). Breathing was measured by whole-body flow barometric plethysmography. Sleep and arousal were determined behaviourally. We found that: (1) the arousal response was present in all age groups; (2) the arousal response occurred during the hypoxic ventilatory decline in all age groups, showing that mechanoreceptor input was not sufficient to trigger arousal; and (3) arousal latency was shorter after than before chemoreceptor resetting, suggesting a contribution of chemoreceptors to arousal. We conclude that arousal may contribute to the hypoxic ventilatory response in the early postnatal period in mice and that it should be taken into consideration in studies of ventilatory control maturation in newborns.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信