Radiologia BrasileiraPub Date : 2025-09-22eCollection Date: 2025-01-01DOI: 10.1590/0100-3984.2025.0015
Viviana Regina Konzen, Alessandro Finkelsztejn, Raquel Prates Dos Santos, Adolfo Moraes de Souza, Matheus de Lima Ruffini, Renata Gomes Londero, Juliana Ávila Duarte
{"title":"The central vein sign and paramagnetic rim lesions: biomarkers for an accurate differential diagnosis between multiple sclerosis and migraine.","authors":"Viviana Regina Konzen, Alessandro Finkelsztejn, Raquel Prates Dos Santos, Adolfo Moraes de Souza, Matheus de Lima Ruffini, Renata Gomes Londero, Juliana Ávila Duarte","doi":"10.1590/0100-3984.2025.0015","DOIUrl":"10.1590/0100-3984.2025.0015","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess whether the evaluation of the central vein sign (CVS) and paramagnetic rim lesions (PRLs) using susceptibility-weighted magnetic resonance imaging (MRI) can distinguish multiple sclerosis (MS) from migraine.</p><p><strong>Materials and methods: </strong>In this single-center observational study, we conducted a cross-sectional analysis of the CVS, determining the proportion of CVS-positive lesions per individual and absolute counts, using thresholds of 3 lesions (select3*) and 6 lesions (select6*), and of PRLs in participants with MS and in those with migraine, from 3.0-T MRI brain scans.</p><p><strong>Results: </strong>The study included 20 participants with MS, 20 with migraine, and 20 included as healthy controls. The proportion of participants with CVS-positive lesions was higher in the MS group than in the migraine group (61.8% vs. 10.4%), and PRLs were observed exclusively in the MS group. The presence of at least one PRL and the select6* criterion demonstrated the highest diagnostic accuracy within the study sample.</p><p><strong>Conclusion: </strong>The detection of the CVS and of a PRL on 3.0-T MRI scans may serve as a reliable biomarker to differentiate MS from migraine.</p>","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"58 ","pages":"e20250015"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia BrasileiraPub Date : 2025-09-01eCollection Date: 2025-01-01DOI: 10.1590/0100-3984.2025.0031
Marilia de Lacerda Silva, Barbara Coppola Oliveira, Felipe Augusto Pereira Dos Santos, Karine Mendonça Davi Rodrigues, Luis Ronan Marquez Ferreira de Sousa, Ana Carolina Rabachini Caetano, Edward Araujo Júnior, Luciano Marcondes Machado Nardozza, Alberto Borges Peixoto
{"title":"First-trimester screening for fetal growth restriction and adverse maternal/perinatal outcomes.","authors":"Marilia de Lacerda Silva, Barbara Coppola Oliveira, Felipe Augusto Pereira Dos Santos, Karine Mendonça Davi Rodrigues, Luis Ronan Marquez Ferreira de Sousa, Ana Carolina Rabachini Caetano, Edward Araujo Júnior, Luciano Marcondes Machado Nardozza, Alberto Borges Peixoto","doi":"10.1590/0100-3984.2025.0031","DOIUrl":"10.1590/0100-3984.2025.0031","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association between first-trimester screening for fetal growth restriction (FGR) and the effect of aspirin use as prophylaxis for this condition, as well as its effect on adverse maternal and perinatal outcomes. A secondary objective was to evaluate the association between a high risk of FGR and adverse perinatal outcomes.</p><p><strong>Materials and methods: </strong>This was a retrospective cohort study of pregnant women who did or did not undergo first-trimester screening for FGR. Screening for FGR involved the evaluation of maternal characteristics, mean arterial pressure, and the results of uterine artery Doppler. Pregnancies with an estimated risk ≥ 1:155 were categorized as high risk, whereas those with an estimated risk < 1:155 were categorized as low risk.</p><p><strong>Results: </strong>We evaluated 499 pregnant women who did not undergo first-trimester screening for FGR (unscreened group) and 615 who did (screened group). The risk of gestational hypertension was lower in the screened group, as evidenced by an adjusted odds ratio (aOR) of 0.24 (95% CI: 0.14-0.39; <i>p</i> < 0.001), as was the risk of spontaneous preterm birth at < 37 weeks of gestation (aOR: 0.22; 95% CI: 0.10-0.45; <i>p</i> < 0.001). The risk of delivery at < 32 weeks was higher in the screened group (aOR: 8.25; 95% CI: 1.05-65.71; <i>p</i> < 0.045) as was the risk of delivery at < 37 weeks (aOR: 5.91; 95% CI: 2.62-13.31; <i>p</i> < 0.001). Among all of the pregnancies at high risk of FGR (in both groups), there was an increased risk of delivery at < 32 weeks (3.1% vs. 0.2%; OR: 16.20; 95% CI: 2.20-190.90; <i>p</i> = 0.004), and at < 37 weeks (10.7% vs. 1.4%; OR: 8.41; 95% CI: 3.60-22.10; <i>p</i> < 0.0001). The use of aspirin was associated with a greater prevalence of gestational hypertension (8.0% vs. 2.1%; OR: 4.1; 95% CI: 1.77-10.10; <i>p</i> = 0.0014) and of a birth weight < 2,500 g (14.5% vs. 7.3%; OR: 2.14; 95% CI: 1.25-3.71; <i>p</i> = 0.009).</p><p><strong>Conclusion: </strong>First-trimester screening for FGR seems to be associated with a higher risk of preterm birth (at < 32 and < 37 weeks). Pregnancies that are at high risk of FGR appear to also be at a higher risk of adverse perinatal outcomes. Aspirin use seems to be associated with a greater prevalence of developing gestational hypertension and of a birth weight < 2,500 g.</p>","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"58 ","pages":"e20250031"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia BrasileiraPub Date : 2025-09-01eCollection Date: 2025-01-01DOI: 10.1590/0100-3984.2025.0021
Andréa de Lima Bastos, Marcelo Mamede
{"title":"Radiomics in PET/CT and HRCT for systemic sclerosis-associated interstitial lung disease: breakthroughs and future directions.","authors":"Andréa de Lima Bastos, Marcelo Mamede","doi":"10.1590/0100-3984.2025.0021","DOIUrl":"10.1590/0100-3984.2025.0021","url":null,"abstract":"<p><p>Systemic sclerosis (SSc) is a multifaceted autoimmune condition that leads to fibrosis in the skin and various internal organs, including the lungs. One of its most serious complications is interstitial lung disease (ILD), which has a profound impact on the prognosis and on patient quality of life. High-resolution computed tomography (HRCT) plays a critical role by offering detailed structural information, whereas positron-emission tomography/CT (PET/CT) provides a deeper understanding of disease activity by combining metabolic and anatomical data. Radiomics expands on those modalities, extracting subtle imaging features undetectable by visual analysis, thereby enabling superior diagnostic accuracy, staging, and prognostic accuracy. This review explores the current applications of radiomics in SSc-ILD, highlighting breakthroughs such as the integration of artificial intelligence for early ILD prediction and risk stratification. Studies have demonstrated that radiomics is efficacious in overcoming traditional diagnostic limitations, enhancing precision in identifying the patterns of usual interstitial pneumonia and monitoring disease progression. When applied to PET/CT, especially that using advanced tracers, radiomics can complement HRCT by identifying metabolic biomarkers of ILD activity, thus supporting personalized treatment strategies. Although radiomics holds significant transformative potential, its routine use in clinical practice still faces several obstacles, such as the need for standardization, validation, and consistency across institutions. Future efforts will be focused on combining radiomics with genetic and molecular data, developing artificial intelligence-driven longitudinal models, and adopting multimodal approaches to improve the management of SSc-ILD. These advances promise to drive a shift toward precision medicine, ultimately improving outcomes for patients with this complex disease.</p>","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"58 ","pages":"e20250021"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia BrasileiraPub Date : 2025-09-01eCollection Date: 2025-01-01DOI: 10.1590/0100-3984.2025.58.e2
Tatiane Mendes Gonçalves de Oliveira
{"title":"New developments in the BI-RADS for MRI.","authors":"Tatiane Mendes Gonçalves de Oliveira","doi":"10.1590/0100-3984.2025.58.e2","DOIUrl":"10.1590/0100-3984.2025.58.e2","url":null,"abstract":"","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"58 ","pages":"e2"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia BrasileiraPub Date : 2025-08-25eCollection Date: 2025-01-01DOI: 10.1590/0100-3984.2025.0003
Federico Biafore, Jorge Docampo, Germán Duca
{"title":"Automated hippocampal volume measurement: agreement analysis between HIPS and volBrain software.","authors":"Federico Biafore, Jorge Docampo, Germán Duca","doi":"10.1590/0100-3984.2025.0003","DOIUrl":"10.1590/0100-3984.2025.0003","url":null,"abstract":"<p><strong>Objective: </strong>To perform an agreement analysis between volBrain and HIPS software for measuring hippocampal volume and its associated asymmetry index.</p><p><strong>Materials and methods: </strong>We evaluated volumetric T1-weighted magnetic resonance imaging scans from radiologically normal subjects (n = 50; age range, 25-75 years). Correlation and Bland-Altman plots were generated. The Pearson correlation coefficient (<i>r</i>) and the intraclass correlation coefficient of absolute agreement between volBrain and HIPS software were calculated for each measurement.</p><p><strong>Results: </strong>For each hippocampus and its combined volume, a very high correlation was found between the methods (<i>r</i> ≥ 0.96 for absolute values and <i>r</i> ≥ 0.93 for relative values), along with a systematic bias (primarily additive). Consistently, HIPS (with the Kulaga-Yoskovitz protocol) reported smaller volumes than did volBrain. The average difference ranged from 8.2% to 9.1% for absolute values and from 7.9% to 8.7% for relative values. The asymmetry index exhibited a strong correlation (<i>r</i> = 0.82) with no significant bias, although 14% of cases showed opposite signs. The average asymmetry index difference was 32.7%. The intraclass correlation coefficient of absolute agreement ranged from 0.61 to 0.83, reflecting moderate to good agreement overall.</p><p><strong>Conclusion: </strong>Our results indicate that the two methods are not interchangeable for evaluating hippocampal volume and its associated asymmetry index.</p>","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"58 ","pages":"e20250003"},"PeriodicalIF":0.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia BrasileiraPub Date : 2025-08-18eCollection Date: 2025-01-01DOI: 10.1590/0100-3984.2025.0002
Renan Fonseca Cardozo, Fernando Maia Peixoto-Filho, Edward Araujo Júnior
{"title":"Uterine cervical volume: comparison between two- and three-dimensional ultrasound methods at 20-24 weeks of gestation.","authors":"Renan Fonseca Cardozo, Fernando Maia Peixoto-Filho, Edward Araujo Júnior","doi":"10.1590/0100-3984.2025.0002","DOIUrl":"10.1590/0100-3984.2025.0002","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to evaluate the agreement between and reproducibility of specific two-dimensional (2D) and three-dimensional (3D) ultrasound methods in assessing cervical volume in pregnant women in their second trimester.</p><p><strong>Materials and methods: </strong>This was a prospective cross-sectional study of 48 asymptomatic pregnant women at 20-24 weeks of gestation. All cervical volumes were determined by transvaginal ultrasound, with a 2D method employing a geometric formula {π * [(anteroposterior diameter + transverse diameter) * ¼] * length}, where π = 3.14, and a 3D method employing a virtual organ computer-aided analysis. Intraobserver and interobserver reliability was analyzed by calculating the intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>The mean maternal age and timing of the ultrasound examination were 26 ± 6 years and 21 ± 1 weeks of gestation, respectively. The mean cervical volumes measured by the 2D and 3D ultrasound methods were 27.71 ± 9.27 cm<sup>3</sup> and 35.21 ± 8.85 cm<sup>3</sup>, respectively. Cervical length and volume showed a positive correlation with both methods-r = 0.77 (<i>p</i> < 0.001) and r = 0.70 (<i>p</i> < 0.001), respectively. Intraobserver reliability was excellent for both methods, with ICCs of 0.92 and 0.93 for the 2D and 3D methods, respectively. Interobserver reliability was good (ICC: 0.81) for the 3D method, whereas it was poor (ICC: 0.37) for the 2D method. Reproducibility of the transverse diameter measurement was low, with an intraobserver ICC of 0.41 and an interobserver ICC of 0.48.</p><p><strong>Conclusion: </strong>Cervical volume measurements obtained with 2D and 3D ultrasound methods seem to show satisfactory agreement and good intraobserver reliability. In our study sample, the 2D ultrasound method showed low interobserver reliability, whereas the 3D ultrasound method was more reliable, with good intraobserver and interobserver reliability.</p>","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"58 ","pages":"e20250002"},"PeriodicalIF":0.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia BrasileiraPub Date : 2025-08-13eCollection Date: 2025-01-01DOI: 10.1590/0100-3984.2025.0019-en
Camila Vilas Boas Machado, Roberto Sasdelli Neto, Gilberto Szarf, Walther Yoshiharu Ishikawa, Eduardo Kaiser Ururahy Nunes Fonseca
{"title":"The spectrum of imaging findings in takotsubo cardiomyopathy: a pictorial essay.","authors":"Camila Vilas Boas Machado, Roberto Sasdelli Neto, Gilberto Szarf, Walther Yoshiharu Ishikawa, Eduardo Kaiser Ururahy Nunes Fonseca","doi":"10.1590/0100-3984.2025.0019-en","DOIUrl":"10.1590/0100-3984.2025.0019-en","url":null,"abstract":"<p><p>Takotsubo cardiomyopathy is an important differential diagnosis for acute chest pain. Imaging tests, such as ventriculography, echocardiography, computed tomography of the heart, and cardiac magnetic resonance, are valuable tools for diagnostic confirmation in this context. This study reviews the literature and exemplifies the spectrum of typical and atypical cardiac magnetic resonance findings in this disease, on the basis of the experience of our facility. Recognition of these characteristics underscores the roles that radiologists and cardiologists play in the care of patients with acute chest pain, enabling an accurate diagnosis and appropriate treatment.</p>","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"58 ","pages":"e20250019"},"PeriodicalIF":0.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Radiologia BrasileiraPub Date : 2025-08-01eCollection Date: 2025-01-01DOI: 10.1590/0100-3984.2024.0089-en
Luciana Paula Benício Arcas, Felipe Carlos Dias Arcas, Laís Regiane da Silva Concilio, Marina Amaral
{"title":"Maintaining mouth opening to optimize magnetic resonance imaging of the temporomandibular joint: proposal for a new device.","authors":"Luciana Paula Benício Arcas, Felipe Carlos Dias Arcas, Laís Regiane da Silva Concilio, Marina Amaral","doi":"10.1590/0100-3984.2024.0089-en","DOIUrl":"10.1590/0100-3984.2024.0089-en","url":null,"abstract":"","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"58 ","pages":"e20240089"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}