Progress in Neurobiology最新文献_第3页

Memory load influences our preparedness to act on visual representations in working memory without affecting their accessibility 记忆负荷影响我们对工作记忆中的视觉表征采取行动的准备，而不影响其可及性。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.pneurobio.2025.102717

Rose Nasrawi, Mika Mautner-Rohde, Freek van Ede

{"title":"Memory load influences our preparedness to act on visual representations in working memory without affecting their accessibility","authors":"Rose Nasrawi, Mika Mautner-Rohde, Freek van Ede","doi":"10.1016/j.pneurobio.2025.102717","DOIUrl":"10.1016/j.pneurobio.2025.102717","url":null,"abstract":"<div><div>It is well established that when we hold more content in working memory, we are slower to act upon part of that content when it becomes relevant for behavior. Here, we asked whether this load-related slowing is due to slower access to the sensory representations held in working memory (as predicted by serial working-memory search), or by a reduced preparedness to act upon those sensory representations once accessed. To address this, we designed a visual-motor working-memory task in which participants memorized the orientation of two or four colored bars, of which one was cued for reproduction. We independently tracked EEG markers associated with the selection of visual (cued item location) and motor (relevant manual action) information from the EEG time-frequency signal, and compared their latencies as a function of memory load. We confirm slower memory-guided behavior with higher working-memory load and show that this is associated with delayed motor selection. In contrast, we find no evidence for a concomitant delay in the latency of visual selection. Moreover, we show that variability in decision times within each memory-load condition is associated with corresponding changes in the latency of motor, but not visual selection. These results reveal how memory load affects our preparedness to act on sensory representations in working memory, while leaving sensory access itself unaffected. This posits action readiness as a key factor that shapes the speed of memory-guided behavior and that underlies delayed responding with higher working-memory load.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"245 ","pages":"Article 102717"},"PeriodicalIF":6.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Face pareidolia minimally engages macaque face selective neurons 猕猴面部选择神经元对面部视错觉的影响最小。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2025-02-01 DOI: 10.1016/j.pneurobio.2024.102709

Kenji W. Koyano , Jessica Taubert , William Robison , Elena N. Waidmann , David A. Leopold

{"title":"Face pareidolia minimally engages macaque face selective neurons","authors":"Kenji W. Koyano , Jessica Taubert , William Robison , Elena N. Waidmann , David A. Leopold","doi":"10.1016/j.pneurobio.2024.102709","DOIUrl":"10.1016/j.pneurobio.2024.102709","url":null,"abstract":"<div><div>The macaque cerebral cortex contains concentrations of neurons that prefer faces over inanimate objects. Although these so-called face patches are thought to be specialized for the analysis of facial signals, their exact tuning properties remain unclear. For example, what happens when an object by chance resembles a face? Everyday objects can sometimes, through the accidental positioning of their internal components, appear as faces. This phenomenon is known as face pareidolia. Behavioral experiments have suggested that macaques, like humans, perceive illusory faces in such objects. However, it is an open question whether such stimuli would naturally stimulate neurons residing in cortical face patches. To address this question, we recorded single unit activity from four fMRI-defined face-selective regions: the anterior medial (AM), anterior fundus (AF), prefrontal orbital (PO), and perirhinal cortex (PRh) face patches. We compared neural responses elicited by images of real macaque faces, pareidolia-evoking objects, and matched control objects. Contrary to expectations, we found no evidence of a general preference for pareidolia-evoking objects over control objects. Although a subset of neurons exhibited stronger responses to pareidolia-evoking objects, the population responses to both categories of objects were similar, and collectively much less than to real macaque faces. These results suggest that neural responses in the four regions we tested are principally concerned with the analysis of realistic facial characteristics, whereas the special attention afforded to face-like pareidolia stimuli is supported by activity elsewhere in the brain.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"245 ","pages":"Article 102709"},"PeriodicalIF":6.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Background white noise increases neuronal activity by reducing membrane fluctuations and slow-wave oscillations in auditory cortex

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2025-01-24 DOI: 10.1016/j.pneurobio.2025.102720

Rasmus Kordt Christensen , Florian Studer, Tania Rinaldi Barkat

{"title":"Background white noise increases neuronal activity by reducing membrane fluctuations and slow-wave oscillations in auditory cortex","authors":"Rasmus Kordt Christensen , Florian Studer, Tania Rinaldi Barkat","doi":"10.1016/j.pneurobio.2025.102720","DOIUrl":"10.1016/j.pneurobio.2025.102720","url":null,"abstract":"<div><div>The brain faces the challenging task of preserving a consistent portrayal of the external world in the face of disruptive sensory inputs. What alterations occur in sensory representation amidst noise, and how does brain activity adapt to it? Although it has previously been shown that background white noise (WN) decreases responses to salient sounds, a mechanistic understanding of the brain processes responsible for such changes is lacking. We investigated the effect of background WN on neuronal spiking activity, membrane potential, and network oscillations in the mouse central auditory system. We found that, in addition to increasing background spiking activity in the auditory cortex and thalamus, background WN decreases neural activity fluctuations, as reflected in the membrane potential of single neurons and the local field potential. Blocking acetylcholine signaling in the auditory cortex eliminated the WN-dependent increase in background activity as well as the shift in slow-wave oscillations. Together, our observations show that background WN is not filtered away along the auditory pathway, but rather drives sustained changes in cortical activity that can be reverted by blocking cholinergic inputs.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"246 ","pages":"Article 102720"},"PeriodicalIF":6.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2025-01-22 DOI: 10.1016/j.pneurobio.2025.102718

Odra Santander , Sebastián B. Arredondo , Francisca García-Rojas , Sebastián F. Estay , Juan E. Belforte , Andrés E. Chávez , Lorena Varela-Nallar , Marco Fuenzalida

{"title":"Ketamine administration during adolescence impairs synaptic integration and inhibitory synaptic transmission in the adult dentate gyrus","authors":"Odra Santander , Sebastián B. Arredondo , Francisca García-Rojas , Sebastián F. Estay , Juan E. Belforte , Andrés E. Chávez , Lorena Varela-Nallar , Marco Fuenzalida","doi":"10.1016/j.pneurobio.2025.102718","DOIUrl":"10.1016/j.pneurobio.2025.102718","url":null,"abstract":"<div><div>Ketamine administration during adolescence affects cognitive performance; however, its long-term impact on synaptic function and neuronal integration in the hippocampus a brain region critical for cognition remains unclear. Using functional and molecular analyses, we found that chronic ketamine administration during adolescence exerts long-term effects on synaptic integration, expanding the temporal window in an input-specific manner affecting the inner molecular layer but not the medial perforant path inputs in the adult mouse dorsal hippocampal dentate gyrus. Ketamine also alters the excitatory/inhibitory balance by reducing the efficacy of inhibitory inputs likely due to a reduction in parvalbumin-positive interneurons number and function. These findings indicate that during adolescence, ketamine exerts a strong effect on inhibitory synaptic function mediated by parvalbumin-positive neurons that ultimately impact synaptic integration in the dorsal adult dentate gyrus, which could help to understand the neurobiological and functional bases that confer greater vulnerability to the adolescent brain.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"246 ","pages":"Article 102718"},"PeriodicalIF":6.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143041485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal network dynamics and structural correlates in the human cerebral cortex in vitro

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2025-01-21 DOI: 10.1016/j.pneurobio.2025.102719

Joana Covelo , Alessandra Camassa , Jose Manuel Sanchez-Sanchez , Arnau Manasanch , Leonardo Dalla Porta , Nathalia Cancino-Fuentes , Almudena Barbero-Castillo , Rita M. Robles , Miquel Bosch , Silvia Tapia-Gonzalez , Paula Merino-Serrais , Mar Carreño , Estefania Conde-Blanco , Jordi Rumià Arboix , Pedro Roldán , Javier DeFelipe , Maria V. Sanchez-Vives

{"title":"Spatiotemporal network dynamics and structural correlates in the human cerebral cortex in vitro","authors":"Joana Covelo , Alessandra Camassa , Jose Manuel Sanchez-Sanchez , Arnau Manasanch , Leonardo Dalla Porta , Nathalia Cancino-Fuentes , Almudena Barbero-Castillo , Rita M. Robles , Miquel Bosch , Silvia Tapia-Gonzalez , Paula Merino-Serrais , Mar Carreño , Estefania Conde-Blanco , Jordi Rumià Arboix , Pedro Roldán , Javier DeFelipe , Maria V. Sanchez-Vives","doi":"10.1016/j.pneurobio.2025.102719","DOIUrl":"10.1016/j.pneurobio.2025.102719","url":null,"abstract":"<div><div>Elucidating human cerebral cortex function is essential for understanding the physiological basis of both healthy and pathological brain states. We obtained extracellular local field potential recordings from slices of neocortical tissue from refractory epilepsy patients. Multi-electrode recordings were combined with histological information, providing a two-dimensional spatiotemporal characterization of human cortical dynamics in control conditions and following modulation of the excitation/inhibition balance<em>.</em> Slices expressed spontaneous rhythmic activity consistent with slow wave activity, comprising alternating active (Up) and silent (Down) states (Up-duration: 0.08 ± 0.03 s, Down-duration: 2.62 ± 2.12 s, frequency: 0.75 ± 0.39 Hz). Up states propagated from deep to superficial layers, with faster propagation speeds than in other species (vertical: 64.6 mm/s; horizontal: 65.9 mm/s). GABA<sub>A</sub> blockade progressively transformed the emergent activity into epileptiform discharges, marked by higher firing rates, faster network recruitment and propagation, and infraslow rhythmicity (0.01 Hz). This dynamical characterization broadens our understanding of the mechanistic organization of the human cortical network at the micro- and mesoscale.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"246 ","pages":"Article 102719"},"PeriodicalIF":6.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The unanticipated contribution of Zap70 in retinal degeneration: Implications for microglial inflammatory activation Zap70在视网膜变性中的意外贡献：对小胶质细胞炎症激活的影响。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2025-01-01 DOI: 10.1016/j.pneurobio.2024.102706

Kausik Bishayee , Seung-Hee Lee , Yeon-Jin Heo , Mi-La Cho , Yong Soo Park

{"title":"The unanticipated contribution of Zap70 in retinal degeneration: Implications for microglial inflammatory activation","authors":"Kausik Bishayee , Seung-Hee Lee , Yeon-Jin Heo , Mi-La Cho , Yong Soo Park","doi":"10.1016/j.pneurobio.2024.102706","DOIUrl":"10.1016/j.pneurobio.2024.102706","url":null,"abstract":"<div><div>Inflammation is a major mechanism of photoreceptor cell death in the retina during macular degeneration leading to the blindness. In this study, we investigated the role of the kinase molecule Zap70, which is an inflammatory regulator of the systemic immune system, to elucidate the control mechanism of inflammation in the retina. We observed activated microglial cells migrated and populated the retinal layer following blue LED-induced photoreceptor degeneration and activated microglial cells in the LED-injured retina expressed Zap70, unlike the inactive microglial cells in the normal retina. Visual function was considerably decreased in blue-LED light-exposed mice, and animals with Zap70 mutations were adversely affected. Furthermore, extensive photoreceptor cell death was observed in the SKG mice, bearing a Zap70 mutation that induces autoimmune disease. In the blue-LED light-exposed groups, SKG retinas had significantly higher levels of inflammatory cytokines than those in wild-type mice. Furthermore, regulating Zap70 activity has a significant influence on microglial inflammatory state. We discovered that active microglial cells expressing Zap70 could modify vascular endothelial growth factor A (Vegfa) signaling in primary retinal pigment epithelial (RPE) cells. Our novel study revealed that the production of Zap70 by retinal microglial cells is responsible for inflammatory signals that promote apoptosis in photoreceptor cells. Furthermore, Zap70-positive microglial cells were capable of regulating Vegfa signaling in RPE cells, which matches the hallmark of macular degeneration. Overall, we discovered Zap70's inflammatory activity in the retina, which is necessary for upregulating multiple inflammatory cytokines and cell death. Zap70 represents a novel therapeutic target for treating retinal degeneration.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"244 ","pages":"Article 102706"},"PeriodicalIF":6.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutamatergic neurons of basolateral amygdala mediate increased exploratory behaviors produced by mildly chronic restraint stress in adolescent mice 青春期小鼠基底外侧杏仁核谷氨酸能神经元介导轻度慢性约束应激产生的探索行为增加。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2025-01-01 DOI: 10.1016/j.pneurobio.2024.102705

Beining Wang , Huan Liu , Yunxia Shang , Yujie Xiong , Jiayi Yang , Zihao Zhan , Zhi Zhang , Kai Wang , Tingting Sun

{"title":"Glutamatergic neurons of basolateral amygdala mediate increased exploratory behaviors produced by mildly chronic restraint stress in adolescent mice","authors":"Beining Wang , Huan Liu , Yunxia Shang , Yujie Xiong , Jiayi Yang , Zihao Zhan , Zhi Zhang , Kai Wang , Tingting Sun","doi":"10.1016/j.pneurobio.2024.102705","DOIUrl":"10.1016/j.pneurobio.2024.102705","url":null,"abstract":"<div><div>In response to stressors, individuals manifest varied behavioral responses directed toward satisfying physiological survival needs. Although the enduring effects of adolescent stress on both humans and animals are well-documented, the underlying mechanisms remain insufficiently elucidated. Utilizing immunofluorescence, viral injections, and brain slice electrophysiological recordings, we have delineated that heightened excitability among glutamatergic neurons in the basolateral amygdala (BLA) is responsible for inducing heightened exploratory behaviors in adolescent mice subjected to mild, chronic restraint stress. Activation of BLA glutamatergic neurons through chemogenetics increases exploratory behaviors in emotional assessments, whereas inhibition of these neurons diminishes exploratory behaviors in measures such as the open field and elevated plus maze test. Furthermore, an upregulation of glutamate receptor expression and a concomitant downregulation of GABA receptor expression in BLA glutamatergic neurons have been associated with enhanced exploratory behaviors, validated through in vivo receptor antagonists. These findings unveil the protective role of mild stress exposure during adolescence against adversity, providing novel insights for addressing stressful events.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"244 ","pages":"Article 102705"},"PeriodicalIF":6.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustained EEG responses to rapidly unfolding stochastic sounds reflect Bayesian inferred reliability tracking 对快速展开的随机声音的持续脑电图反应反映了贝叶斯推断的可靠性跟踪。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2025-01-01 DOI: 10.1016/j.pneurobio.2024.102696

Sijia Zhao , Benjamin Skerritt-Davis , Mounya Elhilali , Frederic Dick , Maria Chait

{"title":"Sustained EEG responses to rapidly unfolding stochastic sounds reflect Bayesian inferred reliability tracking","authors":"Sijia Zhao , Benjamin Skerritt-Davis , Mounya Elhilali , Frederic Dick , Maria Chait","doi":"10.1016/j.pneurobio.2024.102696","DOIUrl":"10.1016/j.pneurobio.2024.102696","url":null,"abstract":"<div><div>How does the brain track and process rapidly changing sensory information? Current computational accounts suggest that our sensations and decisions arise from the intricate interplay between bottom-up sensory signals and constantly changing expectations regarding the statistics of the surrounding world. A significant focus of recent research is determining which statistical properties are tracked by the brain as it monitors the rapid progression of sensory information. Here, by combining EEG (three experiments N ≥ 22 each) and computational modelling, we examined how the brain processes rapid and stochastic sound sequences that simulate key aspects of dynamic sensory environments. Passively listening participants were exposed to structured tone-pip arrangements that contained transitions between a range of stochastic patterns. Predictions were guided by a Bayesian predictive inference model. We demonstrate that listeners automatically track the statistics of unfolding sounds, even when these are irrelevant to behaviour. Transitions between sequence patterns drove a shift in the sustained EEG response. This was observed to a range of distributional statistics, and even in situations where behavioural detection of these transitions was at floor. These observations suggest that the modulation of the EEG sustained response reflects a process of belief updating within the brain. By establishing a connection between the outputs of the computational model and the observed brain responses, we demonstrate that the dynamics of these transition-related responses align with the tracking of “precision” – the confidence or reliability assigned to a predicted sensory signal - shedding light on the intricate interplay between the brain's statistical tracking mechanisms and its response dynamics.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"244 ","pages":"Article 102696"},"PeriodicalIF":6.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decade of TRAP progress: Insights and future prospects for advancing functional network research in epilepsy TRAP进展的十年：癫痫功能网络研究的见解和未来展望。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2025-01-01 DOI: 10.1016/j.pneurobio.2024.102707

Zhisheng Li , Wangjialu Lu , Lin Yang , Nanxi Lai , Yi Wang , Zhong Chen

{"title":"Decade of TRAP progress: Insights and future prospects for advancing functional network research in epilepsy","authors":"Zhisheng Li , Wangjialu Lu , Lin Yang , Nanxi Lai , Yi Wang , Zhong Chen","doi":"10.1016/j.pneurobio.2024.102707","DOIUrl":"10.1016/j.pneurobio.2024.102707","url":null,"abstract":"<div><div>Targeted Recombination in Active Populations (TRAP) represents an effective and extensively applied technique that has earned significant utilization in neuroscience over the past decade, primarily for identifying and modulating functionally activated neuronal ensembles associated with diverse behaviors. As epilepsy is a neurological disorder characterized by pathological hyper-excitatory networks, TRAP has already been widely applied in epilepsy research. However, the deployment of TRAP in this field remains underexplored, and there is significant potential for further application and development in epilepsy-related investigations. In this review, we embark on a concise examination of the mechanisms behind several TRAP tools, introduce the current applications of TRAP in epilepsy research, and collate the key advantages as well as limitations of TRAP. Furthermore, we sketch out perspectives on potential applications of TRAP in future epilepsy research, grounded in the present landscape and challenges of the field, as well as the ways TRAP has been embraced in other neuroscience domains.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"244 ","pages":"Article 102707"},"PeriodicalIF":6.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prefrontal excitation/inhibition balance supports adolescent enhancements in circuit signal to noise ratio 前额叶激励/抑制平衡支持青春期电路信噪比的增强。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-12-01 DOI: 10.1016/j.pneurobio.2024.102695

Shane D. McKeon , Maria I. Perica , Finnegan J. Calabro , Will Foran , Hoby Hetherington , Chan-Hong Moon , Beatriz Luna

{"title":"Prefrontal excitation/inhibition balance supports adolescent enhancements in circuit signal to noise ratio","authors":"Shane D. McKeon , Maria I. Perica , Finnegan J. Calabro , Will Foran , Hoby Hetherington , Chan-Hong Moon , Beatriz Luna","doi":"10.1016/j.pneurobio.2024.102695","DOIUrl":"10.1016/j.pneurobio.2024.102695","url":null,"abstract":"<div><div>The development and refinement of neuronal circuitry allow for stabilized and efficient neural recruitment, supporting adult-like behavioral performance. During adolescence, the maturation of PFC is proposed to be a critical period (CP) for executive function, driven by a break in balance between glutamatergic excitation and GABAergic inhibition (E/I) neurotransmission. During CPs, cortical circuitry fine-tunes to improve information processing and reliable responses to stimuli, shifting from spontaneous to evoked activity, enhancing the SNR, and promoting neural synchronization. Harnessing 7 T MR spectroscopy and EEG in a longitudinal cohort (N = 164, ages 10–32 years, 283 neuroimaging sessions), we outline associations between age-related changes in glutamate and GABA neurotransmitters and EEG measures of cortical SNR. We find developmental decreases in spontaneous activity and increases in cortical SNR during our auditory steady state task using 40 Hz stimuli. Decreases in spontaneous activity were associated with glutamate levels in DLPFC, while increases in cortical SNR were associated with more balanced Glu and GABA levels. These changes were associated with improvements in working memory performance. This study provides evidence of CP plasticity in the human PFC during adolescence, leading to stabilized circuitry that allows for the optimal recruitment and integration of multisensory input, resulting in improved executive function.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"243 ","pages":"Article 102695"},"PeriodicalIF":6.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0