Renal Failure最新文献_第7页

Chronic kidney disease management in patients with a failing graft: a comparative study with incident non-transplant hemodialysis patients. 移植失败患者的慢性肾脏疾病管理：与非移植血液透析患者的比较研究

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-13 DOI: 10.1080/0886022X.2024.2447791

Ana Rita Silva, Maria Guedes Marques, Luís Rodrigues, Lídia Santos, Catarina Romãozinho, Francisco Caramelo, Helena Sá, Arnaldo Figueiredo, Rui Alves, Rita Leal

引用次数: 0

Bidirectional Mendelian Randomization analysis of iron status and uremia: no evidence of a causal relationship. 铁状态和尿毒症的双向孟德尔随机分析：没有因果关系的证据。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-04-29 DOI: 10.1080/0886022X.2025.2488138

Jianwei Chen, Hu Zhao, Yang He, Chen Lin, Yu Wang

{"title":"Bidirectional Mendelian Randomization analysis of iron status and uremia: no evidence of a causal relationship.","authors":"Jianwei Chen, Hu Zhao, Yang He, Chen Lin, Yu Wang","doi":"10.1080/0886022X.2025.2488138","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2488138","url":null,"abstract":"Iron status and uremia have been linked, but the causality remains ambiguous. This bidirectional study aimed to explore the causal association between genetically predicted iron status and uremia. Utilizing summary data from genome-wide association studies (GWAS) of iron status and uremia, a two-sample Mendelian Randomization (MR) design was employed. Iron status was assessed through serum iron (SI), serum ferritin (SF), total iron-binding capacity (TIBC), and transferrin saturation (TS), while uremia included renal failure and dialysis. The primary analysis was conducted using the Inverse Variance Weighted (IVW) method. Additional MR evaluation included the weighted median, weighted mode, simple mode, and MR-Egger regression methods. Sensitivity analysis included MR-Egger for pleiotropy, MR-PRESSO for detecting outliers, Cochran's Q test for heterogeneity, and leave-one-out analysis for robustness. Genetically determined iron status did not have a causal effect on the risk of uremia (renal failure or dialysis). The primary IVW results indicated no statistically significant relationship between iron status and uremia (all p > 0.05). Consistent results were found through various methods. Similarly, there were no significant causal effects of uremia on iron status (all p > 0.05). Heterogeneity was observed in some associations, but pleiotropy was generally not evident. This bidirectional MR study provides no evidence for a causal relationship between genetically predicted iron status and the risk of uremia. These findings challenge prior observational associations and highlight the need for further mechanistic and interventional studies to elucidate the complex interplay between iron metabolism and kidney disease.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2488138"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the trajectory of cognitive function changes and influencing factors in maintenance hemodialysis patients: a prospective longitudinal study. 维持性血液透析患者认知功能改变轨迹及影响因素分析：一项前瞻性纵向研究。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-04-14 DOI: 10.1080/0886022X.2025.2489722

Wenbin Xu, Xiaolian Long, Yuhe Xiang, Aiyin Yu, Ting Luo, Yuhang Chen, Yan Chen, Qian Yang

{"title":"Analysis of the trajectory of cognitive function changes and influencing factors in maintenance hemodialysis patients: a prospective longitudinal study.","authors":"Wenbin Xu, Xiaolian Long, Yuhe Xiang, Aiyin Yu, Ting Luo, Yuhang Chen, Yan Chen, Qian Yang","doi":"10.1080/0886022X.2025.2489722","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2489722","url":null,"abstract":"Objectives: To explore the trajectory of cognitive function changes and influencing factors in maintenance hemodialysis (MHD) patients.Methods: A convenience sampling method was used to select MHD patients from a tertiary hospital in Chengdu from August 2023 to April 2024. The general information questionnaire, Chinese version of the Montreal Cognitive Assessment (MoCA), Pittsburgh Sleep Quality Index (PSQI), Appetite Visual Analogue Scale (VAS), and Family Care Index (APGAR) were used for the investigation. Patients' cognitive function levels were assessed at baseline and at 3, 6, and 9 months after the initial survey. A latent growth model was used to identify potential categories of cognitive function trajectory, and univariate and binary logistic regression analyses were performed to analyze the influencing factors.Results: A total of 154 MHD patients completed the entire study. The trajectory of cognitive function changes was divided into two potential categories: low cognitive function-fast decline group and high cognitive function-slow decline group. Binary logistic regression results showed that educational level, hypertension, sleep quality, appetite, and family care were influencing factors for the trajectory of cognitive function changes in MHD patients.Conclusions: Cognitive function in MHD patients showed an overall declining trend over time. The cognitive function change trajectory could be divided into two potential categories: fast decline group and high cognitive function-slow decline group. Healthcare professionals can develop targeted nursing intervention programs based on the characteristics of different patient types and their influencing factors to improve cognitive function and enhance quality of life.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2489722"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequent hypoglycemia during hemodialysis in ESRD patients leads to higher risk of death. ESRD患者血液透析期间频繁出现低血糖导致死亡风险增高。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-04-23 DOI: 10.1080/0886022X.2025.2484471

Yuwen Shi, Tao Wang, Zhihui Ding, Lijuan Yan, Chunlei Yao, Hua Qian

{"title":"Frequent hypoglycemia during hemodialysis in ESRD patients leads to higher risk of death.","authors":"Yuwen Shi, Tao Wang, Zhihui Ding, Lijuan Yan, Chunlei Yao, Hua Qian","doi":"10.1080/0886022X.2025.2484471","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2484471","url":null,"abstract":"Objective: With the increase of patients with end-stage renal disease (ESRD), most of are receiving hemodialysis, hypoglycemia is a frequent occurrence in ESRD patients due to alterations in glucose and insulin metabolism. The purpose of our study was to explore the correlation between hypoglycemia and long-term survival in patients with ESRD during hemodialysis.Methods: Using the database of Hemodialysis Center in Taizhou Second People's Hospital, 268 ESRD patients undergoing maintenance hemodialysis (MHD) for more than 3 months between January 1, 2019 and September 30, 2023 were enrolled. Basic information, laboratory tests and treatment conditions of patients were collected. We analyzed the impact of hypoglycemia during hemodialysis on survival rate, and explored whether hypoglycemia is an independent risk factor for mortality in MHD patients.Results: We found that factors such as BMI, smoking, and alcohol consumption didn't affect survival rate in ESRD patients, while all-cause mortality was higher in ESRD patients with diabetes, cardiovascular diseases, cerebrovascular disease and experienced hypoglycemia during hemodialysis (p < 0.05). We also observed that almost all ESRD patients with diabetes experienced hypoglycemia during dialysis, and 87.5% experienced ≥3 times, while this phenomenon was hardly observed in nondiabetic ESRD patients. Cox proportional hazards model analysis found that, frequent hypoglycemia (≥3 times) was associated with higher mortality risk in ESRD patients (p = 0.041), adjusted hazard ratios (95% confidence intervals) 3.998 (2.462-6.492).Conclusions: Occurrence of hypoglycemia during dialysis was associated with a higher risk of death, frequent hypoglycemia (≥3 times) was an independent risk factor for death in MHD patients.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2484471"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dapagliflozin ameliorates kidney injury following limb ischemia-reperfusion via the AMPK/SIRT1/NLRP3 pathway. 达格列净通过AMPK/SIRT1/NLRP3通路改善肢体缺血再灌注后的肾损伤。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-04-23 DOI: 10.1080/0886022X.2025.2495111

Qiuxiao Zhu, Huiyao Hao, Ya Gao, Na Li, Zibo Liu, Linyi Shu, Qian Wang, Lihui Zhang

{"title":"Dapagliflozin ameliorates kidney injury following limb ischemia-reperfusion via the AMPK/SIRT1/NLRP3 pathway.","authors":"Qiuxiao Zhu, Huiyao Hao, Ya Gao, Na Li, Zibo Liu, Linyi Shu, Qian Wang, Lihui Zhang","doi":"10.1080/0886022X.2025.2495111","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2495111","url":null,"abstract":"Limb ischemia-reperfusion (I/R) results in both localized tissue harm and injury to distant organs, particularly affecting the kidneys and leading to acute kidney injury. This study evaluates the renoprotective effect of dapagliflozin, a drug frequently prescribed for type 2 diabetes management, in relation to kidney injury caused by limb I/R. The extent of kidney injury was detected through serum marker testing in the rat model. Oxidative stress indicators and inflammatory factors were evaluated in rat and cellular models. Histological changes in the kidneys were examined using HE staining and electron microscopy. Cell pyroptosis was quantified using both TUNEL staining and flow cytometry. Cellular mitochondrial function was analyzed with JC-1 staining. AMPK/SIRT1/NLRP3 pathway-related proteins and their mRNAs were assessed via western blotting and RT-qPCR techniques. We showed that dapagliflozin reduced serum CRE, BUN, NGAL and KIM-1 levels and improved renal pathology in rat. Additionally, dapagliflozin significantly raised the concentrations of GSH-Px and SOD, concurrently reduced MDA and ROS levels in vivo and in vitro. It also lowered the levels of IL-6 and TNF-α and reduced cell pyroptosis. Furthermore, it was observed that dapagliflozin elevated AMPK and SIRT1 expressions, while decreasing NLRP3, ASC, GSDMD, IL-1β, and caspase-1 expressions. Notably, these effects of dapagliflozin were diminished in the presence of AMPK siRNA. Taken together, dapagliflozin exhibits a significant protective effect against kidney injury resulting from limb I/R. This protective effect operates through the inhibition of pyroptosis by activating the AMPK/SIRT1/NLRP3 signaling pathway.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2495111"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safflower injection against obesity-induced mice podocyte injury by improving insulin resistance through increasing renal INSR and eNOS expression. 红花注射液通过增加肾INSR和eNOS表达改善胰岛素抵抗抗肥胖小鼠足细胞损伤

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-04-21 DOI: 10.1080/0886022X.2025.2482888

Zhaodi Han, Xinyu Wang, Jing Liu, Rui Wang, Wenyan Zhao, Hui Liao

{"title":"Safflower injection against obesity-induced mice podocyte injury by improving insulin resistance through increasing renal INSR and eNOS expression.","authors":"Zhaodi Han, Xinyu Wang, Jing Liu, Rui Wang, Wenyan Zhao, Hui Liao","doi":"10.1080/0886022X.2025.2482888","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2482888","url":null,"abstract":"Background: Podocyte injury is a common pathologic mechanism in obesity-related glomerulopathy (ORG). Safflower injection (SFI), scientifically extracted and refined from safflower, is used to treat diabetic kidney disease according to clinical guideline. Our previous study confirmed that the main active compounds of SFI ameliorated high glucose-induced podocyte injury. It is uncertain whether SFI has an effect on ORG-related podocyte injury.Objectives: This study aimed to explore the pharmacological effects and related mechanisms of SFI on podocyte injury of ORG mice.Methods: First, by combining ultra-high performance liquid chromatography tandem mass spectrometry analysis with online databases, the pathway enrichment, target-pathway analysis, and human protein-protein interaction network were conducted to discover the possible crucial mechanism of SFI against ORG. Then, ORG mice model was established by high-fat diet and biochemical assays, histopathology and western blot were used to explore the effects of SFI on obesity and podocyte injury. Finally, system pharmacology-based findings were evaluated in ORG mice.Results: The results of system pharmacology suggested that SFI could alleviate ORG through insulin resistance (IR)-related pathway by regulating insulin receptor (INSR) and endothelial nitric oxide synthase (eNOS) expressions. The in vivo experiment confirmed that SFI ameliorated obesity, lipid metabolism-related indicators, podocyte injury of ORG mice. The mechanism relationships among IR, INSR, and eNOS were further verified in ORG mice.Conclusions: Our findings imply that by up-regulating the expression of renal INSR and eNOS, thereby inhibiting IR, SFI may be a promising candidate for the treatment of ORG.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2482888"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sodium aescinate protects renal ischemia-reperfusion and pyroptosis through AKT/NLRP3 signaling pathway. 七叶皂苷钠通过AKT/NLRP3信号通路保护肾缺血再灌注和焦亡。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-04-22 DOI: 10.1080/0886022X.2025.2488140

Liu Xin, Ning Kanghao, Li Jiacheng, Yan Xiaodong, Yan Juhan, Zhao Xinyang, Li Xiangdong

{"title":"Sodium aescinate protects renal ischemia-reperfusion and pyroptosis through AKT/NLRP3 signaling pathway.","authors":"Liu Xin, Ning Kanghao, Li Jiacheng, Yan Xiaodong, Yan Juhan, Zhao Xinyang, Li Xiangdong","doi":"10.1080/0886022X.2025.2488140","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2488140","url":null,"abstract":"Renal ischemia-reperfusion injury (RIRI) is a common cause of acute renal injury. Studies have shown that sodium aescinate (SA) may serve as a potential therapeutic agent, although its exact mechanism remains unclear. This study first evaluated the efficacy of SA using a mouse renal ischemia-reperfusion model. Subsequently, its mechanism was elucidated through systematic bioinformatics, and finally validated through in vitro and in vivo experiments. The results demonstrated that SA has a protective effect on renal function in mice with RIRI. Bioinformatic analysis indicated that the pyroptosis pathway is significantly activated during renal ischemia-reperfusion injury, and immunohistochemistry showed that the level of renal pyroptosis is upregulated during ischemia-reperfusion injury. Administration of SA was able to reduce the expression of pyroptosis-related proteins (GSDMD, NLRP3, IL-1β) in RIRI. In vitro and in vivo experiments further confirmed that SA exerts an anti-pyroptotic effect by inhibiting the AKT/NLRP3 signaling pathway. Ultimately, SA mitigates kidney injury in IRI mice by suppressing renal failure through inhibition of the AKT/NLRP3 signaling pathway.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2488140"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of mitochondrial gene expression and immune landscape in acute kidney injury prediction. 线粒体基因表达与免疫景观在急性肾损伤预测中的整合。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-05-14 DOI: 10.1080/0886022X.2025.2502608

Xiaoping Xia, Renyang Liu, Xiaohui Jiang

{"title":"Integration of mitochondrial gene expression and immune landscape in acute kidney injury prediction.","authors":"Xiaoping Xia, Renyang Liu, Xiaohui Jiang","doi":"10.1080/0886022X.2025.2502608","DOIUrl":"10.1080/0886022X.2025.2502608","url":null,"abstract":"Background: Acute kidney injury (AKI) is a life-threatening condition with limited early biomarkers. Mitochondrial dysfunction is central to AKI pathophysiology, yet its potential for predicting AKI remains underexplored.Methods: Gene expression data from three publicly available AKI datasets (GSE30718, GSE61739, and GSE139061) were analyzed to identify differentially expressed genes (DEGs). A set of 11 mitochondrial-related genes was selected and used to construct a mitochondrial risk score (MRS) model via Lasso and elastic net regression. The model was validated across multiple datasets. Immune infiltration was assessed using the xCell algorithm to explore the relationship between MRS and immune cell dynamics in AKI. Stable HK-2 cells were constructed of XRCC3 knockdown and overexpression to investigate the effects of XRCC3 on cell activities. Additionally, the impact of XRCC3 on mitochondrial structure and function was examined in vivo and in vitro.Results: Eleven mitochondrial-related genes were consistently dysregulated across all datasets. PCA demonstrated a clear separation between AKI and normal samples. Functional enrichment analysis revealed that upregulated genes were linked to extracellular matrix remodeling and stress responses, while downregulated genes were associated with mitochondrial dysfunction. The MRS model showed strong predictive performance. We found that XRCC3 significantly promoted the activities of HK-2 cells and improved the integrity of mitochondrial structure and function in vivo and in vitro.Conclusion: The mitochondrial gene-based MRS model is a robust tool for predicting AKI. Our findings underscore the critical role of mitochondrial dysfunction and immune modulation in AKI, offering potential avenues for targeted therapeutic strategies.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2502608"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the role of oxidative stress in ANCA-associated glomerulonephritis through integrated machine learning and bioinformatics analyses. 通过综合机器学习和生物信息学分析揭示氧化应激在anca相关肾小球肾炎中的作用。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-05-14 DOI: 10.1080/0886022X.2025.2499905

Liyuan Xie, Xianying Qiu, Junya Jia, Tiekun Yan, Pengcheng Xu

{"title":"Unveiling the role of oxidative stress in ANCA-associated glomerulonephritis through integrated machine learning and bioinformatics analyses.","authors":"Liyuan Xie, Xianying Qiu, Junya Jia, Tiekun Yan, Pengcheng Xu","doi":"10.1080/0886022X.2025.2499905","DOIUrl":"10.1080/0886022X.2025.2499905","url":null,"abstract":"Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease often leading to rapidly progressive glomerulonephritis. Oxidative stress plays a critical role in the development and progression of ANCA-associated glomerulonephritis (AAGN), but the underlying mechanisms remain poorly understood. Targeting genes related to oxidative stress may provide novel insights and supplementary therapeutic benefits for AAGN. In the current study, we obtained differentially expressed genes from AAGN-related microarray datasets in the Gene Expression Omnibus database, and oxidative stress-related genes (OSRGs) from the GeneCards and Gene Ontology databases to identify differentially expressed OSRGs. Then, by integrating weighted gene co-expression network analysis, and machine learning algorithms, we identified four upregulated hub OSRGs (all p < 0.01) with strong diagnostic potential (all AUC > 0.9)-CD44, ITGB2, MICB, and RAC2 - in the AAGN glomerular training dataset GSE104948 and validation dataset GSE108109, along with two hub OSRGs (all p < 0.05) with better diagnostic potential (all AUC > 0.7) - upregulated gene VCAM1 and downregulated gene VEGFA-in the AAGN tubulointerstitial training dataset GSE104954 and validation dataset GSE108112. The GSEA analysis suggested that these hub genes may play a role in inflammatory and immune response processes. Moreover, we constructed regulatory networks and identified drugs that potentially target these hub genes. It's to be noted that RAC2 and ITGB2 were associated with cyclophosphamide in the AAGN glomerular compartment, while VCAM1 and VEGFA were associated with dexamethasone in the tubulointerstitial compartment. This study offers novel insights into immune-associated OSRGs within the glomerular and tubulointerstitial compartments of AAGN which may serve as innovative targets for diagnosing and treating AAGN.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2499905"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of a risk prediction model for autologous arteriovenous fistula thrombosis in patients receiving maintenance hemodialysis. 维持性血液透析患者自体动静脉瘘血栓形成风险预测模型的建立与验证。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-05-13 DOI: 10.1080/0886022X.2025.2477832

Jinping Ying, Genlian Cai, Yujiao Zhang, Minmin Zhu, Mengyan Pan, Ping Zhang

{"title":"Development and validation of a risk prediction model for autologous arteriovenous fistula thrombosis in patients receiving maintenance hemodialysis.","authors":"Jinping Ying, Genlian Cai, Yujiao Zhang, Minmin Zhu, Mengyan Pan, Ping Zhang","doi":"10.1080/0886022X.2025.2477832","DOIUrl":"10.1080/0886022X.2025.2477832","url":null,"abstract":"Background: Thrombosis can lead to fistula failure and affect the smooth progress of hemodialysis. This study aims to develop and validate a nomogram for predicting the risk of autologous arteriovenous fistula thrombosis in patients undergoing maintenance hemodialysis.Methods: A total of 1,016 patients who underwent hemodialysis at a tertiary A hospital in East China from February 2020 to March 2024 were retrospectively enrolled. The participants were randomly divided into a training set (711 people) and a validation set (305 people) at a ratio of 7:3. A risk prediction model was established according to the results of multivariate logistic regression analysis. The performance of the model was evaluated with the area under the receiver operating characteristic (ROC) curve (AUC), calibration curve analysis, the Hosmer-Lemeshow (H-L) test and decision curve analysis (DCA).Results: The incidence of autologous arteriovenous fistula thrombosis in patients on maintenance hemodialysis was 32%. High-sensitivity C-reactive protein (hs-CRP), catheterization history, hemodialysis duration, autologous arteriovenous fistula stenosis and non-high-density lipoprotein cholesterol (non-HDL-C) were independent risk factors for autologous arteriovenous fistula thrombosis. These five predictors were used to construct a predictive nomogram. The AUC was 0.818 in the training set and 0.826 in the validation set. The calibration curve of the nomogram was close to the standard curve, indicating that the model was well calibrated. The DCA results confirmed that the model provided good net clinical benefits.Conclusion: In this study, a predictive nomogram for arteriovenous fistula thrombosis was established and validated.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2477832"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0