Respiratory Physiology & Neurobiology最新文献_第3页

The activity of suprahyoid muscles during sevoflurane-induced gasping in mice 七氟醚诱导小鼠喘息时耳上肌的活动。

IF 1.9 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-10-05 DOI: 10.1016/j.resp.2024.104355

Saki Taiji, Takashi Nishino, Hisayo Jin, Mayumi Hashida, Shiroh Isono

{"title":"The activity of suprahyoid muscles during sevoflurane-induced gasping in mice","authors":"Saki Taiji, Takashi Nishino, Hisayo Jin, Mayumi Hashida, Shiroh Isono","doi":"10.1016/j.resp.2024.104355","DOIUrl":"10.1016/j.resp.2024.104355","url":null,"abstract":"<div><div>Sevoflurane-induced gasping in mice involves an enormous increase in inspiratory effort, mandibular movement, and a marked decrease in respiratory frequency (fR). We examined differences in breathing patterns and electromyogram activity (EMG<sub>SH</sub>) of the suprahyoid muscles (SHMs) during eupnea under 3.2 % (1 MAC: minimum alveolar concentration) sevoflurane inhalation and sevoflurane-induced gasping under 6.5 % (2 MAC) sevoflurane inhalation in eight spontaneously breathing, tracheally intubated, adult mice. We found that the phasic EMG<sub>SH</sub> is obtained only during inspiration in eupnea and gasping and that integrated EMG<sub>SH</sub> increases more, as a percent of baseline (% baseline) than tidal volume (V<sub>T</sub>) during gasping (median [interquartile range]; integrated EMG<sub>SH</sub>: 720 [425–1965] vs. V<sub>T</sub>: 300 [238–373], P < 0.05). We also found that the onset of EMG<sub>SH</sub> precedes the start of airflow while maintaining a bell-shaped EMG<sub>SH</sub> contour, which characterizes the EMG of upper airway dilator (UAD) muscles during eupnea and gasping. Vigorous respiratory-related mandibular movements were never observed during eupnea but were observed in seven of 8 mice during sevoflurane-induced gasping. Our observations indicate that SHMs act as a preferentially activating UAD muscle, contributing to the development of mandibular respiratory movements.</div></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":"331 ","pages":"Article 104355"},"PeriodicalIF":1.9,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breathing pattern alteration from weanling to old age in male Sprague-Dawley rats 雄性 Sprague-Dawley 大鼠从断奶到老年呼吸模式的改变

IF 1.9 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.resp.2024.104357

Mehdi Eslami-Behroozi, Payam Shahsavar, Reyhaneh Vali, Mohammad Reza Raoufy

引用次数: 0

Safety and effectiveness of acute intermittent hypoxia during a single treatment at different hypoxic severities 不同缺氧严重程度下单次急性间歇性缺氧治疗的安全性和有效性

IF 1.9 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-09-29 DOI: 10.1016/j.resp.2024.104358

Cory M. Smith, Owen F. Salmon

{"title":"Safety and effectiveness of acute intermittent hypoxia during a single treatment at different hypoxic severities","authors":"Cory M. Smith, Owen F. Salmon","doi":"10.1016/j.resp.2024.104358","DOIUrl":"10.1016/j.resp.2024.104358","url":null,"abstract":"<div><h3>Purpose</h3><div>Examine the cardiovascular, muscular function, cognitive, and neural plastic responses to determine the safety and effectiveness of acute Intermittent hypoxia (AIH) at a low, high, and control fractional inspired oxygen (FiO<sub>2</sub>) dosage</div></div><div><h3>Methods</h3><div>Thirteen human participants performed 30-min of AIH in 60-s intervals at FiO2’s of 0.21 (AIH<sub>21</sub>), 0.15 (AIH<sub>15</sub>), and 0.09 (AIH<sub>9</sub>). Heart rate variability (root mean squared of successive differences; RMSSD), heart rate, oxygen saturation (SpO2), blood pressure, muscular strength, neuromuscular activation, cerebral hemodynamic responses, cognition, symptomology, and brain-derived neurotrophic factor (BDNF) responses were measured before (Pre-AIH), after (post-AIH), and at 20-min of recovery (Recovery-AIH)</div></div><div><h3>Results</h3><div>There were no differences between AIH protocols for heart rate, RMSSD, blood pressure, or SpO2. Muscular strength improved Post-AIH for AIH<sub>15</sub> (10 %) and AIH<sub>9</sub> (14 %) and remained elevated (6 %) at Recovery-AIH. Neuromuscular activation increased Pre-AIH to Post-AIH for AIH15 (10 %) and AIH<sub>9</sub> (11 %). Cerebral hemodynamic responses were not impacted between conditions. Both AIH<sub>15</sub> and AIH9 increased BDNF Post-AIH (62 %) and Recovery-AIH (63 %)</div></div><div><h3>Conclusion</h3><div>Acute intermittent hypoxia is generally safe and effective at producing neural plastic responses, but further examination of co-occurring cardiovascular diseases is needed. This study provides safety focused findings which will widen the adoption and refinement of AIH protocols</div></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":"331 ","pages":"Article 104358"},"PeriodicalIF":1.9,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ratings of perceived effort during expiratory pressure tasks in healthy adults 健康成年人在完成呼气压力任务时对感知努力程度的评分。

IF 1.9 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-09-24 DOI: 10.1016/j.resp.2024.104356

Avery E. Dakin , Michelle S. Troche

{"title":"Ratings of perceived effort during expiratory pressure tasks in healthy adults","authors":"Avery E. Dakin , Michelle S. Troche","doi":"10.1016/j.resp.2024.104356","DOIUrl":"10.1016/j.resp.2024.104356","url":null,"abstract":"<div><h3>Purpose</h3><div>Expiratory muscle strength training (EMST) is a resistance exercise used to improve maximal expiratory pressure and airway protective functions (cough and swallow) in clinical populations. Although ratings of perceived exertion/effort (RPE) are commonly used in exercise prescription and monitoring, they have been underutilized in EMST and require investigation. Our study aims were to: (1) examine how healthy adults rate their effort using the EMST-150 device and MicroRPM respiratory manometer; (2) assess variability in RPE; and (3) compare RPE and relative expiratory pressures obtained from the two devices.</div></div><div><h3>Method</h3><div>Healthy adults completed thirty randomized expiratory maneuvers into a respiratory manometer and an EMST-150 device. RPE was measured using the Borg Category Ratio Scale. Linear mixed multilevel models were used for Aim 1 and 3, and coefficient of variation was used for Aim 2.</div></div><div><h3>Results</h3><div>Twenty healthy adults (Median age: 24.5 years) participated. Results demonstrated a strong positive relationship between resistive load and perceived effort when using both devices. Intra-individual variability in perceived effort decreased as resistive load increased. Participants produced an average of 18.2 % lower expiratory pressure when blowing into the manometer (relative to their maximum) than when blowing into the EMST device.</div></div><div><h3>Discussion</h3><div>Our results support the utilization of RPE in EMST research and clinical practice. The addition of RPE as a measure of intensity during respiratory exercise prescription may be used in future research to help refine EMST protocols and improve rehabilitation outcomes.</div></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":"331 ","pages":"Article 104356"},"PeriodicalIF":1.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endomorphin-2 (Endo2) and substance P (SubP) co-application attenuates SubP-induced excitation and alters frequency plasticity in neonatal rat in vitro preparations 在新生大鼠体外制备中，内啡肽-2（Endo2）和P物质（SubP）联合应用可减轻SubP诱导的兴奋并改变频率可塑性。

IF 1.9 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-09-19 DOI: 10.1016/j.resp.2024.104351

Stephen M. Johnson, Sarah M. Johnson, Jyoti J. Watters, Tracy L. Baker

{"title":"Endomorphin-2 (Endo2) and substance P (SubP) co-application attenuates SubP-induced excitation and alters frequency plasticity in neonatal rat in vitro preparations","authors":"Stephen M. Johnson, Sarah M. Johnson, Jyoti J. Watters, Tracy L. Baker","doi":"10.1016/j.resp.2024.104351","DOIUrl":"10.1016/j.resp.2024.104351","url":null,"abstract":"<div><div>Substance P (SubP) and endomorphin-2 (Endo2) are co-localized presynaptically in vesicles of neurons adjacent to inspiratory rhythm-generating pre-Botzinger Complex (preBotC) neurons but the effects of co-released SubP and Endo2 on respiratory motor control are not known. To address this question, SubP alone or a combination of SubP and Endo2 (SubP/Endo2) were bath-applied in a sustained (15-min) or intermittent (5-min application, 5-min washout, x3) pattern at 10–100 nM to neonatal rat brainstem-spinal cord preparations. During neuropeptide application, SubP/Endo2 co-applications generally attenuated SubP-induced increases in burst frequency and decreases in burst amplitude. With respect to frequency plasticity (long-lasting increase in burst frequency 60 min post-neuropeptide application), SubP-induced frequency plasticity was increased with sustained SubP/Endo2 co-applications at 20 and 100 nM. Intermittent SubP/Endo2 co-applications tended to decrease the level of frequency plasticity induced by intermittent SubP alone applications. SubP/Endo2 co-applications revealed potentially new functions for neurokinin-1 (NK1R) and mu-opioid (MOR) receptors on respiratory rhythm-generating medullary neurons.</div></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":"331 ","pages":"Article 104351"},"PeriodicalIF":1.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The acute effect of respiratory muscle training on cortisol, testosterone, and testosterone-to-cortisol ratio in well-trained triathletes - exploratory study 呼吸肌训练对训练有素的铁人三项运动员的皮质醇、睾酮和睾酮-皮质醇比率的急性影响--探索性研究。

IF 1.9 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-09-17 DOI: 10.1016/j.resp.2024.104353

Tomasz Kowalski , Zbigniew Obmiński , Wojciech Waleriańczyk , Andrzej Klusiewicz

{"title":"The acute effect of respiratory muscle training on cortisol, testosterone, and testosterone-to-cortisol ratio in well-trained triathletes - exploratory study","authors":"Tomasz Kowalski , Zbigniew Obmiński , Wojciech Waleriańczyk , Andrzej Klusiewicz","doi":"10.1016/j.resp.2024.104353","DOIUrl":"10.1016/j.resp.2024.104353","url":null,"abstract":"<div><div>The study investigated acute changes in cortisol (C) and testosterone (T) associated with a popular RMT method, voluntary isocapnic hyperpnoea (VIH), in well-trained triathletes. 19 athletes (7 females, 12 males) performed a VIH training session with pre- and post- serum C and T measurements. Repeated measures ANOVA was employed to analyze hormone changes during VIH, with additional time-sex interaction. Pearson correlation coefficient has been computed to identify the relationship between hormonal changes and age, anthropometric indices, respiratory muscle strength, and training experience. There was a statistically significant effect for C changes (F = 13.101, p = 0.002, η<sub>p</sub><sup>2</sup> = 0.421, ω<sup>2</sup> = 0.08). The C concentration was significantly lower after VIH (Mean Difference = −32.49 <em>± 39.13</em> nmol*L<sup>−1</sup>). No significant effects for T, T/C ratio, and time-sex interactions were observed (p > 0.05). Amongst many, significant correlations between the percentage of body fat and changes in C (r=-0.464, p=0.045), body mass and changes in T (r=0.516, p=0.024), height and changes in T (r=0.509, p=0.026) were found. VIH significantly lowered C concentration. No significant effects for T, T/C ratio, and no between-sex differences were observed. Noteworthy individual variability was observed in all the monitored indices. Significant correlations were found between acute hormone changes associated with VIH and selected anthropometric indices. The study provides initial insight into VIH’s role in athletes’ hormonal balance to possibly guide exercise prescription, autoregulation, arousal state management, and recovery practices in athletes.</div></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":"331 ","pages":"Article 104353"},"PeriodicalIF":1.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1569904824001460/pdfft?md5=95f9e5352d854d42eb2f88ba588c5cf9&pid=1-s2.0-S1569904824001460-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lateral hypothalamic astrocytes contribute to the hypercapnic chemoreflex in a light-dark cycle-dependent manner in unanesthetized rats 在未麻醉的大鼠体内，下丘脑外侧星形胶质细胞以光暗周期依赖的方式促进高碳酸血症化学反射。

IF 1.9 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-09-17 DOI: 10.1016/j.resp.2024.104352

Marcelo Rafanelli Rosatti , Luciane H. Gargaglioni , Mirela B. Dias

{"title":"Lateral hypothalamic astrocytes contribute to the hypercapnic chemoreflex in a light-dark cycle-dependent manner in unanesthetized rats","authors":"Marcelo Rafanelli Rosatti , Luciane H. Gargaglioni , Mirela B. Dias","doi":"10.1016/j.resp.2024.104352","DOIUrl":"10.1016/j.resp.2024.104352","url":null,"abstract":"<div><div>Brainstem astrocytes are important for CO<sub>2</sub><sup>/</sup>H<sup>+</sup> chemoreception. Lateral Hypothalamus/Perifornicial Area (LH/PFA) neurons have an excitatory effect on the ventilatory response to CO<sub>2</sub>, however the role of the astrocytes is unknown. We hypothesized that LH/PFA astrocytes play an excitatory role in the hypercapnic ventilatory response in a sleep-wake and light-dark cycles-dependent manner. We manipulated the activity of astrocytes in the LH/PFA of male Wistar rats through microinjection of Fluorocitrate (Fct), which selectively affects astrocytes, inducing the exocytosis of gliotransmitters. We investigated the effects of intra-LH/PFA Fct microinjection on resting breathing and ventilatory responses to hypercapnia and hypoxia during wakefulness and NREM sleep, in the light and dark phases. Fct increased ventilation during hypercapnia but not during room air or hypoxia. The hypercapnic chemoreflex was increased exclusively during the dark-active phase during both, wakefulness and NREM sleep, indicating that LH/PFA astrocytes play an excitatory role in hypercapnic ventilatory response in a light-dark cycle-dependent manner.</div></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":"331 ","pages":"Article 104352"},"PeriodicalIF":1.9,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 1.9 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-09-16 DOI: 10.1016/j.resp.2024.104349

Enver Ahmet Demir, Okan Gonder

引用次数: 0

4-Hydroxychalcone attenuates ovalbumin-induced allergic airway inflammation and oxidative stress by activating Nrf2/GPx4 pathway 4-羟基查尔酮通过激活Nrf2/GPx4通路减轻卵清蛋白诱导的过敏性气道炎症和氧化应激反应

IF 1.9 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-09-12 DOI: 10.1016/j.resp.2024.104348

Islam Ahmed Abdelmawgood , Mohamed A. Kotb , Hassan Samy Hassan , Abeer Mahmoud Badr , Noha A. Mahana , Ayman Saber Mohamed , Marina Lotfy Khalaf , Nouran Khalid Mostafa , Basant Ehab Diab , Nada Nasser Ahmed , Zeinab Abdeltawab Alamudddin , Laila Alhoussin Soliman , Mariam Khaled Fahim , Asmaa Elsayed Abdelkader

{"title":"4-Hydroxychalcone attenuates ovalbumin-induced allergic airway inflammation and oxidative stress by activating Nrf2/GPx4 pathway","authors":"Islam Ahmed Abdelmawgood , Mohamed A. Kotb , Hassan Samy Hassan , Abeer Mahmoud Badr , Noha A. Mahana , Ayman Saber Mohamed , Marina Lotfy Khalaf , Nouran Khalid Mostafa , Basant Ehab Diab , Nada Nasser Ahmed , Zeinab Abdeltawab Alamudddin , Laila Alhoussin Soliman , Mariam Khaled Fahim , Asmaa Elsayed Abdelkader","doi":"10.1016/j.resp.2024.104348","DOIUrl":"10.1016/j.resp.2024.104348","url":null,"abstract":"<div><p>Asthma is a lung condition characterized by impaired respiratory function and an apparent infiltration of inflammatory cells. Chalcones are substances that have attracted considerable interest in the disciplines of pharmaceutical chemistry and drug discovery due to their diverse biochemical processes, such as antioxidant, anti-inflammatory, anticancer, antibacterial, and others, but whether they can be used in asthma treatment has yet to be investigated. This study aimed to investigate the immunomodulatory effect of 4 hydroxychalcone (4-HC) against allergic asthma in mice. In this research, we investigated how 4-HC affected asthmatic behavior, leukocyte infiltration, histopathological alterations, oxidative stress, immunoglobulin E (IgE) production, and airway inflammation. Moreover, ELISA and immunohistochemistry (IHC) were used to measure the expression of Nrf2 and GPx4. 4-HC treatment significantly decreased lung oxidative stress, inflammatory cell infiltration, and IgE levels. According to our findings, we imply that 4-HC may be utilized as an anti-asthmatic agent through the upregulation of Nrf2/GPx4 signaling pathway.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":"331 ","pages":"Article 104348"},"PeriodicalIF":1.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental and numerical investigation of pressure distribution in human upper airway passage before and after maxillary sinus surgery 上颌窦手术前后人体上气道压力分布的实验和数值研究

IF 1.9 4区医学

Respiratory Physiology & Neurobiology Pub Date : 2024-09-12 DOI: 10.1016/j.resp.2024.104347

Mehrab Abbasi , Hossein Amjadimanesh , Sasan Sadrizadeh , Omid Abouali

{"title":"Experimental and numerical investigation of pressure distribution in human upper airway passage before and after maxillary sinus surgery","authors":"Mehrab Abbasi , Hossein Amjadimanesh , Sasan Sadrizadeh , Omid Abouali","doi":"10.1016/j.resp.2024.104347","DOIUrl":"10.1016/j.resp.2024.104347","url":null,"abstract":"<div><p>Sinusitis, a common disease of the maxillary sinus, is initially managed with saline solution and medication, resulting in the resolution of symptoms within a few days in most cases. However, Functional Endoscopic Sinus Surgeries are recommended if pharmacological treatments prove ineffective. This research aims to investigate the effects of maxillary sinus surgery on the airflow field, pressure distribution within the nasal cavity, and overall ventilation. This study utilized a three-dimensional realistic nasal cavity model constructed from CT images of a healthy adult. Virtual surgery including uncinectomy with Middle Meatal Antrostomy, two standard procedures performed during such surgeries, was performed on the model under the supervision of a clinical specialist. Two replicas representing pre- and post-operative cases were created using 3D printing for experimental purposes. Various breathing rates ranging from 3.8 to 42.6 L/min were examined through experimental and numerical simulations. To ensure the accuracy of the numerical simulations, the results were compared to measured pressure data, showing a reasonable agreement between the two. The findings demonstrate that uncinectomy and Middle Meatal Antrostomy significantly enhance the ventilation of the maxillary sinuses. Furthermore, increasing inspiratory rates leads to further improvements in ventilation. The static pressure distribution within the maxillary sinuses remains relatively uniform, except in regions close to the sinus ostium, even after surgical intervention.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":"331 ","pages":"Article 104347"},"PeriodicalIF":1.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0