Renal Failure最新文献_第10页

Association between the initiation of loop diuretics and changes in 2-hour creatinine clearance in critically ill patients. 危重病人开始使用利尿剂与2小时肌酐清除率变化之间的关系

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-02-04 DOI: 10.1080/0886022X.2025.2457514

Kwok M Ho, Prakkash Ananthan, David J R Morgan

引用次数: 0

Real-world assessment of sparsentan's drug safety framework. 对斯帕森坦药物安全框架的实际评估。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-02-19 DOI: 10.1080/0886022X.2025.2461668

Wenjing Fu, Jingyu Wang, Yuzhou Xue, Dikang Pan

{"title":"Real-world assessment of sparsentan's drug safety framework.","authors":"Wenjing Fu, Jingyu Wang, Yuzhou Xue, Dikang Pan","doi":"10.1080/0886022X.2025.2461668","DOIUrl":"10.1080/0886022X.2025.2461668","url":null,"abstract":"Background: Sparsentan has been approved for reducing proteinuria in adult patients with primary IgA nephropathy (IgAN) at risk of rapid disease progression, yet comprehensive studies evaluating its drug safety framework are lacking.Methods: Adverse event (AE) reports following the market release of sparsentan were collected from the U.S. Food and Drug Administration AE Reporting System. Disproportionate analysis was used to identify previously unrecognized positive novel signals at both the system organ class and preferred term levels. Additionally, analysis on clinical priorities and subgroup analysis were conducted.Results: A total of 504 patients with IgAN were included. Two novel system organ classes and 14 novel preferred terms were identified. Hypotension and dizziness were established as moderate clinical priority events. Males had a higher relative risk of nausea, peripheral edema, feeling abnormal, decreased blood pressure, and hypotension, while females were at greater risk for fatigue, pain, increased blood creatinine, dizziness, and somnolence. Among those aged 18-45, the relative risk of experiencing fatigue, pain, and dizziness was higher, individuals aged 45 and older had a higher relative risk of peripheral edema, decreased blood pressure, and hypotension.Conclusions: Based on the available AE reporting data, sparsentan exhibits a favorable safety profile, with no high-priority clinical events identified. Our findings offer valuable insights to optimize the use of sparsentan and understand its potential side effects.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2461668"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143459294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticosteroid and immunosuppressive treatment are effective for acquired pure red cell aplasia in chronic kidney disease: a case report and literature review. 皮质类固醇和免疫抑制治疗对慢性肾病获得性纯红细胞发育不全是有效的：一个病例描述和文献复习。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-06 DOI: 10.1080/0886022X.2024.2449202

Hongsha Yang, Yurong Zou, Guisen Li, Yunlin Feng

引用次数: 0

Letter to the editor: "Association of Geriatric Nutritional Risk Index with short-term mortality in patients with severe acute kidney injury: retrospective cohort study". 致编辑的信：“严重急性肾损伤患者的老年营养风险指数与短期死亡率的关系：回顾性队列研究”。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-08 DOI: 10.1080/0886022X.2024.2448575

Mariana Dias Pais, Sílvia Coelho

引用次数: 0

Global glomerulosclerosis proportions predict nephropathy progression in IgA nephropathy: a multicenter retrospective analysis with propensity score matching. 全球肾小球硬化比例预测IgA肾病进展：一项倾向评分匹配的多中心回顾性分析。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-05-05 DOI: 10.1080/0886022X.2025.2486567

Wenli Zou, Yueming Liu, Baihui Xu, Juan Wu, Wei Shen, Wei Zhang, Jiawei Zhang, Yao Meng, Yan Zhu, Jingting Yu, Jianguang Gong, Xiaogang Shen, Bin Zhu

{"title":"Global glomerulosclerosis proportions predict nephropathy progression in IgA nephropathy: a multicenter retrospective analysis with propensity score matching.","authors":"Wenli Zou, Yueming Liu, Baihui Xu, Juan Wu, Wei Shen, Wei Zhang, Jiawei Zhang, Yao Meng, Yan Zhu, Jingting Yu, Jianguang Gong, Xiaogang Shen, Bin Zhu","doi":"10.1080/0886022X.2025.2486567","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2486567","url":null,"abstract":"Background: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerular disease worldwide. The role of global glomerulosclerosis (GS) in the patients with IgAN remains controversial. The study aims to evaluate the effect of GS on the kidney outcome in the patients with IgAN.Methods: Based on the median of GS proportion, patients were divided into two groups (GS1 and GS2). Thereafter, the clinical, demographic, and treatment characteristics were evaluated by propensity score matching, Kaplan-Meier survival curves, Cox regression analyses. Next, the receiver operating characteristic curve analysis, continuous net reclassification improvement and integrated discrimination improvement were constructed to assess whether the model contained GS proportion could refine risk prediction and clinical utility.Results: In this three-center retrospective study, a total of 1,626 IgAN patients were recruited. Both in the full and matched cohort, higher GS proportions were found to be independent prognostic factors for the kidney survival via Kaplan-Meier analysis (p < 0.05, p < 0.05, respectively). Additionally, the multivariate Cox regression models identified higher proteinuria, decreased eGFR, higher score of tubular atrophy/interstitial fibrosis (T), higher GS proportions as independent prognostic factors for poor kidney outcomes, and corticosteroids therapy was a protective indicator of kidney outcomes. Lastly, the prediction model based on these prognostic factors were validated to be accurately predict the kidney outcome when including GS proportions.Conclusions: GS proportions are independent predictors for poor prognosis in IgAN patients.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2486567"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress hyperglycemia ratio as a predictor of acute kidney injury and its outcomes in critically ill patients. 应激性高血糖率对危重患者急性肾损伤及其预后的预测作用

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-05-05 DOI: 10.1080/0886022X.2025.2499228

Yingxin Lin, Sheng Zhang, Zeling Chen, Xuwei Lin, Xueqing Wang, Xiaojun Shen, Lei Huang, Yiyu Deng, Chunbo Chen

{"title":"Stress hyperglycemia ratio as a predictor of acute kidney injury and its outcomes in critically ill patients.","authors":"Yingxin Lin, Sheng Zhang, Zeling Chen, Xuwei Lin, Xueqing Wang, Xiaojun Shen, Lei Huang, Yiyu Deng, Chunbo Chen","doi":"10.1080/0886022X.2025.2499228","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2499228","url":null,"abstract":"This study investigated stress hyperglycemia ratio (SHR) for acute kidney injury (AKI) and clinical outcomes in intensive care unit (ICU). Key outcomes were AKI within 48 h after ICU admission, acute kidney disease (AKD), ICU mortality, 28-day mortality, 90-day mortality and 1-year mortality. The associations between SHR and outcomes was estimated via logistic regression, Cox proportional hazards regression, and restricted cubic spline (RCS) analyses. Subgroup analyses assessed the consistency of these associations. Totally 3,714 patients were included from the Medical Information Mart for Intensive Care IV. SHR was associated with an increased risk of AKI (ORadjusted 1.29 95%CI 1.05-1.59). Among AKI patients, SHR was associated with increased risks of AKD (ORadjusted 1.94 95%CI 1.57-2.39), ICU mortality (ORadjusted 2.31 95%CI 1.60-3.32), 28-day mortality (HRadjusted 1.39 95%CI 1.29-1.50), 90-day mortality (HRadjusted 1.37 95%CI 1.26-1.48), and 1-year mortality (HRadjusted 1.37 95%CI 1.27-1.47). RCS analysis revealed a linear relationship with AKI, a J-shaped relationship with AKD, and a U-shaped relationship with mortality. Subgroup analysis confirmed the consistency of relationship between SHR and AKI. SHR demonstrates significant associations with AKI incidence, and correlates with AKD progression/mortality in critically ill adult ICU patients, suggesting its potential as a risk stratification and prognostic tool for AKI management, though further prospective validation is required.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2499228"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged sitting time and all-cause mortality: the mediating and predictive role of kidney function markers. 久坐时间与全因死亡率：肾功能指标的中介和预测作用。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-04-22 DOI: 10.1080/0886022X.2025.2486568

Li Wang, Xuelei Wu, Ziyi Guo, Yishan Dong, Bin Yu

{"title":"Prolonged sitting time and all-cause mortality: the mediating and predictive role of kidney function markers.","authors":"Li Wang, Xuelei Wu, Ziyi Guo, Yishan Dong, Bin Yu","doi":"10.1080/0886022X.2025.2486568","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2486568","url":null,"abstract":"Objective: To investigate the association between daily sitting time and all-cause mortality, with a focus on the mediating effect and predictive value of the makers relating to kidney.Methods: The cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2020. The makers relating to kidney were assessed through estimated glomerular filtration rate (eGFR), urine albumin creatinine ratio (UACR), and other relevant markers.Results: A total of 9,707 adults were included in the analysis. There was a significant increase in the levels of blood urea nitrogen (BUN), creatinine, uric acid, osmolality, and UACR with extended daily sitting time, while eGFR significantly decreased. Notably, individuals sitting ≥ 8 h per day exhibited a 67% higher risk of all-cause mortality (HR = 1.67, 95% CI: 1.43-1.94). A nonlinear (L-shaped) relationship was observed between eGFR (p < 0.001) or UACR (p < 0.001) and all-cause mortality. Mediation analysis revealed that eGFR accounted for 20.98% of the association between sitting time and mortality (p < 0.01). An addition of eGFR or UACR would increase the AUC from 0.585 to 0.762 and 0.656, respectively(p < 0.001). The main mortality caused by daily sitting time included chronic lower respiratory diseases, diabetes mellitus, cerebrovascular diseases and heart diseases.Conclusions: Prolonged daily sitting time is significantly associated with an increased risk of all-cause mortality, potentially mediated by impaired kidney function. Incorporating kidney function markers such as eGFR and UACR enhances the predictive value for mortality risk assessment in sedentary populations.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2486568"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis. 内皮损伤是维持性透析患者血管钙化进展的危险因素之一。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-26 DOI: 10.1080/0886022X.2025.2456690

Dan-Dan Yao, Xiao-Wei Yan, Yan Zhou, Zuo-Lin Li, Fang-Xin Qiu

{"title":"Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis.","authors":"Dan-Dan Yao, Xiao-Wei Yan, Yan Zhou, Zuo-Lin Li, Fang-Xin Qiu","doi":"10.1080/0886022X.2025.2456690","DOIUrl":"10.1080/0886022X.2025.2456690","url":null,"abstract":"Background: Vascular calcification is common and progressive in patients with chronic kidney disease. However, the risk factors associated with the progression of vascular calcification in patients receiving maintenance dialysis have not been fully elucidated. Here, we aimed to evaluate vascular calcification and identify the factors associated with its progression in patients receiving maintenance hemodialysis.Methods: This is a prospective longitudinal study that included 374 patients receiving maintenance hemodialysis. The participants received assessments of coronary artery calcification (CAC) and abdominal aortic calcification (AAC), as measured by computed tomography. After the baseline investigation, a 2 years follow-up was performed. We also detected the markers of endothelial injury [E-selectin and soluble intercellular adhesion molecule-1 (sICAM-1)]. Finally, the risk factors affecting the CAC and AAC progression were examined by multivariate logistic regression analysis.Results: Among 374 patients, the median [interquartile range (IQR)] age was 54.0 (40.0-62.0) years; 59.9% of patients were male. The median (IQR) follow-up time was 1.9 (1.8-2.0) years for all patients. By the end of 2-year follow-up, progression of vascular calcification (including CAC and AAC) was observed in 58.0% of patients. Further, compared with the patients without progression of vascular calcification, the endothelial injury (including E-selectin and sICAM-1) of patients with progression of vascular calcification was markedly enhanced. Moreover, after adjustment for the confounders, endothelial injury was a risk factor for the progression of vascular calcification.Conclusion: The present study indicated that endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance hemodialysis.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2456690"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bibliometric study and visual analysis of postoperative diabetes mellitus in kidney transplant recipients based on WoSCC database. 基于 WoSCC 数据库的肾移植受者术后糖尿病文献计量研究和可视化分析。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-13 DOI: 10.1080/0886022X.2024.2444383

Minhua Qiu, Sheng Chen, Jibing Chen, Hongjun Gao

{"title":"Bibliometric study and visual analysis of postoperative diabetes mellitus in kidney transplant recipients based on WoSCC database.","authors":"Minhua Qiu, Sheng Chen, Jibing Chen, Hongjun Gao","doi":"10.1080/0886022X.2024.2444383","DOIUrl":"10.1080/0886022X.2024.2444383","url":null,"abstract":"Background: In recent years, the increase of the post-transplantation diabetes mellitus (PTDM) after renal transplantation encourages people to do a lot of research on the disease. This paper conducted a bibliometric study on PTDM related literature to explore the risk factors of diabetes after kidney transplantation, as well as the current status, hotspots and development trends of PTDM research, so as to provide reference for researchers in related fields.Methods: We searched the Web of Science Core Collection (WoSCC) database for PTDM literature from January 1, 1990, to August 20, 2023, and used VOSviewer, CiteSpace, and the R package 'bibliometrix' to do bibliometric analysis.Results: Obesity, 3 months after transplantation tacrolimus concentration >10 ng/mL, temporary hyperglycemia, delayed graft function, acute rejection is specific risk factors related to PTDM in renal transplant recipients. In addition, 74 countries led by China and the United States published 1546 papers, and the number of PTDM-related publications is increasing every year. Primary institutions included the University of California, Los Angeles, Mayo Clinic, University of Oslo, and University of Toronto. The Journal of Transplantation is the most widely read journal in the subject. The authors with the most published literature are Trond Jenssen and Adnan Sharif, and the most cited author is Kasiske BL. Expectations for continued growth in global PTDM research are increasingly high. Future studies will mainly focus on exploring the risk factors of PTDM and identifying new therapeutic approaches and targets.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2444383"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute kidney injury in hospitalized children with diphtheria in northwestern Nigeria: incidence and hospitalization outcomes. 尼日利亚西北部白喉住院患儿的急性肾损伤：发病率和住院治疗结果。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-02-23 DOI: 10.1080/0886022X.2025.2465817

Olayinka Rasheed Ibrahim, Abdurrazzaq Alege, Michael Abel Alao, Olanrewaju Timothy Adedoyin

{"title":"Acute kidney injury in hospitalized children with diphtheria in northwestern Nigeria: incidence and hospitalization outcomes.","authors":"Olayinka Rasheed Ibrahim, Abdurrazzaq Alege, Michael Abel Alao, Olanrewaju Timothy Adedoyin","doi":"10.1080/0886022X.2025.2465817","DOIUrl":"10.1080/0886022X.2025.2465817","url":null,"abstract":"Background: Despite the kidney being affected by diphtheria exotoxin, the extent of acute kidney injury (AKI) and its possible impact on outcomes remain unknown. This study examined the incidence, risk factors, and outcomes of AKI in children with diphtheria.Methods: This was a prospective cohort study of confirmed diphtheria managed from July 1, 2023, to April 30, 2024, at a health facility in Nigeria. We obtained data on clinical and laboratory features and treatments received. AKI was defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria.Results: We included 237 children with a median [interquartile range] age of 7.0 [4-10] years. Using KDIGO, 139 (58.6%) had AKI [stage 1:88 (37.1%); stage 2: 18 (7.6%); and stage 3: 33 (13.9%)]. Variables associated with AKI included age, sore throat, inability to swallow, difficulty breathing, nasal blockade, hypoxemia, nasal discharge, pallor, abnormal chest findings, hospitalization duration, vaccination status, white blood cells, lymphocytes, platelets, serum bicarbonate, sodium and potassium, and treatments received, p < 0.05. On multivariable logistic regression, predictors of AKI included age ≤ 60 months [AOR 2.75, 95% CI 1.27-5.95], dexamethasone [AOR 2.57, 95% CI 1.11-4.60], oxygen therapy [4.85, 95% CI 1.24-18.99], and ibuprofen [AOR 2.74, 95 CI% 1.16-6.44]. Mortality rate was 24.5% (58/237) and 33.1% (46/139) in AKI. The odds of deaths with AKI were 3.56 (95% CI 1.76-7.14).Conclusion: There is a high incidence of AKI among children with diphtheria and increased odds of death. Factors that predicted AKI included younger age, oxygen therapy, and medications (ibuprofen and dexamethasone).","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2465817"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0