Psychological Medicine最新文献

{"title":"Seeing the bigger picture: endogenous opioids mediate attentional broadening after reward receipt.","authors":"Henk van Steenbergen, Philip Gable, Harry Fagan, Laura Molteni, Algirdas Midveris, Nathan Huneke","doi":"10.1017/S0033291725101815","DOIUrl":"10.1017/S0033291725101815","url":null,"abstract":"<p><strong>Background: </strong>Contemporary society faces significant challenges that can lead to stress-induced tunnel vision. Positive affect can counteract these effects by expanding humans' attentional scope, potentially promoting resilience and creativity. This preregistered triple-blind study investigated the role of endogenous opioids in mediating attentional broadening following reward receipt.</p><p><strong>Methods: </strong>Using a placebo-controlled crossover design, 40 volunteers underwent two sessions separated by at least 1 week, receiving either 50 mg of naltrexone or a placebo. Participants completed a Navon letters task designed to contrast the effects of reward receipt versus reward anticipation on attentional scope.</p><p><strong>Results: </strong>As predicted, our results show that the attentional broadening observed after reward receipt under placebo was eliminated when opioid receptors were blocked. Naltrexone did not result in blunted reward anticipation effects on task performance or attentional narrowing.</p><p><strong>Conclusions: </strong>This study highlights the role of endogenous opioids in attentional breadth and their potential for cognitive flexibility and resilience through natural positive experiences, with potential implications for mental health and stress management.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e283"},"PeriodicalIF":5.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulation and neural networks in psychiatric disorders: current status and emerging prospects.","authors":"Panayiota G Michalopoulou, Kyrillos M Meshreky, Zoe Hommerich, Sukhi S Shergill","doi":"10.1017/S003329172510158X","DOIUrl":"https://doi.org/10.1017/S003329172510158X","url":null,"abstract":"<p><p>Psychiatric disorders lead to disability, premature mortality and economic burden, highlighting the urgent need for more effective treatments. The understanding of psychiatric disorders as conditions of large-scale brain networks has created new opportunities for developing targeted, personalised, and mechanism-based therapeutic interventions. Non-invasive brain stimulation (NIBS) techniques, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), can directly modulate dysfunctional neural networks, enabling treatments tailored to the individual's unique functional network patterns.As NIBS techniques depend on our understanding of the neural networks involved in psychiatric disorders, this review offers a neural network-informed perspective on their applications. We focus on key disorders, including depression, schizophrenia, and obsessive-compulsive disorder, and examine the role of NIBS on cognitive impairment, a transdiagnostic feature that does not respond to conventional treatments. We discuss the advancements in identifying NIBS response biomarkers with the use of electrophysiology and neuroimaging, which can inform the development of optimised, mechanism-based, personalised NIBS treatment protocols.We address key challenges, including the need for more precise, individualised targeting of dysfunctional networks through integration of neurophysiological, neuroimaging and genetic data and the use of emerging techniques, such as low- intensity focused ultrasound, which has the potential to improve spatial precision and target access. We finally explore future directions to improve treatment protocols and promote widespread clinical use of NIBS as a safe, effective and patient-centred treatment for psychiatric disorders.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e281"},"PeriodicalIF":5.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational attainment and mental health outcomes: A within-sibship Mendelian randomization study.","authors":"María Fernanda Vinueza Veloz, Laxmi Bhatta, Paul R Jones, Martin Tesli, George Davey Smith, Neil M Davies, Ben M Brumpton, Øyvind E Næss","doi":"10.1017/S0033291725101736","DOIUrl":"10.1017/S0033291725101736","url":null,"abstract":"<p><strong>Background: </strong>Observational studies indicate that higher educational attainment (EA) is associated with a lower risk of many mental health conditions (MHC). We assessed to what extent this association is influenced by genetic nurture and demographic factors (i.e., assortative mating and population structure).</p><p><strong>Methods: </strong>We conducted a within-sibship Mendelian randomization (MR) study. The sample consisted of 61 880 siblings (27 507 sibships) from the Trøndelag Health Study-HUNT (Norway) and UK Biobank (United Kingdom). MHC outcomes included symptom scores for anxiety, depression, and neuroticism, measured using the Hospital Anxiety and Depression Scale, the 7-item Generalized Anxiety Disorder Scale, the 9-item Patient Health Questionnaire, and the Eysenck Personality Questionnaire, along with self-reported psychotropic medication use.</p><p><strong>Results: </strong>One standard deviation (SD) increase in liability to EA was associated with lower anxiety (-0.20 SD [95% CI: -0.26, -0.14]), depression (-0.11 SD [-0.43, -0.22]), and neuroticism scores (-0.30 SD [-0.53, -0.06]), as well as lower odds of psychotropic medication use (OR: 0.60 [0.52, 0.69]). Within-sibship MR estimates remained consistent with population-based estimates: anxiety (-0.17 SD [-0.33, -0.00]); depression (-0.18 SD [-1.26, 0.89]); neuroticism (-0.29 SD [-0.43, -0.15]); psychotropic medication use (OR, 0.52 [0.34, 0.82]).</p><p><strong>Conclusions: </strong>Higher EA or genetic liability to education reduces symptoms of anxiety, neuroticism, and psychotropic medication use. These mental health benefits do not seem to be explained by EA-linked genetic nurture or demographic factors. Regarding depression, results were less conclusive due to imprecise estimates, though beneficial effects of genetic liability to higher EA are possible and warrant further investigation.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e282"},"PeriodicalIF":5.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationships between sporadic and repetitive non-suicidal self-injury and mental disorders among first-year college students: results from the World Mental Health International College Student Initiative.","authors":"Penelope Hasking, Glenn Kiekens, Maria V Petukhova, Yesica Albor, Ahmad Al-Hadi, Jordi Alonso, Nouf Al-Saud, Yasmin Altwaijri, Claes Andersson, Lukoye Atwoli, Caroline Ayuya Muaka, Patricia Báez-Mansur, Laura Ballester, Jason Bantjes, Harald Baumeister, Marcus Bendtsen, Corina Benjet, Anne Berman, Ronny Bruffaerts, Paula Carrasco, Silver Chan, Irina Cohut, Maria Covarrubias Díaz Couder, Paula Cristóbal-Narvaez, Pim Cuijpers, Oana David, Dong Dong, David Ebert, Jorge Gaete, Carlos García Forero, Raúl Gutiérrez-García, Josep Haro, Xanthe Hunt, Petra Hurks, Mathilde Husky, Florence Jaguga, Leontien Jansen, Ana Jiménez-Pérez, Fanny Kählke, Elisabeth Klinkenberg, Álvaro Langer, Sue Lee, Rodrigo Antunes Lima, Yan Liu, Christine Lochner, Scarlett Mac-Ginty, Vania Martínez, Andre Mason, Margaret McLafferty, Tiana Mori, Elaine Murray, Catherine Musyoka, Caitalin Nedelcea, Daniel Núñez, Siobhan O'Neill, José Piqueras, Codruta Popescu, Charlene Rapsey, Kealagh Robinson, Miquel Roca, Tiscar Rodriguez-Jimenez, Elske Salemink, Nancy Sampson, Damian Scarf, Oi-Ling Siu, Dan Stein, Sascha Y Struijs, Cristina Tomoiaga, Karla Valdés-García, Claudia van der Heijde, Daniel Vigo, Wouter Voorspoels, Angel Wang, Samuel Wong, Matthew Nock, Ronald Kessler","doi":"10.1017/S0033291725100688","DOIUrl":"10.1017/S0033291725100688","url":null,"abstract":"<p><strong>Background: </strong>Non-suicidal self-injury (NSSI) is associated with mental disorders, yet work regarding the direction of this association is inconsistent. We examined the prevalence, comorbidity, time-order associations with mental disorders, and sex differences in sporadic and repetitive NSSI among emerging adults.</p><p><strong>Methods: </strong>We used survey data from <i>n</i> = 72,288 first-year college students as part of the World Mental Health-International College Student Survey Initiative (WMH-ICS) to explore time-order associations between onset of NSSI and mental disorders, based on retrospective age-of-onset reports using discrete-time survival models. We distinguished between sporadic (1-5 lifetime episodes) and repetitive (≥6 lifetime episodes) NSSI in relation to <i>DSM-5</i> mood, anxiety, and externalizing disorders.</p><p><strong>Results: </strong>We estimated a lifetime NSSI rate of 24.5%, with approximately half reporting sporadic NSSI and half repetitive NSSI. The time-order associations between onset of NSSI and mental disorders were bidirectional, but mental disorders were stronger predictors of the onset of NSSI (median RR = 1.94) than vice versa (median RR = 1.58). These associations were stronger among individuals engaging in repetitive rather than sporadic NSSI. While associations between NSSI and mental disorders generally did not differ by sex, repetitive NSSI was a stronger predictor for the onset of subsequent substance use disorders among females compared to males. Most mental disorders marginally increased the risk for persistent repetitive NSSI (median RR = 1.23).</p><p><strong>Conclusions: </strong>Our findings offer unique insights into the temporal order between NSSI and mental disorders. Further work exploring the mechanism underlying these associations will pave the way for early identification and intervention of both NSSI and mental disorders.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e280"},"PeriodicalIF":5.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12469815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic overlap and causality between depression and preterm birth: a large-scale genome-wide cross-trait analysis.","authors":"Min Zhang, Xinzhen Chen, Wenzheng Zhou, Niya Zhou, Cuihua Zhang, Yunping Yang, Qiyin Li, Xin Ming, Yifu Wu, Hongbo Qi, Wei Zhou","doi":"10.1017/S0033291725100718","DOIUrl":"10.1017/S0033291725100718","url":null,"abstract":"<p><strong>Background: </strong>Little is known regarding the shared genetic architecture underlying the phenotypic associations between depression and preterm birth (PTB). We aim to investigate the genetic overlap and causality of depression with PTB.</p><p><strong>Methods: </strong>Leveraging summary statistics from the largest genome-wide association studies for broad depression (N_total = 807,533), major depression (N_total = 173,005), bipolar disorder (N_total = 414,466), and PTB (N_total = 226,330), we conducted a large-scale genome-wide cross-trait analysis to assess global and local genetic correlations, identify pleiotropic loci, and infer potential causal relationships.</p><p><strong>Results: </strong>Positive genetic correlations were observed between PTB and broad depression (<i>r_g</i> = 0.242), major depression (<i>r_g</i> = 0.236), and bipolar disorder (<i>r_g</i> = 0.133) using the linkage disequilibrium score regression, which were further verified by the genetic covariance analyzer. Local genetic correlation was identified at chromosome 11q22.3 (harbors <i>NCAM1-TTC12-ANKK1-DRD2</i>) for PTB with depression. Cross-trait meta-analysis identified two loci shared between PTB and broad depression, two loci shared with major depression, and five loci shared with bipolar disorder, among which three were novel (rs7813444, rs3132948 and rs9273363). Mendelian randomization demonstrated a significantly increased risk of PTB for genetic liability to broad depression (odds ratio [OR]=1.30; 95% confidence interval [CI]: 1.11-1.52) and major depression (OR=1.27; 95%CI: 1.08-1.49), and the estimates remained significant across the sensitivity analyses.</p><p><strong>Conclusions: </strong>Our findings demonstrate an intrinsic link underlying depression and PTB and shed novel light on the biological mechanisms, highlighting an important role of early screening and effective intervention of depression in PTB prevention, and may provide novel treatment strategies for both diseases.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e279"},"PeriodicalIF":5.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reward processing disruption in anxiety: fMRI evidence of vulnerability to frustration non-reward.","authors":"Jiaming Wan, Yijia Zhou, Xukai Zhang, Hong Li, Yi Lei","doi":"10.1017/S0033291725101840","DOIUrl":"https://doi.org/10.1017/S0033291725101840","url":null,"abstract":"<p><strong>Background: </strong>Anxiety is a persistent trait that disrupts functioning and increases the risk of severe consequences, while reward processing has garnered attention in anxiety research. Here, we report a critical concern in reward processing among individuals with anxiety: although anxious individuals may show similar reward processing abilities as non-anxious individuals in typical environments, they are more vulnerable to disruptions in positive emotions caused by frustrative non-reward, leading to maladaptive reward processing patterns.</p><p><strong>Methods: </strong>The functional magnetic resonance imaging (fMRI) was used in this study. A total of 66 participants were recruited for the experiment, with 33 in the high anxiety (HA) group and 33 in the low anxiety (LA) group. The simulation of frustrative non-reward was conducted during fMRI scanning.</p><p><strong>Results: </strong>Under the low frustration condition, the HA group exhibited task accuracy comparable to the LA group and showed greater activation in visual processing regions (inferior occipital gyrus, superior occipital gyrus, angular gyrus) and cognitive control areas (precuneus, precentral gyrus) during attentional reorienting following frustration. However, in the high frustration condition, the HA group displayed significantly lower accuracy, with maladaptive information processing patterns observed in several brain regions associated with the cognitive-emotional control system (cuneus-precuneus, anterior cingulate cortex, precentral gyrus, inferior frontal gyrus, superior frontal gyrus, orbitofrontal cortex, and amygdala).</p><p><strong>Conclusions: </strong>This demonstration of two contrasting processing patterns deepens the current understanding of reward processing in anxiety. It also holds significance for a broader understanding of the risk factors in cognitive processing among individuals with anxiety.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e277"},"PeriodicalIF":5.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145125813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling attachment - A network analysis of the cognitive pathways linking attachment and prolonged grief.","authors":"Kirsten V Smith, Nora Skjerdingstad, Omid V Ebrahimi, Fiona Maccallum, Anke Ehlers","doi":"10.1017/S0033291725101669","DOIUrl":"https://doi.org/10.1017/S0033291725101669","url":null,"abstract":"<p><strong>Background: </strong>Attachment style is widely recognized as influential in shaping responses to bereavement and prolonged grief disorder (PGD). Although theorized extensively, empirical clarity regarding how attachment styles specifically impact PGD symptoms and therapeutic implications remains limited. This study aimed to identify cognitive-behavioral mechanisms linking attachment styles to PGD symptoms.</p><p><strong>Methods: </strong>Data were collected from a community sample of 695 bereaved adults. Network analysis explored interactions between attachment styles (anxious and avoidant) and various cognitive-behavioral factors associated with PGD, including appraisals, memory characteristics, maladaptive coping strategies, and a sense of social disconnection.</p><p><strong>Results: </strong>The findings reveal attachment styles as peripheral within the network, suggesting that their direct influence on PGD symptoms may be less central than previously theorized. However, anxious attachment correlated positively with injustice rumination and altered social self, while avoidant attachment was positively associated with perceived loss of future and relationships and preferences for solitude, and negatively associated with proximity-seeking behaviors and fear of losing connection to the deceased. Cognitive-behavioral factors, particularly memory characteristics and social disconnection, held central positions within the network, mediating relationships between attachment styles and PGD.</p><p><strong>Conclusions: </strong>Attachment styles indirectly influence PGD through cognitive-behavioral pathways rather than exerting strong direct effects. By bridging the gap between attachment theory and cognitive-behavioral approaches to grief, this study offers a more nuanced understanding of its relationship with PGD and points toward potential new avenues for future interventions aimed at addressing attachment-related challenges in bereaved individuals.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e276"},"PeriodicalIF":5.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining harsh parenting as a moderator in the association between childhood irritability and adolescent suicidal behaviors.","authors":"Kelly Jane Rosialda, Cassandra Zephirin, Wan-Ling Tseng, Manish Jha, Ellen Leibenluft, Massimiliano Orri","doi":"10.1017/S0033291725000704","DOIUrl":"https://doi.org/10.1017/S0033291725000704","url":null,"abstract":"<p><strong>Background: </strong>Childhood irritability increases the risk of later suicidal behaviors, but the moderators of this association have not been identified. We investigated harsh parenting as a moderator in the association of childhood irritability with adolescent suicide attempt and self-harm, and possible sex differences in these associations.</p><p><strong>Method: </strong>Data were from 9,480 children from the Millennium Cohort Study. We averaged parent ratings of child irritability and harsh parenting at ages 3, 5, and 7 years (range 1-3). Suicide attempt and self-harm were self-reported at age 17. Logistic regression models were used to estimate associations of irritability with suicide attempt and self-harm, adjusting for confounding factors. Interaction analyses were used to test the moderating role of harsh parenting and sex in these associations.</p><p><strong>Results: </strong>Children with greater irritability scores were at increased risk to attempt suicide (OR=1.72, 95% CI=1.42-2.08). Interaction analyses suggested that this risk in males was elevated regardless of harsh parenting. However, high levels of harsh parenting interacted with irritability in increasing the risk of suicide attempt in females. Children with high irritability were also more at risk of self-harm (OR = 1.16, 95% CI = 1.03-1.31) but this association was not moderated by harsh parenting in either sex.</p><p><strong>Conclusion: </strong>Parental behaviors may play an important role in the pathway to suicide attempt of children with irritability, especially for females, who may have a heightened sensitivity to interpersonal stressors. Parenting interventions may be helpful in suicide prevention among females with irritability.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e274"},"PeriodicalIF":5.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term dosage effects of psychodynamic and schema therapy in depressed patients with personality disorders: 18 and 24 months follow-up of a randomised controlled trial - CORRIGENDUM.","authors":"Marit Kool, Hannah van den Eshof, Rien Van, Jack Dekker, Jaap Peen, Arnoud Arntz","doi":"10.1017/S003329172510189X","DOIUrl":"https://doi.org/10.1017/S003329172510189X","url":null,"abstract":"","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e273"},"PeriodicalIF":5.5,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain structure and function in adult survivors of developmental trauma with psychosis: A systematic review.","authors":"Michael Bloomfield, Mustapha Modaffar, Alexander Noar, Camilla Walker, Ting-Yun Chang","doi":"10.1017/S0033291724002812","DOIUrl":"10.1017/S0033291724002812","url":null,"abstract":"<p><strong>Background: </strong>Developmental trauma increases psychosis risk in adulthood and is associated with poor prognosis and treatment response. It has been proposed that developmental trauma may give rise to a distinct psychosis phenotype. Our aim was to explore this by systematically reviewing neuroimaging studies of brain structure and function in adults with psychosis diagnoses, according to whether or not they had survived developmental trauma. We registered our search protocol in PROSPERO (CRD42018105021).</p><p><strong>Method: </strong>We systematically searched literature databases for relevant studies published before May 2024. We identified 31 imaging studies (<i>n</i> = 1,761 psychosis patients, <i>n</i> = 1,775 healthy controls or healthy siblings).</p><p><strong>Results: </strong>Developmental trauma was associated with global and regional differences in gray matter; corticolimbic structural dysconnectivity; a potentiated threat detection system; dysfunction in regions associated with mentalization; and elevated striatal dopamine synthesis capacity.</p><p><strong>Conclusion: </strong>These findings warrant further research to elucidate vulnerability and resilience mechanisms for psychosis in developmental trauma survivors.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e272"},"PeriodicalIF":5.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}