A modulatory role for oxygen in shaping rhythmic motor output patterns of neuronal networks

Stefan Clemens , Jean-Charles Massabuau , Pierre Meyrand , John Simmers
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引用次数: 20

Abstract

It is becoming increasingly evident that O2-uptake in animal tissue is not only devoted to energy production. Here we review recent findings on a novel role of tissue oxygenation, notably in controlling the operation of neuronal networks in the central nervous system. Electrophysiological recordings in vivo and in vitro from rhythmically-active motor pattern generating networks in the lobster stomatogastric ganglion (STG) have revealed that oxygen is able to act in a manner equivalent to a classical neuromodulator. Local PO2 variations within the low, but physiological range of 1–6 kPa are able to shape ongoing activity of these networks and therefore the motor behaviours in which they are involved. Oxygen's contribution to two of these, feeding and moulting, have been investigated. Importantly, the PO2 effects are not related to hypoxic depression but are highly specific in terms of the network, neuron and even the synapse targeted. Our results are discussed in terms of functional significance and new research directions for mammalian physiology.

氧在形成神经网络节律性运动输出模式中的调节作用
越来越明显的是,动物组织中的臭氧吸收不仅用于能源生产。在这里,我们回顾了最近关于组织氧合作用的新发现,特别是在控制中枢神经系统神经元网络的运作方面。龙虾口胃神经节(STG)中节律活跃的运动模式生成网络的体内和体外电生理记录表明,氧气能够以相当于经典神经调节剂的方式起作用。在1-6千帕的低但生理范围内的局部PO2变化能够塑造这些网络的持续活动,从而影响它们所涉及的运动行为。氧气对其中两个过程的作用,即取食和换毛,已经被研究过。重要的是,PO2效应与缺氧抑制无关,但在网络、神经元甚至靶向突触方面具有高度特异性。从功能意义和哺乳动物生理学的新研究方向等方面讨论了我们的研究结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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