Radiation research最新文献

{"title":"Low-dose Ionizing Radiation Induces Oxidative Stress through Sirtuin 1-mediated Acetylation of Forkhead Box Protein O1 in the Human B-lymphoblastoid Cell Line IM-9.","authors":"Lili Sun, Shuo Wang, Yixiang Wang, Gang Li","doi":"10.1667/RADE-25-00255.1","DOIUrl":"https://doi.org/10.1667/RADE-25-00255.1","url":null,"abstract":"<p><p>With the increasing use of computed tomography, the biological effects of low-dose ionizing radiation (LDIR) have gained attention. However, its effects on B lymphocytes remain understudied. We investigated LDIR-induced oxidative stress in lymphocytes to establish a theoretical basis for clinical radiation safety. First, we demonstrated that LDIR induces a rapid oxidative response in the human B-lymphoblastoid cell line IM-9. Reactive oxygen species (ROS) levels increased at 0.25 h and decreased at 1 h after LDIR. In parallel, the number and intensity of γ-H2A.X and 53BP1 DNA damage foci significantly increased in the irradiated group. Transcriptome analysis identified Forkhead box protein O1 (FOXO1) as a key gene. Western blotting analysis showed that Sirtuin-1 (SIRT1) activity decreased at 0.25 h after irradiation, while the activity of FOXO1 and acetylated FOXO1 increased. Superoxide dismutase 2 (SOD2) activity decreased initially and then increased at 1 h. A co-immunoprecipitation (Co-IP) assay confirmed the interaction between FOXO1 and SIRT1, supporting their coordinated role in oxidative regulation. LDIR induced oxidative stress via the SIRT1/FOXO1 axis. These results demonstrate that early ROS accumulation suppresses SIRT1 activity, impedes FOXO1 deacetylation, and transiently reduces SOD2 activity, followed by a compensatory induction of SOD2 to restore redox balance.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamine, a Potential Metabolomic Biomarker and Therapeutic Target in Radiation-induced Liver Damage.","authors":"Liming Gu, Yang Jiao, Wei Mo, Wenli Wang, Xiedong Hong, Shihong Li, Jianping Cao, Chang Wang","doi":"10.1667/RADE-25-00236.1","DOIUrl":"https://doi.org/10.1667/RADE-25-00236.1","url":null,"abstract":"<p><p>Radiation-induced liver damage (RILD) significantly limits the clinical application of radiotherapy for upper abdominal malignancies. Radiation can induce metabolic disorder in liver tissues. However, there is no systematic research on the effects of radiation on liver metabolism. In this study, we collected time-series liver tissue samples from irradiated rats at multiple time points, from 3 days to 4 weeks after exposure, to reveal dynamic alterations in metabolic profiles throughout RILD progression. Acetylcholic acid, p-hydroxyphenyl-lactic acid, ascorbic acid, daidzein, and glutamine (Gln) were identified as potential biomarkers, demonstrating good diagnostic sensitivity and specificity. As a metabolomic biomarker, Gln emerged as a potential metabolic target based on pathway enrichment analysis, which could modulate the radiosensitivity of both mouse (JS-1) and human (LX-2) hepatic stellate cells. Transcriptomics, co-immunoprecipitation (Co-IP) and functional rescue experiments demonstrated that the regulation of radiosensitivity by Gln is mediated through the Col1α2/ITGB1/AKT signaling axis. In the mouse RILD model, Gln prevented irradiation-induced body weight loss, preserved liver structure, and reduced TGF-β and TNF-α expression as well as collagen deposition. L-alanyl-glutamine (Ala-Gln) and liposomes were introduced to further enhance the radioprotective effects of Gln. This study provides the necessary theoretical and experimental basis for diagnosis and intervention of RILD.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lysophosphatidic Acid Receptor Activation Regulates Expression of the Immediate Early Gene IEX-1 in Irradiated Cells and Tissues.","authors":"Derek D Norman, Yoojin Shin, Louisa Balázs, Erzsébet Szabó, Zoltán Benyó, Sue Chin Lee, Gábor J Tigyi","doi":"10.1667/RADE-26-00052.1","DOIUrl":"https://doi.org/10.1667/RADE-26-00052.1","url":null,"abstract":"<p><p>Immediate early response gene-3 (IER3/IEX-1) encodes a radiation-inducible stress-response adaptor protein that integrates pro-survival signaling pathways, yet the upstream mechanisms regulating its expression after irradiation remain incompletely understood. Here we investigated whether lysophosphatidic acid receptor (LPAR) signaling regulates IEX-1 expression during the radiation response and examined the radiobiological consequences of IEX-1 deficiency. LPAR activation enhanced IEX-1 expression in irradiated mouse whole blood, bone marrow, intestinal mucosa, and intestinal enteroids. In addition, IEX-1-deficient mice exhibited increased susceptibility to lethal radiation injury after total-body or partial body irradiation, while IEX-1-deficient enteroids displayed delayed growth and altered ERK phosphorylation kinetics. Together, these findings identify IEX-1 as a previously unrecognized downstream target of LPAR signaling after irradiation.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148956402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomic Prediction of Locally Advanced Cervical Squamous Cell Carcinoma Response to Concurrent Chemoradiotherapy using MRI.","authors":"Jing Wang, Jianing Wang, Jingjing Cui, Huan Meng, Qing Wang, Xiaoping Yin","doi":"10.1667/RADE-25-00121.1","DOIUrl":"https://doi.org/10.1667/RADE-25-00121.1","url":null,"abstract":"<p><p>The aim of this study is to assess the predictive efficacy of a radiomics model utilizing magnetic resonance imaging (MRI) for predicting locally advanced cervical squamous cell carcinoma response to concurrent chemoradiotherapy. We enrolled a cohort of 139 patients diagnosed with stage IIB to IV cervical squamous cell carcinoma, based on the 2018 FIGO classification, who underwent concurrent chemoradiotherapy and pre-/post-treatment MRI examinations. These patients were divided into complete response and partial response groups. Prior to the initiation of treatment, the areas of interest within the lesion were delineated on T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and enhanced T1-weighted imaging (T1WI) sequences, from which radiomic features were extracted. The group was randomly divided into training (n = 111) and validation (n = 28) sets (8:2 ratio) to identify the optimal features. Logistic regression models were constructed to predict treatment response, with distinct models based on the following imaging modalities: enhanced T1WI, T2WI, DWI, a combination of T2WI and enhanced T1WI (joint model 1), and a combination of T2WI, DWI, and enhanced T1WI (joint model 2). Model fitness and predictive performance were assessed using receiver operating characteristic curves, while the clinical applicability of the models was analyzed using decision curve analysis. A cumulative count of 2,264 radiomic features was derived from the region of interest in each imaging sequence. Subsequently, 18, 16, 15, 16, and 13 optimal features were selectively identified from the five models. These selected features were employed to formulate a radiomics model designed for the prediction of treatment response. These selected features were used to construct individual radiomics models aimed at predicting treatment response. Subsequently, all models achieved AUCs > 0.8 in the validation set, with Joint Model 2 demonstrating the highest performance (AUC = 0.939, 95% CI: 0.826-1; sensitivity = 0.773, specificity = 0.833). No significant differences were observed between Joint Model 2 and other models (P > 0.05). The MRI-based radiomics model has high potential in effectively predicting the efficacy of concurrent chemoradiotherapy for locally advanced cervical squamous cell carcinoma.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CXCR2 Blockade Improves Response to Hypo-fractionated Radiation Treatment in a Murine Head and Neck Squamous Cell Carcinoma (HNSCC) Model.","authors":"Rachel K Kuehn, Anne Frei, Jamie Foeckler, Joshua House, Tracy Gasperetti, Oscar Villareal Espinosa, Abdullah A Memon, Jennifer Bruening, Becky Massey, Monica Shukla, Julia Kasprzak, Stuart Wong, Musaddiq A Awan, Joseph Zenga, Heather A Himburg","doi":"10.1667/RADE-25-00185.1","DOIUrl":"https://doi.org/10.1667/RADE-25-00185.1","url":null,"abstract":"<p><p>Human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is known for high levels of disease recurrence and resistance to conventional fractionated radiation therapy. In an analysis of primary patient HPV-negative HNSCC biopsies from our institutional tumor bank, we observed circulating and tumor-resident monocytic myeloid-derived suppressor cells (M-MDSCs) were enriched in patient samples from recurrent HPV-negative HNSCCs relative to treatment-naïve samples. To determine if radiation exposure alters myeloid chemotaxis to the tumor site, we measured myeloid chemotactic factor transcript expression in eight cancer-associated fibroblast (CAF) and EpCAM-expressing patient-derived malignant cell lines. In malignant cell lines, radiation exposure increased transcriptional expression of CCL5 and C-X-C ligand receptor 2 (CXCR2) ligands CXCL2 and CXCL8 (IL-8). Based on this finding, we evaluated whether an antagonist of CXCR2 (SB225002) in combination with radiation blocked murine MDSC chemotaxis in vivo and in vitro. Antagonism of CXCR2 signaling with SB225002, in combination with radiation, suppressed tumor growth, improved survival, and reduced intra-tumoral macrophages in a murine MOC1 model. Additionally, radiation-induced MDSC chemotaxis was inhibited by SB225002 in a transwell assay. Together, these data suggest CXCR2 inhibition in combination with radiation has therapeutic potential for treatment of HPV-negative HNSCC.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Induces Persistent Dysregulation and Functional Impairment in CD8+ T Cell Immunity.","authors":"Anika Kot, Lorreta Yun-Tien Lin, Zhinuo Jiang, Albert J Fornace, Heng-Hong Li","doi":"10.1667/RADE-25-00087.1","DOIUrl":"https://doi.org/10.1667/RADE-25-00087.1","url":null,"abstract":"<p><p>In addition to immediate cell lethality, radiation exposure has long-term effects on the immune system, particularly T lymphocytes, causing persistent functional abnormalities post-exposure. Uncertainties remain regarding the long-lasting consequences on T cell immunity in survivors of the acute radiation syndrome and the underlying mechanisms of those consequences. Here, we investigated delayed effects of acute radiation exposure on CD8+ T cell immunity using the Listeria monocytogenes infection model. Impaired CD8+ T cell activation, reduced terminal effector formation upon infection, and exacerbated listeriosis were found in mice at 4 weeks postirradiation with sublethal doses. To elucidate how radiation affects the functionality of CD8+ T cells at various differentiation stages, we performed single-cell transcriptomic profiling. Radiation altered cluster distribution pre-infection and impaired terminal effector and memory precursor effector formation post-infection. Differential gene analysis highlighted radiation-induced gene expression changes, including cytokines and mitochondrial proteins, in a cluster-specific manner post-infection. The study demonstrates dysfunction of newly replenished naïve T cells, which results in impaired CD8+ T cell immunity after irradiation.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148606712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil-to-Lymphocyte Ratio in Laryngeal SQCC Treated by Radiotherapy: Prognostic and Predictive Value.","authors":"Noam Koch, Eyal Yosefof, Ofir Zavdy, Sharon Tzelnick, Yaniv Hamzany, Aron Popovtzer, Noga Kurman","doi":"10.1667/RADE-25-00039.1","DOIUrl":"https://doi.org/10.1667/RADE-25-00039.1","url":null,"abstract":"<p><p>Laryngeal squamous cell carcinoma (SQCC), in both early and advanced stages, is often treated non-surgically with definitive-intent radiotherapy or chemoradiotherapy. In advanced-stage disease, uninvolved lymphatic structures of the neck are electively irradiated, whereas in early-stage disease the larynx alone is irradiated. The neutrophil-to-lymphocyte ratio (NLR) has been implicated as a prognostic marker in head and neck SQCC. As lymphocytes are extremely radiosensitive, the absolute lymphocyte count (ALC) may fluctuate during and after radiotherapy, and consequently, the NLR may vary across these time points. This study aimed to evaluate dynamic changes in NLR, ALC, and absolute neutrophil count (ANC) during and after radiotherapy and to assess their association with oncologic outcomes in patients with laryngeal SQCC. We retrospectively reviewed the charts of patients treated with definitive-intent radiotherapy or chemoradiotherapy for laryngeal carcinoma at our institution between 2015 and 2021. NLR, ANC, and ALC values were recorded at three time points: treatment initiation, treatment completion, and three to six months after treatment completion. Oncologic outcomes were also recorded. A total of 174 patients treated for laryngeal SQCC were included. The mean NLR level was significantly higher at treatment completion than at treatment initiation (6.23 ± 4.61 vs. 3.12 ± 3.32, P < 0.001) and was significantly lower at 3-6 months after treatment than at treatment completion (3.75 ± 2.15 vs. 6.23 ± 4.61, P < 0.001). An NLR level above 4 at treatment completion was associated with worse overall survival (log-rank P = 0.005). NLR above 4 at treatment completion and 3-6 months afterward was associated with worse disease-free survival (log-rank P = 0.047 and P = 0.011, respectively). Mean ALC declined from 1.91 ± 0.70 × 103/µL at baseline to 0.90 ± 0.51 × 103/µL at treatment completion and partially recovered to 1.36 ± 0.52 × 103/µL at follow-up, whereas ANC remained relatively stable (4.95 ± 1.70, 4.38 ± 1.99, and 4.38 ± 1.44 × 103/µL, respectively). NLR significantly increases during oncologic treatment. Our study demonstrates a novel association between NLR at the end of treatment for laryngeal SQCC and survival. Patients whose NLR remains high 3-6 months after treatment experience worse disease-free survival. The transient rise in NLR appears to be largely driven by radiation-induced lymphocyte depletion. These findings support routine monitoring of both NLR and ALC in patients undergoing radiotherapy for laryngeal cancer.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148606756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Therapy with Pharmacological Ascorbate and Rucosopasem Selectively Radiosensitizes Colorectal Tumors to Clinically Relevant Radiation Doses.","authors":"Benjamin N George, Casey F Pulliam, Michael S Petronek, Sarah A King, Krishna Awasthi, Melissa A Fath, Brianne R O'Leary, Bradley T Loeffler, Douglas R Spitz, Michelle E Howard, Robert A Beardsley, Joseph M Caster","doi":"10.1667/RADE-26-00056.1","DOIUrl":"https://doi.org/10.1667/RADE-26-00056.1","url":null,"abstract":"<p><p>Pentaazamacrocyclic Mn (II)-containing (MnPAM) superoxide dismutase mimetics can selectively modulate the effects of radiotherapy in tumors and normal tissues by enhancing oxidative stress in tumors and mitigating it in normal tissues. However, radiosensitizing effects in tumors are only achieved with stereotactic body radiotherapy-type dosing (≥7 Gy per fraction). These effects are limited at lower fractional doses that are clinically relevant for many tumors, including locally advanced rectal cancer. Here, we show that combining the MnPAM dismutase mimetic, rucosopasem manganese (GC4711), with pharmacological ascorbate significantly enhances radiosensitization to fractionated radiation doses relevant in colorectal cancer treatment (2-5 Gy) compared to either agent alone in multiple tumor models in vitro and significantly prolongs tumor growth delay in vivo. Mechanistically, enhanced radiosensitization with combination therapy is mediated by increased oxygen consumption and hydrogen peroxide generation. Despite having no effect on oxygen consumption in tumor cell media on its own, GC4711 significantly increases pharmacological ascorbate-induced oxygen consumption. Inducible catalase expression, or administration of exogenous catalase, attenuates the anti-cancer activity when combined. As predicted, increased peroxide fluxes with combination therapy enhanced postirradiation DNA damage and G2/M cell cycle accumulation. Importantly, treatment with pharmacological ascorbate and/or GC4711 had no significant effect on postirradiation clonogenic survival or DNA damage in non-malignant FHs74 enterocytes. These results support the hypothesis that adding pharmacological ascorbate to MnPAM dismutase mimetics selectively induces more peroxide-mediated radiosensitization than either agent alone in tumors without increasing radiosensitivity in cells treated with clinically relevant radiation fraction sizes used for radiotherapy of colorectal cancers.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148562847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Serum Proteomic Profiling of Nonhuman Primates Exposed to Total-body Gamma Radiation and Treated with BBT-059.","authors":"Alana D Carpenter, Matthew W Brink, Yaoxiang Li, Jeyalakshmi Kandhavelu, Sarah A Petrus, Stephen Y Wise, Oluseyi O Fatanmi, Christine M Fam, Sharon J Carlson, George N Cox, Amrita K Cheema, Vijay K Singh","doi":"10.1667/RADE-26-00020.1","DOIUrl":"https://doi.org/10.1667/RADE-26-00020.1","url":null,"abstract":"<p><p>Several radiation medical countermeasures (MCMs) are currently approved by the United States Food and Drug Administration (US FDA) for the mitigation of hematopoietic acute radiation syndrome (H-ARS). Continued development of additional candidates remains a priority to enhance force protection capabilities, combat readiness, and operational preparedness in nuclear/radiological threat environments. One such candidate under development is BBT-059, a long-acting PEGylated interleukin-11 (IL-11) analog with known hematopoietic-promoting and anti-apoptotic properties. BBT-059 is under advanced development as a potential radiation MCM for H-ARS and has been shown to improve survival in lethally irradiated murine models; however, its proteomic responses after irradiation have not been fully characterized in nonhuman primates (NHPs). In this study, NHPs exposed to 4 Gy total-body gamma radiation were subsequently treated with a single subcutaneous dose of either 37.5 or 75 µg/kg of BBT-059 at 24 h postirradiation, and longitudinal serum proteomic profiling was performed using a mass spectrometry (MS)-based approach. Proteomic changes were compared to baseline levels to comprehensively identify time-dependent changes induced by irradiation and BBT-059 administration. These analyses revealed changes in proteins related to inflammation, innate immune activation, and hematological and platelet functions, which peaked at days 2 and 4 and gradually decreased to near baseline levels by the end of the study. Pathway enrichment analysis identified consistent activation of neutrophil degranulation, platelet degranulation, insulin-like growth factor transport, and calcium signaling pathways.</p>","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building Bridges Across the Radiation Sciences: The Authors' View Initiative.","authors":"Marc S Mendonca, Sue S Yom, Henning Willers","doi":"10.1667/RADE-26-VIEW1.1","DOIUrl":"10.1667/RADE-26-VIEW1.1","url":null,"abstract":"","PeriodicalId":20903,"journal":{"name":"Radiation research","volume":" ","pages":"269"},"PeriodicalIF":2.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}