Progress in Neurobiology最新文献_第4页

Cerebellar impairments in genetic models of autism spectrum disorders: A neurobiological perspective 自闭症谱系障碍遗传模型中的小脑损伤：神经生物学视角

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-11-01 DOI: 10.1016/j.pneurobio.2024.102685

Konstantin Yenkoyan , Artem Grigoryan , Viera Kutna , Susan Shorter , Valerie B. O’Leary , Reza Asadollahi , Saak V. Ovsepian

{"title":"Cerebellar impairments in genetic models of autism spectrum disorders: A neurobiological perspective","authors":"Konstantin Yenkoyan , Artem Grigoryan , Viera Kutna , Susan Shorter , Valerie B. O’Leary , Reza Asadollahi , Saak V. Ovsepian","doi":"10.1016/j.pneurobio.2024.102685","DOIUrl":"10.1016/j.pneurobio.2024.102685","url":null,"abstract":"<div><div>Functional and molecular alterations in the cerebellum are among the most widely recognised associates of autism spectrum disorders (ASD). As a critical computational hub of the brain, the cerebellum controls and coordinates a range of motor, affective and cognitive processes. Despite well-described circuits and integrative mechanisms, specific changes that underlie cerebellar impairments in ASD remain elusive. Studies in experimental animals have been critical in uncovering molecular pathology and neuro-behavioural correlates, providing a model for investigating complex disease conditions. Herein, we review commonalities and differences of the most extensively characterised genetic lines of ASD with reference to the cerebellum. We revisit structural, functional, and molecular alterations which may contribute to neurobehavioral phenotypes. The cross-model analysis of this study provides an integrated outlook on the role of cerebellar alterations in pathobiology of ASD that may benefit future translational research and development of therapies.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"242 ","pages":"Article 102685"},"PeriodicalIF":6.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manipulation of radixin phosphorylation in the nucleus accumbens core modulates risky choice behavior 操纵核团核心的 radixin 磷酸化可调节风险选择行为。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-20 DOI: 10.1016/j.pneurobio.2024.102681

Myung Ji Kwak , Su Jeong Choi , Wen Ting Cai , Bo Ram Cho , Joonyeup Han , Jong Woo Park , Lars Björn Riecken , Helen Morrison , Se-Young Choi , Wha Young Kim , Jeong-Hoon Kim

{"title":"Manipulation of radixin phosphorylation in the nucleus accumbens core modulates risky choice behavior","authors":"Myung Ji Kwak , Su Jeong Choi , Wen Ting Cai , Bo Ram Cho , Joonyeup Han , Jong Woo Park , Lars Björn Riecken , Helen Morrison , Se-Young Choi , Wha Young Kim , Jeong-Hoon Kim","doi":"10.1016/j.pneurobio.2024.102681","DOIUrl":"10.1016/j.pneurobio.2024.102681","url":null,"abstract":"<div><div>Ezrin-Radixin-Moesin (ERM) proteins are actin-binding proteins that contribute to morphological changes in dendritic spines. Despite their significant role in regulating spine structure, the role of ERM proteins in the nucleus accumbnes (NAcc) is not well known, especially in in the context of risk-reward decision-making. Here, we measured the relationship between synaptic excitation and inhibition (E/I ratio) from medium spiny neurons in the NAcc core obtained in the rat after a rat gambling task (rGT). Then, after surgery of a phosphomimetic pseudo-active mutant form of radixin (Rdx-T564D) in the NAcc core, we examined its role in synaptic plasticity and the accompanying risk-choice behavior in rGT. We found that basal E/I ratio in the NAcc core was higher in risk-averse rats than risk-seeking rats. However, it was significantly reduced in risk-averse rats similar to that in risk-seeking rats in the presence of Rdx-T564D in the NAcc core. Furthermore, the head sizes of spines were shifted in risk-averse rats expressing Rdx-T564D in the NAcc core, similar to those observed in risk-seeking rats. The effects of Rdx-T564D in risk-averse rats were again manifested as behavioral changes, with reduced selection of optimal choices and increased selection of disadvantageous ones. In this study, we demonstrated that manipulation of radixin phosphorylation status in the NAcc core can alter glutamatergic synaptic transmission and spine structure at this site, as well as risk choice behaviors in the rGT. These novel findings illustrate that radixin in the NAcc core plays a significant role in determining risk preference during the rGT.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"242 ","pages":"Article 102681"},"PeriodicalIF":6.7,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ERO1A inhibition mitigates neuronal ER stress and ameliorates UBQLN2ALS phenotypes in Drosophila melanogaster 抑制ERO1A可减轻神经元ER压力并改善黑腹果蝇的UBQLN2ALS表型

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-10 DOI: 10.1016/j.pneurobio.2024.102674

Ranchana Yeewa , Apiwat Sangphukieo , Phatcharida Jantaree , Wasinee Wongkummool , Titaree Yamsri , Siwat Poompouang , Parunya Chaiyawat , Luca Lo Piccolo , Salinee Jantrapirom

{"title":"ERO1A inhibition mitigates neuronal ER stress and ameliorates UBQLN2ALS phenotypes in Drosophila melanogaster","authors":"Ranchana Yeewa , Apiwat Sangphukieo , Phatcharida Jantaree , Wasinee Wongkummool , Titaree Yamsri , Siwat Poompouang , Parunya Chaiyawat , Luca Lo Piccolo , Salinee Jantrapirom","doi":"10.1016/j.pneurobio.2024.102674","DOIUrl":"10.1016/j.pneurobio.2024.102674","url":null,"abstract":"<div><div>Modulating the ER stress pathway holds therapeutic promise for neurodegenerative diseases; however, identifying optimal targets remains challenging. In this study, we conducted an unbiased screening to systematically search for commonly up-regulated proteins in ER stress-related neurodegenerative conditions, with endoplasmic reticulum oxidoreductase 1 alpha (ERO1A) emerging as a significant hit. Further experiments conducted in the model organism <em>Drosophila melanogaster</em> demonstrated that elevated levels of <em>Drosophila</em> ERO1A (ERO1L) were indeed detrimental to neurons. Conversely, genetic suppression or pharmacological inhibition of ERO1L activity provided neuroprotection under ER stress and extended the lifespan of flies. To translate these findings, we performed a genetic modifier screening and underscored significant neuroprotective effects against UBQLN2<sup>ALS</sup> pathology. Additionally, administration of the chemical probe inhibitor of ERO1A, known as EN460, enhanced locomotive functions and neuromuscular junction (NMJ) morphology in <em>Drosophila</em> UBQLN2<sup>ALS</sup> model. Mechanistically, targeting ERO1L during environmental or pathological ER stress mitigated proteotoxic stress by lowering either the PERK or IRE1 branches of the unfolded protein response (UPR). These findings suggest ERO1A as a promising therapeutic target in UBQLN2<sup>ALS</sup> and other ER stress-related conditions.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"242 ","pages":"Article 102674"},"PeriodicalIF":6.7,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuronal threshold functions: Determining symptom onset in neurological disorders 神经元阈值功能：确定神经系统疾病的症状发作。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-09 DOI: 10.1016/j.pneurobio.2024.102673

Luc Jordi , Ole Isacson

{"title":"Neuronal threshold functions: Determining symptom onset in neurological disorders","authors":"Luc Jordi , Ole Isacson","doi":"10.1016/j.pneurobio.2024.102673","DOIUrl":"10.1016/j.pneurobio.2024.102673","url":null,"abstract":"<div><div>Synaptic networks determine brain function. Highly complex interconnected brain synaptic networks provide output even under fluctuating or pathological conditions. Relevant to the treatment of brain disorders, understanding the limitations of such functional networks becomes paramount. Here we use the example of Parkinson’s Disease (PD) as a system disorder, with PD symptomatology emerging only when the functional reserves of neurons, and their interconnected networks, are unable to facilitate effective compensatory mechanisms. We have denoted this the “threshold theory” to account for how PD symptoms develop in sequence. In this perspective, threshold functions are delineated in a quantitative, synaptic, and cellular network context. This provides a framework to discuss the development of specific symptoms. PD includes dysfunction and degeneration in many organ systems and both peripheral and central nervous system involvement. The threshold theory accounts for and explains the reasons why parallel gradually emerging pathologies in brain and peripheral systems generate specific symptoms only when functional thresholds are crossed, like tipping points. New and mounting evidence demonstrate that PD and related neurodegenerative diseases are multisystem disorders, which transcends the traditional brain-centric paradigm. We believe that representation of threshold functions will be helpful to develop new medicines and interventions that are specific for both pre- and post-symptomatic periods of neurodegenerative disorders.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"242 ","pages":"Article 102673"},"PeriodicalIF":6.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142401108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A tradeoff between efficiency and robustness in the hippocampal-neocortical memory network during human and rodent sleep 人类和啮齿动物睡眠时海马-皮层记忆网络的效率和稳健性之间的权衡。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-04 DOI: 10.1016/j.pneurobio.2024.102672

Michael A. Hahn , Janna D. Lendner , Matthias Anwander , Katarina S.J. Slama , Robert T. Knight , Jack J. Lin , Randolph F. Helfrich

{"title":"A tradeoff between efficiency and robustness in the hippocampal-neocortical memory network during human and rodent sleep","authors":"Michael A. Hahn , Janna D. Lendner , Matthias Anwander , Katarina S.J. Slama , Robert T. Knight , Jack J. Lin , Randolph F. Helfrich","doi":"10.1016/j.pneurobio.2024.102672","DOIUrl":"10.1016/j.pneurobio.2024.102672","url":null,"abstract":"<div><div>Sleep constitutes a brain state of disengagement from the external world that supports memory consolidation and restores cognitive resources. The precise mechanisms how sleep and its varied stages support information processing remain largely unknown. Synaptic scaling models imply that daytime learning accumulates neural information, which is then consolidated and downregulated during sleep. Currently, there is a lack of in-vivo data from humans and rodents that elucidate if, and how, sleep renormalizes information processing capacities. From an information-theoretical perspective, a consolidation process should entail a reduction in neural pattern variability over the course of a night. Here, in a cross-species intracranial study, we identify a tradeoff in the neural population code during sleep where information coding efficiency is higher in the neocortex than in hippocampal archicortex in humans than in rodents as well as during wakefulness compared to sleep. Critically, non-REM sleep selectively reduces information coding efficiency through pattern repetition in the neocortex in both species, indicating a transition to a more robust information coding regime. Conversely, the coding regime in the hippocampus remained consistent from wakefulness to non-REM sleep. These findings suggest that new information could be imprinted to the long-term mnemonic storage in the neocortex through pattern repetition during sleep. Lastly, our results show that task engagement increased coding efficiency, while medically-induced unconsciousness disrupted the population code. In sum, these findings suggest that neural pattern variability could constitute a fundamental principle underlying cognitive engagement and memory formation, while pattern repetition reflects robust coding, possibly underlying the consolidation process.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"242 ","pages":"Article 102672"},"PeriodicalIF":6.7,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “The Reelin receptor ApoER2 is a cargo for the adaptor protein complex AP-4: Implications for hereditary spastic paraplegia” [Progr. Neurobiol. 234(2024)102575] Reelin受体ApoER2是适配蛋白复合物AP-4的载体：对遗传性痉挛性截瘫的影响"[Progr. Neurobiol.

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.pneurobio.2024.102662

Mario O. Caracci , Héctor Pizarro , Carlos Alarcón-Godoy , Luz M. Fuentealba , Pamela Farfán , Raffaella De Pace , Natacha Santibañez , Viviana A. Cavieres , Tammy P. Pástor , Juan S. Bonifacino , Gonzalo A. Mardones , María-Paz Marzolo

引用次数: 0

The role of frontopolar cortex in adjusting the balance between response execution and action inhibition in anthropoids 前额极皮层在调整猿类反应执行和动作抑制之间平衡中的作用。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.pneurobio.2024.102671

Azadeh Feizpour , Mark J. Buckley , Inaki C. Mundinano , Marcello G.P. Rosa , Farshad Alizadeh Mansouri

{"title":"The role of frontopolar cortex in adjusting the balance between response execution and action inhibition in anthropoids","authors":"Azadeh Feizpour , Mark J. Buckley , Inaki C. Mundinano , Marcello G.P. Rosa , Farshad Alizadeh Mansouri","doi":"10.1016/j.pneurobio.2024.102671","DOIUrl":"10.1016/j.pneurobio.2024.102671","url":null,"abstract":"<div><div>Executive control of behaviour entails keeping a fine balance between response execution and action inhibition. The most anterior part of the prefrontal cortex (frontopolar cortex) is highly developed in anthropoids; however, no previous study has examined its essential (indispensable) role in regulating the interplay between action execution and inhibition. In this cross-species study, we examine the performance of humans and macaque monkeys in the context of a stop-signal task and then assess the consequence of selective and bilateral damage to frontopolar cortex on monkeys’ behaviour. Humans and monkeys showed significant within-session practice-related adjustments in both response execution (increase in response time (RT) and decrease in response variabilities) and action inhibition (enhanced inhibition). Furthermore, both species expressed context-dependent (post-error and post-stop) behavioral adjustments. In post-lesion testing, frontopolar-damaged monkeys had a longer RT and lower percentage of timeout trials, compared to their pre-lesion performance. The practice-related changes in mean RT and in RT variability were significantly heightened in frontopolar-damaged monkeys. They also showed attenuated post-error, but exaggerated post-stop, behavioural adjustments. Importantly, frontopolar damage had no significant effects on monkeys’ inhibition ability. Our findings indicate that frontopolar cortex plays a critical role in allocation of control to response execution, but not action inhibition.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"241 ","pages":"Article 102671"},"PeriodicalIF":6.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sparse representation of neurons for encoding complex sounds in the auditory cortex 听觉皮层中编码复杂声音的神经元稀疏表征。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.pneurobio.2024.102661

HiJee Kang , Patrick O. Kanold

{"title":"Sparse representation of neurons for encoding complex sounds in the auditory cortex","authors":"HiJee Kang , Patrick O. Kanold","doi":"10.1016/j.pneurobio.2024.102661","DOIUrl":"10.1016/j.pneurobio.2024.102661","url":null,"abstract":"<div><div>Listening in complex sound environments requires rapid segregation of different sound sources, e.g., having a conversation with multiple speakers or other environmental sounds. Efficient processing requires fast encoding of inputs to adapt to target sounds and identify relevant information from past experiences. This adaptation process represents an early phase of implicit learning of the sound statistics to form auditory memory. The auditory cortex (ACtx) plays a crucial role in this implicit learning process, but the underlying circuits are unknown. In awake mice, we recorded neuronal responses in different ACtx subfields using in vivo 2-photon imaging of excitatory and inhibitory (parvalbumin; PV) neurons. We used a paradigm adapted from human studies that induced rapid implicit learning from passively presented complex sounds and imaged A1 Layer 4 (L4), A1 L2/3, and A2 L2/3. In this paradigm, a frozen spectro-temporally complex <em>‘Target’</em> sound randomly re-occurred within a stream of other random complex sounds. All ACtx subregions contained distinct groups of cells specifically responsive to complex acoustic sequences, indicating that even thalamocortical input layers (A1 L4) respond to complex sounds. Subgroups of excitatory and inhibitory cells in all subfields showed decreased responses for re-occurring Target sounds, indicating that ACtx is highly involved in the early implicit learning phase. At the population level, activity was more decorrelated to Target sounds independent of the duration of frozen token, subregions, and cell type. These findings suggest that ACtx and its input layers contribute to the early phase of auditory memory for complex sounds, suggesting a parallel strategy across ACtx areas and between excitatory and inhibitory neurons.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"241 ","pages":"Article 102661"},"PeriodicalIF":6.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple dimensions of syntactic structure are resolved earliest in posterior temporal cortex 句法结构的多个维度最早在后颞叶皮层得到解析。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.pneurobio.2024.102669

Elliot Murphy , Patrick S. Rollo , Katrien Segaert , Peter Hagoort , Nitin Tandon

{"title":"Multiple dimensions of syntactic structure are resolved earliest in posterior temporal cortex","authors":"Elliot Murphy , Patrick S. Rollo , Katrien Segaert , Peter Hagoort , Nitin Tandon","doi":"10.1016/j.pneurobio.2024.102669","DOIUrl":"10.1016/j.pneurobio.2024.102669","url":null,"abstract":"<div><div>How we combine minimal linguistic units into larger structures remains an unresolved topic in neuroscience. Language processing involves the abstract construction of ‘vertical’ and ‘horizontal’ information simultaneously (e.g., phrase structure, morphological agreement), but previous paradigms have been constrained in isolating only one type of composition and have utilized poor spatiotemporal resolution. Using intracranial recordings, we report multiple experiments designed to separate phrase structure from morphosyntactic agreement. Epilepsy patients (n = 10) were presented with auditory two-word phrases grouped into pseudoword-verb (‘trab run’) and pronoun-verb either with or without Person agreement (‘they run’ vs. ‘they runs’). Phrase composition and Person violations both resulted in significant increases in broadband high gamma activity approximately 300 ms after verb onset in posterior middle temporal gyrus (pMTG) and posterior superior temporal sulcus (pSTS), followed by inferior frontal cortex (IFC) at 500 ms. While sites sensitive to only morphosyntactic violations were distributed, those sensitive to both composition types were generally confined to pSTS/pMTG and IFC. These results indicate that posterior temporal cortex shows the earliest sensitivity for hierarchical linguistic structure across multiple dimensions, providing neural resources for distinct windows of composition. This region is comprised of sparsely interwoven heterogeneous constituents that afford cortical search spaces for dissociable syntactic relations.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"241 ","pages":"Article 102669"},"PeriodicalIF":6.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to “Astrocyte-secreted C3 signaling impairs neuronal development and cognition in autoimmune diseases” [Prog. Neurobiol. 240 (2024) S 102654] 星形胶质细胞分泌的 C3 信号损害自身免疫性疾病中的神经元发育和认知能力》[Prog. Neurobiol. 240 (2024) S 102654] 的勘误。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.pneurobio.2024.102659

Fan Zhu , Pengyan He , Wei Jiang , Shabbir Khan Afridi , Huiming Xu , Maali Alahmad , Yu-Wen Alvin Huang , Wei Qiu , Guangyou Wang , Changyong Tang

引用次数: 0