Psychophysiology最新文献_第2页

A registered report of a two-site study of variations of the flanker task: ERN experimental effects and data quality. 关于侧翼任务变化的两地研究的注册报告：ERN 实验效果和数据质量。

IF 2.9 2区心理学

Psychophysiology Pub Date : 2024-09-01 Epub Date: 2024-05-13 DOI: 10.1111/psyp.14607

Peter E Clayson, Harold A Rocha, Julia B McDonald, Scott A Baldwin, Michael J Larson

{"title":"A registered report of a two-site study of variations of the flanker task: ERN experimental effects and data quality.","authors":"Peter E Clayson, Harold A Rocha, Julia B McDonald, Scott A Baldwin, Michael J Larson","doi":"10.1111/psyp.14607","DOIUrl":"10.1111/psyp.14607","url":null,"abstract":"Error-related negativity is a widely used measure of error monitoring, and many projects are independently moving ERN recorded during a flanker task toward standardization, optimization, and eventual clinical application. However, each project uses a different version of the flanker task and tacitly assumes ERN is functionally equivalent across each version. The routine neglect of a rigorous test of this assumption undermines efforts to integrate ERN findings across tasks, optimize and standardize ERN assessment, and widely apply ERN in clinical trials. The purpose of this registered report was to determine whether ERN shows similar experimental effects (correct vs. error trials) and data quality (intraindividual variability) during three commonly used versions of a flanker task. ERN was recorded from 172 participants during three versions of a flanker task across two study sites. ERN scores showed numerical differences between tasks, raising questions about the comparability of ERN findings across studies and tasks. Although ERN scores from all three versions of the flanker task yielded high data quality and internal consistency, one version did outperform the other two in terms of the size of experimental effects and the data quality. Exploratory analyses of the error positivity (Pe) provided tentative support for the other two versions of the task over the paradigm that appeared optimal for ERN. The present study provides a roadmap for how to statistically compare psychometric characteristics of ERP scores across paradigms and gives preliminary recommendations for flanker tasks to use for ERN- and Pe-focused studies.","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adiposity influences intraindividual variability in behavioral and neuroelectric indices of attentional inhibition. 肥胖会影响注意力抑制的行为和神经电指数的个体内变异性。

IF 2.9 2区心理学

Psychophysiology Pub Date : 2024-08-30 DOI: 10.1111/psyp.14677

Jeongwoon Kim, Anne M Walk, Shelby A Keye, Christopher J Kinder, Corinne N Cannavale, Nicholas A Burd, Naiman A Khan

{"title":"Adiposity influences intraindividual variability in behavioral and neuroelectric indices of attentional inhibition.","authors":"Jeongwoon Kim, Anne M Walk, Shelby A Keye, Christopher J Kinder, Corinne N Cannavale, Nicholas A Burd, Naiman A Khan","doi":"10.1111/psyp.14677","DOIUrl":"https://doi.org/10.1111/psyp.14677","url":null,"abstract":"While overweight or obesity are thought to affect over 70% of the US population, the effects of adiposity on neurocognitive efficiency and stability remain unclear. Intra-individual variability or trial-to-trial variability (IIV) could provide insights into the influence of adiposity on neurophysiological stability. However, previous work examining the association between adiposity and IIV of cognitive outcomes is limited. Thus, this study examined the association between whole-body fat (%BF) and central tendency and IIV metrics of behavioral performance and event-related potentials. Adults (n = 320; 19-64 yrs) completed the Flanker task to assess attentional inhibition with concurrent electroencephalogram recordings to examine the N2 and P3b components. In addition to central tendency outcomes typically reported (i.e., mean accuracy and reaction time [RT]), dispersion outcomes (e.g., standard deviation [SD] of RT, P3b latency, N2 latency, etc.) were also extracted. Upon controlling for age and sex, %BF was inversely associated with (congruent: β = -.18, p = .016; incongruent: β = -.23, p < .001) accuracy. Increasing %BF was related to greater RT SD (congruent: β = .13, p = .032; incongruent: β = .23, p < .001). Furthermore, increased %BF was associated with slower P3b latencies (congruent: β = .21, p = .003; incongruent: β = .18, p = .010), and greater incongruent N2 (β = .16, p = .017) and P3b (β = .16, p = .025) latency SD. These findings suggest adiposity exerts a generalized negative influence on attentional inhibition for both measures of central tendency and dispersion across behavioral and neuroelectric indices.","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of performance contingent reward prospects flexibly adapts to more versus less specific task goals. 绩效奖励前景的效果可灵活适应更具体和更不具体的任务目标。

IF 2.9 2区心理学

Psychophysiology Pub Date : 2024-08-29 DOI: 10.1111/psyp.14678

Nathalie Liegel, Daniel Schneider, Edmund Wascher, Laura-Isabelle Klatt, Stefan Arnau

{"title":"The effect of performance contingent reward prospects flexibly adapts to more versus less specific task goals.","authors":"Nathalie Liegel, Daniel Schneider, Edmund Wascher, Laura-Isabelle Klatt, Stefan Arnau","doi":"10.1111/psyp.14678","DOIUrl":"https://doi.org/10.1111/psyp.14678","url":null,"abstract":"In some situations, for example, when we expect to gain a reward in case of good performance, goal-driven top-down attention is particularly strong. Little is known about the task specificity of such increases of top-down attention due to environmental factors. To understand to what extent performance-contingent reward prospects can result in specific and unspecific changes in cognitive processing, we here investigate reward effects under different levels of task specification. Thirty-two participants performed a visual or an auditory discrimination task cued by two consecutive visual stimuli: First, a reward cue indicated if good performance was rewarded. Second, a task cue announced either which of the two tasks would follow (precise cue) or that both tasks would follow equally likely (imprecise cue). Reward and task cue preciseness both significantly improved performance. Moreover, the response time difference between precisely and imprecisely cued trials was significantly stronger in rewarded than in unrewarded trials. These effects were reflected in event-related potential (ERP) slow wave amplitudes: Reward and preciseness both significantly enhanced the contingent negative variation (CNV) prior to the task stimulus. In an early CNV time interval, both factors also showed an interaction. A negative slow wave prior to the task cue was also significantly enhanced for rewarded trials. This effect correlated with the reward difference in response times. These results indicate that reward prospects trigger task-specific changes in preparatory top-down attention which can flexibly adapt over time and across different task requirements. This highlights that a reward-induced increase of cognitive control can occur on different specificity levels.","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perinatal adversities as a common factor underlying the association between atypical laterality and neurodevelopmental disorders: A developmental perspective. 围产期逆境是导致非典型侧位和神经发育障碍的共同因素：发展的视角。

IF 2.9 2区心理学

Psychophysiology Pub Date : 2024-08-28 DOI: 10.1111/psyp.14676

Jad Hamaoui, Sebastian Ocklenburg, Hervé Segond

{"title":"Perinatal adversities as a common factor underlying the association between atypical laterality and neurodevelopmental disorders: A developmental perspective.","authors":"Jad Hamaoui, Sebastian Ocklenburg, Hervé Segond","doi":"10.1111/psyp.14676","DOIUrl":"https://doi.org/10.1111/psyp.14676","url":null,"abstract":"Several neurodevelopmental disorders are associated with a higher prevalence of atypical laterality (e.g., left-handedness). Both genetic and non-genetic factors play a role in this association, yet the underlying neurobiological mechanisms are largely unclear. Recent studies have found that stress, mediated by the hypothalamic-pituitary-adrenal (HPA) axis, could be linked to laterality development. These findings provide an opportunity to explore new theoretical perspectives on the association between atypical laterality and neurodevelopmental disorders. This article aims to provide a theoretical framework demonstrating how perinatal adversities could disrupt the typical developmental trajectories of both laterality and neurodevelopment, potentially impacting both the HPA axis and the vestibular system. Additionally, we argue that the relationship between atypical laterality and neurodevelopmental disorders cannot be understood by simply linking genetic and non-genetic factors to a diagnosis, but the developmental trajectories must be considered. Based on these ideas, several perspectives for future research are proposed.","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining recognition, conflict-monitoring and feedback-related ERPs to detect concealed autobiographical information. 结合识别、冲突监测和反馈相关的 ERP 来检测隐藏的自传信息。

IF 2.9 2区心理学

Psychophysiology Pub Date : 2024-08-26 DOI: 10.1111/psyp.14664

Xiaohong Allison Lin, Hong Li, Tingwen Sheng, Genyue Fu, Liyang Sai

{"title":"Combining recognition, conflict-monitoring and feedback-related ERPs to detect concealed autobiographical information.","authors":"Xiaohong Allison Lin, Hong Li, Tingwen Sheng, Genyue Fu, Liyang Sai","doi":"10.1111/psyp.14664","DOIUrl":"https://doi.org/10.1111/psyp.14664","url":null,"abstract":"This study examined the neural signatures associated with conflict-monitoring, recognition and feedback processing in a feedback Concealed Information Test (fCIT), and also examined whether all the ERPs can be used to detect concealed autobiographical information. Participants were randomly assigned to one of two groups (guilty or innocent) and then tested in the fCIT while undergoing electroencephalograms (EEGs). The results showed that the probe (participants' name) elicited a more negative N200, and a more positive recognition P300 than irrelevants among guilty participants. Additionally, feedback following the probe elicited a larger feedback P300 than feedback following irrelevants. Further, we found that three indicators, including the conflict-monitoring N200, recognition P300, and feedback P300, could significantly discriminate between guilty and innocent participants, whereas the FRN could not. Combining them is highly effective in discriminating between guilty and innocent participants (AUC = 0.91). These findings not only shed light on the neural processing of the fCIT but also suggest the potential of using the fCIT to detect concealed autobiographical information.","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resting vagally-mediated heart rate variability in the laboratory is associated with momentary negative affect and emotion regulation in daily life. 实验室中静息迷走神经介导的心率变异与日常生活中的瞬间负面情绪和情绪调节有关。

IF 2.9 2区心理学

Psychophysiology Pub Date : 2024-08-23 DOI: 10.1111/psyp.14668

Lauren M Bylsma, Kenneth G DeMarree, Tierney P McMahon, Juhyun Park, Kaitlyn M Biehler, Kristin Naragon-Gainey

{"title":"Resting vagally-mediated heart rate variability in the laboratory is associated with momentary negative affect and emotion regulation in daily life.","authors":"Lauren M Bylsma, Kenneth G DeMarree, Tierney P McMahon, Juhyun Park, Kaitlyn M Biehler, Kristin Naragon-Gainey","doi":"10.1111/psyp.14668","DOIUrl":"https://doi.org/10.1111/psyp.14668","url":null,"abstract":"Vagally-mediated heart rate variability (vmHRV) is a physiological index reflecting parasympathetic activity that has been linked to emotion regulation (ER) capacity. However, very limited research has examined associations of physiological indices of regulation such as vmHRV with emotional functioning in daily life. The few studies that exist have small samples sizes and typically focus on only a narrow aspect of ER or emotional functioning. In this study, we examined associations between vmHRV assessed in the laboratory and emotional/mental health functioning in daily life using a 7-day ecological momentary assessment design in 303 adult community participants. We hypothesized that higher resting vmHRV would be associated with higher positive affect (PA), lower negative affect (NA), less affective variability, greater well-being, fewer dysphoria symptoms, greater use of engagement ER strategies, and less use of avoidance ER strategies, as assessed in daily life. Results revealed that higher resting vmHRV in the laboratory (as indexed by both high frequency heart rate variability, HF-HRV, and the root mean of successive square deviations between heart beats, RMSSD) was significantly associated with less frequent use of avoidance ER strategies in daily life. Theoretical and clinical implications are discussed, including the association of vmHRV with negatively valenced, rather than positively valenced, daily life experiences.","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Domain-specific control for cognitive and emotional conflict: Evidence from the transfer of proportion congruency effects. 特定领域对认知和情感冲突的控制：比例一致性效应转移的证据。

IF 2.9 2区心理学

Psychophysiology Pub Date : 2024-08-21 DOI: 10.1111/psyp.14673

Ling Xiang, Yu Gao, Tingting Yang, Peter Eugene Clayson, Baoxi Wang

{"title":"Domain-specific control for cognitive and emotional conflict: Evidence from the transfer of proportion congruency effects.","authors":"Ling Xiang, Yu Gao, Tingting Yang, Peter Eugene Clayson, Baoxi Wang","doi":"10.1111/psyp.14673","DOIUrl":"https://doi.org/10.1111/psyp.14673","url":null,"abstract":"There is ongoing debate about whether control-related processing related to cognitive conflict and emotional conflict operate independently. This study manipulated the proportion of congruent to incongruent trials to determine the domain specificity or generality of these two types of conflict control. Two experiments were conducted in which spatial Simon conflict was combined with emotional face-word conflict. In Experiment 1, the proportion congruency (PC) of spatial conflict was manipulated, and in Experiment 2, the PC of emotional conflict was manipulated. The aim was to determine whether control-related processes elicited by cognitive or emotional conflict show domain-specific (within cognitive or within emotional control-related effects) or domain-general effects, where control elicited by cognitive conflict benefits emotional control processes and vice versa. Behavioral findings indicated that spatial and emotional conflict exhibited within-domain PC effects. For event-related brain potential (ERP) activity, PC effects were primarily reflected in a late slow potential, rather than an early negativity, suggesting that control-related adjustments impacted conflict resolution rather than conflict detection. Furthermore, the results did not show evidence of PC effects across domains for behavioral or ERP data, indicating that proactive control elicited by PC manipulation does not transfer across cognitive and emotional conflict. This study supports the modular nature of proactive control for processes related to cognitive and emotional control.","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain signatures of catastrophic events: Emotion, salience, and cognitive control. 灾难性事件的大脑特征：情绪、显著性和认知控制。

IF 2.9 2区心理学

Psychophysiology Pub Date : 2024-08-21 DOI: 10.1111/psyp.14674

Laura Mas-Cuesta, Sabina Baltruschat, Antonio Cándido, Andrés Catena

{"title":"Brain signatures of catastrophic events: Emotion, salience, and cognitive control.","authors":"Laura Mas-Cuesta, Sabina Baltruschat, Antonio Cándido, Andrés Catena","doi":"10.1111/psyp.14674","DOIUrl":"https://doi.org/10.1111/psyp.14674","url":null,"abstract":"Anticipatory brain activity makes it possible to predict the occurrence of expected situations. However, events such as traffic accidents are statistically unpredictable and can generate catastrophic consequences. This study investigates the brain activity and effective connectivity associated with anticipating and processing such unexpected, unavoidable accidents. We asked 161 participants to ride a motorcycle simulator while recording their electroencephalographic activity. Of these, 90 participants experienced at least one accident while driving. We conducted both within-subjects and between-subjects comparisons. During the pre-accident period, the right inferior parietal lobe (IPL), left anterior cingulate cortex (ACC), and right insula showed higher activity in the accident condition. In the post-accident period, the bilateral orbitofrontal cortex, right IPL, bilateral ACC, and middle and superior frontal gyrus also showed increased activity in the accident condition. We observed greater effective connectivity within the nodes of the limbic network (LN) and between the nodes of the attentional networks in the pre-accident period. In the post-accident period, we also observed greater effective connectivity between networks, from the ventral attention network (VAN) to the somatomotor network and from nodes in the visual network, VAN, and default mode network to nodes in the frontoparietal network, LN, and attentional networks. This suggests that activating salience-related processes and emotional processing allows the anticipation of accidents. Once an accident has occurred, integration and valuation of the new information takes place, and control processes are initiated to adapt behavior to the new demands of the environment.","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can transcutaneous auricular vagus nerve stimulation mitigate vigilance loss? Examining the effects of stimulation at individualized versus constant current intensity. 经皮耳迷走神经刺激能减轻警觉性下降吗？研究个体化刺激与恒定电流强度刺激的效果。

IF 2.9 2区心理学

Psychophysiology Pub Date : 2024-08-21 DOI: 10.1111/psyp.14670

Fernando G Luna, Juan Lupiáñez, Stefanie König, Ulrike Garscha, Rico Fischer

{"title":"Can transcutaneous auricular vagus nerve stimulation mitigate vigilance loss? Examining the effects of stimulation at individualized versus constant current intensity.","authors":"Fernando G Luna, Juan Lupiáñez, Stefanie König, Ulrike Garscha, Rico Fischer","doi":"10.1111/psyp.14670","DOIUrl":"https://doi.org/10.1111/psyp.14670","url":null,"abstract":"According to the arousal model of vigilance, the locus coeruleus-norepinephrine (LC-NE) system modulates sustained attention over long periods by regulating physiological arousal. Recent research has proposed that transcutaneous auricular vagus nerve stimulation (taVNS) modulates indirect physiological markers of LC-NE activity, although its effects on vigilance have not yet been examined. Aiming to develop a safe and noninvasive procedure to prevent vigilance failures in prolonged tasks, the present study examined whether taVNS can mitigate vigilance loss while modulating indirect markers of LC-NE activity. Following a preregistered protocol (https://osf.io/tu2xy/), 50 participants completed three repeated sessions in a randomized order, in which either active taVNS at individualized intensity set by participant, active taVNS set at 0.5 mA for all participants, or sham taVNS, was delivered while performing an attentional and vigilance task (i.e., ANTI-Vea). Changes in salivary alpha-amylase and cortisol concentrations were measured as markers of LC-NE activity. Self-reports of feelings associated with stimulation and guessing rate of active/sham conditions supported the efficacy of the single-blind procedure. Contrary to our predictions, the observed vigilance decrement was not modulated by active taVNS. Pairwise comparisons showed a mitigation by active taVNS on cortisol reduction across time. Interestingly, Spearman's correlational analyses showed some interindividual effects of taVNS on indirect markers of LC-NE, evidenced by positive associations between changes in salivary alpha-amylase and cortisol in active but not sham taVNS. We highlight the relevance of replicating and extending the present outcomes, investigating further parameters of stimulation and its effects on other indirect markers of LC-NE activity.","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional signatures of cortical structural changes in chronic insomnia disorder. 慢性失眠症皮质结构变化的转录特征。

IF 2.9 2区心理学

Psychophysiology Pub Date : 2024-08-19 DOI: 10.1111/psyp.14671

Liyong Yu, Daijie Hu, Yucai Luo, Wenting Lin, Hao Xu, Xiangwen Xiao, Zihao Xia, Zeyang Dou, Guangli Zhao, Lu Yang, Dezhong Peng, Qi Zhang, Siyi Yu

{"title":"Transcriptional signatures of cortical structural changes in chronic insomnia disorder.","authors":"Liyong Yu, Daijie Hu, Yucai Luo, Wenting Lin, Hao Xu, Xiangwen Xiao, Zihao Xia, Zeyang Dou, Guangli Zhao, Lu Yang, Dezhong Peng, Qi Zhang, Siyi Yu","doi":"10.1111/psyp.14671","DOIUrl":"https://doi.org/10.1111/psyp.14671","url":null,"abstract":"Chronic insomnia disorder (CID) is a multidimensional disease that may influence various levels of brain organization, spanning the macroscopic structural connectome to microscopic gene expression. However, the connection between genomic variations and morphological alterations in CID remains unclear. Here, we investigated brain structural changes in CID patients at the whole-brain level and whether these link to transcriptional characteristics. Brain structural data from 104 CID patients and 102 matched healthy controls (HC) were acquired to examine cortical structural alterations using morphometric similarity (MS) analysis. Partial least squares (PLS) regression and transcriptome data from the Allen Human Brain Atlas were used to extract genomes related to MS changes. Gene-category enrichment analysis (GCEA) was used to identify potential molecular mechanisms behind the observed structural changes. We found that CID patients exhibited MS reductions in the parietal and limbic regions, along with enhancements in the temporal and frontal regions compared to HCs (pFDR < .05). Subsequently, PLS and GCEA revealed that these MS alterations were spatially correlated with a set of genes, especially those significantly correlated with excitatory and inhibitory neurons and chronic neuroinflammation. This neuroimaging-transcriptomic study bridges the gap between cortical structural changes and the molecular mechanisms in CID patients, providing novel insight into the pathophysiology of insomnia and targeted treatments.","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142005122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0