Respiratory Physiology & Neurobiology最新文献

{"title":"Effect of body position during weaning from total liquid ventilation in piglets","authors":"Alexandru Panaitescu ,&nbsp;Christophe Morin ,&nbsp;Mouhamed Amin Boudaouara ,&nbsp;Sarah-Gabrielle Taillandier-Pensarini ,&nbsp;Nathalie Samson ,&nbsp;Jean-Paul Praud ,&nbsp;Philippe Micheau ,&nbsp;Etienne Fortin-Pellerin","doi":"10.1016/j.resp.2024.104338","DOIUrl":"10.1016/j.resp.2024.104338","url":null,"abstract":"<div><h3>Objective</h3><p>To determine if change in body position improves oxygen requirements and respiratory mechanics during the transition from total liquid ventilation (TLV) to gas ventilation.</p></div><div><h3>Methods</h3><p>Fourteen piglets underwent TLV, followed by a 2-hour weaning period under conventional gas ventilation. Subjects were randomized to the experimental group (Rotating – R), that was in prone position between the 10th and 30th minute of weaning, or to the static control group (Supine – S).</p></div><div><h3>Results</h3><p>Oxygenation index was lower in the R group at 30 minutes in prone position than that in the S group (1.9 [1.6; 2.8] vs 3.5 [3.1; 5.1], p = 0.001). This difference disappeared when subjects resumed the supine position (4.2 [3.8; 4.7] and 4.7 [3.8; 5.4], p = 0.4, for the R and S groups, respectively). The change in body position did not affect respiratory system compliance or inspiratory capacity.</p></div><div><h3>Conclusion</h3><p>Prone position improved oxygenation during weaning from TLV. The effect disappeared once piglets returned to the supine position.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1569904824001319/pdfft?md5=649ca5535e39476d95c2ab3bbfceffaf&pid=1-s2.0-S1569904824001319-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of endogenous circadian clock function in mice alters respiratory cycle timing in a time of day- and sex-specific manner","authors":"Aaron A. Jones ,&nbsp;Deanna M. Arble","doi":"10.1016/j.resp.2024.104337","DOIUrl":"10.1016/j.resp.2024.104337","url":null,"abstract":"<div><p>Resting breathing and ventilatory chemoreflexes are regulated in a 24-hr manner by the endogenous circadian clock. However, it is unclear how circadian biology influences different phases of the breath-to-breath respiratory cycle which are predominantly controlled by pontomedullary regions of the brainstem. Here, we performed whole-body plethysmography during quiet wakefulness in young adult male and female mice lacking the core clock gene Brain and Muscle Arnt-like 1 (BMAL1) to determine the extent to which the molecular clock affects respiratory cycle timing and ventilatory airflow mechanics. Breath waveform analysis revealed that male BMAL1 knockout (KO) mice exhibit time of day-specific differences in inspiratory and expiratory times, total cycle length, end inspiratory pause, relaxation time, and respiratory rate compared to wild-type littermates. Notably, changes in respiratory pattern were not observed in female BMAL1 KO mice when compared to wild-type females. Additionally, BMAL1 deficiency did not disrupt overall minute ventilation or peak airflow in either sex, suggesting total ventilatory function during quiet wakefulness is preserved. Taken together, these findings indicate that genetic disruption of the circadian clock in mice elicits sex-specific changes in respiratory cycle timing.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive ventilation at the boundary of viability: A respiratory pathophysiology study of infants born between 22 and 24 weeks of gestation","authors":"Theodore Dassios ,&nbsp;Richard Sindelar ,&nbsp;Emma Williams ,&nbsp;Ourania Kaltsogianni ,&nbsp;Anne Greenough","doi":"10.1016/j.resp.2024.104339","DOIUrl":"10.1016/j.resp.2024.104339","url":null,"abstract":"<div><h3>Background</h3><p>Invasive ventilation of infants born before 24 weeks of gestation is critical for survival and long-term respiratory outcomes, but currently there is a lack of evidence to guide respiratory management. We aimed to compare respiratory mechanics and gas exchange in ventilated extremely preterm infants born before and after 24 weeks of gestation.</p></div><div><h3>Methods</h3><p>Secondary analysis of two prospective observational cohort studies, comparing respiratory mechanics and indices of gas exchange in ventilated infants born at 22–24 weeks of gestation (<em>N</em>=14) compared to infants born at 25–27 weeks (<em>N</em>=37). The ventilation/perfusion ratio (V_A/Q), intrapulmonary shunt, alveolar dead space (V_Dalv) and adjusted alveolar surface area (S_A) were measured in infants born at the Neonatal Unit of King’s College Hospital NHS Foundation Trust, London, UK.</p></div><div><h3>Results</h3><p>Compared to infants of 25–27 weeks, infants of 22–24 weeks had higher median (IQR) intrapulmonary shunt [18 (4 - 29) % vs 8 (2 – 12) %, p=0.044] and higher V_Dalv [0.9 (0.6 – 1.4) vs 0.6 (0.5 – 0.7) ml/kg, p=0.036], but did not differ in V_A/Q. Compared to infants of 25–27 weeks, the infants of 22–24 weeks had a lower adjusted S_A [509 (322- 687) vs 706 (564 - 800) cm², p=0.044]. The infants in the two groups did not differ in any of the indices of respiratory mechanics.</p></div><div><h3>Conclusion</h3><p>Ventilated infants born before 24 completed weeks of gestation exhibit abnormal gas exchange, with higher alveolar dead space and intrapulmonary shunt and a decreased alveolar surface area compared to extreme preterms born after 24 weeks of gestation.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1569904824001320/pdfft?md5=3ee009b3a9626e7938120d0b544b5944&pid=1-s2.0-S1569904824001320-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the pontine respiratory group in the suppression of cough by codeine in cats","authors":"Michal Simera,&nbsp;Denisa Berikova,&nbsp;Ole-Jacob Hovengen,&nbsp;Marek Laheye,&nbsp;Marcel Veternik,&nbsp;Lukas Martvon ,&nbsp;Zuzana Kotmanova,&nbsp;Lucia Cibulkova,&nbsp;Ivan Poliacek","doi":"10.1016/j.resp.2024.104326","DOIUrl":"10.1016/j.resp.2024.104326","url":null,"abstract":"<div><p>Codeine was microinjected into the area of the Kölliker-Fuse nucleus and the adjacent lateral parabrachial nucleus, within the pontine respiratory group in 8 anesthetized cats. Electromyograms (EMGs) of the diaphragm (DIA) and abdominal muscles (ABD), esophageal pressures (EP), and blood pressure were recorded and analyzed during mechanically induced tracheobronchial cough. Unilateral microinjections of 3.3 mM codeine (3 injections, each 37 ± 1.2 nl) had no significant effect on the cough number. However, the amplitudes of the cough ABD EMG, expiratory EP and, to a lesser extent, DIA EMG were significantly reduced. There were no significant changes in the temporal parameters of the cough. Control microinjections of artificial cerebrospinal fluid in 6 cats did not show a significant effect on cough data compared to those after codeine microinjections. Codeine-sensitive neurons in the rostral dorsolateral pons contribute to controlling cough motor output, likely through the central pattern generator of cough.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovery of ventilatory and metabolic responses to hypoxia in neonatal rats after chronic hypoxia","authors":"Ryan W. Bavis,&nbsp;Darya I. Lee ,&nbsp;Annie C. Kinnally,&nbsp;Payton E. Buxton","doi":"10.1016/j.resp.2024.104317","DOIUrl":"10.1016/j.resp.2024.104317","url":null,"abstract":"<div><p>Chronic hypoxia (CH) during postnatal development attenuates the hypoxic ventilatory response (HVR) in mammals, but there are conflicting reports on whether this plasticity is permanent or reversible. This study tested the hypothesis that CH-induced respiratory plasticity is reversible in neonatal rats and investigated whether the initial plasticity or recovery differs between sexes. Rat pups were exposed to 3 d of normobaric CH (12 % O₂) beginning shortly after birth. Ventilation and metabolic CO₂ production were then measured in normoxia and during an acute hypoxic challenge (12 % O₂) immediately following CH and after 1, 4–5, and 7 d in room air. CH pups hyperventilated when returned to normoxia immediately following CH, but normoxic ventilation was similar to age-matched control rats within 7 d after return to room air. The early phase of the HVR (minute 1) was only blunted immediately following the CH exposure, while the late phase of the HVR (minute 15) remained blunted after 1 and 4–5 d in room air; recovery appeared complete by 7 d. However, when normalized to CO₂ production, the late phase of the hypoxic response recovered within only 1 d. The initial blunting of the HVR and subsequent recovery were similar in female and male rats. Carotid body responses to hypoxia (<em>in vitro</em>) were also normal in CH pups after approximately one week in room air. Collectively, these data indicate that ventilatory and metabolic responses to hypoxia recover rapidly in both female and male neonatal rats once normoxia is restored following CH.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung function parameters are associated with acute mountain sickness and are improved at high and extreme altitude","authors":"Reto Reiser ,&nbsp;Anne-Kathrin Brill ,&nbsp;Christos T. Nakas ,&nbsp;Urs Hefti ,&nbsp;David Berger ,&nbsp;Eveline Perret Hoigné ,&nbsp;Hans-Joachim Kabitz ,&nbsp;Tobias M. Merz ,&nbsp;Jacqueline Pichler Hefti","doi":"10.1016/j.resp.2024.104318","DOIUrl":"10.1016/j.resp.2024.104318","url":null,"abstract":"<div><p>At altitude, factors such as decreased barometric pressure, low temperatures, and acclimatization might affect lung function.</p><p>The effects of exposure and acclimatization to high-altitude on lung function were assessed in 39 subjects by repetitive spirometry up to 6022 m during a high-altitude expedition. Subjects were classified depending on the occurrence of acute mountain sickness (AMS) and summit success to evaluate whether lung function relates to successful climb and risk of developing AMS.</p><p>Peak expiratory flow (PEF), forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) increased with progressive altitude (max. +20.2 %pred, +9.3 %pred, and +6.7 %pred, all p&lt;0.05). Only PEF improved with acclimatization (BC1 vs. BC2, +7.2 %pred, p=0.044). At altitude FEV1 (p=0.008) and PEF (p&lt;0.001) were lower in the AMS group.</p><p>The risk of developing AMS was associated with lower baseline PEF (p&lt;0.001) and longitudinal changes in PEF (p=0.008) and FEV1 (p&lt;0.001). Lung function was not related to summit success (7126 m). Improvement in PEF after acclimatization might indicate respiratory muscle adaptation.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airway mechanics alters generation of cough motor pattern","authors":"Ivan Poliacek ,&nbsp;Marcel Veternik ,&nbsp;Lukas Martvon ,&nbsp;Zuzana Kotmanova ,&nbsp;Lucia Babalova ,&nbsp;Lucia Cibulkova ,&nbsp;Denisa Berikova ,&nbsp;Jana Plevkova ,&nbsp;Teresa Pitts ,&nbsp;Silvia Adzimova ,&nbsp;Michal Simera","doi":"10.1016/j.resp.2024.104315","DOIUrl":"10.1016/j.resp.2024.104315","url":null,"abstract":"<div><p>Effects of sequential increase in airway resistance: no, low (5 kPa.s/l), high (24 kPa.s/l), and complete block in the inspiratory or expiratory phase of mechanically induced cough on the cough motor pattern were studied in 16 anesthetized (pentobarbital) spontaneously breathing cats (3.70±0.15 kg, 11♂, 5♀). Esophageal pressure and electromyographic activities of the diaphragm during inspiration and abdominal muscles during expiration were analyzed. No significant changes in the number of coughs occurred. Inspiratory occlusion caused a prolongation of cough inspiratory phase, cough inspiratory diaphragm activity, and all cough-related activity. Inspiratory occlusion along with high resistance increased inspiratory esophageal pressure amplitude, total cough cycle duration and the time between maximum activity of the diaphragm and abdominal muscles. High expiratory resistance and occlusion resulted in increased cough expiratory esophageal pressure amplitude, a longer active portion of cough expiration, and cough abdominal activity. Expiratory occlusion also prolonged cough expiratory phase, all cough activity, and total cough cycle. Significantly increased airway resistance and occlusion induce secondary, in addition to mechanical, changes in cough by significantly modulating the generated cough motor pattern. A certain level of resistance appears to be successfully compensated, resulting in minimal changes in coughing characteristics, including expiratory airflow and the rising time of the airflow. Afferent feedback from the respiratory tract, particularly volume feedback, represents a significant factor in modulating cough, mainly under various pathological conditions in the respiratory system.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141917368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difference in expiratory flow limitations development in normoxia and hypoxia in healthy individuals","authors":"Antoine Raberin ,&nbsp;Giorgio Manferdelli,&nbsp;Forrest Schorderet,&nbsp;Yannick Monnier,&nbsp;Ruben Tato Perez,&nbsp;Nicolas Bourdillon,&nbsp;Grégoire P. Millet","doi":"10.1016/j.resp.2024.104316","DOIUrl":"10.1016/j.resp.2024.104316","url":null,"abstract":"<div><p>The present study investigated the maintenance/repeatability of expiratory flow limitation (EFL) between normoxia and hypoxia.</p><p>Fifty-one healthy active individuals (27 men and 24 women) performed a lung function test and a maximal incremental cycling test in both normoxia and hypoxia (inspired oxygen fraction = 0.14) on two separate visits.</p><p>During exercise in normoxia, 28 participants exhibited EFL (55 %). In hypoxia, another cohort of 28 participants exhibited EFL. The two groups only partly overlapped.</p><p>Individuals with EFL only in normoxia reported lower maximal ventilation values in hypoxia than in normoxia (n=5; −13.5 ± 7.8 %) compared to their counterparts with EFL only in hypoxia (n=5; +6.7 ± 6.3 %) or without EFL (n=18; +5.1 ± 10.3 %) (p=0.004 and p&lt;0.001, respectively).</p><p>EFL development may be induced by different mechanisms in hypoxia vs. normoxia since the individuals who exhibited flow limitation were not the same between the two environmental conditions. This change seems influenced by the magnitude of the maximal ventilation change.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1569904824001095/pdfft?md5=8fb0a78dbac47078e7fb442521270ba6&pid=1-s2.0-S1569904824001095-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardio-respiratory coupling and myocardial recovery in heart failure with reduced ejection fraction","authors":"Michiaki Nagai,&nbsp;Hallum Ewbank,&nbsp;Sunny S. Po,&nbsp;Tarun W. Dasari","doi":"10.1016/j.resp.2024.104313","DOIUrl":"10.1016/j.resp.2024.104313","url":null,"abstract":"<div><h3>Introduction</h3><p>The interaction between the cardiovascular and respiratory systems in healthy subjects is determined by the autonomic nervous system and reflected in respiratory sinus arrhythmia. Recently, another pattern of cardio-respiratory coupling (CRC) has been proposed linking synchronization of heart and respiratory system. However, CRC has not been studied precisely in heart failure (HF) with reduced ejection fraction (EF) (HFrEF) according to the myocardial recovery.</p></div><div><h3>Methods</h3><p>10-min resting electrocardiography measurements were performed in persistent HFrEF patients (n=40) who had a subsequent left ventricular EF (LVEF) of ≤ 40 %, HF with recovered EF patients (HFrecEF) (n=41) who had a subsequent LVEF of &gt; 40 % and healthy controls (n=40). Respiratory frequency, respiratory rate, CRC index, time-domain, frequency-domain and nonlinear heart rate variability indices were obtained using standardized software-Kubios™. CRC index was defined as respiratory high-frequency peak minus heart rate variability high-frequency peak.</p></div><div><h3>Results</h3><p>Respiratory rate was positively correlated with high-frequency (HF) peak (Hz) in both persistent HFrEF group (p&lt;0.001) and HFrecEF group (p&lt;0.001), while respiratory rate was negatively correlated with HF power (ms²) in the healthy controls (p&lt;0.05). CRC index was lowest in the persistent HFrEF group followed by HFrecEF and was high in healthy controls (0.008 vs 0.012 vs 0.056 Hz, p=0.03).</p></div><div><h3>Conclusion</h3><p>CRC index was lowest in patients with impaired myocardial recovery, which indicates that cardio-respiratory synchrony is stronger in persistent HFrEF. This may represent a higher HF peak (Hz)/lower HF power (ms²) and abnormal sympathovagal balance in persistent HFrEF group compared to healthy controls. Further work is underway to tests this hypothesis and determine the utility of CRC index in HF phenotypes and its utility as a potential biomarker of response with neuromodulation.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of positive allosteric modulation and orthosteric agonism of dopamine D2-like receptors on respiration in mouse models of Rett syndrome","authors":"Sebastian N. Maletz ,&nbsp;Brandon T. Reid ,&nbsp;David M. Baekey ,&nbsp;Jessica R. Whitaker-Fornek ,&nbsp;Jordan T. Bateman ,&nbsp;Keiko Arakawa ,&nbsp;John M. Bissonnette ,&nbsp;Erica S. Levitt","doi":"10.1016/j.resp.2024.104314","DOIUrl":"10.1016/j.resp.2024.104314","url":null,"abstract":"<div><p>Rett syndrome (RTT) is an autism spectrum disorder caused by loss-of-function mutations in the methyl-CPG-binding protein 2 (<em>Mecp2</em>) gene. Frequent apneas and irregular breathing are prevalent in RTT, and also occur in rodent models of the disorder, including <em>Mecp2</em>^Bird and <em>Mecp2</em>^R168X mice. Sarizotan, a serotonin 5-HT1a and dopamine D2-like receptor agonist, reduces the incidence of apneas and irregular breathing in mouse models of RTT (Abdala et al., 2014). Targeting the 5HT1a receptor alone also improves respiration in RTT mice (Levitt et al., 2013). However, the contribution of D2-like receptors in correcting these respiratory disturbances remains untested. PAOPA, a dopamine D2-like receptor positive allosteric modulator, and quinpirole, a dopamine D2-like receptor orthosteric agonist, were used in conjunction with whole-body plethysmography to evaluate whether activation of D2-like receptors is sufficient to improve breathing disturbances in female heterozygous <em>Mecp2</em>^Bird/+ and <em>Mecp2</em>^R168X/+ mice. PAOPA did not significantly change apnea incidence or irregularity score in RTT mice. PAOPA also had no effect on the ventilatory response to hypercapnia (7 % CO₂). In contrast, quinpirole reduced apnea incidence and irregularity scores and improved the hypercapnic ventilatory response in <em>Mecp2</em>^R168X/+ and <em>Mecp2</em>^Bird/+ mice, while also reducing respiratory rate. These results suggest that D2-like receptors could contribute to the positive effects of sarizotan in the correction of respiratory abnormalities in Rett syndrome. However, positive allosteric modulation of D2-like receptors alone was not sufficient to evoke these effects.</p></div>","PeriodicalId":20961,"journal":{"name":"Respiratory Physiology & Neurobiology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}