Braking of expiratory airflow in obese pigs during wakefulness and sleep

Stephanie A Tuck, Joseph C Dort, John E Remmers
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引用次数: 15

Abstract

Braking of expiratory airflow is a phenomenon prominently seen in neonates where it is thought to defend end-expiratory lung volume. This paper describes pronounced expiratory braking in an adult animal, the obese Vietnamese pot-bellied pig. Three obese pigs were chronically instrumented for recording of intrapleural pressure and bioelectric signals related to sleep. Airflow was measured by a pneumotachograph attached to a facemask. Expiratory airflow resistance was calculated for 10 consecutive expirations during wakefulness, NREM, and REM sleep. All animals demonstrated a biphasic expiratory flow pattern characterized by an initial plateau in flow at a low value followed by a rapid increase later in expiration. Airflow resistance during early expiration was on average four-fold higher than during late expiration. A striking observation was the maintenance of pronounced expiratory braking during NREM and REM sleep. Expiratory braking in these animals is likely due to laryngeal mechanisms and may serve to preserve end-expiratory lung volume or improve hemodynamics.

肥胖猪在清醒和睡眠时呼气气流的制动
呼气气流的制动是一种明显的现象,在新生儿中,它被认为是保护呼气末肺容量。本文描述了一种成年动物,肥胖的越南大肚猪明显的呼气制动。3只肥胖猪长期使用仪器记录胸膜内压和与睡眠相关的生物电信号。气流的测量是用附在面罩上的测气仪进行的。在清醒期、非快速眼动期和快速眼动期连续呼气10次,计算呼气气流阻力。所有动物都表现出双相呼气流量模式,其特征是初始流量在低值时达到平台,随后在呼气后期迅速增加。呼气早期的气流阻力平均比呼气后期高4倍。一个引人注目的观察是在非快速眼动和快速眼动睡眠期间维持明显的呼气制动。这些动物的呼气制动可能是由喉部机制引起的,可能有助于保持呼气末肺容量或改善血液动力学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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