Renal Failure最新文献

{"title":"Causal insights into major risk factors for diabetic kidney disease: a comprehensive meta-analysis and Mendelian randomization study.","authors":"Yucong Zhou, Yahong Liu, Liang Wu, Yucai Zhang, Huixin Wen, Jiangwei Hu, Zhenxia Huo, Shuyuan Ju, Ruizheng Sheng","doi":"10.1080/0886022X.2025.2468741","DOIUrl":"10.1080/0886022X.2025.2468741","url":null,"abstract":"<p><strong>Background: </strong>This study aims to identify major risk factors for diabetic kidney disease (DKD) and examine their causal relationships using meta-analysis and Mendelian randomization.</p><p><strong>Materials and methods: </strong>This study reviewed diabetic nephropathy literature up to September 2024, evaluating quality with NOS, AMSTAR 2, and JBI. It analyzed heterogeneity using the Baujat plot and leave-one-out method, and conducted meta-analysis with fixed- or random-effects models based on I². Publication bias was assessed with a funnel plot and Egger's test. Mendelian randomization using GWAS SNPs explored causal links through IVW, MR-Egger, weighted median, and weighted mode, while pleiotropy and heterogeneity were checked with the MR-Egger intercept and Cochran's Q.</p><p><strong>Results: </strong>Meta-analysis identified several significant risk factors for DKD, including hypertension (relative risk [RR] = 6.33), comorbidities (RR = 4.96), poor glycemic control (RR = 3.27), non-adherence to treatment (RR = 3.30), an unhealthy diet (RR = 5.96), physical inactivity (RR = 5.60), and hyperuricemia (RR = 5.24). MR analysis further confirmed a causal relationship between high carbohydrate intake (odds ratio [OR] = 1.393, <i>p</i> = 0.043) and increased DKD risk, while vegetable consumption (OR = 0.816, <i>p</i> = 0.011) was identified as a protective factor. These findings reinforce the critical role of dietary and lifestyle interventions in DKD prevention.</p><p><strong>Conclusions: </strong>By integrating meta-analysis with Mendelian randomization, this study provides robust evidence linking modifiable risk factors, particularly dietary habits and lifestyle behaviors, to DKD development. The findings highlight the need for early preventive strategies targeting glycemic control, hypertension, and dietary modifications to mitigate DKD progression.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2468741"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric insights into systemic sclerosis with renal involvement: trends, contributions, and future directions.","authors":"Haochen Huang, Ling-Ling Zhang, Jiaxin Zhou, Mengtao Li, Xiaofeng Zeng, Dong Xu","doi":"10.1080/0886022X.2025.2463583","DOIUrl":"10.1080/0886022X.2025.2463583","url":null,"abstract":"<p><strong>Background: </strong>Renal involvement is not uncommon in patients with systemic sclerosis (SSc) and presents in various forms, particularly progressing to scleroderma renal crisis (SRC), which is associated with poor prognosis. Therefore, understanding the research trends in this field is critical for advancing clinical management and therapeutic strategies.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted using the Web of Science Core Collection, examining publications related to SSc and renal involvement from January 2000 to November 2024. We analyzed publication trends, key contributors, institutions, and countries.</p><p><strong>Results: </strong>A total of 1,339 publications were identified in the field of SSc and renal involvement, demonstrating an upward trend in publication volume from 2000 to 2024. These articles have been cited a total of 61,234 times, with the majority of contributions coming from the United States, Italy, and East Asian countries. The University of Michigan and University College London were particularly prominent in terms of both publication volume and collaboration networks. Keyword analysis revealed a shift in research focus, with increasing attention on clinical aspects, pathophysiological mechanisms, and vascular complications.</p><p><strong>Conclusions: </strong>This study provides a comprehensive overview of the research landscape on SSc with renal involvement, highlighting the key contributors and emerging trends.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2463583"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of peripheral blood lymphocyte subpopulations after renal transplantation.","authors":"Bo Peng, Xuyu Xiang, Han Tian, Kaiqiang Xu, Quan Zhuang, Junhui Li, Pengpeng Zhang, Yi Zhu, Min Yang, Jia Liu, Yujun Zhao, Ke Cheng, Yingzi Ming","doi":"10.1080/0886022X.2025.2493231","DOIUrl":"10.1080/0886022X.2025.2493231","url":null,"abstract":"<p><p>Immune monitoring is essential for maintaining immune homeostasis after renal transplantation (RT). Peripheral blood lymphocyte subpopulations (PBLSs) are widely used biomarkers for immune monitoring, yet there is no established standard reference for PBLSs during immune reconstitution post-RT. PBLS data from stable recipients at various time points post-RT were collected. Binary and multiple linear regressions, along with a mixed-effect linear model, were used to analyze the correlations between PBLSs and clinical parameters. Predictive models for PBLS reference values were developed using Gradient Boosting Regressor, and the models' performance was also evaluated in infected recipients. A total of 1,736 tests from 494 stable recipients and 98 tests from 82 infected recipients were included. Age, transplant time, induction therapy, dialysis duration, serum creatinine, albumin, hemoglobin, and immunosuppressant drug concentration were identified as major factors influencing PBLSs. CD4⁺ and CD8⁺ T cells and NK cells increased rapidly, stabilizing within three months post-RT. In contrast, B cells peaked at around two weeks and gradually plateaued after four months. Both static and dynamic predictive models provided accurate reference values for PBLSs at any time post-RT, with the static model showing superior performance in distinguishing stable, infected and sepsis patients. Key factors influencing PBLS reconstitution after RT were identified. The predictive models accurately reflected PBLS reconstitution patterns and provided practical, personalized reference values for PBLSs, contributing to precision-guided care. The study was registered on Chinese Clinical Trial Registry (ChiCTR2300068666).</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2493231"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between body mass index and mortality in diabetic patients with end-stage renal disease is different in hemodialysis and peritoneal dialysis.","authors":"Hanri Afghahi, Salmir Nasic, Johan Svensson, Helena Rydell, Anna Wärme, Björn Peters","doi":"10.1080/0886022X.2025.2510549","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2510549","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>There are diverse results in terms of the association between body mass index (BMI) and mortality risk in patients with end-stage renal disease (ESRD). The aim was to examine if there is an association between BMI and the risk of all-cause mortality in patients with diabetes mellitus (DM) and ESRD on hemodialysis (HD) or peritoneal dialysis (PD).</p><p><strong>Methods: </strong>Included were 3,235 patients (mean age 66 ± 14 years, 66% men) with DM on dialysis treatment (2,452 HD, 783 PD) that were followed for 3.9 ± 3.5 years. BMI was calculated as weight (kg)/[height (m)]² and defined as the mean BMI value during the study period. Relationships between BMI and all-cause mortality were examined by Cox-models to estimate hazard ratios (HR) and 95% confidence intervals (CI) in univariate and multivariate analyses adjusted for demographics, laboratory findings and comorbidity. BMI between 18.5 and 25 kg/m² was used as the reference group.</p><p><strong>Results: </strong>During the study, 1,688 (53%) patients died (1,275 on HD, 413 on PD). In multivariate analyses, patients on HD with BMI ≤ 18.5 kg/m² had an increased risk of all-cause mortality (HR1.94, CI 1.47-2.54). In contrast, mortality risk was decreased in the BMI groups of 25.1-30 kg/m² (HR0.84, CI0.73-0.96), 30.1-35 kg/m² (HR0.66, CI0.55-0.78), and 35.1-40 kg/m² (HR0.65, CI0.49-0.85). In multivariate analyses, no associations between BMI and mortality risk were found in patients on PD.</p><p><strong>Conclusion: </strong>An increased risk of mortality in underweight DM patients on HD was found. Overweight, class 1 and class 2 obesity were associated with better survival in HD.</p><p><strong>Key learning points: </strong>The association between BMI and risk of mortality is different in patients with DM on maintenance HD or PD.</p><p><strong>What was known (maximum 50 words): </strong>The association between BMI and risk of mortality in ESRD population on dialysis treatment is very divers and different study have shown different results.</p><p><strong>This study adds (maximum 50 words): </strong>High BMI associated with better survival in patients with diabetes and HD but this finding did not observed with PD.</p><p><strong>Potential impact (on practice or understanding, maximum 50 words): </strong>The importance to examine time-varying BMI frequently as independent covariance in patients with dialysis treatment.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2510549"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intensive water-salt diet nursing intervention on blood pressure and volume load in patients with chronic renal failure.","authors":"Liyan Wu, Wanli Ma, Hui Zhang, Ting Yang, Mengxi Sun, Zhen Yang, Xiaohan Guo","doi":"10.1080/0886022X.2025.2474854","DOIUrl":"10.1080/0886022X.2025.2474854","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the impact of a comprehensive nursing intervention targeting high water and salt intake on blood pressure and volume burden in patients with chronic renal failure.</p><p><strong>Method: </strong>From January 2020 to January 2023, 120 patients diagnosed with chronic renal failure were treated at our hospital. Participants were randomly allocated to either a control group (<i>n</i> = 60) receiving standard dietary education or an observation group (<i>n</i> = 60) receiving intensive water-salt diet nursing intervention alongside standard education. Blood pressure, volume load, and related parameters were compared after a 6-month observation period.</p><p><strong>Result: </strong>Both groups exhibited reduced systolic and diastolic blood pressure post-intervention (<i>p</i> < 0.05). The observation group demonstrated a significantly lower extracellular water-to-total body water ratio (ECW/TBW) compared to the control group (<i>p</i> < 0.05). The observation group also showed higher 24-hour urine volume (<i>p</i> < 0.05), hemoglobin levels, creatinine clearance rates (<i>p</i> < 0.05), and treatment compliance (<i>p</i> < 0.05), alongside a lower complication rate (3.33% vs. 13.33%; χ² = 3.927, <i>p</i> < 0.05). A negative correlation was observed between the Therapeutic Intervention Scoring System (TISS) scale and post-intervention blood pressure/volume load (r = -2.924, -2.184; <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Intensive water-salt diet nursing interventions effectively control blood pressure, reduce volume load, and mitigate complications in chronic renal failure patients. This approach should be widely implemented in clinical practice.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2474854"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hidden danger: prolonged exposure to inorganic contaminants and kidney health in adolescents.","authors":"Xiaoran Xue, Zaiqiu Zhang, Marady Hun, Min Wen, Mingyi Zhao, Qingnan He","doi":"10.1080/0886022X.2025.2506818","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2506818","url":null,"abstract":"<p><p>Research on the impact of prolonged exposure to inorganic contaminants, such as perchlorate, nitrate, and thiocyanate (PNT), on the kidney health of individuals in the 12 ∼ 19 age range is lacking. We analyzed data from the United States National Health and Nutrition Examination Survey (NHANES) over the period 2005-2016 to investigate the linear relationship between chronic kidney disease (CKD)-related parameters and PNT exposure levels, and to explore population heterogeneity from multiple aspects. Weighted multiple regression analysis estimated the independent associations between water or urine exposure indicators and CKD-related parameters. We utilized stratified subgroup analysis and smooth linear fitting as supplements. Lower estimated glomerular filtration rate (eGFR) (non- or new-creatinine (CR)-adjusted), albumin-to-creatinine ratio (ACR), and blood urea nitrogen (BUN) were associated with urine PNT exposure. Water exposure may not be the primary source of PNT exposure. Females had a stronger negative association between nitrate and eGFR after non- or new-CR adjustment. With the most demographic heterogeneity, perchlorate affected eGFR, ACR, and BUN. Our findings associated urinary PNT exposure with altered renal parameters (eGFR, ACR, BUN) in adolescents aged 12-19, suggesting potential environmental health implications that warrant further investigation.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2506818"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding 'the association between nutritional-inflammatory status and chronic kidney disease prognosis: a population-based study'.","authors":"Ailing Chen, Ningxu Li","doi":"10.1080/0886022X.2025.2508292","DOIUrl":"10.1080/0886022X.2025.2508292","url":null,"abstract":"","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2508292"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic kidney disease management in patients with a failing graft: a comparative study with incident non-transplant hemodialysis patients.","authors":"Ana Rita Silva, Maria Guedes Marques, Luís Rodrigues, Lídia Santos, Catarina Romãozinho, Francisco Caramelo, Helena Sá, Arnaldo Figueiredo, Rui Alves, Rita Leal","doi":"10.1080/0886022X.2024.2447791","DOIUrl":"10.1080/0886022X.2024.2447791","url":null,"abstract":"","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2447791"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional Mendelian Randomization analysis of iron status and uremia: no evidence of a causal relationship.","authors":"Jianwei Chen, Hu Zhao, Yang He, Chen Lin, Yu Wang","doi":"10.1080/0886022X.2025.2488138","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2488138","url":null,"abstract":"<p><p>Iron status and uremia have been linked, but the causality remains ambiguous. This bidirectional study aimed to explore the causal association between genetically predicted iron status and uremia. Utilizing summary data from genome-wide association studies (GWAS) of iron status and uremia, a two-sample Mendelian Randomization (MR) design was employed. Iron status was assessed through serum iron (SI), serum ferritin (SF), total iron-binding capacity (TIBC), and transferrin saturation (TS), while uremia included renal failure and dialysis. The primary analysis was conducted using the Inverse Variance Weighted (IVW) method. Additional MR evaluation included the weighted median, weighted mode, simple mode, and MR-Egger regression methods. Sensitivity analysis included MR-Egger for pleiotropy, MR-PRESSO for detecting outliers, Cochran's Q test for heterogeneity, and leave-one-out analysis for robustness. Genetically determined iron status did not have a causal effect on the risk of uremia (renal failure or dialysis). The primary IVW results indicated no statistically significant relationship between iron status and uremia (all <i>p</i> > 0.05). Consistent results were found through various methods. Similarly, there were no significant causal effects of uremia on iron status (all <i>p</i> > 0.05). Heterogeneity was observed in some associations, but pleiotropy was generally not evident. This bidirectional MR study provides no evidence for a causal relationship between genetically predicted iron status and the risk of uremia. These findings challenge prior observational associations and highlight the need for further mechanistic and interventional studies to elucidate the complex interplay between iron metabolism and kidney disease.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2488138"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the trajectory of cognitive function changes and influencing factors in maintenance hemodialysis patients: a prospective longitudinal study.","authors":"Wenbin Xu, Xiaolian Long, Yuhe Xiang, Aiyin Yu, Ting Luo, Yuhang Chen, Yan Chen, Qian Yang","doi":"10.1080/0886022X.2025.2489722","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2489722","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the trajectory of cognitive function changes and influencing factors in maintenance hemodialysis (MHD) patients.</p><p><strong>Methods: </strong>A convenience sampling method was used to select MHD patients from a tertiary hospital in Chengdu from August 2023 to April 2024. The general information questionnaire, Chinese version of the Montreal Cognitive Assessment (MoCA), Pittsburgh Sleep Quality Index (PSQI), Appetite Visual Analogue Scale (VAS), and Family Care Index (APGAR) were used for the investigation. Patients' cognitive function levels were assessed at baseline and at 3, 6, and 9 months after the initial survey. A latent growth model was used to identify potential categories of cognitive function trajectory, and univariate and binary logistic regression analyses were performed to analyze the influencing factors.</p><p><strong>Results: </strong>A total of 154 MHD patients completed the entire study. The trajectory of cognitive function changes was divided into two potential categories: low cognitive function-fast decline group and high cognitive function-slow decline group. Binary logistic regression results showed that educational level, hypertension, sleep quality, appetite, and family care were influencing factors for the trajectory of cognitive function changes in MHD patients.</p><p><strong>Conclusions: </strong>Cognitive function in MHD patients showed an overall declining trend over time. The cognitive function change trajectory could be divided into two potential categories: fast decline group and high cognitive function-slow decline group. Healthcare professionals can develop targeted nursing intervention programs based on the characteristics of different patient types and their influencing factors to improve cognitive function and enhance quality of life.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2489722"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}