Psychological Medicine最新文献

{"title":"Multidimensional outcome of first-episode psychosis: a network analysis - CORRIGENDUM.","authors":"Manuel J Cuesta, Gustavo J Gil-Berrozpe, Ana M Sánchez-Torres, Lucía Moreno-Izco, Elena García de Jalón, Víctor Peralta","doi":"10.1017/S0033291725101098","DOIUrl":"https://doi.org/10.1017/S0033291725101098","url":null,"abstract":"","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e222"},"PeriodicalIF":5.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct and indirect associations of childhood adversities with functional impairment and life stress among military personnel.","authors":"Laura Campbell-Sills, Emily R Edwards, Sam D Strizver, Karmel W Choi, Jason D Kautz, Santiago Papini, James A Naifeh, Pablo A Aliaga, Paul B Lester, Ronald C Kessler, Robert J Ursano, Murray B Stein, Paul D Bliese","doi":"10.1017/S0033291725101189","DOIUrl":"https://doi.org/10.1017/S0033291725101189","url":null,"abstract":"<p><strong>Background: </strong>Adverse childhood experiences (ACEs) are associated with physical and mental health difficulties in adulthood. This study examines the associations of ACEs with functional impairment and life stress among military personnel, a population disproportionately affected by ACEs. We also evaluate the extent to which the associations of ACEs with functional outcomes are mediated through internalizing and externalizing disorders.</p><p><strong>Methods: </strong>The sample included 4,666 STARRS Longitudinal Study (STARRS-LS) participants who provided information about ACEs upon enlistment in the US Army (2011-2012). Mental disorders were assessed in wave 1 (LS1; 2016-2018), and functional impairment and life stress were evaluated in wave 2 (LS2; 2018-2019) of STARRS-LS. Mediation analyses estimated the indirect associations of ACEs with physical health-related impairment, emotional health-related impairment, financial stress, and overall life stress at LS2 through internalizing and externalizing disorders at LS1.</p><p><strong>Results: </strong>ACEs had significant indirect effects via mental disorders on all functional impairment and life stress outcomes, with internalizing disorders displaying stronger mediating effects than externalizing disorders (explaining 31-92% vs 5-15% of the total effects of ACEs, respectively). Additionally, ACEs exhibited significant direct effects on emotional health-related impairment, financial stress, and overall life stress, implying ACEs are also associated with these longer-term outcomes via alternative pathways.</p><p><strong>Conclusions: </strong>This study indicates ACEs are linked to functional impairment and life stress among military personnel in part because of associated risks of mental disorders, particularly internalizing disorders. Consideration of ACEs should be incorporated into interventions to promote psychosocial functioning and resilience among military personnel.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e216"},"PeriodicalIF":5.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-based prediction of depression symptomatology in first-episode psychosis patients: insights from the EUFEST and RAISE-ETP clinical trials.","authors":"Sergio Mena, Fiona Coutts, Jana von Trott, Esin Ucur, Clara Vetter, René R Kahn, W Wolfgang Fleischhacker, John M Kane, Oliver D Howes, Rachel Upthegrove, Paris A Lalousis, Nikolaos Koutsouleris","doi":"10.1017/S0033291725100950","DOIUrl":"https://doi.org/10.1017/S0033291725100950","url":null,"abstract":"<p><strong>Background: </strong>Depressive symptoms are highly prevalent in first-episode psychosis (FEP) and worsen clinical outcomes. It is currently difficult to determine which patients will have persistent depressive symptoms based on a clinical assessment. We aimed to determine whether depressive symptoms and post-psychotic depressive episodes can be predicted from baseline clinical data, quality of life, and blood-based biomarkers, and to assess the geographical generalizability of these models.</p><p><strong>Methods: </strong>Two FEP trials were analyzed: European First-Episode Schizophrenia Trial (EUFEST) (<i>n</i> = 498; 2002-2006) and Recovery After an Initial Schizophrenia Episode Early Treatment Program (RAISE-ETP) (<i>n</i> = 404; 2010-2012). Participants included those aged 15-40 years, meeting Diagnostic and Statistical Manual of Mental Disorders IV criteria for schizophrenia spectrum disorders. We developed support vector regressors and classifiers to predict changes in depressive symptoms at 6 and 12 months and depressive episodes within the first 6 months. These models were trained in one sample and externally validated in another for geographical generalizability.</p><p><strong>Results: </strong>A total of 320 EUFEST and 234 RAISE-ETP participants were included (mean [SD] age: 25.93 [5.60] years, 56.56% male; 23.90 [5.27] years, 73.50% male). Models predicted changes in depressive symptoms at 6 months with balanced accuracy (BAC) of 66.26% (RAISE-ETP) and 75.09% (EUFEST), and at 12 months with BAC of 67.88% (RAISE-ETP) and 77.61% (EUFEST). Depressive episodes were predicted with BAC of 66.67% (RAISE-ETP) and 69.01% (EUFEST), showing fair external predictive performance.</p><p><strong>Conclusions: </strong>Predictive models using clinical data, quality of life, and biomarkers accurately forecast depressive events in FEP, demonstrating generalization across populations.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e221"},"PeriodicalIF":5.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144744549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the longitudinal association between pain characteristics and clinical outcomes in young people with mental ill-health.","authors":"Valerie A Oosterwijk, Caroline X Gao, Jana Menssink, Josh Nguyen, Kate Filia, Amity E Watson, Helen Herrman, Sarah E Hetrick, Alex G Parker, Ian B Hickie, Debra Rickwood, Patrick D McGorry, Susan M Cotton, Lianne Schmaal, Scott D Tagliaferri","doi":"10.1017/S0033291725101104","DOIUrl":"https://doi.org/10.1017/S0033291725101104","url":null,"abstract":"<p><strong>Background: </strong>Mental ill-health has a major impact on young people, with pain often co-occurring. We estimated the prevalence and impact of pain in young people with mental ill-health.</p><p><strong>Methods: </strong>Longitudinal data (baseline and three-month follow-up) of 1,107 Australian young people (aged 12-25 years) attending one of five youth mental health services. Multi-level linear mixed models estimated associations between pain characteristics (frequency, intensity, and limitations) and outcomes with false discovery rate (FDR) adjustment. Pain characteristics were baseline-centered to estimate if the baseline score (<i>between-participant effect</i>) and/or change from baseline (<i>within-participant effect)</i> was associated with outcomes.</p><p><strong>Results: </strong>At baseline, 16% reported serious pain more than 3 days, 51% reported at least moderate pain, and 25% reported pain-related activity limitations in the last week. Between participants, higher serious pain frequency was associated with greater anxiety symptoms (<i>β</i>[95%CI]: 0.90 [0.45, 1.35], FDR-p=0.001), higher pain intensity was associated with greater symptoms of depression (1.50 [0.71, 2.28], FDR-p=0.001), anxiety (1.22 [0.56, 1.89], FDR-p=0.002), and suicidal ideation (3.47 [0.98, 5.96], FDR-p=0.020), and higher pain limitations were associated with greater depressive symptoms (1.13 [0.63, 1.63], FDR-p<0.001). Within participants, increases in pain intensity were associated with increases in tobacco use risk (1.09 [0.48, 1.70], FDR-p=0.002), and increases in pain limitations were associated with increases in depressive symptoms (0.99 [0.54, 1.43], FDR-p<0.001) and decreases in social and occupational functioning (-1.08 [-1.78, -0.38], FDR-p=0.009).</p><p><strong>Conclusions: </strong>One-in-two young people seeking support for mental ill-health report pain. Youth mental health services should consider integrating pain management.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e207"},"PeriodicalIF":5.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144744477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences and similarities between the genetic architecture of lifetime substance use across different substances.","authors":"Uri Bright, Cassie Overstreet, Daniel F Levey, Joel Gelernter","doi":"10.1017/S0033291725101293","DOIUrl":"10.1017/S0033291725101293","url":null,"abstract":"<p><strong>Background: </strong>Illicit drug use may lead to dependence on those drugs, is associated with various psychiatric disorders, and can have hazardous, sometimes life-threatening, consequences. We investigated the genetic architecture underlying the lifetime use (LU) of several drugs, individually and in combination.</p><p><strong>Methods: </strong>We conducted genome-wide association studies of LU of cocaine, methamphetamine, inhalants, illegal opioids, prescription opioids, and prescription stimulants in European (EUR), African (AFR), and Latin American (AMR)-ancestry subjects (cases ranging from <i>n</i> = 4,900-21,850 [EUR], <i>n</i> = 519-9,802 [AFR], and <i>n</i> = 899-5,012 [AMR]; controls from <i>n</i> = 93,763-110,658 [EUR], <i>n</i> = 37,261-46,509 [AFR], and <i>n</i> = 31,412-35,501 [AMR]). We also investigated the use of illicit drugs of any kind and the total count of drugs a person has ever used. Then, we assessed the global and local genetic correlations between substance LU (SubLU) traits and their genetic correlations with other traits.</p><p><strong>Results: </strong>We found numerous genes that affect SubLU traits, with no overlap among the significant loci between traits, suggesting that unique genetic factors may differentially affect the use of different drugs. Nevertheless, the genetic correlations between SubLU traits were very strong; however, the phenotypic correlations were moderate. There were strong genetic correlations between various SubLU traits and psychiatric traits, most notably opioid use disorder, cannabis use disorder, problematic alcohol use, and suicidality.</p><p><strong>Conclusions: </strong>Our findings provide insights into the genetic basis of substance use, identifying several novel genes associated with SubLU traits. This study can provide an improved understanding of the biology underlying SubLU and could potentially facilitate future risk assessments for the use of illicit and hazardous drugs.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e219"},"PeriodicalIF":5.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144744476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted interventions to improve the social and economic circumstances of people with mental ill-health from marginalised communities: a systematic review.","authors":"Helen Baldwin, Anna Greenburgh, Hannah Weir, Zara Asif, Dionne Laporte, Mark Bertram, Achille Crawford, Gabrielle Duberry, Shoshana Lauter, Brynmor Lloyd-Evans, Cassandra Lovelock, Jayati Das-Munshi, Craig Morgan","doi":"10.1017/S0033291725101128","DOIUrl":"10.1017/S0033291725101128","url":null,"abstract":"<p><p>People who experience mental ill-health are typically more disadvantaged across a range of social and economic domains compared with the general population. This disadvantage is further heightened for people from marginalised communities. Social and economic adversities can limit both the access to, and effectiveness of, interventions for mental ill-health; however, these challenges are often overlooked by mental health services. Therefore, adequate support for social needs is urgently required, particularly for those from marginalised and vulnerable groups. We conducted a PRISMA-compliant systematic review of three academic databases to identify social and/or economic interventions which were adapted or developed bespoke for people from marginalised or minoritised communities living with mental ill-health. All records were screened blind by two reviewers; quality appraisal was conducted with the Kmet tool. Seventy-eight papers were included, deriving mostly from high-income countries. The identified interventions targeted nine sociodemographic or socioeconomic groups including: people experiencing homelessness or unstable housing (<i>n</i> = 50), people with an offending history (<i>n</i> = 9), mothers (<i>n</i> = 6), people experiencing economic disadvantage (<i>n</i> = 3), older adults (<i>n</i> = 3), caregivers (<i>n</i> = 2), minority ethnic groups (<i>n</i> = 2), women with experience of intimate partner violence (<i>n</i> = 1), and people with comorbid intellectual disabilities (<i>n</i> = 1). All identified interventions demonstrated feasibility, acceptability, or effectiveness on at least one social and/or economic outcome measure, suggesting that targeted intervention can help to address social and economic needs and reduce systemic inequalities in mental health care. However, the evidence base is still sparse, and further replication is warranted to inform commissioners and policy makers.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e217"},"PeriodicalIF":5.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive processes and pathways between social isolation, loneliness, and paranoia: findings from a cross-lagged network analysis of population-based data.","authors":"Błażej Misiak","doi":"10.1017/S003329172510130X","DOIUrl":"10.1017/S003329172510130X","url":null,"abstract":"<p><strong>Background: </strong>Social disconnection, covering loneliness and social isolation, might be associated with the development of paranoid thoughts. Differential effects of loneliness and social isolation on the occurrence of paranoia have not been tested so far. Moreover, the role of cognitive mechanisms in these associations remains unknown. This study aimed to investigate differential associations of loneliness and social isolation with paranoid thoughts in the general population, considering the role of cognitive mechanisms.</p><p><strong>Methods: </strong>Altogether, 3,275 individuals, enrolled from the general population, completed baseline and follow-up assessments spanning 6-7 months. Cognitive biases (rejection sensitivity, attributional biases, and safety behaviors), social cognitive problems, and subjective cognitive problems were measured. The cross-lagged panel network (CLPN) analysis was performed, controlling for the effects of sociodemographic characteristics, psychiatric treatment, substance use, depressive, and anxiety symptoms. Additionally, mediation was tested for the CLPN paths linking social disconnection with paranoid ideation, with one intermediary node representing cognitive processes.</p><p><strong>Results: </strong>Loneliness was the most important node in terms of predicting other network variables. It was bidirectionally associated with paranoid thoughts. Cognitive processes mediated these associations (partial mediation for ideas of reference and full mediation for ideas of persecution). In turn, social isolation predicted paranoid thoughts through the effects on loneliness. It was also predicted by paranoid thoughts through attributional biases.</p><p><strong>Conclusions: </strong>Social disconnection might be bidirectionally associated with paranoid thoughts. However, loneliness is more closely tied to paranoid thoughts compared to social isolation. Cognitive processes might mediate the association of social disconnection with paranoid thoughts.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e215"},"PeriodicalIF":5.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common and distinct patterns of brain activity alterations during inhibitory control in depression and psychostimulant users: a comparative meta-analysis of task-based fMRI studies.","authors":"Yuanyuan Li, Xiqin Liu, Jianyu Li, Qian Zhang, Nanfang Pan, Kui Luo, Graham J Kemp, Qiyong Gong","doi":"10.1017/S0033291725101141","DOIUrl":"10.1017/S0033291725101141","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) and psychostimulant use disorder (PUD) are common, disabling psychopathologies that pose a major public health burden. They share a common behavioral phenotype: deficits in inhibitory control (IC). However, whether this is underpinned by shared neurobiology remains unclear. In this meta-analytic study, we aimed to define and compare brain functional alterations during IC tasks in MDD and PUD.</p><p><strong>Methods: </strong>We conducted a systematic literature search on IC task-based functional magnetic resonance imaging studies in MDD and PUD (cocaine or methamphetamine use disorder) in PubMed, Web of Science, and Scopus. We performed a quantitative meta-analysis using seed-based d mapping to define common and distinct neurofunctional abnormalities.</p><p><strong>Results: </strong>We identified 14 studies comparing IC-related brain activation in a total of 340 MDD patients with 303 healthy controls (HCs), and 11 studies comparing 258 PUD patients with 273 HCs. MDD showed disorder-differentiating hypoactivation during IC tasks in the median cingulate/paracingulate gyri relative to PUD and HC, whereas PUD showed disorder-differentiating hypoactivation relative to MDD and HC in the bilateral inferior parietal lobule. In conjunction analysis, hypoactivation in the right inferior/middle frontal gyrus was common to both MDD and PUD.</p><p><strong>Conclusions: </strong>The transdiagnostic neurofunctional alterations in prefrontal cognitive control regions may underlie IC deficits shared by MDD and PUD, whereas disorder-differentiating activation abnormalities in midcingulate and parietal regions may account for their distinct features associated with disturbed goal-directed behavior.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e218"},"PeriodicalIF":5.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered morphological cortical thickness and disrupted network attributes and its relationships with drug use characteristics and impulsivity in abstinent male subjects with methamphetamine use disorder.","authors":"Dan Luo, Danlin Shen, Huiting Luo, Jiaxi Zhang, Qiao Tang, Mingfeng Lai, Jia-Jun Xu, Jing Li","doi":"10.1017/S0033291725101165","DOIUrl":"https://doi.org/10.1017/S0033291725101165","url":null,"abstract":"<p><strong>Background: </strong>Methamphetamine (METH) dependence is a globally significant public health concern with no efficacious treatment. Trait impulsivity is associated with the initiation, maintenance, and recurrence of substance abuse. However, the presence of these associations in METH addiction, as well as the underlying neurobiological mechanisms, remains incompletely understood.</p><p><strong>Methods: </strong>We scanned 110 individuals with METH use disorder (MUDs) and 55 matched healthy controls (HCs) using T1-weighted imaging and assessed their drug use characteristics and trait impulsivity. Surface-based morphometry and graph theoretical analysis were used to investigate group differences in brain morphometry and network attributes. Partial correlations were conducted to investigate the relationships between brain morphometric changes, drug use parameters, and trait impulsivity. Mediation analyses examined how trait impulsivity and drug craving influenced the link between brain morphometric change and MUD severity in patients.</p><p><strong>Results: </strong>MUDs exhibited thinner thickness in the left fusiform gyrus and right pars opercularis, as well as diminished small-world properties in their structural covariance networks (SCNs) compared to HCs. Furthermore, reduced cortical thickness in the right pars opercularis was linked to motor impulsivity (MI) and MUD severity, and the association between the right pars opercularis thickness and MUD severity was significantly mediated by both MI and cue-induced craving.</p><p><strong>Conclusions: </strong>These findings suggest that MUDs exhibit distinct brain structural abnormalities in both the cortical thickness and SCNs and highlight the critical role of impulse control in METH addiction. This insight may offer a potential neurobiological target for developing therapeutic interventions to treat addiction and prevent relapse.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e214"},"PeriodicalIF":5.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical decision-making for AI in mental health: the Integrated Ethical Approach for Computational Psychiatry (IEACP) framework.","authors":"Andrea Putica, Rahul Khanna, Wiliam Bosl, Sudeep Saraf, Juliet Edgcomb","doi":"10.1017/S0033291725101311","DOIUrl":"https://doi.org/10.1017/S0033291725101311","url":null,"abstract":"<p><p>The integration of computational methods into psychiatry presents profound ethical challenges that extend beyond existing guidelines for AI and healthcare. While precision medicine and digital mental health tools offer transformative potential, they also raise concerns about privacy, algorithmic bias, transparency, and the erosion of clinical judgment. This article introduces the Integrated Ethical Approach for Computational Psychiatry (IEACP) framework, developed through a conceptual synthesis of 83 studies. The framework comprises five procedural stages - Identification, Analysis, Decision-making, Implementation, and Review - each informed by six core ethical values - beneficence, autonomy, justice, privacy, transparency, and scientific integrity. By systematically addressing ethical dilemmas inherent in computational psychiatry, the IEACP provides clinicians, researchers, and policymakers with structured decision-making processes that support patient-centered, culturally sensitive, and equitable AI implementation. Through case studies, we demonstrate framework adaptability to real-world applications, underscoring the necessity of ethical innovation alongside technological progress in psychiatric care.</p>","PeriodicalId":20891,"journal":{"name":"Psychological Medicine","volume":"55 ","pages":"e213"},"PeriodicalIF":5.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}