Progress in Neurobiology最新文献_第2页

The role of frontopolar cortex in adjusting the balance between response execution and action inhibition in anthropoids 前额极皮层在调整猿类反应执行和动作抑制之间平衡中的作用。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.pneurobio.2024.102671

Azadeh Feizpour , Mark J. Buckley , Inaki C. Mundinano , Marcello G.P. Rosa , Farshad Alizadeh Mansouri

{"title":"The role of frontopolar cortex in adjusting the balance between response execution and action inhibition in anthropoids","authors":"Azadeh Feizpour , Mark J. Buckley , Inaki C. Mundinano , Marcello G.P. Rosa , Farshad Alizadeh Mansouri","doi":"10.1016/j.pneurobio.2024.102671","DOIUrl":"10.1016/j.pneurobio.2024.102671","url":null,"abstract":"<div><div>Executive control of behaviour entails keeping a fine balance between response execution and action inhibition. The most anterior part of the prefrontal cortex (frontopolar cortex) is highly developed in anthropoids; however, no previous study has examined its essential (indispensable) role in regulating the interplay between action execution and inhibition. In this cross-species study, we examine the performance of humans and macaque monkeys in the context of a stop-signal task and then assess the consequence of selective and bilateral damage to frontopolar cortex on monkeys’ behaviour. Humans and monkeys showed significant within-session practice-related adjustments in both response execution (increase in response time (RT) and decrease in response variabilities) and action inhibition (enhanced inhibition). Furthermore, both species expressed context-dependent (post-error and post-stop) behavioral adjustments. In post-lesion testing, frontopolar-damaged monkeys had a longer RT and lower percentage of timeout trials, compared to their pre-lesion performance. The practice-related changes in mean RT and in RT variability were significantly heightened in frontopolar-damaged monkeys. They also showed attenuated post-error, but exaggerated post-stop, behavioural adjustments. Importantly, frontopolar damage had no significant effects on monkeys’ inhibition ability. Our findings indicate that frontopolar cortex plays a critical role in allocation of control to response execution, but not action inhibition.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"241 ","pages":"Article 102671"},"PeriodicalIF":6.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sparse representation of neurons for encoding complex sounds in the auditory cortex 听觉皮层中编码复杂声音的神经元稀疏表征。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.pneurobio.2024.102661

HiJee Kang , Patrick O. Kanold

{"title":"Sparse representation of neurons for encoding complex sounds in the auditory cortex","authors":"HiJee Kang , Patrick O. Kanold","doi":"10.1016/j.pneurobio.2024.102661","DOIUrl":"10.1016/j.pneurobio.2024.102661","url":null,"abstract":"<div><div>Listening in complex sound environments requires rapid segregation of different sound sources, e.g., having a conversation with multiple speakers or other environmental sounds. Efficient processing requires fast encoding of inputs to adapt to target sounds and identify relevant information from past experiences. This adaptation process represents an early phase of implicit learning of the sound statistics to form auditory memory. The auditory cortex (ACtx) plays a crucial role in this implicit learning process, but the underlying circuits are unknown. In awake mice, we recorded neuronal responses in different ACtx subfields using in vivo 2-photon imaging of excitatory and inhibitory (parvalbumin; PV) neurons. We used a paradigm adapted from human studies that induced rapid implicit learning from passively presented complex sounds and imaged A1 Layer 4 (L4), A1 L2/3, and A2 L2/3. In this paradigm, a frozen spectro-temporally complex <em>‘Target’</em> sound randomly re-occurred within a stream of other random complex sounds. All ACtx subregions contained distinct groups of cells specifically responsive to complex acoustic sequences, indicating that even thalamocortical input layers (A1 L4) respond to complex sounds. Subgroups of excitatory and inhibitory cells in all subfields showed decreased responses for re-occurring Target sounds, indicating that ACtx is highly involved in the early implicit learning phase. At the population level, activity was more decorrelated to Target sounds independent of the duration of frozen token, subregions, and cell type. These findings suggest that ACtx and its input layers contribute to the early phase of auditory memory for complex sounds, suggesting a parallel strategy across ACtx areas and between excitatory and inhibitory neurons.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"241 ","pages":"Article 102661"},"PeriodicalIF":6.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple dimensions of syntactic structure are resolved earliest in posterior temporal cortex 句法结构的多个维度最早在后颞叶皮层得到解析。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.pneurobio.2024.102669

Elliot Murphy , Patrick S. Rollo , Katrien Segaert , Peter Hagoort , Nitin Tandon

{"title":"Multiple dimensions of syntactic structure are resolved earliest in posterior temporal cortex","authors":"Elliot Murphy , Patrick S. Rollo , Katrien Segaert , Peter Hagoort , Nitin Tandon","doi":"10.1016/j.pneurobio.2024.102669","DOIUrl":"10.1016/j.pneurobio.2024.102669","url":null,"abstract":"<div><div>How we combine minimal linguistic units into larger structures remains an unresolved topic in neuroscience. Language processing involves the abstract construction of ‘vertical’ and ‘horizontal’ information simultaneously (e.g., phrase structure, morphological agreement), but previous paradigms have been constrained in isolating only one type of composition and have utilized poor spatiotemporal resolution. Using intracranial recordings, we report multiple experiments designed to separate phrase structure from morphosyntactic agreement. Epilepsy patients (n = 10) were presented with auditory two-word phrases grouped into pseudoword-verb (‘trab run’) and pronoun-verb either with or without Person agreement (‘they run’ vs. ‘they runs’). Phrase composition and Person violations both resulted in significant increases in broadband high gamma activity approximately 300 ms after verb onset in posterior middle temporal gyrus (pMTG) and posterior superior temporal sulcus (pSTS), followed by inferior frontal cortex (IFC) at 500 ms. While sites sensitive to only morphosyntactic violations were distributed, those sensitive to both composition types were generally confined to pSTS/pMTG and IFC. These results indicate that posterior temporal cortex shows the earliest sensitivity for hierarchical linguistic structure across multiple dimensions, providing neural resources for distinct windows of composition. This region is comprised of sparsely interwoven heterogeneous constituents that afford cortical search spaces for dissociable syntactic relations.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"241 ","pages":"Article 102669"},"PeriodicalIF":6.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to “Astrocyte-secreted C3 signaling impairs neuronal development and cognition in autoimmune diseases” [Prog. Neurobiol. 240 (2024) S 102654] 星形胶质细胞分泌的 C3 信号损害自身免疫性疾病中的神经元发育和认知能力》[Prog. Neurobiol. 240 (2024) S 102654] 的勘误。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.pneurobio.2024.102659

Fan Zhu , Pengyan He , Wei Jiang , Shabbir Khan Afridi , Huiming Xu , Maali Alahmad , Yu-Wen Alvin Huang , Wei Qiu , Guangyou Wang , Changyong Tang

引用次数: 0

Mnemonically modulated perceptual processing to represent allocentric space in macaque inferotemporal cortex 猕猴颞下部皮层的记忆调节知觉处理，以表示分配中心空间。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.pneurobio.2024.102670

Ao Li , He Chen , Yuji Naya

{"title":"Mnemonically modulated perceptual processing to represent allocentric space in macaque inferotemporal cortex","authors":"Ao Li , He Chen , Yuji Naya","doi":"10.1016/j.pneurobio.2024.102670","DOIUrl":"10.1016/j.pneurobio.2024.102670","url":null,"abstract":"<div><div>To encode allocentric space information of a viewing object, it is important to relate perceptual information in the first-person perspective to the representation of an entire scene which would be constructed before. A substantial number of studies investigated the constructed scene information (e.g., cognitive map). However, only few studies have focused on its influence on perceptual processing. Therefore, we designed a visually guided saccade task requiring monkeys to gaze at objects in different locations on different backgrounds clipped from large self-designed mosaic pictures (parental pictures). In each trial, we presented moving backgrounds prior to object presentations, indicating a frame position of the background image on a parental picture. We recorded single-unit activities from 377 neurons in the posterior inferotemporal (PIT) cortex of two macaques. Equivalent numbers of neurons showed space-related (119 of 377) and object-related (125 of 377) information. The space-related neurons coded the gaze locations and background images jointly rather than separately. These results suggest that PIT neurons represent a particular location within a particular background image. Interestingly, frame positions of background images on parental pictures modulated the space-related responses dependently on parental pictures. As the frame positions could be acquired by only preceding visual experiences, the present results may provide neuronal evidence of a mnemonic effect on current perception, which might represent allocentric object location in a scene beyond the current view.</div></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"241 ","pages":"Article 102670"},"PeriodicalIF":6.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Adiponectin ameliorates hypoperfusive cognitive deficits by boosting a neuroprotective microglial response” [Prog. Neurobiol. 205 (2021) 102125] 对 "脂肪连通素通过增强神经保护性微胶质细胞反应改善低通透性认知障碍 "的更正 [Prog. Neurobiol. 205 (2021) 102125]

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-10-01 DOI: 10.1016/j.pneurobio.2024.102631

引用次数: 0

Distinct 5-HT receptor subtypes regulate claustrum excitability by serotonin and the psychedelic, DOI 不同的 5-HT 受体亚型受血清素和迷幻药的影响而调节视网膜的兴奋性，DOI.

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-09-01 DOI: 10.1016/j.pneurobio.2024.102660

Tanner L. Anderson , Jack V. Keady , Judy Songrady , Navid S. Tavakoli , Artin Asadipooya , Ryson E. Neeley , Jill R. Turner , Pavel I. Ortinski

{"title":"Distinct 5-HT receptor subtypes regulate claustrum excitability by serotonin and the psychedelic, DOI","authors":"Tanner L. Anderson , Jack V. Keady , Judy Songrady , Navid S. Tavakoli , Artin Asadipooya , Ryson E. Neeley , Jill R. Turner , Pavel I. Ortinski","doi":"10.1016/j.pneurobio.2024.102660","DOIUrl":"10.1016/j.pneurobio.2024.102660","url":null,"abstract":"<div><p>Recent evidence indicates that neuronal activity within the claustrum (CLA) may be central to cellular and behavioral responses to psychedelic hallucinogens. The CLA prominently innervates many cortical targets and displays exceptionally high levels of serotonin (5-HT) binding. However, the influence of serotonin receptors, prime targets of psychedelic drug action, on CLA activity remains unexplored. We characterize the CLA expression of all known 5-HT subtypes and contrast the effects of 5-HT and the psychedelic hallucinogen, 2,5-dimethoxy-4-iodoamphetamine (DOI), on excitability of cortical-projecting CLA neurons. We find that the CLA is particularly enriched with 5-HT2C receptors, expressed predominantly on glutamatergic neurons. Electrophysiological recordings from CLA neurons that project to the anterior cingulate cortex (ACC) indicate that application of 5-HT inhibits glutamate receptor-mediated excitatory postsynaptic currents (EPSCs). In contrast, application of DOI stimulates EPSCs. We find that the opposite effects of 5-HT and DOI on synaptic signaling can both be reversed by inhibition of the 5-HT2C, but not 5-HT2A, receptors. We identify specific 5-HT receptor subtypes as serotonergic regulators of the CLA excitability and argue against the canonical role of 5-HT2A in glutamatergic synapse response to psychedelics within the CLA-ACC circuit.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"240 ","pages":"Article 102660"},"PeriodicalIF":6.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naturalistic movies and encoding analysis define areal borders in marmoset third-tier visual cortex 自然电影和编码，分析狨猴第三层视觉皮层中的区域边界定义。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-08-03 DOI: 10.1016/j.pneurobio.2024.102657

Daisuke Shimaoka , Yan Tat Wong , Marcello G.P. Rosa , Nicholas Seow Chiang Price

{"title":"Naturalistic movies and encoding analysis define areal borders in marmoset third-tier visual cortex","authors":"Daisuke Shimaoka , Yan Tat Wong , Marcello G.P. Rosa , Nicholas Seow Chiang Price","doi":"10.1016/j.pneurobio.2024.102657","DOIUrl":"10.1016/j.pneurobio.2024.102657","url":null,"abstract":"<div><p>Accurate definition of the borders of cortical visual areas is essential for the study of neuronal processes leading to perception. However, data used for definition of areal boundaries have suffered from issues related to resolution, uniform coverage, or suitability for objective analysis, leading to ambiguity. Here, we present a novel approach that combines widefield optical imaging, presentation of naturalistic movies, and encoding model analysis, to objectively define borders in the primate extrastriate cortex. We applied this method to test conflicting hypotheses about the third-tier visual cortex, where areal boundaries have remained controversial. We demonstrate pronounced tuning preferences in the third-tier areas, and an organizational structure in which the dorsomedial area (DM) contains representations of both the upper and lower contralateral quadrants, and is located immediate anterior to V2. High-density electrophysiological recordings with a Neuropixels probe confirm these findings. Our encoding-model approach offers a powerful, objective way to disambiguate areal boundaries.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"240 ","pages":"Article 102657"},"PeriodicalIF":6.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0301008224000935/pdfft?md5=bc7941c87bc2ead50297eb74962e4f67&pid=1-s2.0-S0301008224000935-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A free intravesicular C-terminal of otoferlin is essential for synaptic vesicle docking and fusion at auditory inner hair cell ribbon synapses 听觉内毛细胞带状突触的突触囊泡对接和融合离不开自由的囊泡内C端奥托费林。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-08-03 DOI: 10.1016/j.pneurobio.2024.102658

Didier Dulon , Jacques Boutet de Monvel , Baptiste Plion , Adeline Mallet , Christine Petit , Steven Condamine , Yohan Bouleau , Saaid Safieddine

{"title":"A free intravesicular C-terminal of otoferlin is essential for synaptic vesicle docking and fusion at auditory inner hair cell ribbon synapses","authors":"Didier Dulon , Jacques Boutet de Monvel , Baptiste Plion , Adeline Mallet , Christine Petit , Steven Condamine , Yohan Bouleau , Saaid Safieddine","doi":"10.1016/j.pneurobio.2024.102658","DOIUrl":"10.1016/j.pneurobio.2024.102658","url":null,"abstract":"<div><p>Our understanding of how otoferlin, the major calcium sensor in inner hair cells (IHCs) synaptic transmission, contributes to the overall dynamics of synaptic vesicle (SV) trafficking remains limited. To address this question, we generated a knock-in mouse model expressing an otoferlin-GFP protein, where GFP was fused to its C-terminal transmembrane domain. Similar to the wild type protein, the GFP-tagged otoferlin showed normal expression and was associated with IHC SV. Surprisingly, while the heterozygote <em>Otof</em> <sup><em>+/GFP</em></sup> mice exhibited a normal hearing function, homozygote <em>Otof</em> <sup><em>GFP/GFP</em></sup> mice were profoundly deaf attributed to severe reduction in SV exocytosis. Fluorescence recovery after photobleaching revealed a markedly increased mobile fraction of the otof-GFP-associated SV in <em>Otof <sup>GFP/GFP</sup></em> IHCs. Correspondingly, 3D-electron tomographic of the ribbon synapses indicated a reduced density of SV attached to the ribbon active zone. Collectively, these results indicate that otoferlin requires a free intravesicular C-terminal end for normal SV docking and fusion.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"240 ","pages":"Article 102658"},"PeriodicalIF":6.7,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0301008224000947/pdfft?md5=61dac4df5fe8a53220a48368fcbaa2d7&pid=1-s2.0-S0301008224000947-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orientation selectivity mapping in the visual cortex 视觉皮层的方向选择性映射。

IF 6.7 2区医学

Progress in Neurobiology Pub Date : 2024-07-14 DOI: 10.1016/j.pneurobio.2024.102656

Mei-Lan Liu , Yi-Peng Liu , Xin-Xia Guo , Zhi-Yi Wu , Xiao-Tong Zhang , Anna Wang Roe , Jia-Ming Hu

{"title":"Orientation selectivity mapping in the visual cortex","authors":"Mei-Lan Liu , Yi-Peng Liu , Xin-Xia Guo , Zhi-Yi Wu , Xiao-Tong Zhang , Anna Wang Roe , Jia-Ming Hu","doi":"10.1016/j.pneurobio.2024.102656","DOIUrl":"10.1016/j.pneurobio.2024.102656","url":null,"abstract":"<div><p>The orientation map is one of the most well-studied functional maps of the visual cortex. However, results from the literature are of different qualities. Clear boundaries among different orientation domains and blurred uncertain distinctions were shown in different studies. These unclear imaging results will lead to an inaccuracy in depicting cortical structures, and the lack of consideration in experimental design will also lead to biased depictions of the cortical features. How we accurately define orientation domains will impact the entire field of research. In this study, we test how spatial frequency (SF), stimulus size, location, chromatic, and data processing methods affect the orientation functional maps (including a large area of dorsal V4, and parts of dorsal V1) acquired by intrinsic signal optical imaging. Our results indicate that, for large imaging fields, large grating stimuli with mixed SF components should be considered to acquire the orientation map. A diffusion model image enhancement based on the difference map could further improve the map quality. In addition, the similar outcomes of achromatic and chromatic gratings indicate two alternative types of afferents from LGN, pooling in V1 to generate cue-invariant orientation selectivity.</p></div>","PeriodicalId":20851,"journal":{"name":"Progress in Neurobiology","volume":"240 ","pages":"Article 102656"},"PeriodicalIF":6.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0301008224000923/pdfft?md5=d10cbf14051a20a184842cf64d84b05b&pid=1-s2.0-S0301008224000923-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0