Renal Failure最新文献

{"title":"Oxidative stress and inflammation in hemodialysis: a comparison of patients with or without advanced nonalcoholic fatty liver disease (NAFLD).","authors":"Vanja Kalacun, Robert Ekart, Sebastjan Bevc, Pavel Skok, Radovan Hojs, Nina Vodošek Hojs","doi":"10.1080/0886022X.2025.2455523","DOIUrl":"10.1080/0886022X.2025.2455523","url":null,"abstract":"<p><p>Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease are global public health issues associated with high morbidity and mortality. Both diseases are also interlinked. Little is known about the meaning of NAFLD in hemodialysis (HD) patients. Therefore, the aim of our study was to investigate the difference in oxidative stress and inflammation in HD patients with or without advanced NAFLD. Seventy-seven HD patients were included (65.14 ± 12.34 years, 59.2% male) and divided according to abdominal ultrasound and two-dimensional shear wave elastography (2D-SWE) measurements into two groups: 1) no NAFLD or no advanced NAFLD (2D-SWE <9 kPa) and 2) advanced NAFLD (2D-SWE ≥9 kPa). Medical history data and blood results were collected. HD patients with advanced NAFLD had significantly higher levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG; <i>p</i> = 0.025), tumor necrosis factor-alpha (TNF-α; <i>p</i> = 0.023), and intercellular adhesion molecule 1 (ICAM-1; <i>p</i> = 0.015) in comparison to HD patients without advanced NAFLD. Interleukin 6 (IL-6) was higher in the advanced NAFLD group, but the difference was of borderline significance (<i>p</i> = 0.054). There was no significant difference in high-sensitivity C-reactive protein (hs-CRP), and vascular cell adhesion molecule 1 (VCAM-1) between groups. In binary logistic regression analysis, advanced NAFLD was significantly associated with 8-OHdG and ICAM-1. In conclusion, higher oxidative stress and inflammation levels are present in HD patients with advanced NAFLD.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2455523"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated atherogenic index of plasma is associated with increased cardiorenal syndrome prevalence: a cross-sectional study.","authors":"Sikai Xu, Jianping Hu, Zhiyi Ouyang, Maolin Yuan, Yan Zheng, Xin Liu, Yang Shen","doi":"10.1080/0886022X.2025.2472037","DOIUrl":"10.1080/0886022X.2025.2472037","url":null,"abstract":"<p><strong>Purpose: </strong>Cardiorenal syndrome (CRS) is a complex clinical condition characterized by the simultaneous dysfunction of the heart and kidneys. The atherogenic index of plasma (AIP), calculated as the logarithm of the ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C), has emerged as a potential biomarker for cardiovascular risk. This study investigates the association between AIP and CRS, aiming to explore the potential linkage between AIP and CRS.</p><p><strong>Methods: </strong>Data were sourced from the National Health and Nutrition Examination Survey spanning 2005-2018, involving 35,365 participants after applying exclusion criteria. The primary exposure variable was AIP, categorized into quartiles, while the primary outcome variable was CRS, defined by the coexistence of cardiovascular disease (CVD) and chronic kidney disease (CKD). Statistical analyses, considering sample weights, included ANOVA, Chi-square tests, logistic regression models, and restricted cubic spline (RCS) analysis to examine nonlinear relationships.</p><p><strong>Results: </strong>The weighted logistic regression analysis showed a positive correlation between AIP and CRS across all models. In the fully adjusted model, the highest AIP quartile had a significantly increased odds ratio (OR) for CRS (Q4: OR = 1.62; 95% CI: 1.21-2.15). RCS analysis confirmed a positive correlation between AIP and CRS, with TG positively and HDL-C negatively correlated with CRS. Subgroup analysis indicated a significant interaction with hypertension, showing a stronger association in non-hypertensive individuals.</p><p><strong>Conclusion: </strong>Higher AIP levels are associated with an increased prevalence of CRS, with a notable hypertension-specific interaction indicating a higher effect in individuals without hypertension.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2472037"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between drinking patterns and diabetic kidney disease in United States adults: a cross-sectional study based on data from NHANES 1999-2016.","authors":"Xusheng Yang","doi":"10.1080/0886022X.2025.2454970","DOIUrl":"10.1080/0886022X.2025.2454970","url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional study aimed to investigate the association between drinking patterns and prevalence of diabetic kidney disease (DKD) among adults in the United States.</p><p><strong>Methods: </strong>Data were analyzed from the NHANES surveys conducted between 1999 and 2016, including 26,473 participants. Drinking patterns were categorized by frequency (weekly, monthly, or yearly) and quantity (light, moderate, or heavy, based on daily consumption). Among participants with diabetes, DKD was defined using the albumin-to-creatinine ratio (ACR ≥30 mg/g) and estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m²). Multivariable logistic regression models were used to evaluate associations, adjusting for potential confounders across the four models. Subgroup analyses were performed to assess the effects of modification by age, sex, race, BMI.</p><p><strong>Results: </strong>Drinking patterns and DKD were analyzed among 26,473 US adults (mean age, 46.6 years; 53.7% male). After adjusting for multiple confounders, heavy alcohol consumption was associated with a higher risk of DKD than light drinking (OR = 1.23, 95% CI, 1.04-1.46; <i>p</i> = 0.016). Conversely, moderate drinking frequency (3-4 days per week, 2-5 days per month, 3-126 days per year) was associated with a reduced DKD risk (OR = 0.67, 95% CI, 0.49-0.91; OR = 0.75, 95% CI, 0.56-0.99, OR = 0.71, 95% CI, 0.58-0.86, respectively). A nonlinear association was observed between alcohol consumption frequency and DKD in terms of weekly and yearly drinking days.</p><p><strong>Conclusion: </strong>This study highlights the importance of drinking behavior in the management of diabetic kidney disease. Daily alcohol consumption was associated with an increased risk of DKD, whereas moderate alcohol consumption was associated with a reduced risk. These findings suggest that moderate drinking frequency may not exacerbate renal burden in individuals with diabetes and provide new perspectives for clinical interventions.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2454970"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between the cystatin C- and creatinine-based estimated GFR ratio and post-ablation outcomes in patients with atrial fibrillation.","authors":"Wenchao Huang, Luxiang Shang, Yan Luo, Shiqiang Xiong, Shuwei Suo, Zhen Zhang, Hanxiong Liu, Huaxin Sun","doi":"10.1080/0886022X.2025.2466824","DOIUrl":"10.1080/0886022X.2025.2466824","url":null,"abstract":"<p><strong>Background: </strong>The difference between the cystatin C-based eGFR (eGFRcys) and the creatinine-based eGFR (eGFRcr) is associated with the risk of developing atrial fibrillation (AF) risk. However, its impact on AF ablation outcomes is unknown.</p><p><strong>Methods: </strong>The associations between the baseline eGFR ratio (eGFRcys/eGFRcr) and the risk of experiencing post-ablation endpoints were evaluated on a continuous scale (restricted cubic splines) and by a priori defined centile categories with Cox proportional hazards regression models. The primary endpoints were AF recurrence and adverse events; the secondary endpoint was rehospitalization.</p><p><strong>Results: </strong>Among 989 participants (49.2% women; mean age 65.7 years), 313 experienced AF recurrence after a median follow-up of 28 months. After full adjustment for confounding factors, a U-shaped association was observed between eGFR ratio and AF recurrence risk (minimum risk at 0.797). Although a U-shaped trend was observed, there was no statistically significant association between the eGFR ratio and adverse events or rehospitalization. Hazard ratios for AF recurrence, compared to the second quartile, were 1.68 (1.20-2.37) for the first quartile, 1.64 (1.15-2.34) for the third quartile, and 1.96 (1.37-2.80) for the fourth quartile. According to the subgroup analysis, the above association was strongly U-shaped for males and linear for females.</p><p><strong>Conclusion: </strong>In the AF population, both low and high eGFR ratios were associated with an increased risk of post-ablation AF recurrence.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2466824"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of acute kidney injury in Mexico; a systematic review and meta-analysis of pre-pandemic reports.","authors":"Jose J Zaragoza, Jonathan S Chavez-Iñiguez, Armando Vazquez-Rangel","doi":"10.1080/0886022X.2024.2449573","DOIUrl":"10.1080/0886022X.2024.2449573","url":null,"abstract":"<p><strong>Background: </strong>Acute Kidney Injury (AKI) is a health problem worldwide, accounting for high hospital morbidity and mortality. There is little available information regarding the characteristics and incidence of AKI in Latin America (LA), especially in Mexico.</p><p><strong>Objectives: </strong>Systematically search the literature and perform a meta-analysis of the epidemiology of AKI in Mexico, to provide data on AKI and kidney replacement therapy (KRT) that would contribute to general knowledge in this matter.</p><p><strong>Methods: </strong>We performed a systematic search for articles in pediatric and adult patients admitted to the general ward, Emergency Room or Intensive Care Unit published between January 1, 2000, and September 30, 2024. MEDLINE LILIACS, EMBASE and SciELO were searched, as additional reports from supplements, abstracts, and conference sessions. We performed a random-effects meta-analysis for clinically and methodologically comparable studies to estimate the frequency of AKI and KRT. We calculated pooled estimates stratified by age group, year of publication, and setting.</p><p><strong>Results: </strong>83 full-text articles were included. The percentage of AKI was calculated at 35% (95% CI, 28-42). Mortality for AKI adult patients was 36% (95% CI, 28-45). An overall KRT rate was 7% (95% CI, 6-9), all-cause mortality for AKI requiring KRT was 49% (95% CI, 42-56), with a global Ι2 estimated in 99.87% (<i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>AKI is common in Mexico and remains a main public health problem that needs to be addressed at every level of care. Efforts should be made to reinitiate AKI research and control in Mexico and LA.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2449573"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical outcomes of acute kidney injury substages based on serum cystatin C in pediatric patients undergoing cardiac surgery.","authors":"Yinan Li, Dongyun Bie, Chao Xiong, Sheng Shi, Zhongrong Fang, Zhongyuan Lu, Jianhui Wang","doi":"10.1080/0886022X.2025.2466114","DOIUrl":"10.1080/0886022X.2025.2466114","url":null,"abstract":"<p><strong>Background: </strong>Multiple biomarkers have been identified by previous studies to diagnose acute kidney injury (AKI). The combination of biomarkers with conventional criteria to define AKI substages in order to identify high-risk patients and improve diagnostic accuracy was recommended. Our study aimed to explore the incidence of AKI substages defined by serum cystatin C (CysC), determine whether AKI substages diagnosed with combined CysC criteria were associated with worse outcomes.</p><p><strong>Methods: </strong>We prospectively included 2519 pediatric patients (<16 years) undergoing cardiac surgery with cardiopulmonary bypass (CPB) in our cohort between March 2022 and February 2023 in Fuwai Hospital. Demographic and clinical variables were collected. To define AKI substages, Kidney Disease: Improving Global Outcomes AKI definition (based on serum creatinine (SCr) or CysC) was used. The association between AKI exposure and outcomes including length of intensive care unit stay (LOIS), duration of mechanical ventilation (DMV), length of hospital stay (LOHS), and 30-day mortality was assessed. In addition, we determined areas under the receiver operating characteristic (ROC) curve and cutoff value of CysC preoperatively and postoperatively to predict AKI.</p><p><strong>Results: </strong>Five hundred and seven (20.8%) patients developed SCr-AKI, with 337 (13.8%) in stage 1, 77 (3.2%) in stage 2 and 93 (3.8%) in stage 3, respectively. Of the 1925 patients without SCr-AKI, 256 (14.3%) met the definition of sub-AKI. Of the 507 patients with SCr-AKI, 281 (55.4%) patients were defined as AKI substage A, while others (226, 44.6%) were defined as AKI substage B. After adjusting for body surface area, neonates, Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery mortality score ≥ 4, previous sternotomy and CPB time > 120 min, the postoperative LOIS, LOHS, and DMV were prolonged with increasing hospitalization expense (<i>p</i> < .05) in patients with SCr-AKI and/or CysC-AKI. Meanwhile, only the hospitalization expense was increased in patients with SCr-AKI (<i>p</i> < .05) after the same adjustment. The area under curves was 0.691, 0.720, and 0.817 respectively, in ROC curves of preoperative, relative variation, or postoperative serum CysC. DeLong's test showed that postoperative serum CysC might have better diagnostic performance characteristics than preoperative or relative variation of CysC (<i>p</i> < .001), with cutoff point at 1.29 mg/dL (specificity, 0.77; sensitivity, 0.71).</p><p><strong>Conclusions: </strong>Our analysis indicates defining AKI with both CysC and SCr might more significantly affect clinical outcome associations in pediatric patients undergoing cardiac surgery. Moreover, the serum CysC cutoff of 1.29 mg/dL postoperatively is a valuable threshold for AKI risk assessment to define AKI subtypes.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2466114"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of endothelin receptor antagonists in kidney disease.","authors":"Xiaoting Ma, Yuyang Liang, Wenmin Chen, Lingqian Zheng, Haishan Lin, Tianbiao Zhou","doi":"10.1080/0886022X.2025.2465810","DOIUrl":"10.1080/0886022X.2025.2465810","url":null,"abstract":"<p><p>Kidney diseases are among the most prevalent conditions worldwide, impacting over 850 million individuals. They are categorized into acute kidney injury and chronic kidney disease. Current preclinical and clinical trials have demonstrated that endothelin (ET) is linked to the onset and progression of kidney disease. In kidney diseases, pathological conditions such as hyperglycemia, acidosis, insulin resistance, and elevated angiotensin II levels lead to an increase in ET. This elevation activates endothelin receptor type A, resulting in harmful effects like proteinuria and a reduced glomerular filtration rate (GFR). Therefore, to slow the progression of kidney disease, endothelin receptor antagonists (ERAs) have been proposed as promising new therapies. Numerous studies have demonstrated the efficacy of ERAs in significantly reducing proteinuria and improving GFR, thereby slowing the progression of kidney diseases. This review discusses the mechanisms of action of ERAs in treating kidney disease, their efficacy and safety in preclinical and clinical studies, and explores future prospects for ERAs.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2465810"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal insights into major risk factors for diabetic kidney disease: a comprehensive meta-analysis and Mendelian randomization study.","authors":"Yucong Zhou, Yahong Liu, Liang Wu, Yucai Zhang, Huixin Wen, Jiangwei Hu, Zhenxia Huo, Shuyuan Ju, Ruizheng Sheng","doi":"10.1080/0886022X.2025.2468741","DOIUrl":"10.1080/0886022X.2025.2468741","url":null,"abstract":"<p><strong>Background: </strong>This study aims to identify major risk factors for diabetic kidney disease (DKD) and examine their causal relationships using meta-analysis and Mendelian randomization.</p><p><strong>Materials and methods: </strong>This study reviewed diabetic nephropathy literature up to September 2024, evaluating quality with NOS, AMSTAR 2, and JBI. It analyzed heterogeneity using the Baujat plot and leave-one-out method, and conducted meta-analysis with fixed- or random-effects models based on I². Publication bias was assessed with a funnel plot and Egger's test. Mendelian randomization using GWAS SNPs explored causal links through IVW, MR-Egger, weighted median, and weighted mode, while pleiotropy and heterogeneity were checked with the MR-Egger intercept and Cochran's Q.</p><p><strong>Results: </strong>Meta-analysis identified several significant risk factors for DKD, including hypertension (relative risk [RR] = 6.33), comorbidities (RR = 4.96), poor glycemic control (RR = 3.27), non-adherence to treatment (RR = 3.30), an unhealthy diet (RR = 5.96), physical inactivity (RR = 5.60), and hyperuricemia (RR = 5.24). MR analysis further confirmed a causal relationship between high carbohydrate intake (odds ratio [OR] = 1.393, <i>p</i> = 0.043) and increased DKD risk, while vegetable consumption (OR = 0.816, <i>p</i> = 0.011) was identified as a protective factor. These findings reinforce the critical role of dietary and lifestyle interventions in DKD prevention.</p><p><strong>Conclusions: </strong>By integrating meta-analysis with Mendelian randomization, this study provides robust evidence linking modifiable risk factors, particularly dietary habits and lifestyle behaviors, to DKD development. The findings highlight the need for early preventive strategies targeting glycemic control, hypertension, and dietary modifications to mitigate DKD progression.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2468741"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bibliometric insights into systemic sclerosis with renal involvement: trends, contributions, and future directions.","authors":"Haochen Huang, Ling-Ling Zhang, Jiaxin Zhou, Mengtao Li, Xiaofeng Zeng, Dong Xu","doi":"10.1080/0886022X.2025.2463583","DOIUrl":"10.1080/0886022X.2025.2463583","url":null,"abstract":"<p><strong>Background: </strong>Renal involvement is not uncommon in patients with systemic sclerosis (SSc) and presents in various forms, particularly progressing to scleroderma renal crisis (SRC), which is associated with poor prognosis. Therefore, understanding the research trends in this field is critical for advancing clinical management and therapeutic strategies.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted using the Web of Science Core Collection, examining publications related to SSc and renal involvement from January 2000 to November 2024. We analyzed publication trends, key contributors, institutions, and countries.</p><p><strong>Results: </strong>A total of 1,339 publications were identified in the field of SSc and renal involvement, demonstrating an upward trend in publication volume from 2000 to 2024. These articles have been cited a total of 61,234 times, with the majority of contributions coming from the United States, Italy, and East Asian countries. The University of Michigan and University College London were particularly prominent in terms of both publication volume and collaboration networks. Keyword analysis revealed a shift in research focus, with increasing attention on clinical aspects, pathophysiological mechanisms, and vascular complications.</p><p><strong>Conclusions: </strong>This study provides a comprehensive overview of the research landscape on SSc with renal involvement, highlighting the key contributors and emerging trends.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2463583"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of peripheral blood lymphocyte subpopulations after renal transplantation.","authors":"Bo Peng, Xuyu Xiang, Han Tian, Kaiqiang Xu, Quan Zhuang, Junhui Li, Pengpeng Zhang, Yi Zhu, Min Yang, Jia Liu, Yujun Zhao, Ke Cheng, Yingzi Ming","doi":"10.1080/0886022X.2025.2493231","DOIUrl":"10.1080/0886022X.2025.2493231","url":null,"abstract":"<p><p>Immune monitoring is essential for maintaining immune homeostasis after renal transplantation (RT). Peripheral blood lymphocyte subpopulations (PBLSs) are widely used biomarkers for immune monitoring, yet there is no established standard reference for PBLSs during immune reconstitution post-RT. PBLS data from stable recipients at various time points post-RT were collected. Binary and multiple linear regressions, along with a mixed-effect linear model, were used to analyze the correlations between PBLSs and clinical parameters. Predictive models for PBLS reference values were developed using Gradient Boosting Regressor, and the models' performance was also evaluated in infected recipients. A total of 1,736 tests from 494 stable recipients and 98 tests from 82 infected recipients were included. Age, transplant time, induction therapy, dialysis duration, serum creatinine, albumin, hemoglobin, and immunosuppressant drug concentration were identified as major factors influencing PBLSs. CD4⁺ and CD8⁺ T cells and NK cells increased rapidly, stabilizing within three months post-RT. In contrast, B cells peaked at around two weeks and gradually plateaued after four months. Both static and dynamic predictive models provided accurate reference values for PBLSs at any time post-RT, with the static model showing superior performance in distinguishing stable, infected and sepsis patients. Key factors influencing PBLS reconstitution after RT were identified. The predictive models accurately reflected PBLS reconstitution patterns and provided practical, personalized reference values for PBLSs, contributing to precision-guided care. The study was registered on Chinese Clinical Trial Registry (ChiCTR2300068666).</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2493231"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}