Raquel de Freitas Jotz, A. Horbe, G. Coral, Priscila Cavedon Fontana, Beatriz Garcia de Morais, Angelo Alves de Mattos
{"title":"Results of transarterial chemoembolization of hepatocellular carcinoma as a bridging therapy to liver transplantation","authors":"Raquel de Freitas Jotz, A. Horbe, G. Coral, Priscila Cavedon Fontana, Beatriz Garcia de Morais, Angelo Alves de Mattos","doi":"10.1590/0100-3984.2023.0040","DOIUrl":"https://doi.org/10.1590/0100-3984.2023.0040","url":null,"abstract":"Abstract Objective: To evaluate the degree of tumor necrosis after transarterial chemoembolization (TACE), used as a bridging therapy in patients awaiting liver transplantation, and its effect on survival. Materials and Methods: This was a retrospective cohort study involving 118 patients submitted to TACE prior to liver transplantation, after which the degree of tumor necrosis in the explant and post-transplant survival were evaluated. Results: Total necrosis of the neoplastic nodule in the explant was observed in 76 patients (64.4%). Of the patients with total necrosis in the explanted liver, 77.8% had presented a complete response on imaging examinations. Drug-eluting bead TACE (DEB-TACE), despite showing a lower rate of complications than conventional TACE, provided a lower degree of total necrosis, although there was no statistical difference between the two. By the end of the study period, 26 of the patients had died. Survival was longer among the patients with total necrosis than among those with partial or no necrosis (HR = 2.24 [95% CI: 0.91-5.53]; p = 0.078). Conclusion: In patients undergoing TACE as a bridging therapy, total tumor necrosis appears to be associated with improved patient survival.","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"189 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138621674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Júlio Guerra Domingues, Daniella Castro Araujo, Luciana Costa-Silva, A. Machado, Luciana Andrade Carneiro Machado, Adriano Alonso Veloso, S. M. Barreto, Rosa Weiss Telles
{"title":"Development of a convolutional neural network for diagnosing osteoarthritis, trained with knee radiographs from the ELSA-Brasil Musculoskeletal","authors":"Júlio Guerra Domingues, Daniella Castro Araujo, Luciana Costa-Silva, A. Machado, Luciana Andrade Carneiro Machado, Adriano Alonso Veloso, S. M. Barreto, Rosa Weiss Telles","doi":"10.1590/0100-3984.2023.0020-en","DOIUrl":"https://doi.org/10.1590/0100-3984.2023.0020-en","url":null,"abstract":"Abstract Objective: To develop a convolutional neural network (CNN) model, trained with the Brazilian “Estudo Longitudinal de Saúde do Adulto Musculoesquelético” (ELSA-Brasil MSK, Longitudinal Study of Adult Health, Musculoskeletal) baseline radiographic examinations, for the automated classification of knee osteoarthritis. Materials and Methods: This was a cross-sectional study carried out with 5,660 baseline posteroanterior knee radiographs from the ELSA-Brasil MSK database (5,660 baseline posteroanterior knee radiographs). The examinations were interpreted by a radiologist with specific training, and the calibration was as established previously. Results: The CNN presented an area under the receiver operating characteristic curve of 0.866 (95% CI: 0.842-0.882). The model can be optimized to achieve, not simultaneously, maximum values of 0.907 for accuracy, 0.938 for sensitivity, and 0.994 for specificity. Conclusion: The proposed CNN can be used as a screening tool, reducing the total number of examinations evaluated by the radiologists of the study, and as a double-reading tool, contributing to the reduction of possible interpretation errors.","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"52 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138626701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medial condyle hypoplasia in adolescent and young adult patients with trochlear dysplasia: a retrospective study.","authors":"Sruthi Jacob, Harshavardhan Mahalingam","doi":"10.1590/0100-3984.2023.0051","DOIUrl":"https://doi.org/10.1590/0100-3984.2023.0051","url":null,"abstract":"<p><strong>Objective: </strong>To determine the association between medial femoral condyle hypoplasia and trochlear dysplasia by analyzing the knee magnetic resonance imaging scans of young patients with or without trochlear dysplasia.</p><p><strong>Materials and methods: </strong>This was a retrospective analysis of magnetic resonance imaging scans of the knees of young individuals (16-35 years of age): 30 patients with trochlear dysplasia and 30 individuals with no signs of patellofemoral instability. The ratios between the depth, width, and height of the medial and lateral femoral condyles (dLC/dMC, wLC/wMC, and hLC/hMC, respectively) were calculated, as was the ratio between the width of the medial condyle and the total width of the femur (wMC/FW). All of the values were determined in consensus by two radiologists.</p><p><strong>Results: </strong>We evaluated 60 patients: 30 with trochlear dysplasia and 30 without. The mean dLC/dMC, wLC/wMC, and hLC/hMC ratios were higher in the patients than in the controls (<i>p</i> < 0.05), whereas the mean wMC/FW ratio was lower in the patients (<i>p</i> < 0.05). The optimal cutoff values, obtained by calculating the areas under the receiver operating characteristic curves, were 1.0465 for the dLC/dMC ratio (76% sensitivity and 63.3% specificity), 0.958 for the wLC/wMC ratio (80% sensitivity and 73.3% specificity), and 1.080 for the hLC/hMC ratio (93.3% sensitivity and 93.3% specificity).</p><p><strong>Conclusion: </strong>Our findings confirm our hypothesis that trochlear dysplasia is associated with medial condyle hypoplasia.</p>","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"56 6","pages":"321-326"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancing prognostic assessment in primary sclerosing cholangitis: insights from abdominal magnetic resonance imaging and magnetic resonance cholangiopancreatography with Anali scores.","authors":"Renato Jose Kist de Mello, Alice Schuch","doi":"10.1590/0100-3984.2023.56.6e2","DOIUrl":"10.1590/0100-3984.2023.56.6e2","url":null,"abstract":"","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"56 6","pages":"VII"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adriano de Araújo Lima Liguori, Ana Paula Trussardi Fayh
{"title":"Computed tomography: an efficient, opportunistic method for assessing body composition and predicting adverse outcomes in cancer patients.","authors":"Adriano de Araújo Lima Liguori, Ana Paula Trussardi Fayh","doi":"10.1590/0100-3984.2023.56.6e3-en","DOIUrl":"10.1590/0100-3984.2023.56.6e3-en","url":null,"abstract":"","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"56 6","pages":"VIII-IX"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the relationship between patellofemoral instability and bone morphology: discoveries and challenges.","authors":"André Yui Aihara","doi":"10.1590/0100-3984.2023.56.6e4-en","DOIUrl":"10.1590/0100-3984.2023.56.6e4-en","url":null,"abstract":"","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"56 6","pages":"X"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roy López Grove, Florência Vespa, Martina Aineseder, Alejandra Villamil, Juan Carlos Spina
{"title":"Prognostic role of magnetic resonance imaging of the abdomen with intravenous contrast and magnetic resonance cholangiopancreatography in primary sclerosing cholangitis.","authors":"Roy López Grove, Florência Vespa, Martina Aineseder, Alejandra Villamil, Juan Carlos Spina","doi":"10.1590/0100-3984.2023.0041","DOIUrl":"https://doi.org/10.1590/0100-3984.2023.0041","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the usefulness of Anali scores, determined by magnetic resonance imaging, for predicting the prognosis of primary sclerosing cholangitis (PSC) and to analyze interobserver variability, as well as to assess the impact of periportal edema and heterogeneous signal intensity on diffusion-weighted imaging of the liver.</p><p><strong>Materials and methods: </strong>This was a retrospective cohort study of 29 patients with PSC and baseline magnetic resonance imaging. Anali scores, without gadolinium (0-5 points) and with gadolinium (0-2 points), were calculated by two radiologists. Clinical end-points included liver transplantation, cirrhotic decompensation, and death. We calculated intraclass correlation coefficients (ICCs) for interobserver agreement on the Anali scores, performed Kaplan-Meier survival analysis comparing event-free survival among the score strata, and calculated the areas under receiver operating characteristic curves to determine sensitivity and specificity.</p><p><strong>Results: </strong>Among the patients with a clinical event, the median Anali score was 4 (interquartile range [IQR], 2-5) without gadolinium and 2 (IQR, 1-2) with gadolinium, compared with 1 (IQR, 1.0-2.5) and 1 (IQR, 0.25-1.0), respectively, among those without a clinical event. The ICC was 0.79 (95% confidence interval: 0.57-0.91) for the Anali score with gadolinium and 0.99 (95% confidence interval: 0.98-0.99) for the Anali score without gadolinium. Periportal edema and heterogeneous signal intensity in the liver on diffusion-weighted imaging showed no statistical impact on clinical events (<i>p</i> = 0.65 and <i>p</i> = 0.5, respectively).</p><p><strong>Conclusion: </strong>Anali scores correlate with clinical events in PSC, with a high level of interobserver agreement.</p>","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"56 6","pages":"301-307"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natália Borges Nunes Gomes, Ulysses S Torres, Gabriella Souza E Silva, Perla Oliveira Schulz Mamone, Maria Lucia Cardoso Gomes Ferraz, Giuseppe D'ippolito
{"title":"Magnetic resonance imaging findings in autoimmune hepatitis: how frequent and reproducible are they?","authors":"Natália Borges Nunes Gomes, Ulysses S Torres, Gabriella Souza E Silva, Perla Oliveira Schulz Mamone, Maria Lucia Cardoso Gomes Ferraz, Giuseppe D'ippolito","doi":"10.1590/0100-3984.2023.0044","DOIUrl":"https://doi.org/10.1590/0100-3984.2023.0044","url":null,"abstract":"<p><strong>Objective: </strong>To determine the frequency and interobserver reproducibility of the magnetic resonance imaging (MRI) features considered diagnostic for autoimmune hepatitis.</p><p><strong>Materials and methods: </strong>Two abdominal radiologists, blinded to pathology data, reviewed the MRI examinations of 20 patients with autoimmune hepatitis, looking for liver enhancement, lymphadenopathy, portal hypertension, and chronic liver disease. The pattern of liver fibrosis was categorized as reticular, confluent, or mixed. Interobserver agreement was assessed by calculating intraclass correlation coefficients and kappa statistics.</p><p><strong>Results: </strong>The most common abnormal finding on MRI was surface nodularity (in 85%), followed by liver fibrosis with a reticular pattern (in 80%)-categorized as mild (in 25.0%), moderate (in 43.8%), or severe (in 31.2%)-; heterogeneous liver enhancement (in 65%); splenomegaly (in 60%); caudate lobe enlargement (in 50%); and lymphadenopathy (in 40%). The interobserver agreement was almost perfect for surface nodularity (0.83), ascites (0.89), and liver volume (0.95), whereas it was just slight and fair for the degree of fibrosis and for heterogeneous liver enhancement (0.12 and 0.25, respectively). It was also slight and fair for expanded gallbladder fossa and enlarged preportal space (0.14 and 0.36, respectively), both of which are indicative of chronic liver disease.</p><p><strong>Conclusion: </strong>The interobserver agreement was satisfactory for surface nodularity (the most prevalent abnormal MRI finding), ascites, liver volume, and splenomegaly. Conversely, it was only slight or fair for common but less objective criteria.</p>","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"56 6","pages":"308-316"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10948163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140176168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}