Progress in Neurobiology最新文献_第3页

Sustained EEG responses to rapidly unfolding stochastic sounds reflect Bayesian inferred reliability tracking 对快速展开的随机声音的持续脑电图反应反映了贝叶斯推断的可靠性跟踪。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2025-01-01 DOI: 10.1016/j.pneurobio.2024.102696

Sijia Zhao , Benjamin Skerritt-Davis , Mounya Elhilali , Frederic Dick , Maria Chait

{"title":"Sustained EEG responses to rapidly unfolding stochastic sounds reflect Bayesian inferred reliability tracking","authors":"Sijia Zhao , Benjamin Skerritt-Davis , Mounya Elhilali , Frederic Dick , Maria Chait","doi":"10.1016/j.pneurobio.2024.102696","DOIUrl":"10.1016/j.pneurobio.2024.102696","url":null,"abstract":"<div><div>How does the brain track and process rapidly changing sensory information? Current computational accounts suggest that our sensations and decisions arise from the intricate interplay between bottom-up sensory signals and constantly changing expectations regarding the statistics of the surrounding world. A significant focus of recent research is determining which statistical properties are tracked by the brain as it monitors the rapid progression of sensory information. Here, by combining EEG (three experiments N ≥ 22 each) and computational modelling, we examined how the brain processes rapid and stochastic sound sequences that simulate key aspects of dynamic sensory environments. Passively listening participants were exposed to structured tone-pip arrangements that contained transitions between a range of stochastic patterns. Predictions were guided by a Bayesian predictive inference model. We demonstrate that listeners automatically track the statistics of unfolding sounds, even when these are irrelevant to behaviour. Transitions between sequence patterns drove a shift in the sustained EEG response. This was observed to a range of distributional statistics, and even in situations where behavioural detection of these transitions was at floor. These observations suggest that the modulation of the EEG sustained response reflects a process of belief updating within the brain. By establishing a connection between the outputs of the computational model and the observed brain responses, we demonstrate that the dynamics of these transition-related responses align with the tracking of “precision” – the confidence or reliability assigned to a predicted sensory signal - shedding light on the intricate interplay between the brain's statistical tracking mechanisms and its response dynamics.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"244 ","pages":"Article 102696"},"PeriodicalIF":6.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142795016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decade of TRAP progress: Insights and future prospects for advancing functional network research in epilepsy TRAP进展的十年：癫痫功能网络研究的见解和未来展望。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2025-01-01 DOI: 10.1016/j.pneurobio.2024.102707

Zhisheng Li , Wangjialu Lu , Lin Yang , Nanxi Lai , Yi Wang , Zhong Chen

{"title":"Decade of TRAP progress: Insights and future prospects for advancing functional network research in epilepsy","authors":"Zhisheng Li , Wangjialu Lu , Lin Yang , Nanxi Lai , Yi Wang , Zhong Chen","doi":"10.1016/j.pneurobio.2024.102707","DOIUrl":"10.1016/j.pneurobio.2024.102707","url":null,"abstract":"<div><div>Targeted Recombination in Active Populations (TRAP) represents an effective and extensively applied technique that has earned significant utilization in neuroscience over the past decade, primarily for identifying and modulating functionally activated neuronal ensembles associated with diverse behaviors. As epilepsy is a neurological disorder characterized by pathological hyper-excitatory networks, TRAP has already been widely applied in epilepsy research. However, the deployment of TRAP in this field remains underexplored, and there is significant potential for further application and development in epilepsy-related investigations. In this review, we embark on a concise examination of the mechanisms behind several TRAP tools, introduce the current applications of TRAP in epilepsy research, and collate the key advantages as well as limitations of TRAP. Furthermore, we sketch out perspectives on potential applications of TRAP in future epilepsy research, grounded in the present landscape and challenges of the field, as well as the ways TRAP has been embraced in other neuroscience domains.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"244 ","pages":"Article 102707"},"PeriodicalIF":6.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prefrontal excitation/inhibition balance supports adolescent enhancements in circuit signal to noise ratio 前额叶激励/抑制平衡支持青春期电路信噪比的增强。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-12-01 DOI: 10.1016/j.pneurobio.2024.102695

Shane D. McKeon , Maria I. Perica , Finnegan J. Calabro , Will Foran , Hoby Hetherington , Chan-Hong Moon , Beatriz Luna

{"title":"Prefrontal excitation/inhibition balance supports adolescent enhancements in circuit signal to noise ratio","authors":"Shane D. McKeon , Maria I. Perica , Finnegan J. Calabro , Will Foran , Hoby Hetherington , Chan-Hong Moon , Beatriz Luna","doi":"10.1016/j.pneurobio.2024.102695","DOIUrl":"10.1016/j.pneurobio.2024.102695","url":null,"abstract":"<div><div>The development and refinement of neuronal circuitry allow for stabilized and efficient neural recruitment, supporting adult-like behavioral performance. During adolescence, the maturation of PFC is proposed to be a critical period (CP) for executive function, driven by a break in balance between glutamatergic excitation and GABAergic inhibition (E/I) neurotransmission. During CPs, cortical circuitry fine-tunes to improve information processing and reliable responses to stimuli, shifting from spontaneous to evoked activity, enhancing the SNR, and promoting neural synchronization. Harnessing 7 T MR spectroscopy and EEG in a longitudinal cohort (N = 164, ages 10–32 years, 283 neuroimaging sessions), we outline associations between age-related changes in glutamate and GABA neurotransmitters and EEG measures of cortical SNR. We find developmental decreases in spontaneous activity and increases in cortical SNR during our auditory steady state task using 40 Hz stimuli. Decreases in spontaneous activity were associated with glutamate levels in DLPFC, while increases in cortical SNR were associated with more balanced Glu and GABA levels. These changes were associated with improvements in working memory performance. This study provides evidence of CP plasticity in the human PFC during adolescence, leading to stabilized circuitry that allows for the optimal recruitment and integration of multisensory input, resulting in improved executive function.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"243 ","pages":"Article 102695"},"PeriodicalIF":6.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The primate putamen processes cognitive flexibility alongside the caudate and ventral striatum with similar speeds of updating values 灵长类动物壳核与尾状体和腹侧纹状体一起处理认知灵活性，更新值的速度相似。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-12-01 DOI: 10.1016/j.pneurobio.2024.102651

Shin-young An , Seong-Hwan Hwang , Keonwoo Lee, Hyoung F. Kim

{"title":"The primate putamen processes cognitive flexibility alongside the caudate and ventral striatum with similar speeds of updating values","authors":"Shin-young An , Seong-Hwan Hwang , Keonwoo Lee, Hyoung F. Kim","doi":"10.1016/j.pneurobio.2024.102651","DOIUrl":"10.1016/j.pneurobio.2024.102651","url":null,"abstract":"<div><div>The putamen is thought to generate habitual actions by processing value information relayed from the ventral striatum through the caudate nucleus. However, it is a question what value the putamen neurons process and whether the putamen receives serially processed value through the striatal structures. We found that neurons in the primate putamen, caudate, and ventral striatum selectively encoded flexibly updated values for adaptive behaviors with similar learning speeds, rather than stably sustained values for habit. In reversal value learning, rostral striatum neurons dynamically adjusted their responses to object values in alignment with changes in saccade reaction times following reversals. Notably, the value acquisition speeds within trials were similar, proposing a parallel value update in each striatal region. However, in stable value retrieval, most did not encode the values for habitual saccades. Our findings suggest that the rostral striatum including the putamen is selectively involved in the parallel processing of cognitive flexibility.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"243 ","pages":"Article 102651"},"PeriodicalIF":6.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microproteins encoded by short open reading frames: Vital regulators in neurological diseases 短开放阅读框编码的微蛋白：神经系统疾病中的重要调节因子

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-11-23 DOI: 10.1016/j.pneurobio.2024.102694

Xiao Xiao , Yitian Wang , Tingyu Li , Qiang Wang , Xiaolei Luo , Jingdong Li , Linbo Gao

引用次数: 0

Purinergic-associated immune responses in neurodegenerative diseases 神经退行性疾病中与嘌呤能相关的免疫反应。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-11-22 DOI: 10.1016/j.pneurobio.2024.102693

Sara Carracedo , Agathe Launay , Paul-Alexandre Dechelle-Marquet , Emilie Faivre , David Blum , Cécile Delarasse , Eric Boué-Grabot

{"title":"Purinergic-associated immune responses in neurodegenerative diseases","authors":"Sara Carracedo , Agathe Launay , Paul-Alexandre Dechelle-Marquet , Emilie Faivre , David Blum , Cécile Delarasse , Eric Boué-Grabot","doi":"10.1016/j.pneurobio.2024.102693","DOIUrl":"10.1016/j.pneurobio.2024.102693","url":null,"abstract":"<div><div>The chronic activation of immune cells can participate in the development of pathological conditions such as neurodegenerative diseases including Alzheimer’s disease (AD), Multiple Sclerosis (MS), Parkinson’s disease (PD), Huntington’s disease (HD) and Amyotrophic Lateral Sclerosis (ALS).</div><div>In recent years, compelling evidence indicates that purinergic signaling plays a key role in neuro-immune cell functions. The extracellular release of adenosine 5′-triphosphate (ATP), and its breakdown products (ADP and adenosine) provide the versatile basis for complex purinergic signaling through the activation of several families of receptors. G-protein coupled adenosine A<sub>2A</sub> receptors, ionotropic P2X and G-protein coupled P2Y receptors for ATP and other nucleotides are abundant and widely distributed in neurons, microglia, and astrocytes of the central nervous system as well as in peripheral immune cells. These receptors are strongly linked to inflammation, with a functional interplay that may influence the intricate purinergic signaling involved in inflammatory responses.</div><div>In the present review, we examine the roles of the purinergic receptors in neuro-immune cell functions with particular emphasis on A<sub>2A</sub>R, P2X4 and P2X7 and their possible relevance to specific neurodegenerative disorders. Understanding the molecular mechanisms governing purinergic receptor interaction will be crucial for advancing the development of effective immunotherapies targeting neurodegenerative diseases.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"243 ","pages":"Article 102693"},"PeriodicalIF":6.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics R7 RGS 蛋白对神经元 GIRK 通道信号动态的受体依赖性影响

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-11-13 DOI: 10.1016/j.pneurobio.2024.102686

Haichang Luo , Allison Anderson , Ikuo Masuho , Ezequiel Marron Fernandez de Velasco , Lutz Birnbaumer , Kirill A. Martemyanov , Kevin Wickman

{"title":"Receptor-dependent influence of R7 RGS proteins on neuronal GIRK channel signaling dynamics","authors":"Haichang Luo , Allison Anderson , Ikuo Masuho , Ezequiel Marron Fernandez de Velasco , Lutz Birnbaumer , Kirill A. Martemyanov , Kevin Wickman","doi":"10.1016/j.pneurobio.2024.102686","DOIUrl":"10.1016/j.pneurobio.2024.102686","url":null,"abstract":"<div><div>Most neurons are influenced by multiple neuromodulatory inputs that converge on common effectors. Mechanisms that route these signals are key to selective neuromodulation but are poorly understood. G protein-gated inwardly rectifying K<sup>+</sup> (GIRK or Kir3) channels mediate postsynaptic inhibition evoked by G protein-coupled receptors (GPCRs) that signal via inhibitory G proteins. GIRK-dependent signaling is modulated by Regulator of G protein Signaling proteins RGS6 and RGS7, but their selectivity for distinct GPCR-GIRK signaling pathways in defined neurons is unclear. We compared how RGS6 and RGS7 impact GIRK channel regulation by the GABA<sub>B</sub> receptor (GABA<sub>B</sub>R), 5HT<sub>1A</sub> receptor (5HT<sub>1A</sub>R), and A<sub>1</sub> adenosine receptor (A<sub>1</sub>R) in hippocampal neurons. Our data show that RGS6 and RGS7 make non-redundant contributions to GABA<sub>B</sub>R- and 5HT<sub>1A</sub>R-GIRK signaling and compartmentalization and suggest that GPCR-G protein preferences and the substrate bias of RGS proteins, as well as receptor-dependent differences in Gα<sub>o</sub> engagement and effector access, shape GPCR-GIRK signaling dynamics in hippocampal neurons.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"243 ","pages":"Article 102686"},"PeriodicalIF":6.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CB1 receptors in NG2 cells mediate cannabinoid-evoked functional myelin regeneration NG2 细胞中的 CB1 受体可介导由 CANNABINOID 引起的功能性髓鞘再生。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-11-09 DOI: 10.1016/j.pneurobio.2024.102683

Aníbal Sánchez de la Torre , Sara Ezquerro-Herce , Alba Huerga-Gómez , Ester Sánchez-Martín , Juan Carlos Chara , Carlos Matute , Krisztina Monory , Susana Mato , Beat Lutz , Manuel Guzmán , Tania Aguado , Javier Palazuelos

{"title":"CB1 receptors in NG2 cells mediate cannabinoid-evoked functional myelin regeneration","authors":"Aníbal Sánchez de la Torre , Sara Ezquerro-Herce , Alba Huerga-Gómez , Ester Sánchez-Martín , Juan Carlos Chara , Carlos Matute , Krisztina Monory , Susana Mato , Beat Lutz , Manuel Guzmán , Tania Aguado , Javier Palazuelos","doi":"10.1016/j.pneurobio.2024.102683","DOIUrl":"10.1016/j.pneurobio.2024.102683","url":null,"abstract":"<div><div>Defects in myelin homeostasis have been reported in many neuropathological conditions. Cannabinoid compounds have been shown to efficiently promote myelin regeneration in animal models of demyelination. However, it is still unknown whether this action relies mostly on a cell autonomous effect on oligodendroglial-lineage-NG2 cells. By using conditional genetic mouse models, here we found that cannabinoid CB<sub>1</sub> receptors located on NG2 cells are required for oligodendroglial differentiation and myelin regeneration after demyelination. Selective CB<sub>1</sub> receptor gene depletion in NG2 cells following toxin-induced demyelination disrupted oligodendrocyte regeneration and functional remyelination and exacerbated axonal damage. These deficits were rescued by pharmacological blockade of the RhoA/ROCK/Cofilin pathway. Conversely, tetrahydrocannabinol administration promoted oligodendrocyte regeneration and functional remyelination in wild-type but not <em>Ng2</em>-CB<sub>1</sub>-deficient mice. Overall, this study identifies CB<sub>1</sub> receptors as essential modulators of remyelination and support the therapeutic potential of cannabinoids for promoting remyelination in neurological disorders.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"243 ","pages":"Article 102683"},"PeriodicalIF":6.7,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opposing effects of nicotine on hypothalamic arcuate nucleus POMC and NPY neurons 尼古丁对下丘脑弓状核 POMC 和 NPY 神经元的相反作用

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-11-01 DOI: 10.1016/j.pneurobio.2024.102682

E. Ramírez-Sánchez, A. Mondragón-García, J. Garduño, F. Hernández-Vázquez, S. Ortega-Tinoco, S. Hernández-López

{"title":"Opposing effects of nicotine on hypothalamic arcuate nucleus POMC and NPY neurons","authors":"E. Ramírez-Sánchez, A. Mondragón-García, J. Garduño, F. Hernández-Vázquez, S. Ortega-Tinoco, S. Hernández-López","doi":"10.1016/j.pneurobio.2024.102682","DOIUrl":"10.1016/j.pneurobio.2024.102682","url":null,"abstract":"<div><div>The hypothalamic arcuate nucleus (ARC) contains two main populations of neurons essential for energy homeostasis: neuropeptide Y (NPY) neurons, which are orexigenic and stimulate food intake, and proopiomelanocortin (POMC) neurons, which have an anorexigenic effect. Located near the blood-brain barrier, ARC neurons sense blood-borne signals such as leptin, insulin, and glucose. Exogenous substances, such as nicotine, can also alter ARC neuron activity and energy balance. Nicotine, an addictive drug used worldwide, inhibits appetite, and reduces body weight, although its mechanisms in regulating ARC neurons are not well understood. Using electrophysiological techniques in brain slices, we investigated the effects of nicotine on POMC and NPY neurons at physiological glucose concentrations. We found that nicotine increased the firing rate of POMC and inhibited NPY neurons. Additionally, nicotine-enhanced glutamatergic inputs to POMC cells and GABAergic inputs to NPY neurons, mediated by α7 and α4β2 nicotinic acetylcholine receptors (nAChRs), respectively. These findings can contribute to the understanding of the anorexigenic effects of nicotine in smokers.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"242 ","pages":"Article 102682"},"PeriodicalIF":6.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations of synaptic plasticity in Angelman syndrome model mice are rescued by 5-HT7R stimulation 安杰尔曼综合征模型小鼠突触可塑性的改变可通过 5-HT7R 刺激得到缓解。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-11-01 DOI: 10.1016/j.pneurobio.2024.102684

Amelia Pizzella , Eduardo Penna , Yan Liu , Natalia Abate , Enza Lacivita , Marcello Leopoldo , Carla Perrone-Capano , Marianna Crispino , Michel Baudry , Xiaoning Bi

{"title":"Alterations of synaptic plasticity in Angelman syndrome model mice are rescued by 5-HT7R stimulation","authors":"Amelia Pizzella , Eduardo Penna , Yan Liu , Natalia Abate , Enza Lacivita , Marcello Leopoldo , Carla Perrone-Capano , Marianna Crispino , Michel Baudry , Xiaoning Bi","doi":"10.1016/j.pneurobio.2024.102684","DOIUrl":"10.1016/j.pneurobio.2024.102684","url":null,"abstract":"<div><div>Angelman syndrome (AS) is a severe neurodevelopmental disorder characterized by motor disfunction, seizures, intellectual disability, speech deficits, and autism-like behavior, showing high comorbidity with Autism Spectrum Disorders (ASD). It is known that stimulation of the serotonin receptor 7 (5-HT7R) can rescue some of the behavioral and neuroplasticity dysfunctions in animal models of Fragile X and Rett syndrome, two pathologies associated with ASD. In view of these observations, we hypothesised that alterations of 5-HT7R signalling might also be involved in AS. To test this hypothesis, we stimulated 5-HT7R with the selective agonist LP-211 to investigate its possible beneficial effects on synaptic dysfunctions and altered behavior in the AS mice model. In mutant mice, we observed impairment of the synaptic machinery of protein synthesis, which was reversed by 5-HT7R activation. Moreover, stimulation of 5-HT7R was able to: i) enhance dendritic spine density in hippocampal neurons, which was reduced in AS mice; ii) restore impaired long-term potentiation (LTP) in hippocampal slices of the AS mice; iii) improve cognitive performance of the mutant animals subjected to the fear conditioning paradigm. Altogether, our results, showing beneficial effects of 5-HT7R stimulation in restoring molecular and cognitive deficits associated with AS, suggest that targeting 5-HT7R could be a promising therapeutic approach for the pathology.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"242 ","pages":"Article 102684"},"PeriodicalIF":6.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0