Renal Failure最新文献_第7页

Leveraging large language models for preoperative prevention of cardiopulmonary bypass-associated acute kidney injury. 利用大型语言模型术前预防心肺旁路相关急性肾损伤。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-05-29 DOI: 10.1080/0886022X.2025.2509786

Kai Wang, Ling Lin, Rui Zheng, Shan Nan, Xudong Lu, Huilong Duan

{"title":"Leveraging large language models for preoperative prevention of cardiopulmonary bypass-associated acute kidney injury.","authors":"Kai Wang, Ling Lin, Rui Zheng, Shan Nan, Xudong Lu, Huilong Duan","doi":"10.1080/0886022X.2025.2509786","DOIUrl":"10.1080/0886022X.2025.2509786","url":null,"abstract":"Background: Acute kidney injury (AKI) usually occurs after cardiopulmonary bypass (CPB) and threatens life without timely intervention. Early assessment and prevention are critical for saving AKI patients. However, numerical data-driven models make it difficult to predict the AKI risk using preoperative data and lack preventive measures. Large language models (LLM) have demonstrated significant potential for medical decision-making, offering a promising approach.Objective: For preoperative assessment and prevention of CPB-associated AKI (CPB-AKI).Methods: Clinical variables were converted into text through prompt engineering and a LLM was used to extract information hidden in the semantics of subtle changes. A multimodal fusion model, fuzing semantic and numerical information, was proposed to assess the AKI risk before surgery. We then used a structural equation model to analyze the impact of preoperative features and intraoperative interventions on CPB-AKI prevention.Results: A total of 2,056 patients who underwent CPB were enrolled from the intensive care unit of Sir Run Run Shaw Hospital between 2014 and 2022, with 40.5% progressing to AKI. Our model performed better with an area under the receiver operating characteristic curve of 0.9201 compared with the baseline models. The structural equation model's chi-square to degrees of freedom ratio was 0.46, less than 2.0. We discussed how the preoperative prediction model could optimize intraoperative interventions to prevent CPB-AKI.Conclusions: The prediction model can predict CPB-AKI risk earlier after fuzing the clinical characteristics and their semantics. Preoperative assessment and intraoperative interventions provide decision-making to prevent CPB-AKI.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2509786"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mediation effects of age, intramuscular adipose tissue index and serum albumin on survival status in initial dialysis patients. 年龄、肌内脂肪组织指数和血清白蛋白对初次透析患者生存状况的中介作用。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-06-26 DOI: 10.1080/0886022X.2025.2519822

Meng-Huan Wu, Yu-Ting Gao, Yu-Xin Ren, Wen Zhou, Jing Zheng, Shi-Mei Hou, Yao Wang, Jing-Yuan Cao, Xiao-Xu Wang, Yan Yang, Bin Wang, Min Yang, Jing-Ting Jiang, Min Li

{"title":"Mediation effects of age, intramuscular adipose tissue index and serum albumin on survival status in initial dialysis patients.","authors":"Meng-Huan Wu, Yu-Ting Gao, Yu-Xin Ren, Wen Zhou, Jing Zheng, Shi-Mei Hou, Yao Wang, Jing-Yuan Cao, Xiao-Xu Wang, Yan Yang, Bin Wang, Min Yang, Jing-Ting Jiang, Min Li","doi":"10.1080/0886022X.2025.2519822","DOIUrl":"10.1080/0886022X.2025.2519822","url":null,"abstract":"Background: To explore the associations of age, intramuscular adipose tissue index (IATI), and serum albumin with survival status in initial dialysis patients and the mediating effects.Methods: Totally 1,044 Chinese initial dialysis patients from four hospitals (2014-2020) were eventually enrolled and followed up to December 31, 2022 or until death in this retrospective cohort study. IATI was defined as the ratio of low attenuation muscle density to skeletal muscle density assessed by CT at the first lumbar vertebra level. Multivariate Cox regression and two-piecewise Cox proportional hazards models were used to determine the risk factors for all-cause mortality and to perform stratified analysis. Mediation analysis was conducted to identify mediators.Results: High IATI, age > 60 years, and low serum albumin were significant independent risk factors for all-cause mortality. The association between IATI and all-cause mortality remained significant in female patients, and those with low neutrophil/lymphocyte ratios, or without coronary heart disease. When age and IATI were categorical variables, age had a significant indirect effect on all-cause mortality (0.015) and survival time (-1.262) via IATI, while IATI indirectly influenced all-cause mortality through serum albumin (0.012).Conclusions: Age > 60 years and high IATI are risk factors for all-cause mortality while serum albumin is protective in initial dialysis patients. The relationship between age and survival status may be mediated by IATI, while the effect of IATI on all-cause mortality may be mediated by serum albumin.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2519822"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-omics study of mitochondrial dysfunction in the pathogenesis of hyperuricemia. 线粒体功能障碍在高尿酸血症发病机制中的多组学研究。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-07-23 DOI: 10.1080/0886022X.2025.2532855

Yuechang Hong, Minghui Yang, Xin Xu, Peng Wang, Minqiang Fu, Renying Xiong, Jianjiang OuYang

{"title":"Multi-omics study of mitochondrial dysfunction in the pathogenesis of hyperuricemia.","authors":"Yuechang Hong, Minghui Yang, Xin Xu, Peng Wang, Minqiang Fu, Renying Xiong, Jianjiang OuYang","doi":"10.1080/0886022X.2025.2532855","DOIUrl":"10.1080/0886022X.2025.2532855","url":null,"abstract":"Background: Mitochondrial dysfunction is linked to hyperuricemia (HUA), but its genetic pathophysiology is not yet fully understood. We employed Mendelian randomization (MR) to integrate multi-omics data and explore the associations between mitochondrial-related genes and HUA.Methods: We conducted a summary data-based MR analysis to investigate potential targets associated with HUA by integrating mitochondrial-related DNA methylation, gene expression, and protein quantitative trait loci. Additionally, to further explore the potential associations between DNA methylation, gene expression, and protein abundance, we performed MR and co-localization analyses to examine causal relationships between candidate gene methylation and expression, as well as between gene expression and protein abundance.Result: Through the integration of multi-omics evidence, we identified one primary gene, NUDT2, and three secondary genes, BOLA1, COMT, and HAGH. At the protein level, NUDT2 and COMT are negatively correlated with HUA risk, whereas BOLA1 and HAGH are positively correlated with HUA risk. Our analysis revealed a positive correlation between the methylation of cg06605933 in BOLA1 and its protein levels, which aligns with the negative effect of cg06605933 methylation on HUA risk. Additionally, we observed a positive correlation between NUDT2 gene expression and protein levels, confirming its beneficial effect on HUA risk. Strong co-localization support was found between the methylation of cg06605933 (PPH4 = 85.1%) in BOLA1 and protein abundance, as well as between NUDT2 gene expression (PPH4 = 96.6%) and protein levels.Conclusion: Our study identified mitochondrial genes NUDT2, BOLA1, COMT, and HAGH as potentially associated with HUA risk, supported by evidence from various omics levels.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2532855"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of risk factors for perioperative hyperamylasemia in kidney transplant recipients. 肾移植受者围手术期高淀粉酶血症的危险因素分析。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-07-23 DOI: 10.1080/0886022X.2025.2529444

Yang Zhang, Liubing Xia, You Luo, Jinhua Zhang, Zoufu Tang, Xiaorong Chen, Ning Na

{"title":"Analysis of risk factors for perioperative hyperamylasemia in kidney transplant recipients.","authors":"Yang Zhang, Liubing Xia, You Luo, Jinhua Zhang, Zoufu Tang, Xiaorong Chen, Ning Na","doi":"10.1080/0886022X.2025.2529444","DOIUrl":"10.1080/0886022X.2025.2529444","url":null,"abstract":"Background: Perioperative hyperamylasemia has been observed in several kidney transplant recipients (KTRs) at our center. However, there are currently no published reports on this observation. This study aimed to identify the risk factors associated with perioperative hyperamylasemia in KTRs.Methods: The data from 540 deceased-donor kidney recipients in our hospital from January 2020 to December 2023 were retrospectively analyzed. Variables such as gender, past medical history, relevant laboratory tests, and trough concentration of calcineurin inhibitors (CNIs) at the time of serum amylase maximum were collected for all patients. Univariate and multivariate logistic regression analyses were used to determine the risk factors associated with perioperative hyperamylasemia.Results: Among all KTRs, 153 patients (28.3%) developed perioperative hyperamylasemia. Multivariate logistic regression analysis indicated that preoperative serum phosphate (odds ratio [OR] = 1.62, 95% confidence interval [CI]: 1.160 - 2.266, p = 0.005), preoperative serum amylase (OR = 1.01, 95% CI: 1.006 - 1.015, p < 0.001), and high perioperative CNIs trough concentration (OR = 2.335, 95% CI: 1.560 - 3.494, p < 0.001) were risk factors associated with perioperative hyperamylasemia. In addition, we used all three as a hybrid model to predict perioperative hyperamylasemia, which demonstrated good predictive value (area under the ROC curve [AUC] = 0.687, 95% CI: 0.64-0.734).Conclusion: Elevated preoperative serum phosphate levels, preoperative serum amylase levels, and high perioperative CNIs trough concentrations are risk factors for perioperative hyperamylasemia. This study may provide valuable insights for clinicians to identify the causes of perioperative hyperamylasemia and formulate prevention and treatment strategies.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2529444"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA stratified by age and renal function: CHANCE-2 trial substudy. 替格瑞洛与氯吡格雷对按年龄和肾功能分层的卒中或TIA CYP2C19功能丧失携带者的疗效：CHANCE-2试验亚研究

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-07-23 DOI: 10.1080/0886022X.2025.2526684

Yu Wu, Yilun Zhou, Yuesong Pan, Aoming Jin, Xia Meng, Hao Li, Yilong Wang, Yong Jiang, Yongjun Wang

{"title":"Ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA stratified by age and renal function: CHANCE-2 trial substudy.","authors":"Yu Wu, Yilun Zhou, Yuesong Pan, Aoming Jin, Xia Meng, Hao Li, Yilong Wang, Yong Jiang, Yongjun Wang","doi":"10.1080/0886022X.2025.2526684","DOIUrl":"10.1080/0886022X.2025.2526684","url":null,"abstract":"Objective: To compare the efficacy and safety of ticagrelor versus clopidogrel in stroke patients who were CYP2C19 loss-of-function (LOF) carriers stratified by age and renal function.Methods: Patients in the CHANCE-2 trial were randomized to ticagrelor-aspirin or clopidogrel-aspirin treatment. The primary efficacy outcome was occurrence of a new stroke within 90 days, while bleeding was assessed for safety. Patients were categorized based on age and estimated glomerular filtration rate (eGFR).Results: In patients with eGFR >90 mL/min/1.73 m2, ticagrelor-aspirin was associated with a significantly lower risk of the subsequent stroke within 90 days compared with the clopidogrel-aspirin in those aged over 65 years (HR 0.53, 95% CI 0.33-0.85, p = 0.008) and under 65 years (HR, 0.67, 95% CI, 0.47-0.96, p = 0.03). While in those with eGFR 60-89 mL/min/1.73 m2, ticagrelor did not show superiority over clopidogrel in reducing stroke regardless of age category (age ≥ 65: HR 1.14, 95% CI 0.71-1.84, p = 0.59; age < 65: HR 0.40, 95% CI 0.12-1.33, p = 0.13). The incidence of mild bleeding events was higher with ticagrelor-aspirin treatment in those aged < 65 years with eGFR ≥90 mL/min/1.73 m2 (HR 3.33, 95% CI 2.18-5.10, p < 0.001) and in those aged ≥ 65 years with eGFR <60mL/min/1.73 m2 (HR 8.68, 95% CI 1.06-71.1, p = 0.04).Conclusions: Elderly patients with normal renal function appear to benefit from ticagrelor compared with clopidogrel. Both younger patients with normal renal function and those with advanced age and renal insufficiency are prone to mild bleeding.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2526684"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a convenient and rapid screening zebrafish model to investigate lethal effects and immunocompromised states of uremic toxins. 建立一种方便、快速筛选的斑马鱼模型来研究尿毒症毒素的致死效应和免疫功能低下状态。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-06-08 DOI: 10.1080/0886022X.2025.2514183

Pema Jo, Rui Zhang, Yuhua Zhang, Zhilian Li, Yanhua Wu, Shuqiong Zhang, Tsring Lhamo, Yuanhan Chen

{"title":"Development of a convenient and rapid screening zebrafish model to investigate lethal effects and immunocompromised states of uremic toxins.","authors":"Pema Jo, Rui Zhang, Yuhua Zhang, Zhilian Li, Yanhua Wu, Shuqiong Zhang, Tsring Lhamo, Yuanhan Chen","doi":"10.1080/0886022X.2025.2514183","DOIUrl":"10.1080/0886022X.2025.2514183","url":null,"abstract":"Background: Uremia is characterized by high mortality and immune dysfunction owing to the accumulation of uremic toxins. Traditional rodent models are complex and time consuming. This study aimed to develop a simple and rapid zebrafish model for investigating the toxicological effects of uremic toxins.Methods: Uremic solutions containing small (SUT) and medium-to-large (MLUT) uremic toxins were prepared using waste solution of peritoneal dialysis by a dialysis method. Wild-type zebrafish larvae were used to assess mortality, whereas transgenic (TG) (zlyz:EGFP) zebrafish, with macrophages labeled with green fluorescent protein, were used to evaluate immune status through macrophage migration assays.Results: The mortality rates were significantly higher in the SUT- and MLUT-treated groups than in the controls, with SUT showing the strongest lethal effect. Macrophage migration was significantly inhibited in both SUT- and MLUT-treated groups, indicating an immunocompromise. This model effectively mimicked the lethal and immunosuppressive effects of uremia.Conclusion: This zebrafish model provides a simple and rapid platform for studying the toxicological effects of uremic toxins and evaluating potential therapeutic interventions.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2514183"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dexmedetomidine improves septic acute kidney injury by inhibiting inflammation and oxidative stress through the activation of the Pink1/Park2 autophagy pathway. 右美托咪定通过激活Pink1/Park2自噬通路抑制炎症和氧化应激，改善脓毒性急性肾损伤。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-06-08 DOI: 10.1080/0886022X.2025.2513677

Qiuxia Liao, Zhi Feng, Hairong Lin, Ye Zhou, Xinxin Lin, Xiao Lin, Huichang Zhuo

{"title":"Dexmedetomidine improves septic acute kidney injury by inhibiting inflammation and oxidative stress through the activation of the Pink1/Park2 autophagy pathway.","authors":"Qiuxia Liao, Zhi Feng, Hairong Lin, Ye Zhou, Xinxin Lin, Xiao Lin, Huichang Zhuo","doi":"10.1080/0886022X.2025.2513677","DOIUrl":"10.1080/0886022X.2025.2513677","url":null,"abstract":"Impaired autophagy is a key factor in the development of septic acute kidney injury (SAKI). Dexmedetomidine-an α2 adrenergic agonist widely used as a sedative-exerts protective effects in SAKI. However, its correlation with autophagy remains unclear. Consequently, this study aimed to investigate whether the protective effect of dexmedetomidine against SAKI is related to the Pink1/Park2 autophagy pathway. Dexmedetomidine was intraperitonally administered to mice before inducing SAKI with lipopolysaccharide. Subsequently, kidney structure, inflammatory markers, renal function, oxidative stress levels, mitochondrial 16S rRNA expression, autophagy-related protein levels (Pink1, Park2, and Optineurin), and renal cell apoptosis rates were evaluated. Dexmedetomidine reduced inflammatory factors, such as tumor necrosis factor-α, interleukin (IL)-18, IL-6, and IL-1β, and improved kidney function by decreasing serum cystatin C, creatinine, blood urea nitrogen, kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin. Furthermore, it also alleviated kidney tissue damage. Additionally, dexmedetomidine enhanced mitochondrial function; reduced kidney tissue levels of reactive oxygen species, catalase, malondialdehyde, and glutathione; increased superoxide dismutase activity; upregulated mt16S expression; promoted the expression of autophagy-related proteins (Pink1, Park2, and Optineurin); and reduced renal cell apoptosis rates. Notably, all results were statistically significant. Overall, our findings revealed that dexmedetomidine may mitigate inflammation, oxidative stress, and renal dysfunction in mice with SAKI by upregulating the Pink1/Park2-mediated autophagy pathway. These preliminary findings highlight dexmedetomidine's potential role in SAKI management and warrant further validation in large scale studies.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2513677"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12150617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144249329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA-PKcs participates in the repair of renal tubular epithelial cell injury. DNA-PKcs参与肾小管上皮细胞损伤的修复。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-07-29 DOI: 10.1080/0886022X.2025.2537811

Dan Feng, Yu-Jie Hu, Lei Sun, Jing Zhang, Xiao-Ling Niu, Wen-Yan Huang

{"title":"DNA-PKcs participates in the repair of renal tubular epithelial cell injury.","authors":"Dan Feng, Yu-Jie Hu, Lei Sun, Jing Zhang, Xiao-Ling Niu, Wen-Yan Huang","doi":"10.1080/0886022X.2025.2537811","DOIUrl":"10.1080/0886022X.2025.2537811","url":null,"abstract":"Ischemia/reperfusion (I/R) injury is a major cause of acute kidney injury (AKI) and plays a central role in mediating cell damage and ultimately acute tubular necrosis. Renal proximal tubular epithelial cells (PTECs) possess intrinsic repair mechanisms, yet the molecular pathways underpinning their ability to recover after I/R injury remain incompletely understood. DNA-dependent protein kinase catalytic subunit (DNA-PKcs), a serine/threonine kinase, is pivotal in DNA damage repair, genomic stability, cell cycle regulation, and mitochondrial dysfunction. Given its central roles in maintaining cellular homeostasis, we hypothesized that DNA-PKcs is critically involved in orchestrating the intrinsic repair mechanisms of renal tubular epithelial cells following I/R injury. In this study, we investigate the involvement of DNA-PKcs in the repair of tubular epithelial cell damage induced by renal I/R injury. Using both in vitro and in vivo models, we demonstrate that DNA-PKcs expression is significantly upregulated during the acute phase of kidney injury and returns to baseline levels upon resolution of the damage. In the hypoxia/reoxygenation (H/R) model using NRK-52E cells, treatment with the DNA-PKcs inhibitor NU7441 resulted in mitochondrial swelling. Additionally, the expression levels of DNA damage and epithelial-mesenchymal transition markers such as γ-H2AX, α-SMA, and vimentin were notably prolonged. Moreover, DNA-PKcs inhibition significantly impaired cell proliferation, induced a G1/S phase arrest under normoxic conditions, and resulted in G2/M phase arrest following H/R. Our study provides that DNA-PKcs acts as a promising therapeutic target for mitigating AKI and promoting renal regeneration.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2537811"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144744546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimated pulse wave velocity and the risk of acute kidney injury in patients undergoing coronary revascularization: a retrospective cohort study from MIMIC-IV. 冠状动脉血管重建术患者脉搏波速度和急性肾损伤的风险：来自MIMIC-IV的回顾性队列研究

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-07-29 DOI: 10.1080/0886022X.2025.2532859

Xinping Yang, Lizi Zhang, Hao Wei, Fan Zhang, Han Yang, Jiahua Shi

{"title":"Estimated pulse wave velocity and the risk of acute kidney injury in patients undergoing coronary revascularization: a retrospective cohort study from MIMIC-IV.","authors":"Xinping Yang, Lizi Zhang, Hao Wei, Fan Zhang, Han Yang, Jiahua Shi","doi":"10.1080/0886022X.2025.2532859","DOIUrl":"10.1080/0886022X.2025.2532859","url":null,"abstract":"Acute kidney injury (AKI) commonly complicates coronary revascularization, worsening outcomes. Estimated pulse wave velocity (ePWV), a simple arterial stiffness marker, independently predicts cardiovascular risk. This study aimed to evaluate the association between ePWV and AKI in patients undergoing coronary revascularization. Based on the Medical Information Mart for Intensive Care (MIMIC)-IV database, this retrospective cohort study obtained the data of patients who underwent coronary revascularization, including percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). The ePWV was calculated based on the patients' age and blood pressure. Univariable and multivariable logistics regression were utilized to evaluate the association between ePWV and AKI in this population, with odds ratio (ORs) and 95% confidence intervals (CIs). Stratified analyses based on age, gender, surgery types, complications were further conducted to verify this association. This study ultimately included 2,842 eligible patients who underwent coronary revascularization. Among them, 1,174 (41.31%) occurred AKI. We observed high ePWV is associated with high risk of AKI in patients received coronary revascularization (OR = 1.36, 95%CI: 1.10-1.69). Similar results were also observed in patients who underwent CABG (OR = 1.08, 95%CI: 0.96-1.21), without the history of acute myocardial infarction (OR = 1.39, 95%CI: 1.06-1.82), or atrial fibrillation (OR = 1.36, 95%CI: 1.07-1.73), or with the history of hypertension (OR = 1.48, 95%CI: 1.12-1.95) or had higher estimated glomerular filtration rate (eGFR) level (OR = 1.45, 95%CI: 1.16-1.81). The results suggested high ePWV is associated with the high risk of AKI among patients underwent coronary revascularization. The ePWV is a simple and noninvasive indicator that could be used for risk stratification of AKI after coronary revascularization.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2532859"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144744547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

U-shaped association between serum calcium and all-cause mortality in coronary heart disease with chronic kidney disease: evidence from two cohort studies in China and the United States. 血清钙与冠心病合并慢性肾脏疾病的全因死亡率之间的u型关联：来自中国和美国两项队列研究的证据

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-07-16 DOI: 10.1080/0886022X.2025.2528097

Shuling Su, Yongluan Lin, Weixin Ni, Haoxian Tang, Chuqi Gao, Xiulian Deng, Shiwan Wu, Yequn Chen, Xiaobin Ni

{"title":"U-shaped association between serum calcium and all-cause mortality in coronary heart disease with chronic kidney disease: evidence from two cohort studies in China and the United States.","authors":"Shuling Su, Yongluan Lin, Weixin Ni, Haoxian Tang, Chuqi Gao, Xiulian Deng, Shiwan Wu, Yequn Chen, Xiaobin Ni","doi":"10.1080/0886022X.2025.2528097","DOIUrl":"10.1080/0886022X.2025.2528097","url":null,"abstract":"Background: Chronic kidney disease (CKD), as a major risk factor for coronary heart disease (CHD), had a large fluctuation of serum calcium in clinical research. Our study aims to identify the association between serum calcium and all-cause mortality in CHD patients with CKD.Methods: A retrospective cohort study was conducted, involving 2,286 participants from the CHD sub-cohort from the Eastern Guangdong Health and Disease Cohort Platform (EGHDCP) and 1,278 participants from National Health and Nutrition Examination Survey (NHANES) database. Cox proportional hazards regression models, stratified analysis with interaction, restricted cubic splines (RCS), and threshold effect analysis were applied to investigate the association between serum calcium and all-cause mortality of CHD with CKD.Results: The association between serum calcium and all-cause mortality of CHD patients with CKD from EGHDCP-CHD exhibited an U-shaped curve in RCS, which was similar to be observed in NHANES cohort. In EGHDCP-CHD cohort, Cox regression models demonstrated that subjects in the lowest or the highest serum calcium group had a significantly higher risk of mortality. Besides, both cohorts showed similar inflection points in the threshold analysis. In EGHDCP-CHD cohort, the risk of all-cause mortality reduced by 9.73% with every 0.1 mmol/L increased in serum calcium (Hazard ratio (HR) = 0.027, 95% confidence interval (CI): 0.005-0.145, p < 0.001), while it increased by 30.46% when the serum calcium evaluated more than 2.27 mmol/L increased every 0.1 mmol/L (HR = 4.046, 95% CI: 1.143-14.319, p = 0.0302).Conclusion: There was an U-shaped connection between serum calcium and all-cause mortality in CHD patients with CKD.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2528097"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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