Renal Failure最新文献

{"title":"The efficacy and safety of difelikefalin for pruritus in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials.","authors":"Abdallah Saeed, Iman Abdelhady Elshnoudy, Yehya Khlidj, Radwa Radwan, Mariam Kamal, Mahmoud Hamdi, Abdullah Alsaid, Mustafa Turkmani, Mohamed Abuelazm","doi":"10.1080/0886022X.2024.2384590","DOIUrl":"10.1080/0886022X.2024.2384590","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease-associated pruritus (CKD-ap) is a common complication that negatively affects the quality of life. Difelikefalin has emerged as a novel FDA-approved drug to manage CKD-ap. This systematic review and meta-analysis will assess the efficacy and safety of Difelikefalin versus placebo to manage CKD-ap.</p><p><strong>Methods: </strong>PubMed, Scopus, WOS, Central, and Embase were systematically searched until November 2023. RevMan was used to perform meta-analysis. Quality assessment was conducted using the Cochrane RoB 2.0 tool. Results were reported as risk ratio (RR) and mean difference (MD) with a 95% confidence interval (CI). PROSPERO ID: (CRD42023485979).</p><p><strong>Results: </strong>Five RCTs with a total of 896 participants were included. Difelikefalin significantly decreased the weekly mean WI-NRS score (MD: -0.99 [-1.22, -0.75], <i>p</i> ˂ .00001), 5-D itch scale total score (MD: -1.51 [-2.26, -0.76], <i>p</i> > .0001), and Skindex-10 total score (MD: -7.39 [-12.51, -2.28], <i>p</i> = .005), but showed significantly higher adverse events (RR: 1.26 [1.03, 1.55], <i>p</i> = .03), versus placebo. However, there was no significant difference between both groups in serious adverse events (RR: 1.42 [0.78, 2.57], <i>p</i> = .25) or death (RR: 0.81 [0.19, 3.34], <i>p</i> = .77).</p><p><strong>Conclusion: </strong>Difelikefalin appears to be a promising agent for the management of CKD-induced pruritus in patients with end-stage renal disease. However, evidence is still underpowered due to the paucity of the current data; therefore, more robust RCTs are required to confirm the benefit of Difelikefalin.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute kidney injury in hospitalized children in 20 hospitals of China's Hunan Province: a cross-sectional survey.","authors":"Qianliang Sun, Ying Pan, Zhihui Li","doi":"10.1080/0886022X.2024.2379003","DOIUrl":"10.1080/0886022X.2024.2379003","url":null,"abstract":"<p><strong>Objective: </strong>The incidence of acute kidney injury (AKI) in pediatric patients has been increasing over the years, and AKI significantly impacts children's health and quality of life. This article reviews the current epidemiological research on pediatric AKI.</p><p><strong>Methods: </strong>The clinical data of hospitalized children aged 0 to 14 years from 20 different hospitals in Hunan Province, China, collected from December 2017 to February 2018, were analyzed. The incidence rate, misdiagnosis rate, main causes, and medical costs of AKI in hospitalized children were examined.</p><p><strong>Results: </strong>A total of 29,639 patients were included, with an AKI incidence rate of 4.34% (1286/29,639). Among the 1286 AKI patients, 863 (67.11%) were classified as AKI stage 1324 (25.19%) as AKI stage 2, and 99 (7.7%) as AKI stage 3. AKI patients had significantly longer hospital stays [6.0 (4.0, 10) days vs. 6.0 (4.0, 8.0) days, <i>p</i> < 0.001] and higher hospitalization costs [3375.22 (1600, 6083.83) yuan vs. 2729.4 (1659.45, 8216.65) yuan, <i>p =</i> 0.003] than non-AKI patients. The mortality rate (1.2% vs. 0.1%, <i>p</i> < 0.001), intensive care unit (ICU) transfer rate (8.7% vs. 5.97%, <i>p</i> < 0.001), and use of invasive mechanical ventilation (3.6% vs. 1%, <i>p</i> < 0.001) were significantly greater in patients with AKI than in those without AKI patients. The etiology of AKI varied among different age groups, and dehydration, diarrhea, and shock were the main causes of pre-renal AKI.</p><p><strong>Conclusion: </strong>The incidence and missed diagnosis rates of AKI in hospitalized children were high. AKI prolongs hospital stays, increases hospitalization costs, and increases the risk of mortality in children.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Mahuang Fuzi and Shenzhuo Decoction for treatment of primary membranous nephropathy: a multicenter prospective trial.","authors":"Naiqian Zhang, Hanxue Jiang, Haoran Dai, Shuxian Huang, Qihan Zhao, Na Zhang, Wenbin Liu, Zhaocheng Dong, Yu Gao, Xuan Dong, Yuehong Hu, Fanyu Hou, Hongliang Rui, Qingquan Liu, Baoli Liu","doi":"10.1080/0886022X.2024.2320834","DOIUrl":"10.1080/0886022X.2024.2320834","url":null,"abstract":"<p><strong>Background: </strong>This study aims to undertake a comprehensive assessment of the effectiveness and safety profile of Mahuang Fuzi and Shenzhuo Decoction (MFSD) in the management of primary membranous nephropathy (PMN), within the context of a prospective clinical investigation.</p><p><strong>Methods: </strong>A multicenter, open-label clinical trial was executed on patients diagnosed with PMN. These individuals were subjected to MFSD therapy for a duration of at least 24 months, with primary outcome of clinical remission rates. The Cox regression analysis was employed to discern the pertinent risk factors exerting influence on the efficacy of MFSD treatment, with scrupulous monitoring of any adverse events.</p><p><strong>Results: </strong>The study comprised 198 participants in total. Following 24 months of treatment, the remission rate was 58.6% (116/198). Among the subgroup of 130 participants subjected to a 36-month follow-up, the remission rate reached 70% (91/130). Subgroup analysis revealed that neither a history of immunosuppressive therapy (HIST) nor an age threshold of ≥60 years exhibited a statistically significant impact on the remission rate at the 24-month mark (<i>p</i> > .05). Multivariate Cox regression analyses elucidated HIST, nephrotic syndrome, or mass proteinuria, and a high-risk classification as noteworthy risk factors in the context of MFSD treatment. Remarkably, no fatalities resulting from side effects were documented throughout the study's duration.</p><p><strong>Conclusions: </strong>This trial establishes the efficacy of MFSD as a treatment modality for membranous nephropathy. MFSD demonstrates a favorable side effect profile, and remission rates are consistent across patients, irrespective of HIST and age categories.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10946256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140120482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study.","authors":"Wenjie Dong, Qiuyu Li, Lei Chen, Hui Tang, Kun Tu, Li Luo, Longyang Jiang, Yilan Huang","doi":"10.1080/0886022X.2024.2357746","DOIUrl":"10.1080/0886022X.2024.2357746","url":null,"abstract":"<p><p>Numerous studies have revealed a correlation between the risk of developing diabetic nephropathy (DN) and the gut microbiota (GM) composition. However, it remains uncertain whether the GM composition causes DN. We aimed to explore any potential causal links between the GM composition and the risk of developing DN. A meta-analysis conducted by the MiBioGen consortium of the largest genome-wide association study (GWAS) provided aggregated data on the GM. DN data were obtained from the IEU database. The inverse-variance weighting (IVW) method was employed as the primary analytical approach. The IVW analysis indicated that genus <i>Dialister</i> (OR = 0.51, 95% CI: 0.34-0.77, <i>p</i> = 0.00118) was protective against DN. In addition, class <i>Gammaproteobacteria</i> (OR = 0.47, 95% CI: 0.27-0.83, <i>p</i> = 0.0096), class <i>Lentisphaeria</i> (OR =0.76, 95% CI: 0.68-0.99, <i>p</i> = 0.04), order <i>Victivallales</i> (OR = 0.76, 95% CI: 0.58-0.99, <i>p</i> = 0.04), and phylum <i>Proteobacteria</i> (OR = 0.53, 95% CI: 0.33-0.85, <i>p</i> = 0.00872) were negatively associated with the risk of developing DN. Genus <i>LachnospiraceaeUCG008</i> (OR =1.45, 95% CI: 1.08-1.95, <i>p</i> = 0.01), order <i>Bacteroidales</i> (OR = 1.59, 95% CI: 1.02-2.49, <i>p</i> = 0.04), and genus <i>Terrisporobacter</i> (OR = 1.98, 95% CI: 1.14-3.45, <i>p</i> = 0.015) were positively associated with the risk of developing DN. In this study, we established a causal relationship between the genus <i>Dialister</i> and the risk of developing DN. Further trials are required to confirm the protective effects of probiotics on DN and to elucidate the precise protective mechanisms involving genus <i>Dialister</i> and DN.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic association between celiac disease and chronic kidney disease: a two-sample Mendelian randomization study.","authors":"Zhimin Chen, Zigui Zheng, Bingjing Jiang, Yanfang Xu","doi":"10.1080/0886022X.2024.2357246","DOIUrl":"10.1080/0886022X.2024.2357246","url":null,"abstract":"<p><strong>Objective: </strong>A two-sample Mendelian randomization (MR) analysis was performed to elucidate the causal impact of celiac disease on the risk of chronic kidney disease (CKD).</p><p><strong>Methods: </strong>The study comprised data from three genome-wide association studies involving individuals of European ancestry. The study groups included participants with celiac disease (<i>n</i> = 24,269), CKD (<i>n</i> = 117,165), and estimated glomerular filtration rate levels based on serum creatinine (eGFRcrea, <i>n</i> = 133,413). We employed four widely recognized causal inference algorithms: MR-Egger, inverse variance weighted (IVW), weighted median, and weighted mode. To address potential issues related to pleiotropy and overall effects, MR-Egger regression and the MR-PRESSO global test were performed. Heterogeneity was assessed using Cochran's Q test.</p><p><strong>Results: </strong>We identified 14 genetic variants with genome-wide significance. The MR analysis provided consistent evidence across the various methodologies, supporting a causal relationship between celiac disease and an elevated risk of CKD (odds ratio (OR)_IVW = 1.027, <i>p</i> = 0.025; OR_{weighted median} = 1.028, <i>P</i> = 0.049; OR_{weighted mode} = 1.030, <i>p</i> = 0.044). Furthermore, we observed a causal link between celiac disease and a decreased eGFRcrea (OR_IVW = 0.997, <i>P</i> = 2.94E-06; OR_{weighted median} = 0.996, <i>P</i> = 1.68E-05; OR_{weighted mode} = 0.996, <i>P</i> = 3.11E-04; OR_{MR Egger} = 0.996, <i>P</i> = 5.00E-03). We found no significant evidence of horizontal pleiotropy, heterogeneity, or bias based on MR-Egger regression, MR-PRESSO, and Cochran's Q test.</p><p><strong>Conclusion: </strong>The results of this study indicate a causal relationship between celiac disease and an increased risk of CKD.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11151793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with risk analysis for asymptomatic left ventricular diastolic dysfunction in nondialysis patients with chronic kidney disease.","authors":"Yajuan Gao, Shengnan Chen, Jiani Fu, Cui Wang, Yali Tang, Yongbai Luo, Xiaozhen Zhuo, Xueying Chen, Yan Shen","doi":"10.1080/0886022X.2024.2353334","DOIUrl":"10.1080/0886022X.2024.2353334","url":null,"abstract":"<p><p>Heart failure (HF) constitutes a major determinant of outcome in chronic kidney disease (CKD) patients. The main pattern of HF in CKD patients is preserved ejection fraction (HFpEF), and left ventricular diastolic dysfunction (LVDD) is a frequent pathophysiological mechanism and specific preclinical manifestation of HFpEF. Therefore, exploring and intervention of the factors associated with risk for LVDD is of great importance in reducing the morbidity and mortality of cardiovascular disease (CVD) complications in CKD patients. We designed this retrospective cross-sectional study to collect clinical and echocardiographic data from 339 nondialysis CKD patients without obvious symptoms of HF to analyze the proportion of asymptomatic left ventricular diastolic dysfunction (ALVDD) and its related factors associated with risk by multivariate logistic regression analysis. Among the 339 nondialysis CKD patients, 92.04% had ALVDD. With the progression of CKD stage, the proportion of ALVDD gradually increased. The multivariate logistic regression analysis revealed that increased age (OR 1.237; 95% confidence interval (CI) 1.108-1.381, per year), diabetic nephropathy (DN) and hypertensive nephropathy (HTN) (OR 25.000; 95% CI 1.355-48.645, DN and HTN <i>vs</i> chronic interstitial nephritis), progression of CKD stage (OR 2.785; 95% CI 1.228-6.315, per stage), increased mean arterial pressure (OR 1.154; 95% CI 1.051-1.268, per mmHg), increased urinary protein (OR 2.825; 95% CI 1.484-5.405, per g/24 h), and low blood calcium (OR 0.072; 95% CI 0.006-0.859, per mmol/L) were factors associated with risk for ALVDD in nondialysis CKD patients after adjusting for other confounding factors. Therefore, dynamic monitoring of these factors associated with risk, timely diagnosis and treatment of ALVDD can delay the progression to symptomatic HF, which is of great importance for reducing CVD mortality, and improving the prognosis and quality of life in CKD patients.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11133225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between circulatory complement activation and hypertensive renal damage: a case-control study.","authors":"Zhongli Wang, Tingting Zhang, Xinyu Wang, Jianlong Zhai, Lili He, Sai Ma, Qingjuan Zuo, Guorui Zhang, Yifang Guo","doi":"10.1080/0886022X.2024.2365396","DOIUrl":"10.1080/0886022X.2024.2365396","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.</p><p><strong>Methods: </strong>Serum complement C3, complement Factor H (CFH) and AP activation were assessed in 66 participants with established essential hypertension with renal damage (RD). Fifty-nine patients with age- and sex-matched essential hypertension without renal damage (NRD) and 58 healthy participants (normal) were selected.</p><p><strong>Results: </strong>Our study revealed that C3 and AP50 continuously increased from normal to NRD to RD (<i>p</i> < 0.05, respectively), while CFH was significantly lower than that in NRD and healthy participants (<i>p</i> < 0.05, respectively). After multifactorial logistic regression analysis corrected for confounders, elevated serum C3 (<i>p</i> = 0.001) and decreased CFH (<i>p</i> < 0.001) were found to be independent risk factors for hypertension in healthy participants; elevated serum C3 (<i>p</i> = 0.034), elevated AP50 (<i>p</i> < 0.001), decreased CFH (<i>p</i> < 0.001), increased age (<i>p</i> = 0.011) and increased BMI (<i>p</i> = 0.013) were found to be independent risk factors for the progression of hypertension to hypertensive renal damage; elevated serum C3 (<i>p</i> = 0.017), elevated AP50 (<i>p</i> = 0.023), decreased CFH (<i>p</i> = 0.005) and increased age (<i>p</i> = 0.041) were found to be independent risk factors for the development of hypertensive renal damage in healthy participants.</p><p><strong>Conclusion: </strong>Abnormal activation of complement, particularly complement AP, may be a risk factor for the development and progression of hypertensive renal damage.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11182054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of volume indices in bioelectrical impedance measurement on the assessment of cardiac function indices by echocardiography in hemodialysis patients.","authors":"Yudan Wang, Yang Wang, Shun Wu, Na Xu, Zhaoyong Zhang, Zhenmin Ruan, Rui Wang, Xin Geng, Chuanzhen Zhang, Zhiyong Luan, Guofang Chen, Hongqi Ren","doi":"10.1080/0886022X.2024.2375103","DOIUrl":"10.1080/0886022X.2024.2375103","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiovascular events resulting from volume overload are a primary cause of mortality in hemodialysis patients. Bioelectrical impedance analysis (BIA) is significantly valuable for assessing the volume status of hemodialysis (HD) patients. In this article, we explore the correlation between the volume index measured by BIA and the cardiac function index assessed by echocardiography (ECG) in HD patients.</p><p><strong>Methods: </strong>Between April and November 2018, we conducted a cross-sectional study involving randomly selected 126 maintenance HD patients. Comprehensive data on medical history and laboratory test results were collected. Subsequently, we investigated the correlation between volume indices measured by BIA and cardiac function parameters by ECG.</p><p><strong>Results: </strong>We discovered a significant correlation between the volume indices measured by BIA and various parameter of cardiac function. The Left Ventricular Hypertrophy (LVH) group exhibited higher levels of the percentage of Extracellular Water (ECW%) and the percentage of Total Body Water (TBW%) compared to the Non-LVH group. Extracellular Water (ECW) and Third Interstitial Fluid Volume (TSFV) were identified as independent risk factors for Left Ventricular Mass (LVM), and both demonstrated a high predictive value for LVM. ECW% emerged as an independent risk factor for the Left Ventricular Mass Index (LVMI), with a high predictive value for LVMI.</p><p><strong>Conclusion: </strong>ECW and TSFV were found to be positively associated with cardiac function parameters in HD patients.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141555406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a combined aerobic and core stabilization exercise training program on functional capacity, pain, and health-related quality of life in hemodialysis and kidney transplant patients.","authors":"Enikő Király, Gergő József Szőllősi, Zoltán Jenei, József Balla, István Kárpáti","doi":"10.1080/0886022X.2024.2370439","DOIUrl":"10.1080/0886022X.2024.2370439","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) poses a significant public health challenge globally while impacting patients' physical function and quality of life. Addressing the issues of physical inactivity and pain management is essential during treatment to improve health-related quality of life. The present study investigated the effect of an aerobic training program with core stabilization exercises for hemodialysis (HD) patients on a transplant waiting list and renal transplant (RTx) patients.</p><p><strong>Methods: </strong>A total of 45 patients with CKD were included in the 12-week study: 25 patients receiving HD (12 HD treatment group, 13 HD control group) and 20 patients with RTx (9 RTx treatment group, 11 RTx control group). Functional capacity was measured using the 6-min walk test, pain was measured using the visual analog scale, and health-related quality of life was measured using the Kidney Disease Quality of Life-Short Form 12 questionnaire. Nonparametric statistical tests were performed at a significance level of 0.05.</p><p><strong>Results: </strong>Both the HD and RTx treatment groups showed significantly reduced times for the 6-min walking test (<i>p</i> = 0.002 and <i>p</i> = 0.008, respectively), significantly reduced pain severity (<i>p</i> = 0.002 and <i>p</i> = 0.008, respectively), and significantly improved quality of life scores (<i>p</i> = 0.006 and <i>p</i> = 0.041, respectively) by the end of the study compared with control groups.</p><p><strong>Conclusion: </strong>Based on the results, structured exercise programs could be effective therapies in CKD management. Therefore, health providers should promote their integration into routine care practices to enhance patient outcomes and well-being.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141470419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal role of immune cells in IgA nephropathy: a mendelian randomization study.","authors":"Jinlian Shu, Yating Ge, Yonggui Wu","doi":"10.1080/0886022X.2024.2381593","DOIUrl":"10.1080/0886022X.2024.2381593","url":null,"abstract":"<p><strong>Background: </strong>Previous observational studies have shown that immune cells play an important role in IgA nephropathy. However, the specific causal relationship between the two is inconsistent.</p><p><strong>Methods: </strong>We used a two-sample mendelian randomization(MR) analysis to investigate the causal association between 731 immune cell signatures and IgA nephropathy in this study. Based on published GWAS data, immune cells were characterized by four immune types absolute cell (AC) counts, median fluorescence intensity (MFI), morphological parameters (MP), relative cell (RC) counts. Meanwhile, heterogeneity test, horizontal pleiotropy and sensitivity test were used to evaluate the robustness and reliability of the results.</p><p><strong>Results: </strong>An important causal association was achieved for 14 RC traits/IgA nephropathy, 3 AC traits/IgA nephropathy, 10 MFI traits/IgA nephropathy, and 1 MP trait/IgA nephropathy. However, after false discovery rate (FDR) correction, only one immunophenotype was found to be protective against IgA nephropathy. The OR of herpesvirus entry mediator (HVEM) on terminally differentiated CD4+ T cell (maturation stages of T-cell panel) on IgA nephropathy risk was estimated to be 0.727 (95%CI: 0.624-0.847, <i>p</i> = 4.20e - 05, P_FDR = 0.023) according to inverse variance weighting (IVW) method, and the weighted-median method yielded similar results (OR = 0.743, 95% CI: 0.596-0.927, <i>p</i> = 0.008). Although not statistically significant, the association was consistent with MR-Egger, simple mode and weighted mode.</p><p><strong>Conclusions: </strong>Our study further confirmed that immune cells play a complex and important role in the pathogenesis of IgA nephropathy, providing evidence for clinical research.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}