Reactive & Functional Polymers最新文献_第5页

Influence of different experimental conditions on bond strength of self-adhesive synthetic polymer system hydrogels for biological applications

IF 4.5 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-03-12 DOI: 10.1016/j.reactfunctpolym.2025.106264

Sebastian Romero-Gilbert , Héctor Díaz-Chamorro , Oscar G. Marambio , Julio Sánchez , Rudy Martin-Trasancos , Matías Inostroza , Claudio García-Herrera , Guadalupe del C. Pizarro

{"title":"Influence of different experimental conditions on bond strength of self-adhesive synthetic polymer system hydrogels for biological applications","authors":"Sebastian Romero-Gilbert , Héctor Díaz-Chamorro , Oscar G. Marambio , Julio Sánchez , Rudy Martin-Trasancos , Matías Inostroza , Claudio García-Herrera , Guadalupe del C. Pizarro","doi":"10.1016/j.reactfunctpolym.2025.106264","DOIUrl":"10.1016/j.reactfunctpolym.2025.106264","url":null,"abstract":"<div><div>Poly(2-hydroxyethyl methacrylate) P(HEMA) is a biocompatible and hydrophilic polymer with significant potential for drug delivery and various biomedical applications. The main goal is to adapt these materials for biological applications. This work contributes to designing an adhesive polymeric system based on hydrophilic polymers using vinyl monomers via radical polymerization. The hydrogels were produced via free radical polymerization in an aqueous environment, with variations in the initial experimental conditions, including different ratios of initial monomers and the cross-linking agent. This was done to analyze the strength of the self-adhesive bond of synthetic hydrogels for potential biological applications. The functional groups of the hydrophilic monomers were employed to explore possible chemical modifications in the environment (adhesive properties) through physical interactions, such as hydrogen bonding and van der Waals forces between the polymer chains. This could allow for the incorporation of active biomolecules, potentially enhancing physical bonding through hydrogen bridges between polymer chains. These hydrogels have been characterized by their thermal stability, swelling behavior, and adhesive strength in a wet medium. The hydrogel demonstrated the highest adhesive strength at a 2:1 feed monomer ratio with 0.5 mol-% of <em>N</em>'<em>N</em>-methylene bisacrylamide (MBA) in a damp medium, indicating significantly improved adhesive properties compared to other MBA percentages. Moreover, a reduction in hydrogel swelling correlated with enhanced adhesion, showing more than a 6.5-fold increase in adhesion compared to the 1:1 feed monomer ratio at 0.5 mol-% MBA and an 18-fold increase compared to the 1:1 feed monomer ratio at 0.1 mol-% MBA.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"213 ","pages":"Article 106264"},"PeriodicalIF":4.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrosilylation of solution-polymerized styrene-butadiene rubber with triphenylsilane

IF 4.5 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-03-11 DOI: 10.1016/j.reactfunctpolym.2025.106258

Hanyu Li , Ling Liu , Yuxi Zhang , Xue Wang , Junquan Meng , Lin Xu , Liqun Zhang

引用次数: 0

Room temperature photolytic C-H insertion of azidoformate for virucidal polypropylene non-woven fabric with enhanced durability

IF 4.5 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-03-11 DOI: 10.1016/j.reactfunctpolym.2025.106262

Sevin Oh , Jiyoon Cho , Changha Lee , Sung Chul Hong

{"title":"Room temperature photolytic C-H insertion of azidoformate for virucidal polypropylene non-woven fabric with enhanced durability","authors":"Sevin Oh , Jiyoon Cho , Changha Lee , Sung Chul Hong","doi":"10.1016/j.reactfunctpolym.2025.106262","DOIUrl":"10.1016/j.reactfunctpolym.2025.106262","url":null,"abstract":"<div><div>Polypropylene non-woven fabrics (PNWs) are widely utilized in sectors such as healthcare and filtration due to their favorable properties, including low density, chemical resistance, and cost-effectiveness. However, their use in personal protective equipment (PPE), particularly during the COVID-19 pandemic, highlighted limitations such as the risk of viral adherence and secondary transmission, as well as concerns regarding single-use waste management. This study presents a method for developing durable antiviral PNWs by covalently grafting Polyquaternium-11 (PQ), a biocompatible cationic polymer, onto PNW surfaces using tri(ethylene glycol)di(azidoformate) as a crosslinker through photolytic C-H insertion at ambient temperature. The process was confirmed via FT-IR, while thermal, crystallinity, and tensile characterization indicated stable integration of PQ without compromising the mechanical properties of the PNW. The modified PNW exhibited significant antiviral and antibacterial performance, achieving 98.97% virus inactivation and 99.20% inhibition of <em>S. aureus</em>. This study demonstrates an effective approach for creating antimicrobial PNWs with potential applications in medical, hygiene, and PPE products.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"212 ","pages":"Article 106262"},"PeriodicalIF":4.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

1,5-hexadiene and 1,7-octadiene polymerization by linked-half titanocene catalysts and thermal stability of cycloolefin polymer containing pendant vinyl group

IF 4.5 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-03-11 DOI: 10.1016/j.reactfunctpolym.2025.106263

Tomoyuki Toda , Jin Iwasaki , Hitomi Toda , Katsuhiko Takenaka , Kei Nishii

{"title":"1,5-hexadiene and 1,7-octadiene polymerization by linked-half titanocene catalysts and thermal stability of cycloolefin polymer containing pendant vinyl group","authors":"Tomoyuki Toda , Jin Iwasaki , Hitomi Toda , Katsuhiko Takenaka , Kei Nishii","doi":"10.1016/j.reactfunctpolym.2025.106263","DOIUrl":"10.1016/j.reactfunctpolym.2025.106263","url":null,"abstract":"<div><div>We investigated the coordination polymerization of non-conjugated α,ω-dienes, specifically 1,5-hexadiene (HD) and 1,7-octadiene (OD), using linked-half titanocene catalysts. The two catalysts examined were a pentamethylcyclopentadienylamido-ligated titanocene (complex <strong>1</strong>) and an indenylamido-ligated titanocene (complex <strong>2</strong>), both were combined with dried modified methylaluminoxane. HD polymerization with both catalysts yielded cross-linked polymers in 24 h. Polymerization of HD with complex <strong>1</strong> for 5 min yielded soluble polymers with a unimodal molecular weight distribution and a cyclization selectivity of 70 %. In contrast, OD polymerization was slower than HD polymerization even though soluble polymers were obtained in 24 h as well. PolyODs with a molecular weight of more than 10 kg/mol were obtained with an approximate 1:1 ratio of cyclization to monomer-insertion whether complex <strong>1</strong> or <strong>2</strong> was used. The effect of solvents was studied, and the cyclization selectivity was found to decrease when a solvent with a low dielectric constant, i.e. hexane, was used (66 % of the pendant vinyl group). The glass-transition temperatures of polyOD were found to vary from −26 °C to −3 °C depending on its microstructure, and the melting temperature of the sample containing 73 % cyclic structure was observed to be 159 °C. Furthermore, the thermal stability of polyOD was investigated through heating experiments both in film and in solution.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"213 ","pages":"Article 106263"},"PeriodicalIF":4.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile preparation of recyclable porous poly(glycidyl methacrylate) microsphere with in-situ grown UiO-66-NH2 MOF for adsorption of fluoroquinolone antibiotics

IF 4.5 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-03-09 DOI: 10.1016/j.reactfunctpolym.2025.106261

Yipeng Zhang , Yani Wang , Kewei Wang , Xiaopeng Xiong

{"title":"Facile preparation of recyclable porous poly(glycidyl methacrylate) microsphere with in-situ grown UiO-66-NH2 MOF for adsorption of fluoroquinolone antibiotics","authors":"Yipeng Zhang , Yani Wang , Kewei Wang , Xiaopeng Xiong","doi":"10.1016/j.reactfunctpolym.2025.106261","DOIUrl":"10.1016/j.reactfunctpolym.2025.106261","url":null,"abstract":"<div><div>The persistent presence of antibiotic contaminants, such as fluoroquinolones (FQs), in aquatic environments poses significant environmental risks. In this study, a porous poly(glycidyl methacrylate) (PPGMA) microsphere adsorbent was designed for the efficient removal of FQs. Acrylate monomers were dispersed in water to prepare an oil-in-water high internal phase emulsion, which was subsequently subjected to ultraviolet (UV) irradiation for 3 min to prepare the microsphere with high yield. To template the porous structure, cyclohexane, a poor solvent for the polymer, was introduced into the initial monomer oil phase, and its influence on the evolution of porous morphology was systematically investigated. Thereafter, the porous microsphere was modified through grafting with polyethyleneimine to facilitate the in-situ growth of a metal-organic framework, UiO-66-NH<sub>2</sub>. The modification progress was monitored, and the final UiO@PPGMA microspheres were comprehensively characterized. Based on adsorption kinetics and thermodynamics, the microsphere containing only 2.78 % UiO-66-NH<sub>2</sub> exhibits significantly enhanced adsorption rate and capacity, which can be attributed to the in-situ grown UiO-66-NH<sub>2</sub> nanoparticles. Furthermore, the UiO@PPGMA microsphere can be easily regenerated, allowing it to be packed in a column for cyclic fixed-bed adsorption. Consequently, our results demonstrate a facile strategy for preparing porous microsphere adsorbents, which may have promising applications in the removal of antibiotic contaminants from water sources.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"212 ","pages":"Article 106261"},"PeriodicalIF":4.5,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HA/HTC-PVA coated with superphosphate to prepare slow-release phosphorus fertilizer: For hydroponic plant growth

IF 4.5 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-03-08 DOI: 10.1016/j.reactfunctpolym.2025.106257

Shuo Zhang, Shaoqi Ma, Qi Zhu

{"title":"HA/HTC-PVA coated with superphosphate to prepare slow-release phosphorus fertilizer: For hydroponic plant growth","authors":"Shuo Zhang, Shaoqi Ma, Qi Zhu","doi":"10.1016/j.reactfunctpolym.2025.106257","DOIUrl":"10.1016/j.reactfunctpolym.2025.106257","url":null,"abstract":"<div><div>In recent years, the low fertilizer utilization efficiency is prominent in the soil, and the application of fertilizer to hydroponic plants has also encountered the same problem. Due to the continuous accumulation of soluble fertilizers in the water, it is necessary to frequently change the water to ensure the appropriate nutrient concentration.To improve the utilization rate of nutrients,in this study, the core particles were prepared by bentonite and superphosphate, and the slow-release film raw materials hydrothermal carbon(<em>HTC</em>)and humic acid(<em>HA</em>)were prepared by resource utilization of agricultural waste rape stalks. Together with polyvinyl alcohol(PVA), the slow-release film was prepared by in-situ polymerization, and the slow-release particles were obtained by impregnation. The material was characterized and the results showed that hydrothermal carbon, humic acid and polyvinyl alcohol could improve the water absorption and swelling performance of the slow-release materials, and had a good slow-release effect on phosphorus(<em>P</em>)release. The initial phosphorus release rate was 10.2 % on the first day, and the nutrient release rate was 73.6 % on the 28th day, which met the slow-release standard of fertilizer. Therefore, the slow-release material has the potential to be widely used in aquatic plant cultivation.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"212 ","pages":"Article 106257"},"PeriodicalIF":4.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Main-chain hybrid azobenzene-1,2,3-triazoleoligo(dimethylsiloxane) liquid-crystalline photoactive copolymers 主链混合偶氮苯-1,2,3-三唑啉基（二甲基硅氧烷）液晶光活性共聚物

IF 4.5 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-03-08 DOI: 10.1016/j.reactfunctpolym.2025.106256

Dmitry Migulin , Kseniya Bezlepkina , Mikhail Buzin , Artem Bakirov

{"title":"Main-chain hybrid azobenzene-1,2,3-triazoleoligo(dimethylsiloxane) liquid-crystalline photoactive copolymers","authors":"Dmitry Migulin , Kseniya Bezlepkina , Mikhail Buzin , Artem Bakirov","doi":"10.1016/j.reactfunctpolym.2025.106256","DOIUrl":"10.1016/j.reactfunctpolym.2025.106256","url":null,"abstract":"<div><div>The development of well-designed anisotropically ordered photoactive liquid-crystalline polymers has potential in the development of a number of areas related to high-tech light-responsive materials and devices, including photonics, optical switching, image storage, soft actuators, etc.</div><div>The synthesis and characterization of a new type of photoactive linear main chain liquid-crystalline hybrid copolymers with regularly alternating molecular architectures is achieved for the first time through the use of azide-alkyne cycloaddition chemical reactions between a series of alkyne-terminated azobenzene molecules and azide-functional oligo(dimethylsiloxane) telechelics.</div><div>The present investigation encompasses an array of chemical structures and molecular morphologies, thermodynamic properties, thermotropic liquid-crystalline and photoisomerization behaviors, and the influence of the azo-copolymer molecular composition on the polymers' microstructure, morphologies, and propensity towards thermotropic self-assembly into lamellar spherulitic structures.</div><div>The kinetics of non-degradative reversible <em>E-Z</em> photoisomerization transitions and the relationship between the molecular composition of the polymers and their photoinduced isomerization behavior were investigated.</div><div>The morphology and degree of anisotropy of physically cross-linked LCPs fibers prepared by the simple melt spinning method were studied.</div><div>The results obtained provide important insights into the structure-property relationship of photoactive main chain hybrid azobenzene-siloxane LCPs, which are useful for the design of novel advanced photoactive polymers.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"212 ","pages":"Article 106256"},"PeriodicalIF":4.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zwitterion polymer-modified graphene oxides enhance antibacterial activity with improved biocompatibility and osteogenesis: An in vitro study

IF 4.5 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-03-07 DOI: 10.1016/j.reactfunctpolym.2025.106229

Liying Peng , Li Chang , Rushui Bai , Qiannan Sun , Yunfan Zhang , Hongliang Liu , Chuao Ma , Jiuxiang Lin , Bing Han

{"title":"Zwitterion polymer-modified graphene oxides enhance antibacterial activity with improved biocompatibility and osteogenesis: An in vitro study","authors":"Liying Peng , Li Chang , Rushui Bai , Qiannan Sun , Yunfan Zhang , Hongliang Liu , Chuao Ma , Jiuxiang Lin , Bing Han","doi":"10.1016/j.reactfunctpolym.2025.106229","DOIUrl":"10.1016/j.reactfunctpolym.2025.106229","url":null,"abstract":"<div><div>This study utilized surface-initiated atom transfer radical polymerization (SI-ATRP) to graft the zwitterionic polymer poly(carboxybetaine methacrylate) (PCBMA) onto graphene oxide (GO) (GO/PCBMA), enhancing its physicochemical properties and biomedical potential. X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR) confirmed successful grafting, while thermogravimetric analysis (TGA) indicated a PCBMA loading of 0.54 mg/mg GO. Gel permeation chromatography (GPC) showed a monomer conversion efficiency of ∼40 %, demonstrating good polymerization control. GO/PCBMA exhibited superior antibacterial performance, reducing <em>Streptococcus mutans</em> viability by 87.6 % at 80 μg/mL within 5 h, while GO required 160 μg/mL to achieve a 78.3 % reduction. Long-term antibacterial effects were further validated through three-day colony-forming unit (CFU) counts. GO/PCBMA also improved L929 fibroblast viability and promoted osteogenic differentiation in human bone marrow mesenchymal stem cells (hBMMSCs), as evidenced by increased alkaline phosphatase (ALP) activity and osteocalcin (OCN) expression. These findings highlight GO/PCBMA as a promising material for applications requiring both antibacterial activity and biocompatibility, particularly for long-term biomedical implants. This study provides insights for the development of multifunctional graphene oxide-based biomaterials.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"212 ","pages":"Article 106229"},"PeriodicalIF":4.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-performance thermoplastic polyimide enabled by ketone-based diamine monomer

IF 4.5 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-03-05 DOI: 10.1016/j.reactfunctpolym.2025.106230

Qi-Yuan Du , Wei-Peng Chen , Hao Guo , Zhi Wang , Xiao-Kun Qiu , Wan-Yi Tan , Yonggang Min , Yidong Liu

{"title":"High-performance thermoplastic polyimide enabled by ketone-based diamine monomer","authors":"Qi-Yuan Du , Wei-Peng Chen , Hao Guo , Zhi Wang , Xiao-Kun Qiu , Wan-Yi Tan , Yonggang Min , Yidong Liu","doi":"10.1016/j.reactfunctpolym.2025.106230","DOIUrl":"10.1016/j.reactfunctpolym.2025.106230","url":null,"abstract":"<div><div>Thermoplastic polyimide (TPI) as adhesive can meet the requirements of flexible copper clad laminates (FCCLs) applied under extreme condition. Incorporating flexible groups, asymmetric structures and bulky side groups into the main chain, and copolymerization are common ways to achieve thermoplasticity, through reducing the rigidity of polymer chains or intermolecular interaction. However, it induces a trade-off between thermoplasticity and thermal dimensional stability as well as mechanical property. Furthermore, the adhesion strength between TPI film and copper foil is highly desirable in FCCL. Herein, we develop a ketone-based diamine 1,3-phenylenebis((3′-amino-[1,1′-biphenyl]-4-yl)methanone) (Ph-BiAmMe) to afford copolymerized TPI with 4,4′-oxydianiline (ODA) and 3,3′,4,4’-Biphenyltetracarboxylic dianhydride (BPDA). As for thermoplasticity, flexible linkages such as ether and ketone enhance the movability of polymer chains, and copolymerization weakens the intermolecular interaction between polymer chains to some extent. Furthermore, the incorporation of Ph-BiAmMe promotes denser chain packing and stronger CTC effect, thereby maintaining good thermal dimensional stability and mechanical properties. Simultaneously, ketone moieties enhance the peel strength of TPI when bonded with copper. Based on this strategy, the as-prepared TPI shows good thermoplasticity with a proper <em>T</em><sub>g</sub> of 274 °C. Meanwhile, it preserves a low CTE of 46.5 ppm K<sup>−1</sup>, high tensile strength of 117.4 MPa, elongation at break of 27.3 % and peel strength of 1.11 N mm<sup>−1</sup>.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"212 ","pages":"Article 106230"},"PeriodicalIF":4.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and post-polymerization functionalization of bromide-terminated polyesters via 1,1,3,3-tetramethylguanidine (TMG)-promoted polyesterification for biomedical applications

IF 4.5 3区工程技术

Reactive & Functional Polymers Pub Date : 2025-03-05 DOI: 10.1016/j.reactfunctpolym.2025.106248

Pengfei Shan , Yupeng Qiu , Honglei Wang , Qingyue Zhang , Tingting Xiang , Wenwen Lin , Qiji Zhou , Suyang Chen , Liwen Li , Zhenyu Yan , Yangchun Ge , Yuying Xie , Zhuochao Shen , Qilun Li , Zhongyu Li , Zhihui Li

{"title":"Synthesis and post-polymerization functionalization of bromide-terminated polyesters via 1,1,3,3-tetramethylguanidine (TMG)-promoted polyesterification for biomedical applications","authors":"Pengfei Shan , Yupeng Qiu , Honglei Wang , Qingyue Zhang , Tingting Xiang , Wenwen Lin , Qiji Zhou , Suyang Chen , Liwen Li , Zhenyu Yan , Yangchun Ge , Yuying Xie , Zhuochao Shen , Qilun Li , Zhongyu Li , Zhihui Li","doi":"10.1016/j.reactfunctpolym.2025.106248","DOIUrl":"10.1016/j.reactfunctpolym.2025.106248","url":null,"abstract":"<div><div>This study explores the synthesis of functionalized polyesters using 1,1,3,3-tetramethylguanidine (TMG)-promoted polyesterification between dicarboxylic acids and dibromides. Traditional polyesters face limitations due to a lack of functional groups, hindering their biomedical utility. The TMG-mediated method enables efficient polymerization under mild conditions, producing linear and hyperbranched polyesters with reactive bromide termini. These bromide-terminated polyesters serve as versatile precursors for post-polymerization modifications, allowing the introduction of diverse functionalities (e.g., stimuli-responsiveness, fluorescence, drug conjugation) and the creation of block copolymers, hydrogels, and polymer-drug conjugates. The platform demonstrates broad monomer compatibility, scalability, and tunability, making it promising for applications such as drug delivery, tissue engineering, and multifunctional biomaterials.</div></div>","PeriodicalId":20916,"journal":{"name":"Reactive & Functional Polymers","volume":"212 ","pages":"Article 106248"},"PeriodicalIF":4.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0