Radiation research最新文献

{"title":"Octamer-Binding Transcription Factor 4 Inhibits HSC Functions via the NF-κB Signaling Pathway After 60Co Irradiation.","authors":"Wenjing Yang, Xiaoe Jin, Chao Chen, Qianqian Zhang, Junyang Wang, Jinjia Liu, Lina Song, Xiaolong Jiang, Yunjian Liu, Weihong Li, Shufang Cui","doi":"10.1667/RADE-24-00258.1","DOIUrl":"10.1667/RADE-24-00258.1","url":null,"abstract":"<p><p>High doses of radiation can cause irreversible bone marrow hematopoietic damage and even death. No effective strategies have been developed to protect against radiation effects in hematopoietic stem cells (HSCs). A total-body irradiation model was used to determine damage to HSCs. HSCs were sorted for transcriptome sequencing, and gene function analysis showed that Octamer-Binding Transcription Factor 4 (Oct4) increased significantly after irradiation. Oct4 deletion or inhibition of nuclear factor kappa-B (NF-κB) significantly reversed HSC apoptosis, promoted HSC colony formation, reduced cellular DNA damage, and promoted bone marrow regeneration after irradiation. ChIP assays showed that Oct4 binds to the IκB kinase (IKK) promoter region and increases the level of IKK. Overexpression of Oct4 significantly increased the entry of NF-κB into the nucleus after irradiation. NF-κB activators reversed the protective roles of knocking out Oct4. In vivo, the knockout of Oct4 and inhibition of NF-κB significantly improved the survival rate of mice after irradiation. We further found that the expression level of Oct4 decreased significantly in human leukemia cells, while the overexpression of Oct4 significantly increased the level of apoptosis in leukemia cells after irradiation. This study demonstrated a novel role of Oct4 in mediating apoptosis of HSCs after irradiation through the NF-κB pathway, providing an important biomedical strategy for the functional protection of HSCs in bone marrow after irradiation.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":"433-444"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERRATUM.","authors":"","doi":"10.1667/RADE-25-e0001.1","DOIUrl":"10.1667/RADE-25-e0001.1","url":null,"abstract":"","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":"203 6","pages":"447"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between DNA Double-Strand Break Distribution in 3D Genome and Ionizing Radiation-Induced Cell Death.","authors":"Ankang Hu, Wanyi Zhou, Xiyu Luo, Rui Qiu, Junli Li","doi":"10.1667/RADE-24-00277.1","DOIUrl":"10.1667/RADE-24-00277.1","url":null,"abstract":"<p><p>The target theory is the most classical hypothesis explaining radiation-induced cell death, yet the physical or biological nature of the \"target\" remains ambiguous. This study hypothesizes that the distribution of DNA double-strand breaks (DSBs) within the 3D genome is a pivotal factor affecting the probability of radiation-induced cell death. We propose that clustered DSBs in DNA segments with high-interaction frequencies are more susceptible to leading to cell death than isolated DSBs. Topologically associating domains (TAD) can be regarded as the reference unit for evaluating the impact of DSB clustering in the 3D genome. To quantify this correlation between the DSB distribution in 3D genome and radiation-induced effect, we developed a simplified model considering the DSB distribution across TADs. Utilizing track-structure Monte Carlo codes to simulate the electron and carbon ion irradiation, and we calculated the incidence of each DSB case across a variety of radiation doses and linear energy transfers (LETs). Our simulation results indicate that DSBs in TADs with frequent interactions (case 3) are significantly more likely to induce cell death than clustered DSBs within a single TAD (case 2). Moreover, case 2 is significantly more likely to induce cell death than isolated DSBs (case 1). The curves of the incidence of cases 2 and 3 compared with LETs have a similar shape to the radiation quality factor (Q) used in radiation protection. This indicates that these two cases are also associated with the stochastic effects induced by high-LET radiation. Our study underscores the crucial significance of the 3D genome structure in the fundamental mechanisms of radiobiological effects. The hypothesis in our research offers novel perspectives on the mechanisms that regulate radiobiological effects. Moreover, it serves as a valuable reference for the establishment of mechanistic models that can predict cell survival under different doses and LETs.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":"421-432"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidants Ameliorates Ionizing Radiation-Induced Microcephaly in Cerebral Organoid Derived from Human-induced Pluripotent Stem Cells.","authors":"Mikio Shimada, Yoshihisa Matsumoto","doi":"10.1667/RADE-25-00017.1","DOIUrl":"10.1667/RADE-25-00017.1","url":null,"abstract":"<p><p>Ionizing radiation exposure induces DNA damage and chromosome aberrations through both direct and indirect effect. The indirect effects are primarily mediated by the generation of hydroxyl radicals, a process attributed to radiation. Dimethyl sulfoxide (DMSO) and ascorbic acid (AA) are known as radical scavengers and have radioprotective effects. Radiation therapy is widely employed in the treatment of malignant tumors such as glioblastoma; however, its side effects, including cognitive impairments resulting from damage to healthy neurons, pose significant challenges. To ameliorate these effects, radioprotective reagents have been sought. In this study, we used cerebral organoids derived from human-induced pluripotent stem cells to address the radioprotective effect of radical scavengers, DMSO and AA in brain exposure. Although exposure to radiation for 20-day-old cerebral organoids results in DNA double-strand breaks and apoptosis leading to microcephaly phenotype, treatment with DMSO or AA not only before but also after radiation alleviated DNA damage, cell death, and the microcephaly phenotype. Our results suggest that DMSO and AA are candidates for the radioprotective reagents for brain tumor therapy.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":"410-420"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-144-3p Regulates the Radiation Sensitivity of Nasopharyngeal Carcinoma Through Targeting the NFE2L2 Pathway.","authors":"Jingjing Chen, Yilong Wang, Na Zhao, Jie Song, Yongjun Fong","doi":"10.1667/RADE-24-00130.1","DOIUrl":"https://doi.org/10.1667/RADE-24-00130.1","url":null,"abstract":"<p><p>Radiation therapy is one of the most critical methods for the comprehensive treatment of nasopharyngeal carcinoma (NPC). However, radiation resistance limits the effectiveness of radiotherapy. MicroRNAs (miRNAs) are associated with the radiosensitivity of NPC, but their impacts and mechanisms of action require further investigation. Aberrantly expressed miRNAs were screened in NPC and normal tissue. A series of gain-of-function and loss-of-function experiments were conducted to evaluate the biological behavior of miR-144-3p in NPC cells. The role of miR-144-3p in the proliferation and apoptosis of NPC cells was studied. Downstream mechanisms of miR-144-3p were explored through bioinformatics analysis and RNA sequencing, confirmed by dual-luciferase reporter gene assays. We observed downregulation of miR-144-3p in NPC tissue and radiation-resistant cells. Furthermore, upregulation of miR-144-3p in radiation-resistant cells suppressed the enhancement of radiosensitivity in NPC cells. Conversely, inhibiting miR-144-3p decreased radiosensitivity. We also found that miR-144-3p directly targets nuclear factor erythroid 2-related factor 2 (NFE2L2) and inhibits its expression. The results of this study indicate that the miR-144-3p/Nrf2 pathway contributes to reducing the radioresistance of NPC, making it a potential therapeutic target.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144161955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Dose and Solid Cancer Mortality Risk in the Techa River and East Urals Radioactive Trace Cohorts in 1950-2016.","authors":"D L Preston, L Y Krestinina, D O Stram, S B Epifanova, E A Shishkina, B A Napier, B E Moroz, N V Startsev, M O Degteva, A V Akleyev","doi":"10.1667/RADE-24-00195.1","DOIUrl":"https://doi.org/10.1667/RADE-24-00195.1","url":null,"abstract":"<p><p>The objective of the work was to estimate the dose dependence of mortality risk from solid cancers in a cohort that includes members of two cohorts of residents of the Southern Urals who received chronic environmental low-dose, low-dose-rate radiation exposure from releases of the Mayak Plutonium Production Association. These analyses use dose and dose uncertainty estimates from a recently developed Monte-Carlo dosimetry system. The 47,950 members of the cohort include the Techa River Cohort of people who lived in the villages on the Techa River between 1950 and the end of 1960 and the East Urals Radioactive Trace Cohort of people who lived in territories of Chelyabinsk Oblast contaminated by the explosion of a radioactive waste depository on September 29, 1957, between the date of the accident and the end of 1959. As of the end of 2016, there were 25,723 deaths, including 3,783 solid cancer deaths, with 1,392,394 person years among non-migrant cohort members. The solid cancer mortality rate dose-response adjusted for the effect of smoking was estimated using an excess relative risk model. Parameter estimates and confidence intervals were computed using maximum likelihood methods. The corrected information matrix method was used to determine risk estimate confidence intervals (CI) adjusted for dose uncertainty using information on the statistical uncertainty of the parameter estimates and individual dose uncertainty information provided by the dosimetry system. The smoking-adjusted linear excess relative risk (ERR) per 100 mGy for solid cancer mortality was 0.060 (95% CI 0.018 to 0.108) at age 70. The ERR increased significantly in proportion to age to the power 3.1 (95% CI 0.44 to 6.4). The joint effect of radiation and smoking on solid cancer rates appeared to be multiplicative. Adjustment for smoking had little impact on the estimated ERR. Adjusting the ERR confidence interval for dose uncertainty slightly increased the upper confidence bound (adjusted 95% CI 0.018 to 0.120). There was no evidence of nonlinearity in the solid cancer dose response. Except for liver cancer, ERR estimates for various specific types of cancer were positive. However, they were statistically significant only for stomach and female breast cancers. Statistically significant smoking effects were seen for cancers of the lung, stomach, and esophagus. Risk estimates for the two groups in the cohort did not differ significantly. The risk estimates in this cohort were consistent with data in two major occupational cohorts, they were higher than those seen in the Mayak Worker Cohort. While the ERR estimates at age 70 are like those seen in the atomic bomb survivor life span study, the ERR age dependencies were strikingly different. These findings strengthen the evidence for low-dose, low-dose-rate radiation effects on solid cancer mortality rates.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiosarcoma of the Liver and Other Hepatic Malignancies in the Russian Cohort of Mayak Nuclear Workers.","authors":"Christopher A Loffredo, Felicia D Atkinson, Bhaskar Kallakury, Jan Blancato, Galina V Zhuntova, Evgeniya S Grigoryeva, David S Goerlitz, Timothy J Jorgensen, Gleb V Sychugov, Scott C Miller, Tamara V Azizova","doi":"10.1667/RADE-23-00240.1","DOIUrl":"https://doi.org/10.1667/RADE-23-00240.1","url":null,"abstract":"<p><p>Human occupational exposure to ionizing radiation has been linked to increased risks of developing cancers, including solid tumors. In particular, 239Pu, used in the production of nuclear weapons, has been associated with a higher risk of malignancies of the lungs, liver, and bones, but the specific patterns of malignant histology have not been well described in humans. We assessed the pathological characteristics of liver cancers that occurred in a Russian cohort of nuclear workers from the Mayak Production Association, with a special emphasis on angiosarcoma, and studied the relationships between dosimetry, sex, and histology. The subjects included two main groups of workers whose biological specimens were collected during autopsies: thirty-one were diagnosed with liver cancers (cases), and 38 workers were cancer-free (controls). An independent pathologist reviewed all liver tissues from these cancer cases and performed immunohistochemistry to confirm the diagnoses (angiosarcoma, hepatocellular carcinoma, or cholangiocarcinoma). A third group consisted of 36 workers who developed liver cancer but for whom no biological samples were available. Radiation dose levels, along with sex and age distributions, were compared statistically among the three types of liver tumors and the control groups. There was a predominance of females (9 of 13, 69%) among the workers who developed angiosarcoma of the liver, whereas a male predominance characterized both hepatocellular carcinoma (9 of 9, 100%) and cholangiocarcinoma (8 of 9, 89%). A male predominance was also observed in the group of workers with liver cancer but without biological samples (22 of 36, 61%) and in the group of workers without liver cancer (30 of 38, 79%). Occupational differences were evident, with angiosarcoma patients who had biological samples representing the largest proportion (9 of 13) of plutonium metallurgical plant workers (the most highly exposed occupation to plutonium in the cohort), while the remainder (4 of 13) occurred among the radiochemical plant workers. Compared to other groups, those workers with biological samples who developed angiosarcoma had the largest accumulated and widest range of external doses absorbed by the liver, as well as the highest absorbed doses of 239Pu to the liver. Females with biological samples who developed liver cancer also had some of the highest accumulated doses from 239Pu, exceeding 1 Gy in some instances. Our observations of histology, sex, occupation, and dose patterns provide possible clues to the unusual pattern of liver malignancies, particularly angiosarcoma, related to aspects of plutonium exposure.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Urinary Metabolite Profiles between Survivors and Non-Survivors of Radiation-induced Lung Injury in the C57L/J Murine Model.","authors":"Evan L Pannkuk, Evagelia C Laiakis, Guy Y Garty, Igor Shuryak, Kamendra Kumar, Shubhankar Suman, Shanaz A Ghandhi, Yuewen Tan, Brian Ponnaiya, Xuefeng Wu, Sally A Amundson, David J Brenner, Albert J Fornace","doi":"10.1667/RADE-25-00066.1","DOIUrl":"https://doi.org/10.1667/RADE-25-00066.1","url":null,"abstract":"<p><p>Novel biodosimetry assays are needed to categorize both acute ionizing radiation injury and delayed effects of radiation exposure, such as radiation-induced lung injury (RILI) -associated mortality. In this study, we utilized the C57L/J mouse model, a well-established system for replicating the clinical pathology of RILI. Lung injury was induced using a combination of neutron total-body irradiation (TBI) (30% of total dose +7% of total dose concomitant gamma rays) and whole-thoracic X-irradiation (WTI) boost for the balance of the required dose at total doses of 9, 9.5, 10 and 10.5 Gy. The animals were monitored for a period of 180 days postirradiation to evaluate the progression of injury. Both male and female mice were included in the study, with cohorts exposed to either sham dose (0 Gy) or 100% X-ray WTI at 11.35 Gy (LD50/180 dose) to serve as controls. Tissue injury was characterized using whole-body plethysmography, histopathology, and targeted lipidomics. Urinary metabolites were detected using untargeted metabolomic profiling to determine if they could serve as early predictors of RILI survival. A survival rate of 40-45% was observed at 180 days postirradiation consistent with the established LD50/180 value for WTI (11.35 Gy), except at 10.5 Gy, where survival dropped to 20%. Irradiated mice exhibited increased pulmonary immune infiltration and collagen deposition, reduced alveolar spaces, thickened bronchiolar walls, and dose-independent alterations in lipid profiles that were not sex-specific. We developed a multiplex urinary metabolite panel that was associated with RILI and radiation exposure. Some compounds were statistically different between sham-irradiated male and female mice, with sex specific differences at 120 days were observed for homocitrulline, xanthosine, acetyl-arginine, methylhistidine, niacinamide, xanthurenic acid, cyclic adenosine monophosphate, taurine, and prolyl-proline urinary metabolite levels. Baseline differences in sham-irradiated C57L/J mice show sex needs to be considered as a variable when developing biomarker panels for long-term RILI effects. However, urinary metabolite panels can provide excellent to very good sensitivity and specificity at predicting survival from RILI.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Two Stable Biodosimeters for Absorbed Ionizing Radiation Dose Estimation in Multiple Combined Injury Models.","authors":"Le Ma, Zhihe Hu, Yan Chen, Zhuo Cheng, Chunmeng Shi","doi":"10.1667/RADE-24-00261.1","DOIUrl":"https://doi.org/10.1667/RADE-24-00261.1","url":null,"abstract":"<p><p>Radiation damage and deposition caused by radiological or nuclear public health incidents (e.g., accidents or attacks) may lead to acute radiation syndrome and other complications. Accurate and effective radiation dose assessment is necessary for triaging irradiated patients and determining treatment plans. However, there is no systematic evaluation of whether radiation biodosimetry is affected by comorbidities. The weighted gene co-expression network analysis (WGCNA) and differentially expressed genes (DEG) co-analysis of the RNA-sequencing data in human peripheral blood after irradiation from the Gene Expression Omnibus (GEO) database identified seven radiation-specific genes, including five upregulated genes and two downregulated genes. Five radiation-specific genes (CCNG1, CDKN1A, GADD45A, GZMB, PHLDA3) showed a strong linear correlation with the total-body X-ray radiation model. The above five genes were used to validate further several radiation combined injury models, including infection, trauma, and burns, while considering different sexes and ages in animal studies on the radiation response from 0 to 10 Gy. The receiving operator characteristic (ROC) curve analysis revealed that the CCNG1 and CDKN1A genes performed the best in radiation dose-response across both mice and humans. Moreover, the CCNG1 protein could accurately predict the absorbed doses for up to 28 days after exposure (>95%). Our findings suggested that the CCNG1 and CDKN1A mRNA performed optimally in radiation dose response, independent of trauma, burns, age, and sex. Additionally, the CCNG1 protein revealed a strong linear correlation between radiation dose and time postirradiation. Our study demonstrated the potential feasibility of using CCNG1 and CDKN1A as injury biomarkers in radiation accident management.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Changes in Preterminal Serum Samples of Rhesus Macaques Exposed to Two Different Doses of Acute Lethal Total-body Gamma Radiation.","authors":"Alana D Carpenter, Issa Melendez-Miranda, Yaoxiang Li, Jeyalakshmi Kandhavelu, Oluseyi O Fatanmi, Stephen Y Wise, Amrita K Cheema, Vijay K Singh","doi":"10.1667/RADE-25-00029.1","DOIUrl":"https://doi.org/10.1667/RADE-25-00029.1","url":null,"abstract":"<p><p>Ionizing radiation exposure induces cellular and molecular damage, leading to a chain of events that results in tissue and organ injury. Proteomics studies help identify, validate, and quantify alterations in protein abundance downstream of radiation-induced genomic changes. The current study strives to characterize and validate the proteomic changes in the preterminal stage (moribund animals) serum samples collected from rhesus macaques lethally and acutely irradiated with two different doses of cobalt-60 gamma-radiation. Peripheral blood samples were collected prior to exposure, after exposure, and at the preterminal stage from nonhuman primates (NHPs) that did not survive after 7.2 or 7.6 Gy total-body irradiation (LD60-80/60). Using mass spectrometry-based proteomics, we analyzed samples collected at various time points after irradiation. Our findings revealed that radiation induced significant time-dependent proteomic alterations compared to pre-exposure samples. More pronounced dysregulation in pathways related to immune response and hemostasis, specifically platelet function, was present in preterminal samples, suggesting that alterations in these pathways may indicate the preterminal phenotype. These results offer important insights for the identification and validation of biomarkers for radiation-induced lethality that would be of great importance for triage during a radiological/nuclear mass casualty event.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}