Renal Failure最新文献_第6页

Vitexin enhances mitophagy and improves renal ischemia-reperfusion injury by regulating the p38/MAPK pathway.

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-02-17 DOI: 10.1080/0886022X.2025.2463572

Jianan Chen, Chaowei Chen, Chang Lv, Runtao Feng, Weibo Zhong, Yongguang Liu, Song Zhou, Ming Zhao

{"title":"Vitexin enhances mitophagy and improves renal ischemia-reperfusion injury by regulating the p38/MAPK pathway.","authors":"Jianan Chen, Chaowei Chen, Chang Lv, Runtao Feng, Weibo Zhong, Yongguang Liu, Song Zhou, Ming Zhao","doi":"10.1080/0886022X.2025.2463572","DOIUrl":"10.1080/0886022X.2025.2463572","url":null,"abstract":"Vitexin (VI) is a naturally occurring flavonoid derived from the leaves and seeds of Vitex, recognized for its strong antioxidant properties. This study aims to explore its effects on renal ischemia-reperfusion injury (IRI) and investigate the underlying mechanisms. We utilized hypoxia-reoxygenation (H/R) models with HK-2 cell lines and renal ischemia-reperfusion (I/R) models in mice, applying vitexin preconditioning to assess its influence on renal IRI. Our findings reveal that vitexin mitigated oxidative stress, decreased cell apoptosis, and reduced the expression of renal damage indicators such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL), along with an overall improvement in renal function. To further investigate the mechanism, we used network pharmacology and molecular docking techniques to predict potential vitexin targets in renal IRI. Results from Western blotting and immunofluorescence assays indicate that vitexin may promote mitophagy by suppressing the phosphorylation of the pivotal p38 protein in the p38/MAPK signaling pathway, offering protection against renal IRI. The findings indicate that vitexin could potentially be used as a therapeutic agent to alleviate renal IRI.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2463572"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Public interest in chronic kidney disease and dialysis: a 20-year data analysis.

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-02-17 DOI: 10.1080/0886022X.2025.2462253

Jose Arriola-Montenegro, Wisit Cheungpasitporn, Charat Thongprayoon, Iasmina M Craici, Jing Miao

{"title":"Public interest in chronic kidney disease and dialysis: a 20-year data analysis.","authors":"Jose Arriola-Montenegro, Wisit Cheungpasitporn, Charat Thongprayoon, Iasmina M Craici, Jing Miao","doi":"10.1080/0886022X.2025.2462253","DOIUrl":"10.1080/0886022X.2025.2462253","url":null,"abstract":"Chronic kidney disease (CKD) is a growing global health challenge. As the disease progresses, it can lead to end-stage renal disease, necessitating dialysis or kidney transplantation. However, access to these life-saving treatments is often limited by geographic, financial, and resource constraints, underscoring the importance of public awareness and interest. This study examined global and U.S. search trends related to CKD and dialysis using Google Trends™ data from 2004 to 2024. Public search activity was measured using the Relative Search Interest (RSI) index, which ranges from 0 to 100. Both CKD and dialysis exhibited an upward trend in search activity worldwide and in the U.S., as indicated by a positive slope in linear regression analysis (all p < .0001), though some fluctuations and regional differences were observed. Pearson's correlation analysis demonstrated a strong relationship between the U.S. dialysis RSI scores from Google Trends and real-world dialysis incidence rates from the United States Renal Data System (USRDS) (r = 0.961, p < .0001). Notably, in 2020, search activity for both CKD and dialysis declined, likely due to disruptions caused by the COVID-19 pandemic. The study highlights the potential of Google Trends as a valuable tool for assessing public interest and awareness of kidney health, providing insights that can inform public health strategies and educational initiatives. However, relying solely on Google Trends data to assess public interest is insufficient, due to inherent limitations and biases. Findings derived from search trends should be interpreted with caution and ideally supplemented with additional research methodologies.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2462253"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary habits and risk of diabetic kidney disease: a two-sample and multivariate Mendelian randomization study. 饮食习惯与糖尿病肾病风险：一项双样本和多变量孟德尔随机研究。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-03-12 DOI: 10.1080/0886022X.2024.2438848

Ziqi Zhang, Jieyu Niu, Wenhao Sun, Yuqing Sun, Ying Tan, Jiangyi Yu

{"title":"Dietary habits and risk of diabetic kidney disease: a two-sample and multivariate Mendelian randomization study.","authors":"Ziqi Zhang, Jieyu Niu, Wenhao Sun, Yuqing Sun, Ying Tan, Jiangyi Yu","doi":"10.1080/0886022X.2024.2438848","DOIUrl":"10.1080/0886022X.2024.2438848","url":null,"abstract":"Objective: We explored the causal relationship between certain dietary habits and the risk of developing diabetic kidney disease (DKD) using two-sample Mendelian randomization and multivariate Mendelian randomization.Research design and methods: This study is based on pooled data from a genome-wide association study (GWAS) of 83 dietary habits in a European population. We performed a two-sample Mendelian randomization analysis using GAWS data on diabetic nephropathy in a European population. Validation was then performed against positive results (p < 0.05) in different GAWS data on diabetic nephropathy of European origin. Finally, multivariate Mendelian randomization analyses were performed on dietary habits with positive results (p < 0.05) in both datasets and GWAS data on postprandial glucose in the European population.Results: This study showed causal relationships between 18 dietary habits and the risk of developing DKD. After validation, causal relationships were found between the risk of DKD and two dietary habits: abstaining from sugar consumption (OR 2.86; 95%CI 1.35, 6.08; p = 0.006) and consuming whole grain/multigrain bread (OR 0.53; 95%CI 0.32, 0.89; p = 0.016). Correcting for the effect of postprandial glucose, the multivariate MR results showed that never eating sugar increased the risk of developing DKD (OR 0.08; 95%CI 0.018, 0.36; p = 0.001), whereas eating whole grain/multigrain bread did not reduce the risk of developing DKD (OR 1.37; 95%CI 0.55, 3.41; p = 0.50).Conclusions: Our MR results suggest a causal relationship between never eating sugar and an increased risk of developing DKD. Therefore, people with diabetes need a reasonable range of sugar intake.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2438848"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corticosteroid and immunosuppressive treatment are effective for acquired pure red cell aplasia in chronic kidney disease: a case report and literature review. 皮质类固醇和免疫抑制治疗对慢性肾病获得性纯红细胞发育不全是有效的：一个病例描述和文献复习。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-06 DOI: 10.1080/0886022X.2024.2449202

Hongsha Yang, Yurong Zou, Guisen Li, Yunlin Feng

引用次数: 0

Letter to the editor: "Association of Geriatric Nutritional Risk Index with short-term mortality in patients with severe acute kidney injury: retrospective cohort study". 致编辑的信：“严重急性肾损伤患者的老年营养风险指数与短期死亡率的关系：回顾性队列研究”。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-08 DOI: 10.1080/0886022X.2024.2448575

Mariana Dias Pais, Sílvia Coelho

引用次数: 0

Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis.

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-26 DOI: 10.1080/0886022X.2025.2456690

Dan-Dan Yao, Xiao-Wei Yan, Yan Zhou, Zuo-Lin Li, Fang-Xin Qiu

{"title":"Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis.","authors":"Dan-Dan Yao, Xiao-Wei Yan, Yan Zhou, Zuo-Lin Li, Fang-Xin Qiu","doi":"10.1080/0886022X.2025.2456690","DOIUrl":"10.1080/0886022X.2025.2456690","url":null,"abstract":"Background: Vascular calcification is common and progressive in patients with chronic kidney disease. However, the risk factors associated with the progression of vascular calcification in patients receiving maintenance dialysis have not been fully elucidated. Here, we aimed to evaluate vascular calcification and identify the factors associated with its progression in patients receiving maintenance hemodialysis.Methods: This is a prospective longitudinal study that included 374 patients receiving maintenance hemodialysis. The participants received assessments of coronary artery calcification (CAC) and abdominal aortic calcification (AAC), as measured by computed tomography. After the baseline investigation, a 2 years follow-up was performed. We also detected the markers of endothelial injury [E-selectin and soluble intercellular adhesion molecule-1 (sICAM-1)]. Finally, the risk factors affecting the CAC and AAC progression were examined by multivariate logistic regression analysis.Results: Among 374 patients, the median [interquartile range (IQR)] age was 54.0 (40.0-62.0) years; 59.9% of patients were male. The median (IQR) follow-up time was 1.9 (1.8-2.0) years for all patients. By the end of 2-year follow-up, progression of vascular calcification (including CAC and AAC) was observed in 58.0% of patients. Further, compared with the patients without progression of vascular calcification, the endothelial injury (including E-selectin and sICAM-1) of patients with progression of vascular calcification was markedly enhanced. Moreover, after adjustment for the confounders, endothelial injury was a risk factor for the progression of vascular calcification.Conclusion: The present study indicated that endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance hemodialysis.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2456690"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bibliometric study and visual analysis of postoperative diabetes mellitus in kidney transplant recipients based on WoSCC database. 基于 WoSCC 数据库的肾移植受者术后糖尿病文献计量研究和可视化分析。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-13 DOI: 10.1080/0886022X.2024.2444383

Minhua Qiu, Sheng Chen, Jibing Chen, Hongjun Gao

{"title":"Bibliometric study and visual analysis of postoperative diabetes mellitus in kidney transplant recipients based on WoSCC database.","authors":"Minhua Qiu, Sheng Chen, Jibing Chen, Hongjun Gao","doi":"10.1080/0886022X.2024.2444383","DOIUrl":"10.1080/0886022X.2024.2444383","url":null,"abstract":"Background: In recent years, the increase of the post-transplantation diabetes mellitus (PTDM) after renal transplantation encourages people to do a lot of research on the disease. This paper conducted a bibliometric study on PTDM related literature to explore the risk factors of diabetes after kidney transplantation, as well as the current status, hotspots and development trends of PTDM research, so as to provide reference for researchers in related fields.Methods: We searched the Web of Science Core Collection (WoSCC) database for PTDM literature from January 1, 1990, to August 20, 2023, and used VOSviewer, CiteSpace, and the R package 'bibliometrix' to do bibliometric analysis.Results: Obesity, 3 months after transplantation tacrolimus concentration >10 ng/mL, temporary hyperglycemia, delayed graft function, acute rejection is specific risk factors related to PTDM in renal transplant recipients. In addition, 74 countries led by China and the United States published 1546 papers, and the number of PTDM-related publications is increasing every year. Primary institutions included the University of California, Los Angeles, Mayo Clinic, University of Oslo, and University of Toronto. The Journal of Transplantation is the most widely read journal in the subject. The authors with the most published literature are Trond Jenssen and Adnan Sharif, and the most cited author is Kasiske BL. Expectations for continued growth in global PTDM research are increasingly high. Future studies will mainly focus on exploring the risk factors of PTDM and identifying new therapeutic approaches and targets.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2444383"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age, creatinine, and ejection fraction score is a risk factor for acute kidney injury after surgical aortic valve replacement. 年龄、肌酐和射血分数评分是手术主动脉瓣置换术后急性肾损伤的风险因素。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-13 DOI: 10.1080/0886022X.2024.2444401

Tingting Wu, Rui Li, Jing Chen, Xiaqiu Tian, Ran Zhang, Xiaotong Hou

{"title":"Age, creatinine, and ejection fraction score is a risk factor for acute kidney injury after surgical aortic valve replacement.","authors":"Tingting Wu, Rui Li, Jing Chen, Xiaqiu Tian, Ran Zhang, Xiaotong Hou","doi":"10.1080/0886022X.2024.2444401","DOIUrl":"10.1080/0886022X.2024.2444401","url":null,"abstract":"Background: The incidence of acute kidney injury (AKI) increases after surgical aortic valve replacement (SAVR). This study aimed to characterize the risk factors of AKI after SAVR.Methods and results: We conducted a retrospective registry study based on data from 299 consecutive patients undergoing SAVR. At 48 h after SAVR, 41 patients developed AKI. There was a significantly higher prevalence of older age, higher body mass index (BMI), and diabetes mellitus in the AKI group. Previous use of angiotensin-converting enzyme inhibitors/angiotensin receptor blocker (ACEI/ARB) and β-blocker, intake and output volumes within 24 h, mechanical ventilation time, length of intensive care unit and hospital stay, baseline creatinine, baseline, 24 h, and 48 h estimated glomerular filtration rate were strongly associated with the incidence of AKI. BMI >24, history of hypertension, use of ACEI/ARB and β-blocker, and mechanical ventilation time were associated with AKI. Univariate logistic regression indicated that overweight, hypertension, use of ACEI/ARB and β-blocker, and mechanical ventilation time were associated with AKI. Notably, the ACEF score was an independent predictor of AKI. The receiver operating characteristic curve was employed to assess the ACEF score for predicting AKI and the best cutoff was 1.1. After dividing ACEF into quartiles, each one-unit increment in ACEF led to a 2.27-fold risk in the incidence of AKI among patients.Conclusions: AKI is a generalizable phenomenon occurring frequently after SAVR. The ACEF score is an independent predictor of AKI among patients undergoing SAVR.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2444401"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the connection between triglyceride-glucose (TyG) index and the risk of acute kidney injury in septic patients - a retrospective analysis utilizing the MIMIC-IV database. 调查甘油三酯-葡萄糖（TyG）指数与脓毒症患者急性肾损伤风险之间的关系-利用MIMIC-IV数据库的回顾性分析

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-06 DOI: 10.1080/0886022X.2024.2449199

Pirun Zhang, Wenli Zhang, Yan Han, Tong Yang, Jiayi Zhong, Han Yun, Lai Fang

{"title":"Investigation of the connection between triglyceride-glucose (TyG) index and the risk of acute kidney injury in septic patients - a retrospective analysis utilizing the MIMIC-IV database.","authors":"Pirun Zhang, Wenli Zhang, Yan Han, Tong Yang, Jiayi Zhong, Han Yun, Lai Fang","doi":"10.1080/0886022X.2024.2449199","DOIUrl":"10.1080/0886022X.2024.2449199","url":null,"abstract":"The TyG index serves as a valuable tool for evaluating insulin resistance. An elevated TyG has shown a strong association with the occurrence of acute kidney injury (AKI). Nevertheless, existing literature does not address the relationship between the TyG index and acute kidney injury in patients with sepsis. Sepsis patients were identified from the MIMIC-IV database and categorized into four groups according to quadrilles of their TyG index values. The primary outcome of this study was the incidence of AKI. The relationship between the TyG index and the risk of AKI in septic patients was evaluated using Cox proportional hazards and restricted cubic spline models. Subgroup analyses were conducted to investigate the prognostic value of the TyG index in different subgroups. A total of 2,616 patients with sepsis (57% of whom were male) were included in this study. The incidence of AKI was found to be 78%. Cox proportional hazards analysis revealed a significant correlation between the TyG index and the occurrence of AKI in septic patients. Furthermore, a restricted cubic spline model revealed an approximately linear relationship between a higher TyG index and an elevated risk of AKI in septic patients. The trend of the hazard ratio (HR) remained consistent across various subgroups. These findings emphasize the reliability of the TyG index as an independent predictor for the occurrence of AKI and unfavorable renal outcomes in sepsis patients. Nevertheless, establishing a causal relationship between the two requires demonstration through larger prospective studies.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2449199"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mean arterial pressure at the initiation of continuous renal replacement therapy as a prognostic indicator in patients with acute kidney injury. 持续肾替代治疗开始时的平均动脉压作为急性肾损伤患者的预后指标。

IF 3 3区医学

Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-01-06 DOI: 10.1080/0886022X.2024.2448582

Haiying Song, Yuheng Liao, Haofei Hu, Qijun Wan

{"title":"Mean arterial pressure at the initiation of continuous renal replacement therapy as a prognostic indicator in patients with acute kidney injury.","authors":"Haiying Song, Yuheng Liao, Haofei Hu, Qijun Wan","doi":"10.1080/0886022X.2024.2448582","DOIUrl":"10.1080/0886022X.2024.2448582","url":null,"abstract":"Background: Acute kidney injury (AKI) is a common complication in critically ill patients, with approximately 5% requiring continuous renal replacement therapy (CRRT). This study investigated the relationship between mean arterial pressure (MAP) and 28- and 90-day mortality in critically ill AKI patients treated with CRRT.Methods: This secondary analysis of a bicenter, retrospective, observational study included patients with AKI who were treated with CRRT from January 2009 to September 2016. Mortality at 28 and 90 days post-CRRT initiation was analyzed using multivariate regression, generalized additive models, smooth curve fitting, and sensitivity analyses.Results: A total of 1,142 patients were included, with 28-day and 90-day mortality rates of 62.1% and 71.8%, respectively. In multivariable-adjusted Cox models, MAP was inversely correlated with the risk of 28-day and 90-day mortality after adjusting for covariates. Hazard ratios (HRs) were calculated per 1 mmHg increment of MAP: adjusted HR for 28-day mortality 0.985 (p < 0.00001) and for 90-day mortality 0.987 (p = 0.00002). The adjusted HRs for 28-day and 90-day mortality in patients in the highest tertile of MAP compared with those in the lowest tertile were 0.682 (95% CI 0.543-0.857) and 0.730 (95% CI 0.592-0.899), respectively. Patients were grouped using MAP thresholds of <65 mmHg, 65-71.85 mmHg, and ≥71.85 mmHg, with similar results observed. Sensitivity analyses confirmed the inverse relationship between higher MAP before CRRT and lower mortality.Conclusion: The higher the MAP before CRRT is, the lower the 28- and 90-day mortality of critically ill patients with AKI who are treated with CRRT.","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2448582"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142962431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0