Viviana Regina Konzen, Alessandro Finkelsztejn, Raquel Prates Dos Santos, Adolfo Moraes de Souza, Matheus de Lima Ruffini, Renata Gomes Londero, Juliana Ávila Duarte
{"title":"中心静脉征象和顺磁边缘病变：多发性硬化症和偏头痛准确鉴别诊断的生物标志物。","authors":"Viviana Regina Konzen, Alessandro Finkelsztejn, Raquel Prates Dos Santos, Adolfo Moraes de Souza, Matheus de Lima Ruffini, Renata Gomes Londero, Juliana Ávila Duarte","doi":"10.1590/0100-3984.2025.0015","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess whether the evaluation of the central vein sign (CVS) and paramagnetic rim lesions (PRLs) using susceptibility-weighted magnetic resonance imaging (MRI) can distinguish multiple sclerosis (MS) from migraine.</p><p><strong>Materials and methods: </strong>In this single-center observational study, we conducted a cross-sectional analysis of the CVS, determining the proportion of CVS-positive lesions per individual and absolute counts, using thresholds of 3 lesions (select3*) and 6 lesions (select6*), and of PRLs in participants with MS and in those with migraine, from 3.0-T MRI brain scans.</p><p><strong>Results: </strong>The study included 20 participants with MS, 20 with migraine, and 20 included as healthy controls. The proportion of participants with CVS-positive lesions was higher in the MS group than in the migraine group (61.8% vs. 10.4%), and PRLs were observed exclusively in the MS group. The presence of at least one PRL and the select6* criterion demonstrated the highest diagnostic accuracy within the study sample.</p><p><strong>Conclusion: </strong>The detection of the CVS and of a PRL on 3.0-T MRI scans may serve as a reliable biomarker to differentiate MS from migraine.</p>","PeriodicalId":20842,"journal":{"name":"Radiologia Brasileira","volume":"58 ","pages":"e20250015"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482283/pdf/","citationCount":"0","resultStr":"{\"title\":\"The central vein sign and paramagnetic rim lesions: biomarkers for an accurate differential diagnosis between multiple sclerosis and migraine.\",\"authors\":\"Viviana Regina Konzen, Alessandro Finkelsztejn, Raquel Prates Dos Santos, Adolfo Moraes de Souza, Matheus de Lima Ruffini, Renata Gomes Londero, Juliana Ávila Duarte\",\"doi\":\"10.1590/0100-3984.2025.0015\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to assess whether the evaluation of the central vein sign (CVS) and paramagnetic rim lesions (PRLs) using susceptibility-weighted magnetic resonance imaging (MRI) can distinguish multiple sclerosis (MS) from migraine.</p><p><strong>Materials and methods: </strong>In this single-center observational study, we conducted a cross-sectional analysis of the CVS, determining the proportion of CVS-positive lesions per individual and absolute counts, using thresholds of 3 lesions (select3*) and 6 lesions (select6*), and of PRLs in participants with MS and in those with migraine, from 3.0-T MRI brain scans.</p><p><strong>Results: </strong>The study included 20 participants with MS, 20 with migraine, and 20 included as healthy controls. The proportion of participants with CVS-positive lesions was higher in the MS group than in the migraine group (61.8% vs. 10.4%), and PRLs were observed exclusively in the MS group. The presence of at least one PRL and the select6* criterion demonstrated the highest diagnostic accuracy within the study sample.</p><p><strong>Conclusion: </strong>The detection of the CVS and of a PRL on 3.0-T MRI scans may serve as a reliable biomarker to differentiate MS from migraine.</p>\",\"PeriodicalId\":20842,\"journal\":{\"name\":\"Radiologia Brasileira\",\"volume\":\"58 \",\"pages\":\"e20250015\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482283/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiologia Brasileira\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1590/0100-3984.2025.0015\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiologia Brasileira","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/0100-3984.2025.0015","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
目的：探讨敏感性加权磁共振成像（MRI）对中心静脉征象（CVS）和顺磁环病变（PRLs）的评价是否能区分多发性硬化症（MS）和偏头痛。材料和方法：在这项单中心观察性研究中，我们对CVS进行了横断面分析，确定每个人的CVS阳性病变比例和绝对计数，使用3个病变（select3*）和6个病变（select6*）的阈值，以及MS和偏头痛患者的prl，来自3.0 t MRI脑部扫描。结果：该研究包括20名MS患者，20名偏头痛患者和20名健康对照。MS组出现cvs阳性病变的比例高于偏头痛组（61.8%比10.4%），且prl仅在MS组中观察到。在研究样本中，存在至少一个PRL和select6*标准显示出最高的诊断准确性。结论：3.0 t MRI扫描中CVS和PRL的检测可作为鉴别MS与偏头痛的可靠生物标志物。
The central vein sign and paramagnetic rim lesions: biomarkers for an accurate differential diagnosis between multiple sclerosis and migraine.
Objective: This study aimed to assess whether the evaluation of the central vein sign (CVS) and paramagnetic rim lesions (PRLs) using susceptibility-weighted magnetic resonance imaging (MRI) can distinguish multiple sclerosis (MS) from migraine.
Materials and methods: In this single-center observational study, we conducted a cross-sectional analysis of the CVS, determining the proportion of CVS-positive lesions per individual and absolute counts, using thresholds of 3 lesions (select3*) and 6 lesions (select6*), and of PRLs in participants with MS and in those with migraine, from 3.0-T MRI brain scans.
Results: The study included 20 participants with MS, 20 with migraine, and 20 included as healthy controls. The proportion of participants with CVS-positive lesions was higher in the MS group than in the migraine group (61.8% vs. 10.4%), and PRLs were observed exclusively in the MS group. The presence of at least one PRL and the select6* criterion demonstrated the highest diagnostic accuracy within the study sample.
Conclusion: The detection of the CVS and of a PRL on 3.0-T MRI scans may serve as a reliable biomarker to differentiate MS from migraine.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
