Renal Failure最新文献_第10页

Usp9x contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of the TLR4/nf-κb pathway. Usp9x 通过激活 TLR4/nf-κb 通路促进肾小管上皮细胞的炎症和凋亡，从而导致脓毒症诱发的急性肾损伤的发生。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-06-14 DOI: 10.1080/0886022X.2024.2361089

Shuhao Gong, Huawei Xiong, Yingchao Lei, Shipeng Huang, Yingdong Ouyang, Chunshui Cao, Ying Wang

{"title":"Usp9x contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of the TLR4/nf-κb pathway.","authors":"Shuhao Gong, Huawei Xiong, Yingchao Lei, Shipeng Huang, Yingdong Ouyang, Chunshui Cao, Ying Wang","doi":"10.1080/0886022X.2024.2361089","DOIUrl":"10.1080/0886022X.2024.2361089","url":null,"abstract":"As a pattern recognition receptor, Toll-like receptor 4 (TLR4) is crucial for the development and progression of acute kidney injury (AKI). This study aims to explore whether the deubiquitinase Usp9x influences the TLR4/NF-B pathway to cause sepsis-induced acute kidney injury (S-AKI). The model of AKI was established in Sprague-Dawley rats using the cecal ligation and puncture (CLP) method, while renal tubular epithelial cell NRK-52E was stimulated with lipopolysaccharide (LPS) in vitro. All plasmids were transfected into NRK-52E cells according to the indicated group. The deubiquitinase of TLR4 was predicted by the online prediction software Ubibrowser. Subsequently, Western blot and Pearson correlation analysis identified Usp9x protein as a potential candidate. Co-IP analysis verified the interaction between TLR4 and Usp9x. Further research revealed that overexpression of Usp9x inhibited degradation of TLR4 protein by downregulating its ubiquitination modification levels. Both in vivo and in vitro experiments observed that interference with Usp9x effectively alleviated the inflammatory response and apoptosis of renal tubular epithelial cells (RTECs) induced by CLP or LPS, whereas overexpression of TLR4 reversed this situation. Transfection with sh-Usp9x in NRK-52E cells suppressed the expression of proteins associated with the TLR4/NF-κB pathway induced by LPS. Moreover, the overexpression of TLR4 reversed the effect of sh-Usp9x transfection. Therefore, the deubiquitinase Usp9x interacts with TLR4, leading to the upregulation of its expression through deubiquitination modification, and the activation of the TLR4/NF-κB signaling pathway, thereby promoting inflammation and apoptosis in renal tubular epithelial cells and contributing to sepsis-induced acute kidney injury.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 2","pages":"2361089"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11182076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141318161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and effectiveness of laparoscopic renal biopsy: a single-center review and meta-analysis. 腹腔镜肾活检的安全性和有效性：单中心回顾和荟萃分析。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-02-02 DOI: 10.1080/0886022X.2024.2312536

Lingling Xu, Xueqin Bian, Jian Yang, Hongying Xu, Yi Fang, Junwei Yang, Lei Jiang, Ping Wen

{"title":"Safety and effectiveness of laparoscopic renal biopsy: a single-center review and meta-analysis.","authors":"Lingling Xu, Xueqin Bian, Jian Yang, Hongying Xu, Yi Fang, Junwei Yang, Lei Jiang, Ping Wen","doi":"10.1080/0886022X.2024.2312536","DOIUrl":"10.1080/0886022X.2024.2312536","url":null,"abstract":"Background: While renal biopsy remains the preferred diagnostic method for assessing proteinuria, hematuria, or renal failure, laparoscopic renal biopsy (LRB) can serve as an alternative for high-risk patients when percutaneous kidney biopsy (PKB) is not recommended. This study was aimed to evaluate the safety of LRB.Methods: In study 1, Fourteen patients from January 2021 to January 2023 had a LRB taken for various indications, such as morbid obesity, abnormal kidney construction, uncontrolled hypertension, and coagulopathy. We also conducted a Meta-analysis of the success rate and complication rate of previous LRB in study 2.Results: All the patients completed biopsies and adequate renal tissues were obtained. The success rate was 100%. The median number of glomeruli obtained was 22.5 (range:12.0, 45.0). The complication rate was 7.1% (urinary tract infection). There were no significant differences between levels of hemoglobin, serum creatinine, and urinary NAGL before and after surgery. In the meta-analysis, the success rate of operation, satisfactory rate of sample, and complication rate of surgery were 99.9%, 99.1%, and 2.6% respectively.Conclusion: LRB can achieve a good success rate and specimen retrieval and does not increase the risk of complications for high-risk patients. It can present as one of the alternative methods for patients with glomerular diseases.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 1","pages":"2312536"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10840595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139672538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonlinear association between proteinuria levels and the risk of cardiovascular disease events and all-cause mortality among chronic kidney disease patients. 慢性肾病患者的蛋白尿水平与心血管疾病事件风险和全因死亡率之间的非线性关系。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-02-12 DOI: 10.1080/0886022X.2024.2310727

Haiying Song, Yuheng Liao, Haofei Hu, Qijun Wan

{"title":"Nonlinear association between proteinuria levels and the risk of cardiovascular disease events and all-cause mortality among chronic kidney disease patients.","authors":"Haiying Song, Yuheng Liao, Haofei Hu, Qijun Wan","doi":"10.1080/0886022X.2024.2310727","DOIUrl":"10.1080/0886022X.2024.2310727","url":null,"abstract":"Background: The association between proteinuria levels and cardiovascular disease (CVD) development and all-cause mortality in chronic kidney disease (CKD) patients remains controversial.Methods: In this investigation, we conducted a retrospective analysis involving 1138 patients who were registered in the CKD-Research of Outcomes in Treatment and Epidemiology (ROUTE) study. The primary outcome of this study was the composite of cardiovascular events or all-cause death. Cox proportional hazards regression, smooth curve fitting, piecewise linear regression, and subgroup analyses were used.Results: The mean age of the included individuals was 67.3 ± 13.6 years old. Adjusted hazard ratios (HRs) for UPCR in middle and high groups, compared to the low group, were 1.93 (95% CI: 1.28-2.91) and 4.12 (95% CI: 2.87-5.92), respectively, after multivariable adjustment. Further adjustments maintained significant associations; HRs for middle and high groups were 1.71 (95% CI: 1.12-2.61) and 3.07 (95% CI: 2.08-4.54). A nonlinear UPCR-primary outcome relationship was observed, with an inflection point at 3.93 g/gCr.Conclusion: Among non-dialyzed patients with stage G2-G5 CKD, a nonlinear association between UPCR and the primary outcome was observed. A higher UPCR (when UPCR < 3.93 g/gCr) was an independent predictor of the primary outcome. Importantly, our study predates SGLT2 inhibitor use, showcasing outcomes achievable without these medications. Future research considerations will involve factors like SGLT-2 inhibitor utilization.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 1","pages":"2310727"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of Mahuang Fuzi and Shenzhuo Decoction for treatment of primary membranous nephropathy: a multicenter prospective trial. 麻黄附子神曲汤治疗原发性膜性肾病的有效性和安全性：一项多中心前瞻性试验。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-03-14 DOI: 10.1080/0886022X.2024.2320834

Naiqian Zhang, Hanxue Jiang, Haoran Dai, Shuxian Huang, Qihan Zhao, Na Zhang, Wenbin Liu, Zhaocheng Dong, Yu Gao, Xuan Dong, Yuehong Hu, Fanyu Hou, Hongliang Rui, Qingquan Liu, Baoli Liu

{"title":"Efficacy and safety of Mahuang Fuzi and Shenzhuo Decoction for treatment of primary membranous nephropathy: a multicenter prospective trial.","authors":"Naiqian Zhang, Hanxue Jiang, Haoran Dai, Shuxian Huang, Qihan Zhao, Na Zhang, Wenbin Liu, Zhaocheng Dong, Yu Gao, Xuan Dong, Yuehong Hu, Fanyu Hou, Hongliang Rui, Qingquan Liu, Baoli Liu","doi":"10.1080/0886022X.2024.2320834","DOIUrl":"10.1080/0886022X.2024.2320834","url":null,"abstract":"Background: This study aims to undertake a comprehensive assessment of the effectiveness and safety profile of Mahuang Fuzi and Shenzhuo Decoction (MFSD) in the management of primary membranous nephropathy (PMN), within the context of a prospective clinical investigation.Methods: A multicenter, open-label clinical trial was executed on patients diagnosed with PMN. These individuals were subjected to MFSD therapy for a duration of at least 24 months, with primary outcome of clinical remission rates. The Cox regression analysis was employed to discern the pertinent risk factors exerting influence on the efficacy of MFSD treatment, with scrupulous monitoring of any adverse events.Results: The study comprised 198 participants in total. Following 24 months of treatment, the remission rate was 58.6% (116/198). Among the subgroup of 130 participants subjected to a 36-month follow-up, the remission rate reached 70% (91/130). Subgroup analysis revealed that neither a history of immunosuppressive therapy (HIST) nor an age threshold of ≥60 years exhibited a statistically significant impact on the remission rate at the 24-month mark (p > .05). Multivariate Cox regression analyses elucidated HIST, nephrotic syndrome, or mass proteinuria, and a high-risk classification as noteworthy risk factors in the context of MFSD treatment. Remarkably, no fatalities resulting from side effects were documented throughout the study's duration.Conclusions: This trial establishes the efficacy of MFSD as a treatment modality for membranous nephropathy. MFSD demonstrates a favorable side effect profile, and remission rates are consistent across patients, irrespective of HIST and age categories.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 1","pages":"2320834"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10946256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140120482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity. 没食子酸对镍诱导的肾损伤的保护作用：抗氧化剂和转录因子对肾毒性发生率的影响

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-04-29 DOI: 10.1080/0886022X.2024.2344656

Areej I Alhazmi, Mohamed F El-Refaei, Eman A A Abdallah

{"title":"Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity.","authors":"Areej I Alhazmi, Mohamed F El-Refaei, Eman A A Abdallah","doi":"10.1080/0886022X.2024.2344656","DOIUrl":"https://doi.org/10.1080/0886022X.2024.2344656","url":null,"abstract":"Nickel (Ni) is a common metal with a nephrotoxic effect, damaging the kidneys. This study investigated the mechanism by which gallic acid (GA) protects mice kidneys against renal damage induced by Nickel oxide nanoparticles (NiO-NPs). Forty male Swiss albino mice were randomly assigned into four groups, each consisting of ten mice (n = 10/group): Group I the control group, received no treatment; Group II, the GA group, was administrated GA at a dosage of 110 mg/kg/day body weight; Group III, the NiO-NPs group, received injection of NiO-NPs at a concentration of 20 mg/kg body weight for 10 consecutive days; Group IV, the GA + NiO-NPs group, underwent treatment with both GA and NiO-NPs. The results showed a significant increase in serum biochemical markers and a reduction in antioxidant activities. Moreover, levels of 8-hydroxy-2'-deoxyguanosine (8-OH-dG), phosphorylated nuclear factor kappa B (p65), and protein carbonyl (PC) were significantly elevated in group III compared with group I. Furthermore, the western blot analysis revealed significant high NF-κB p65 expression, immunohistochemistry of the NF-κB and caspase-1 expression levels were significantly increased in group III compared to group I. Additionally, the histopathological inspection of the kidney in group III exhibited a substantial increase in extensive necrosis features compared with group I. In contrast, the concomitant coadministration of GA and NiO-NPs in group IV showed significant biochemical, antioxidant activities, immunohistochemical and histopathological improvements compared with group III. Gallic acid has a protective role against kidney dysfunction and renal damage in Ni-nanoparticle toxicity.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 1","pages":"2344656"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11062283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher atherogenic index of plasma is associated with intradialytic hypotension: a multicenter cross-sectional study. 血浆中较高的动脉粥样硬化指数与椎管内低血压有关：一项多中心横断面研究。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-09-26 DOI: 10.1080/0886022X.2024.2407885

Yanzhe Peng, Dan Shuai, Yuqi Yang, Yan Ran, Jing Yuan, Yan Zha

{"title":"Higher atherogenic index of plasma is associated with intradialytic hypotension: a multicenter cross-sectional study.","authors":"Yanzhe Peng, Dan Shuai, Yuqi Yang, Yan Ran, Jing Yuan, Yan Zha","doi":"10.1080/0886022X.2024.2407885","DOIUrl":"10.1080/0886022X.2024.2407885","url":null,"abstract":"Background: Patients receiving maintenance hemodialysis (MHD) frequently encounter a drop in blood pressure during dialysis, known as intradialytic hypotension (IDH). The AIP is associated with diseases such as diabetes and cardiovascular events. It remains unclear whether the AIP is associated with IDH. The present study aimed to explore the association between AIP and IDH in MHD patients.Methods: In this multi-center cross-sectional study, we included 1946 adult hemodialysis patients from twenty dialysis centers. Patients were divided into four groups based on the AIP quartiles. Linear regression and multiple logistic regression models were used to analyze the relationship between AIP and IDH. Subgroup analyses were further conducted to assess the robustness of the association between the AIP and IDH.Results: After adjusting for potential confounding variables, each 1-unit increase in AIP was associated with a 21% increase in the odds of IDH. The odds ratios (ORs) of IDH increased gradually with higher quartiles of AIP compared with the Q1 reference group (Q2: OR, 1.41, 95% CI: 0.91-2.18; Q3: OR, 1.63, 95% CI: 1.07-2.49; Q4: OR, 1.57, 95% CI: 1.01-2.42). No interaction was observed in the subgroup analysis stratified by age, sex, history of diabetes, heart failure, and myocardial infarction.Conclusion: Elevated AIP levels are associated with a heightened risk of IDH in MHD patients.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 2","pages":"2407885"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11429463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142352711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of hemodialysis access in intradialysis and interdialysis vital sign variabilities and the development of dialysis headache. 血液透析通路在透析内和透析间期生命体征变化及透析头痛发展中的作用。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-10-08 DOI: 10.1080/0886022X.2024.2411367

Yuqin Xiong, Nujia You, Shuoyue Qin, Ruoxi Liao, Yang Yu

{"title":"The role of hemodialysis access in intradialysis and interdialysis vital sign variabilities and the development of dialysis headache.","authors":"Yuqin Xiong, Nujia You, Shuoyue Qin, Ruoxi Liao, Yang Yu","doi":"10.1080/0886022X.2024.2411367","DOIUrl":"10.1080/0886022X.2024.2411367","url":null,"abstract":"To determine the relationship of hemodialysis access with vital sign variability and hemodialysis-related headache (HRH). Adult outpatients receiving maintenance hemodialysis (MHD) were prospectively recruited, and 12 consecutive dialysis sessions were monitored. Intradialysis (hour-to-hour) and interdialysis (dialysis day-to-day) vital sign variabilities were assessed via three metrics: the difference between the maximum and minimum values, average real variability (ARV), and residuals. Multivariate logistic regression analysis was used to explore the factors triggering HRH. A total of 91 Chinese MHD patients (60.4% male) aged 58.5 ± 17.2 years were included, with 59 patients using radiocephalic arteriovenous fistulas (RCAVFs) and 32 patients using tunneled cuffed catheters (TCCs) for dialysis. The median dialysis vintage was 26.8 (12.0-44.7) months. Compared with the RCAVF group, the TCC group had significantly greater urea reduction (71.1 ± 9.3% vs. 61.7 ± 10.5%, p < 0.001) and clearance (1.5 (1.2-1.8) vs. 1.1 (1.0-1.4), p < 0.001) rates, higher intradialysis pulse variability and lower intradialysis diastolic blood pressure variability. Some of interdialysis variability indexes in pulse, systolic blood pressure (SBP), and SpO2 were significantly greater in the TCC group than that in the RCAVF group. Age (OR = 0.880, 95% CI = 0.785-0.986, p = 0.028), TCC use (OR = 22.257, 95% CI = 1.190-416.399, p = 0.038), intradialysis SBP-ARV (OR = 2.768, 95% CI = 1.069-7.171, p = 0.036), and blood sodium level (OR = 0.400, 95% CI = 0.192-0.832, p = 0.014) were shown to be independent risk factors for HRH. In conclusion, the use of TCCs has multifaceted effects on intradialysis and interdialysis vital sign variabilities and is independently associated with an increased risk of HRH.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 2","pages":"2411367"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute kidney injury in hospitalized children in 20 hospitals of China's Hunan Province: a cross-sectional survey. 中国湖南省 20 家医院住院儿童急性肾损伤横断面调查。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-07-31 DOI: 10.1080/0886022X.2024.2379003

Qianliang Sun, Ying Pan, Zhihui Li

{"title":"Acute kidney injury in hospitalized children in 20 hospitals of China's Hunan Province: a cross-sectional survey.","authors":"Qianliang Sun, Ying Pan, Zhihui Li","doi":"10.1080/0886022X.2024.2379003","DOIUrl":"10.1080/0886022X.2024.2379003","url":null,"abstract":"Objective: The incidence of acute kidney injury (AKI) in pediatric patients has been increasing over the years, and AKI significantly impacts children's health and quality of life. This article reviews the current epidemiological research on pediatric AKI.Methods: The clinical data of hospitalized children aged 0 to 14 years from 20 different hospitals in Hunan Province, China, collected from December 2017 to February 2018, were analyzed. The incidence rate, misdiagnosis rate, main causes, and medical costs of AKI in hospitalized children were examined.Results: A total of 29,639 patients were included, with an AKI incidence rate of 4.34% (1286/29,639). Among the 1286 AKI patients, 863 (67.11%) were classified as AKI stage 1324 (25.19%) as AKI stage 2, and 99 (7.7%) as AKI stage 3. AKI patients had significantly longer hospital stays [6.0 (4.0, 10) days vs. 6.0 (4.0, 8.0) days, p < 0.001] and higher hospitalization costs [3375.22 (1600, 6083.83) yuan vs. 2729.4 (1659.45, 8216.65) yuan, p = 0.003] than non-AKI patients. The mortality rate (1.2% vs. 0.1%, p < 0.001), intensive care unit (ICU) transfer rate (8.7% vs. 5.97%, p < 0.001), and use of invasive mechanical ventilation (3.6% vs. 1%, p < 0.001) were significantly greater in patients with AKI than in those without AKI patients. The etiology of AKI varied among different age groups, and dehydration, diarrhea, and shock were the main causes of pre-renal AKI.Conclusion: The incidence and missed diagnosis rates of AKI in hospitalized children were high. AKI prolongs hospital stays, increases hospitalization costs, and increases the risk of mortality in children.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 2","pages":"2379003"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy and safety of difelikefalin for pruritus in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials. 地匹福林治疗血液透析患者瘙痒症的有效性和安全性：随机对照试验的系统回顾和荟萃分析。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-08-01 DOI: 10.1080/0886022X.2024.2384590

Abdallah Saeed, Iman Abdelhady Elshnoudy, Yehya Khlidj, Radwa Radwan, Mariam Kamal, Mahmoud Hamdi, Abdullah Alsaid, Mustafa Turkmani, Mohamed Abuelazm

{"title":"The efficacy and safety of difelikefalin for pruritus in hemodialysis patients: a systematic review and meta-analysis of randomized controlled trials.","authors":"Abdallah Saeed, Iman Abdelhady Elshnoudy, Yehya Khlidj, Radwa Radwan, Mariam Kamal, Mahmoud Hamdi, Abdullah Alsaid, Mustafa Turkmani, Mohamed Abuelazm","doi":"10.1080/0886022X.2024.2384590","DOIUrl":"10.1080/0886022X.2024.2384590","url":null,"abstract":"Background: Chronic kidney disease-associated pruritus (CKD-ap) is a common complication that negatively affects the quality of life. Difelikefalin has emerged as a novel FDA-approved drug to manage CKD-ap. This systematic review and meta-analysis will assess the efficacy and safety of Difelikefalin versus placebo to manage CKD-ap.Methods: PubMed, Scopus, WOS, Central, and Embase were systematically searched until November 2023. RevMan was used to perform meta-analysis. Quality assessment was conducted using the Cochrane RoB 2.0 tool. Results were reported as risk ratio (RR) and mean difference (MD) with a 95% confidence interval (CI). PROSPERO ID: (CRD42023485979).Results: Five RCTs with a total of 896 participants were included. Difelikefalin significantly decreased the weekly mean WI-NRS score (MD: -0.99 [-1.22, -0.75], p ˂ .00001), 5-D itch scale total score (MD: -1.51 [-2.26, -0.76], p > .0001), and Skindex-10 total score (MD: -7.39 [-12.51, -2.28], p = .005), but showed significantly higher adverse events (RR: 1.26 [1.03, 1.55], p = .03), versus placebo. However, there was no significant difference between both groups in serious adverse events (RR: 1.42 [0.78, 2.57], p = .25) or death (RR: 0.81 [0.19, 3.34], p = .77).Conclusion: Difelikefalin appears to be a promising agent for the management of CKD-induced pruritus in patients with end-stage renal disease. However, evidence is still underpowered due to the paucity of the current data; therefore, more robust RCTs are required to confirm the benefit of Difelikefalin.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 2","pages":"2384590"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of citrate dialysate in pre- and post-dilution online hemodiafiltration: effect on clot formation and adequacy of dialysis in hemodialysis patients. 比较稀释前和稀释后在线血液透析中的枸橼酸透析液：对血液透析患者血凝块形成和透析充分性的影响。

IF 3 3区医学

Renal Failure Pub Date : 2024-12-01 Epub Date: 2024-01-08 DOI: 10.1080/0886022X.2024.2302109

Pasu Nakornchai, Arisara Jitraree, Monpinya Charttong Homjan, Thanachit Laykhram, Thananda Trakarnvanich

{"title":"Comparison of citrate dialysate in pre- and post-dilution online hemodiafiltration: effect on clot formation and adequacy of dialysis in hemodialysis patients.","authors":"Pasu Nakornchai, Arisara Jitraree, Monpinya Charttong Homjan, Thanachit Laykhram, Thananda Trakarnvanich","doi":"10.1080/0886022X.2024.2302109","DOIUrl":"10.1080/0886022X.2024.2302109","url":null,"abstract":"Background: Citrate dialysate (CD) has been successfully used in conventional hemodialysis and continuous renal replacement therapy; however, no study has compared pre- and post-dilution online hemodiafiltration (oL-HDF). Therefore, we aimed to investigate the efficacy of citrate anticoagulation for oL-HDF and the metabolic changes and quality of life of patients on hemodialysis treated using both modes.Method: Eight dialysis patients were treated with CD containing 0.8 mmol of citric acid for 4 weeks in each phase. Visual clotting scores were investigated as the primary endpoints. Adequacy of dialysis, laboratory parameters, and quality of life were measured as secondary objectives.Results: The mean clotting scores in the pre-dilution mode were significantly lower than those in the post-dilution mode and in all phases except the heparin-free phase (p < 0.001 in the baseline phase, p = 0.001 in phase 1, and p = 0.023 in phase 2). The values of Kt/V in both modalities were comparable except during the baseline phase, in which the values of pre-dilution were significantly greater than post-dilution (2.36 ± 0.52/week vs. 1.87 ± 0.33/week;95% CI -0.81 to -0.19, p = 0.002). The patient's quality of life regarding their physical activity level was significantly higher in the post-dilution mode than in the pre-dilution mode at baseline and in phase 1 (p = 0.014 and 0.004 at baseline and in phase 1, respectively). Metabolic changes did not differ between the two modes.Conclusion: Citrate dialysate decreased or prevented anticoagulation in both pre- and post-dilution modes of oL-HDF without significant side effects and had comparable adequacy of dialysis.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"46 1","pages":"2302109"},"PeriodicalIF":3.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10776067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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