基于c反应蛋白-白蛋白淋巴细胞指数的维持性血液透析患者全因死亡率预测模型的构建

IF 3 3区 医学 Q1 UROLOGY & NEPHROLOGY
Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-14 DOI:10.1080/0886022X.2024.2444396
Junmin Huang, Junfeng Hao, Huasheng Luo, Lu Chen, Hongying Luo, Huafeng Liu, Yongzhi Xu, Peng Wang
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引用次数: 0

摘要

目的:接受维持性血液透析(MHD)的患者死亡率居高不下。C 反应蛋白-白蛋白-淋巴细胞(CALLY)指数是一种新型生物标志物,它能反映炎症、营养和免疫状态,并将所有这些因素合并为一个单一的衍生参数。目前还没有研究将 CALLY 指数与血液透析患者的存活率联系起来。本研究旨在探讨 CALLY 指数与血液透析患者死亡率之间的相关性,并开发和验证一个估计该人群死亡可能性的提名图:这项回顾性队列研究收集了 436 名患者的数据,并将他们分为生存组(335 人)和非生存组(101 人)。研究人员采用多变量逻辑回归分析筛选与死亡相关的因素,并绘制了用于估算MHD患者死亡风险的提名图。使用接收器操作特征曲线下面积(AUC)和校准曲线验证了提名图的区分度和校准度。研究还进行了分层分析和协变量调整,以探讨CALLY指数与MHD患者死亡率之间的相关性:在最终模型中,逻辑回归显示 CALLY 指数、肌酐、甘油三酯、透析时间、绝对中性粒细胞计数、血尿素氮、钠和铁蛋白是与 MHD 患者死亡率相关的变量。为评估血液透析患者的死亡风险,制定了一个提名图。该模型的AUC为0.821(95% CI:0.778-0.861)。分层分析和校准模型的结果显示,CALLY指数是维持MHD患者死亡率的保护因素:结论:CALLY指数与MHD患者的死亡率密切相关。根据 CALLY 指数构建的提名图可以有效评估 MHD 患者的死亡风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Construction of a C-reactive protein-albumin-lymphocyte index-based prediction model for all-cause mortality in patients on maintenance hemodialysis.

Objective: The mortality rate of patients undergoing maintenance hemodialysis (MHD) remains high. The C-reactive protein-albumin-lymphocyte (CALLY) index is a novel biomarker that reflects inflammation, nutritional and immune status, all merged into one single derived parameter. No study has yet linked the CALLY index to survival in hemodialysis. This study aims to explore the correlation between the CALLY index and mortality in MHD patients, and develop and validate a nomogram to estimate the likelihood of death in this population.

Methods: This retrospective cohort study collected data from 436 patients and they were divided into survival group (n = 335) and non-survival group (n = 101). Multivariate logistic regression analysis was used to screen factors associated with death, and nomograms were developed to estimate the risk of death in MHD patients. The discrimination and calibration of nomograms were validated using the area under the receiver operating characteristic (ROC) curve (AUC) and calibration curve. In the study, stratification analysis and covariate adjustment were conducted to explore the correlation between the CALLY index and the mortality of MHD patients.

Results: In the final model, logistic regression showed that the CALLY index, creatinine, triglycerides, dialysis duration, absolute neutrophil count, blood urea nitrogen, sodium and ferritin were variables associated with mortality in MHD patients. A nomogram was developed to assess the risk of death in MHD patients. The AUC of the model was 0.821 (95% CI: 0.778-0.861). The results of stratified analysis and calibration model showed that the CALLY index was a protective factor for maintaining the mortality of MHD patients.

Conclusions: The CALLY index is closely related to the mortality of MHD patients. A nomogram constructed based on CALLY index can effectively evaluate the mortality risk of MHD patients.

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来源期刊
Renal Failure
Renal Failure 医学-泌尿学与肾脏学
CiteScore
3.90
自引率
13.30%
发文量
374
审稿时长
1 months
期刊介绍: Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.
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