PTSD and epigenetic aging: a longitudinal meta-analysis.

IF 5.5 2区医学 Q1 PSYCHIATRY

Psychological Medicine Pub Date : 2025-05-14 DOI:10.1017/S0033291725000558

Xiang Zhao, Seyma Katrinli, Beth M McCormick, Mark W Miller, Nicole R Nugent, Agaz H Wani, Anthony S Zannas, Allison E Aiello, Dewleen G Baker, Marco P Boks, Chia-Yen Chen, Catherine B Fortier, Joel Gelernter, Elbert Geuze, Karestan C Koenen, Sarah D Linnstaedt, Jurjen J Luykx, Adam X Maihofer, Samuel A McLean, William P Milberg, Andrew Ratanatharathorn, Kerry J Ressler, Victoria B Risbrough, Bart P F Rutten, Jordan W Smoller, Murray B Stein, Robert J Ursano, Eric Vermetten, Christiaan H Vinkers, Erin B Ware, Derek E Wildman, Ying Zhao, Mark W Logue, Caroline M Nievergelt, Alicia K Smith, Monica Uddin, Erika J Wolf

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引用次数: 0

Abstract

Background: Posttraumatic stress disorder (PTSD) has been associated with advanced epigenetic age cross-sectionally, but the association between these variables over time is unclear. This study conducted meta-analyses to test whether new-onset PTSD diagnosis and changes in PTSD symptom severity over time were associated with changes in two metrics of epigenetic aging over two time points.

Methods: We conducted meta-analyses of the association between change in PTSD diagnosis and symptom severity and change in epigenetic age acceleration/deceleration (age-adjusted DNA methylation age residuals as per the Horvath and GrimAge metrics) using data from 7 military and civilian cohorts participating in the Psychiatric Genomics Consortium PTSD Epigenetics Workgroup (total N = 1,367).

Results: Meta-analysis revealed that the interaction between Time 1 (T1) Horvath age residuals and new-onset PTSD over time was significantly associated with Horvath age residuals at T2 (meta β = 0.16, meta p = 0.02, p-adj = 0.03). The interaction between T1 Horvath age residuals and changes in PTSD symptom severity over time was significantly related to Horvath age residuals at T2 (meta β = 0.24, meta p = 0.05). No associations were observed for GrimAge residuals.

Conclusions: Results indicated that individuals who developed new-onset PTSD or showed increased PTSD symptom severity over time evidenced greater epigenetic age acceleration at follow-up than would be expected based on baseline age acceleration. This suggests that PTSD may accelerate biological aging over time and highlights the need for intervention studies to determine if PTSD treatment has a beneficial effect on the aging methylome.

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PTSD与表观遗传衰老：一项纵向荟萃分析。

背景：创伤后应激障碍（PTSD）与晚期表观遗传年龄横断面相关，但这些变量之间随时间的关系尚不清楚。本研究进行了荟萃分析，以测试新发PTSD诊断和PTSD症状严重程度随时间的变化是否与两个时间点表观遗传衰老的两个指标的变化相关。方法：我们使用参加精神病学基因组学联盟PTSD表观遗传学工作组的7个军人和平民队列（总N = 1,367）的数据，对PTSD诊断和症状严重程度的变化与表观遗传年龄加速/减缓（根据Horvath和GrimAge指标调整年龄的DNA甲基化年龄残差）的变化之间的关系进行了meta分析。结果：meta分析显示，时间1 (T1) Horvath年龄残差与新发PTSD随时间的相互作用与T2时Horvath年龄残差显著相关（meta β = 0.16, meta p = 0.02, p-adj = 0.03）。T1时Horvath年龄残差与PTSD症状严重程度随时间变化的交互作用与T2时Horvath年龄残差显著相关（meta β = 0.24, meta p = 0.05）。没有观察到GrimAge残差的关联。结论：结果表明，随着时间的推移，新发PTSD或PTSD症状严重程度增加的个体在随访中表现出比基于基线年龄加速的预期更大的表观遗传年龄加速。这表明创伤后应激障碍可能随着时间的推移加速生物衰老，并强调需要进行干预研究，以确定创伤后应激障碍治疗是否对衰老的甲基组有有益的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychological Medicine 医学-精神病学

CiteScore

11.30

自引率

4.30%

发文量

711

审稿时长

3-6 weeks

期刊介绍： Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.