Renal Failure最新文献_第7页

Acute kidney disease in mice is associated with early cardiovascular dysfunction. 小鼠急性肾病与早期心血管功能障碍有关。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1080/0886022X.2024.2415510

Pauline Caillard, Youssef Bennis, Cédric Boudot, Denis Chatelain, Pierre Rybarczyk, Agnès Boullier, Sabrina Poirot, Dimitri Titeca-Beauport, Sandra Bodeau, Gabriel Choukroun, Saïd Kamel, Isabelle Six, Julien Maizel

{"title":"Acute kidney disease in mice is associated with early cardiovascular dysfunction.","authors":"Pauline Caillard, Youssef Bennis, Cédric Boudot, Denis Chatelain, Pierre Rybarczyk, Agnès Boullier, Sabrina Poirot, Dimitri Titeca-Beauport, Sandra Bodeau, Gabriel Choukroun, Saïd Kamel, Isabelle Six, Julien Maizel","doi":"10.1080/0886022X.2024.2415510","DOIUrl":"10.1080/0886022X.2024.2415510","url":null,"abstract":"Acute kidney injury (AKI) and chronic kidney disease (CKD) are major health concerns due to their increasing incidence and high mortality. They are interconnected syndromes; AKI without recovery evolves into acute kidney disease (AKD), which can indicate an AKI-to-CKD transition. Both AKI and CKD are associated with a risk of long-term cardiovascular complications, but whether vascular and cardiac dysfunctions can occur as early as the AKD period has not been studied extensively. In a mouse model of kidney injury (KI) with non-recovery, we performed vasoreactivity and echocardiography analyses on days 15 (D15) and 45 (D45) after KI. We determined the concentrations of two major gut-derived protein-bound uremic toxins known to induce cardiovascular toxicity-indoxyl sulfate (IS) and para-cresyl sulfate (PCS)-and the levels of inflammation and contraction markers on D7, D15, and D45. Mice with KI showed acute tubular and interstitial kidney lesions on D7 and D15 and chronic glomerulosclerosis on D45. They showed significant impairment of aorta relaxation and systolic-diastolic heart function, both on D15 and D45. Such dysfunction was associated with downregulation of the expression of two contractile proteins, αSMA and SERCA2a, with a more pronounced effect on D15 than on D45. KI was also followed by a rapid increase in IS and PCS serum concentrations and the expression induction of pro-inflammatory cytokines and endothelial adhesion molecules in serum and cardiovascular tissues. Therefore, these results highlight that AKD leads to early cardiac and vascular dysfunctions. How these dysfunctions could be managed to prevent cardiovascular events deserves further study.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 2","pages":"2415510"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of tolvaptan on renal replacement therapy in patients with autosomal dominant polycystic kidney disease: a retrospective cohort study from the TriNetX global collaborative network. 托伐普坦对常染色体显性多囊肾患者肾脏替代疗法的疗效：来自 TriNetX 全球协作网络的一项回顾性队列研究。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1080/0886022X.2024.2412721

Ming-Ju Wu, Cheng-Hsu Chen, Shang-Feng Tsai

{"title":"Effectiveness of tolvaptan on renal replacement therapy in patients with autosomal dominant polycystic kidney disease: a retrospective cohort study from the TriNetX global collaborative network.","authors":"Ming-Ju Wu, Cheng-Hsu Chen, Shang-Feng Tsai","doi":"10.1080/0886022X.2024.2412721","DOIUrl":"10.1080/0886022X.2024.2412721","url":null,"abstract":"Background and hypothesis: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a major genetic contributor to end-stage kidney disease (ESKD). Current evidence on tolvaptan primarily focuses on slowing estimated glomerular filtration rate (eGFR) decline and kidney volume growth. However, direct confirmation of its effectiveness in reducing the need for hemodialysis in ESKD remains limited.Methods: We included ADPKD patients aged ≥18 years using TriNetx data from Sep 2, 2018, to Sep 3, 2023. Propensity score matching (PSM) ensured baseline comparability (standardized mean difference (SMD) <0.1). Hazard ratios (HRs) with 95% confidence intervals (CIs) evaluated outcomes, and subgroup analyses were performed.Results: After 1:1 PSM, both groups comprised 673 patients. The average age was 45, with generally good health (3-5% diabetes, 2-3% ischemic heart disease). Baseline eGFR averaged ∼55 ml/min/1.732m2. Post-matching, all SMDs were <0.1, indicating successful matching. Tolvaptan users exhibited lower eGFR (51.45 ± 30.09 vs. 57.37 ± 33.65, p < 0.001) and higher risk of stage 4-CKD (HR: 2.436, 95% CI:1.649, 3.599) compared to non-users. However, tolvaptan users showed significantly reduced chances of initiating hemodialysis (HR:0.362, 95%CI:0.176, 0.745), experiencing urinary tract infections (HR:0.581, 95%CI:0.354, 0.956), and all-cause mortality (HR:0.355, 95% CI:0.180, 0.700). Kaplan-Meier curves for hemodialysis initiation indicated higher survival rates among tolvaptan users across age and number of medication refill subgroups.Conclusions: This real-world study, employing precise matching, reveals tolvaptan's role in reducing hemodialysis initiation risk in ADPKD, despite initial hemodynamic-induced lower eGFR.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 2","pages":"2412721"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction. Piezo1 通过介导细胞凋亡和线粒体功能障碍，促进肾脏纤维化的发生和发展。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-11-04 DOI: 10.1080/0886022X.2024.2415519

Yanping Zhang, Lei Lv, Zhaokai Zhou, He Zhang, Qi Li, Shuai Yang, Yibo Wen, Qingwei Wang, Jinjin Feng, Wei Lu, Wei Jia, Jian Guo Wen

{"title":"Piezo1 facilitates the initiation and progression of renal fibrosis by mediating cell apoptosis and mitochondrial dysfunction.","authors":"Yanping Zhang, Lei Lv, Zhaokai Zhou, He Zhang, Qi Li, Shuai Yang, Yibo Wen, Qingwei Wang, Jinjin Feng, Wei Lu, Wei Jia, Jian Guo Wen","doi":"10.1080/0886022X.2024.2415519","DOIUrl":"10.1080/0886022X.2024.2415519","url":null,"abstract":"Renal fibrosis is the major pathological changes of Chronic kidney disease (CKD). Piezo1, a mechanical sensitive ion channel, is implicated in organ fibrosis. However, the precise role of Piezo1 in CKD fibrosis is unknown. The aims of this study were to identify that the role of Piezo1 in CKD fibrosis and its potential involvement of mitochondrial dysfunction. We performed the study with the Piezo1 agonist Yoda1, Bax inhibitor BAI1, Piezo1 inhibitor GsMTx4 and detected the injury, fibrosis, apoptosis markers and mitochondrial dysfunction. The results showed that the levels of apoptosis, mitochondrial dysfunction, injury and fibrosis increased in TCMK-1 cells after treatment with Yoda1. However, these changes that induced by Yoda1 were relieved by BAI1. Similarly, inhibition Piezo1 with GsMTx4 also partly relieved the renal injury, renal fibrosis, apoptosis and mitochondrial dysfunction in vivo and vitro. In conclusion, we found Piezo1 promoted the initiation and development of renal fibrosis and inhibiting Piezo1 improved the fibrosis.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 2","pages":"2415519"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic review of microRNAs in human acute kidney injury. 人类急性肾损伤中的 microRNA 系统综述。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-10-30 DOI: 10.1080/0886022X.2024.2419960

Adrianna Douvris, Jose L Viñas, Shareef Akbari, Karishma Tailor, Manoj M Lalu, Dylan Burger, Kevin D Burns

{"title":"Systematic review of microRNAs in human acute kidney injury.","authors":"Adrianna Douvris, Jose L Viñas, Shareef Akbari, Karishma Tailor, Manoj M Lalu, Dylan Burger, Kevin D Burns","doi":"10.1080/0886022X.2024.2419960","DOIUrl":"10.1080/0886022X.2024.2419960","url":null,"abstract":"Introduction: Early diagnosis of acute kidney injury (AKI) is limited with current tools. MicroRNAs (miRNAs) are implicated in AKI pathogenesis in preclinical models, but less is known about their role in humans. We conducted a systematic review to identify dysregulated miRNAs in humans with AKI.Methods: We searched Ovid MEDLINE, Embase, Web of Science, and CENTRAL (August 21, 2023) for studies of human subjects with AKI. We excluded reviews and pre-clinical studies without human data. The primary outcome was dysregulated miRNAs in AKI. Two reviewers screened abstracts, reviewed full texts, performed data extraction and quality assessment (Newcastle Ottawa Scale).Results: We screened 2,456 reports and included 92 for synthesis without meta-analysis. All studies except one were observational. Studies were grouped by etiology of AKI: cardiac surgery-associated (CS-AKI, n = 13 studies), sepsis (n = 25), nephrotoxic (n = 9), kidney transplant (n = 26), and other causes (n = 19). In total, 128 miRNAs were identified to be dysregulated across AKI studies (45 miRNAs upregulated, 55 downregulated, 28 both). miR-21 was the most frequently reported (n = 17 studies) and it was increased in all etiologies except CS-AKI where it was decreased (n = 3 studies). Study limitations included bias due to targeted approaches, absence of clinical data/controls, and miRNA normalization methods. Overall study quality was fair (median 5/9, range 2-8 points).Conclusion: Dysregulated miRNAs, particularly miR-21, have potential as AKI biomarkers. These results should be interpreted cautiously due to methodological limitations. Standardized methods and unbiased approaches are needed to validate candidate miRNA biomarkers.Registration: International Prospective Register of Systematic Reviews (PROSPERO CRD42020201253).","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 2","pages":"2419960"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of computed tomography in the diagnosis of encapsulating peritoneal sclerosis in patients undergoing peritoneal dialysis. 计算机断层扫描在诊断腹膜透析患者包裹性腹膜硬化症中的作用。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-02-12 DOI: 10.1080/0886022X.2024.2312214

Aomei Li, Longkai Li, Fujia Guo, Dan Zhou, Wei Yang, Wengting Cui, Shuran Wu, Lin Li, Changqing Yu, Hongli Lin

引用次数: 0

The association between bone density of lumbar spines and different daily protein intake in different renal function. 不同肾功能患者腰椎骨密度与每日蛋白质摄入量的关系

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-01-08 DOI: 10.1080/0886022X.2023.2298080

Chia-Lin Lee, Kun-Hui Chen, Wei-Ju Liu, Ching-Hsien Chen, Shang-Feng Tsai

{"title":"The association between bone density of lumbar spines and different daily protein intake in different renal function.","authors":"Chia-Lin Lee, Kun-Hui Chen, Wei-Ju Liu, Ching-Hsien Chen, Shang-Feng Tsai","doi":"10.1080/0886022X.2023.2298080","DOIUrl":"10.1080/0886022X.2023.2298080","url":null,"abstract":"Background: Low protein intake (LPI) has been suggested as a treatment for chronic kidney disease (CKD). However, protein intake is essential for bone health.Methods: We studied the database of the National Health and Nutrition Examination Survey, 2005-2010. Basic variables, metabolic diseases, and bone density of different femoral areas were stratified into four subgroups according to different protein intake (DPI) (that is, <0.8, 0.8-1.0, 1.0-1.2, and >1.2 g/kg/day).Results: Significant differences were found among all lumbar area bone mineral density (BMD) and T-scores (p < 0.0001). There was an apparent trend between a decreasing BMD in the CKD groups with increasing DPI in all single lumbar spines (L1, L2, L3, and L4) and all L spines (L1-L4). Compared with DPI (0.8-1.0 g/day/kg), higher risks of osteoporosis were noticed in the subgroup of >1.2 g/day/kg over L2 (relative risk (RR)=1.326, 95% confidence interval (CI)=1.062-1.656), subgroup >1.2 g/day/kg over L3 (RR = 1.31, 95%CI = 1.057-1.622), subgroup <0.8 g/day/kg over L4 (RR = 1.276, 95%CI = 1.015-1.605), subgroup <0.8 g/day/kg over all L spines (RR = 11.275, 95%CI = 1.051-1.548), and subgroup >1.2 g/day/kg over all L spines (RR = 0.333, 95%CI = 1.098-1.618). However, a higher risk of osteoporosis was observed only in the non-CKD group. There was an apparent trend of higher DPI coexisting with lower BMD and T scores in patients with CKD. For osteoporosis (reference:0.8-1.0 g/day/kg), lower (<0.8 g/day/kg) or higher DPI (>1.2 g/day/kg) was associated with higher risks in the non-CKD group, but not in the CKD group.Conclusions: In the CKD group, LPI for renal protection was safe without threatening L spine bone density and without causing a higher risk of osteoporosis.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 1","pages":"2298080"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10776072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway. 奥利多宁通过抑制Wnt/β-catenin信号通路改善糖尿病肾病的肾脏纤维化。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-06-04 DOI: 10.1080/0886022X.2024.2347462

Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu

{"title":"Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway.","authors":"Jushuang Li, Lan Shu, Qianqian Jiang, Baohong Feng, Zhimin Bi, Geli Zhu, Yanxia Zhang, Xiangyou Li, Jun Wu","doi":"10.1080/0886022X.2024.2347462","DOIUrl":"10.1080/0886022X.2024.2347462","url":null,"abstract":"Diabetic nephropathy (DN) is one of the most serious and frequent complications among diabetes patients and presently constitutes vast the cases of end-stage renal disease worldwide. Tubulointerstitial fibrosis is a crucial factor related to the occurrence and progression of DN. Oridonin (Ori) is a diterpenoid derived from rubescens that has diverse pharmacological properties. Our previous study showed that Ori can protect against DN by decreasing the inflammatory response. However, whether Ori can alleviate renal fibrosis in DN remains unknown. Here, we investigated the mechanism through which Ori affects the Wnt/β-catenin signaling pathway in diabetic rats and human proximal tubular epithelial cells (HK-2) exposed to high glucose (HG) levels. Our results revealed that Ori treatment markedly decreased urinary protein excretion levels, improved renal function and alleviated renal fibrosis in diabetic rats. In vitro, HG treatment increased the migration of HK-2 cells while reducing their viability and proliferation rate, and treatment with Ori reversed these changes. Additionally, the knockdown of β-catenin arrested cell migration and reduced the expression levels of Wnt/β-catenin signaling-related molecules (Wnt4, p-GSK3β and β-catenin) and fibrosis-related molecules (α-smooth muscle actin, collagen I and fibronectin), and Ori treatment exerted an effect similar to that observed after the knockdown of β-catenin. Furthermore, the combination of Ori treatment and β-catenin downregulation exerted more pronounced biological effects than treatment alone. These findings may provide the first line of evidence showing that Ori alleviates fibrosis in DN by inhibiting the Wnt/β-catenin signaling pathway and thereby reveal a novel therapeutic avenue for treating tubulointerstitial fibrosis.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 1","pages":"2347462"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Budapest nephrology school - 30 years of history - from modest start to an international success: systematic summary of the 27th BNS held between 28^th August and 2^nd of September 2023. 布达佩斯肾脏病学校 - 30 年历史 - 从微不足道的起步到国际性的成功：2023 年 8 月 28 日至 9 月 2 日举行的第 27 届布达佩斯肾脏病学校系统总结。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-04-29 DOI: 10.1080/0886022X.2023.2282709

Orsolya Cseprekál, Laszlo Rosivall

{"title":"Budapest nephrology school - 30 years of history - from modest start to an international success: systematic summary of the 27th BNS held between 28th August and 2nd of September 2023.","authors":"Orsolya Cseprekál, Laszlo Rosivall","doi":"10.1080/0886022X.2023.2282709","DOIUrl":"https://doi.org/10.1080/0886022X.2023.2282709","url":null,"abstract":"Budapest Nephrology School (BNS) could have celebrated its 30th event if it had not been interrupted by COVID pandemic for a few years. Yet, the organization of 27th BNS in August 2023 resumed its successful and traditional activities at Semmelweis University, in the beautiful central European city of Budapest. In over two decades, BNS has faithfully adapted to the changes and developments of medical science and clinical nephrology, the fact which has kept it unique and attractive for nephrologists from across the globe. With such a long history and representing the top international professors of nephrology, BNS has proved to be a successful one-week, in-person refreshing course which has attracted over 1600 medical doctors from more than 60 countries. It has well served as an academic meeting point suitable for networking and exchange of up-to-date knowledge presented by the best international experts in nephrology. The dedication and focus of these experts on education, research and patient care represent the very concept of translational medicine. The invaluable experience of the past 27 years has set the standards for BNS to contribute to the evolution of translational nephrology in Europe in the next decade.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 1","pages":"2282709"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injury. 乳酸与白蛋白比值对急性肾损伤重症患者预后的临床意义。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-05-09 DOI: 10.1080/0886022X.2024.2350238

Xiaoyun Shi, Lei Zhong, Jianhong Lu, Beiping Hu, Qikai Shen, Penghui Gao

{"title":"Clinical significance of the lactate-to-albumin ratio on prognosis in critically ill patients with acute kidney injury.","authors":"Xiaoyun Shi, Lei Zhong, Jianhong Lu, Beiping Hu, Qikai Shen, Penghui Gao","doi":"10.1080/0886022X.2024.2350238","DOIUrl":"10.1080/0886022X.2024.2350238","url":null,"abstract":"Objective: To explore the relationship between lactate-to-albumin ratio (LAR) at ICU admission and prognosis in critically ill patients with acute kidney injury (AKI).Methods: A retrospective analysis was conducted. Patients were divided into low (<0.659) LAR and high LAR (≥0.659) groups. Least absolute shrinkage and selection operator regression analysis was conducted to select variables associated with the 30-day prognosis. Cox regression analyses were performed to assess the association between LAR and mortality. Kaplan-Meier curves were plotted to compare cumulative survival rates between high and low LAR groups. Subgroup analysis was employed to assess the stability of the results. ROC curve was used to determine the diagnostic efficacy of LAR on prognosis.Results: A nonlinear relationship was observed between LAR and the risk of 30-day and 360-day all-cause mortality in AKI patients (p < 0.001). Cox regulation showed that high LAR (≥ 0.659) was an independent risk factor for 30-day and 360-day all-cause mortality in patients with AKI (p < 0.001). The Kaplan-Meier survival curves demonstrated a noteworthy decrease in cumulative survival rates at both 30 and 360 days for the high LAR group in comparison to the low LAR group (p < 0.001). Subgroup analyses demonstrated the stability of the results. ROC curves showed that LAR had a diagnostic advantage when compared with lactate or albumin alone (p < 0.001).Conclusion: High LAR (≥0.659) at ICU admission was an independent risk factor for both short-term (30-day) and long-term (360-day) all-cause mortality in patients with AKI.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 1","pages":"2350238"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140899440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemoglobin level and erythropoietin response in hemodialysis patients: what can we pay attention to? 血液透析患者的血红蛋白水平和促红细胞生成素反应：我们应该注意什么？

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-05-13 DOI: 10.1080/0886022X.2024.2353338

Yu Zhao, Kun Zhao, Jingchen Fang, Wenyun Wang

引用次数: 0