Renal Failure最新文献

{"title":"Prediction of peripheral blood lymphocyte subpopulations after renal transplantation.","authors":"Bo Peng, Xuyu Xiang, Han Tian, Kaiqiang Xu, Quan Zhuang, Junhui Li, Pengpeng Zhang, Yi Zhu, Min Yang, Jia Liu, Yujun Zhao, Ke Cheng, Yingzi Ming","doi":"10.1080/0886022X.2025.2493231","DOIUrl":"10.1080/0886022X.2025.2493231","url":null,"abstract":"<p><p>Immune monitoring is essential for maintaining immune homeostasis after renal transplantation (RT). Peripheral blood lymphocyte subpopulations (PBLSs) are widely used biomarkers for immune monitoring, yet there is no established standard reference for PBLSs during immune reconstitution post-RT. PBLS data from stable recipients at various time points post-RT were collected. Binary and multiple linear regressions, along with a mixed-effect linear model, were used to analyze the correlations between PBLSs and clinical parameters. Predictive models for PBLS reference values were developed using Gradient Boosting Regressor, and the models' performance was also evaluated in infected recipients. A total of 1,736 tests from 494 stable recipients and 98 tests from 82 infected recipients were included. Age, transplant time, induction therapy, dialysis duration, serum creatinine, albumin, hemoglobin, and immunosuppressant drug concentration were identified as major factors influencing PBLSs. CD4⁺ and CD8⁺ T cells and NK cells increased rapidly, stabilizing within three months post-RT. In contrast, B cells peaked at around two weeks and gradually plateaued after four months. Both static and dynamic predictive models provided accurate reference values for PBLSs at any time post-RT, with the static model showing superior performance in distinguishing stable, infected and sepsis patients. Key factors influencing PBLS reconstitution after RT were identified. The predictive models accurately reflected PBLS reconstitution patterns and provided practical, personalized reference values for PBLSs, contributing to precision-guided care. The study was registered on Chinese Clinical Trial Registry (ChiCTR2300068666).</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2493231"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between body mass index and mortality in diabetic patients with end-stage renal disease is different in hemodialysis and peritoneal dialysis.","authors":"Hanri Afghahi, Salmir Nasic, Johan Svensson, Helena Rydell, Anna Wärme, Björn Peters","doi":"10.1080/0886022X.2025.2510549","DOIUrl":"10.1080/0886022X.2025.2510549","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>There are diverse results in terms of the association between body mass index (BMI) and mortality risk in patients with end-stage renal disease (ESRD). The aim was to examine if there is an association between BMI and the risk of all-cause mortality in patients with diabetes mellitus (DM) and ESRD on hemodialysis (HD) or peritoneal dialysis (PD).</p><p><strong>Methods: </strong>Included were 3,235 patients (mean age 66 ± 14 years, 66% men) with DM on dialysis treatment (2,452 HD, 783 PD) that were followed for 3.9 ± 3.5 years. BMI was calculated as weight (kg)/[height (m)]² and defined as the mean BMI value during the study period. Relationships between BMI and all-cause mortality were examined by Cox-models to estimate hazard ratios (HR) and 95% confidence intervals (CI) in univariate and multivariate analyses adjusted for demographics, laboratory findings and comorbidity. BMI between 18.5 and 25 kg/m² was used as the reference group.</p><p><strong>Results: </strong>During the study, 1,688 (53%) patients died (1,275 on HD, 413 on PD). In multivariate analyses, patients on HD with BMI ≤ 18.5 kg/m² had an increased risk of all-cause mortality (HR1.94, CI 1.47-2.54). In contrast, mortality risk was decreased in the BMI groups of 25.1-30 kg/m² (HR0.84, CI0.73-0.96), 30.1-35 kg/m² (HR0.66, CI0.55-0.78), and 35.1-40 kg/m² (HR0.65, CI0.49-0.85). In multivariate analyses, no associations between BMI and mortality risk were found in patients on PD.</p><p><strong>Conclusion: </strong>An increased risk of mortality in underweight DM patients on HD was found. Overweight, class 1 and class 2 obesity were associated with better survival in HD.</p><p><strong>Key learning points: </strong>The association between BMI and risk of mortality is different in patients with DM on maintenance HD or PD.</p><p><strong>What was known (maximum 50 words): </strong>The association between BMI and risk of mortality in ESRD population on dialysis treatment is very divers and different study have shown different results.</p><p><strong>This study adds (maximum 50 words): </strong>High BMI associated with better survival in patients with diabetes and HD but this finding did not observed with PD.</p><p><strong>Potential impact (on practice or understanding, maximum 50 words): </strong>The importance to examine time-varying BMI frequently as independent covariance in patients with dialysis treatment.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2510549"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hidden danger: prolonged exposure to inorganic contaminants and kidney health in adolescents.","authors":"Xiaoran Xue, Zaiqiu Zhang, Marady Hun, Min Wen, Mingyi Zhao, Qingnan He","doi":"10.1080/0886022X.2025.2506818","DOIUrl":"10.1080/0886022X.2025.2506818","url":null,"abstract":"<p><p>Research on the impact of prolonged exposure to inorganic contaminants, such as perchlorate, nitrate, and thiocyanate (PNT), on the kidney health of individuals in the 12 ∼ 19 age range is lacking. We analyzed data from the United States National Health and Nutrition Examination Survey (NHANES) over the period 2005-2016 to investigate the linear relationship between chronic kidney disease (CKD)-related parameters and PNT exposure levels, and to explore population heterogeneity from multiple aspects. Weighted multiple regression analysis estimated the independent associations between water or urine exposure indicators and CKD-related parameters. We utilized stratified subgroup analysis and smooth linear fitting as supplements. Lower estimated glomerular filtration rate (eGFR) (non- or new-creatinine (CR)-adjusted), albumin-to-creatinine ratio (ACR), and blood urea nitrogen (BUN) were associated with urine PNT exposure. Water exposure may not be the primary source of PNT exposure. Females had a stronger negative association between nitrate and eGFR after non- or new-CR adjustment. With the most demographic heterogeneity, perchlorate affected eGFR, ACR, and BUN. Our findings associated urinary PNT exposure with altered renal parameters (eGFR, ACR, BUN) in adolescents aged 12-19, suggesting potential environmental health implications that warrant further investigation.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2506818"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12123952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding 'the association between nutritional-inflammatory status and chronic kidney disease prognosis: a population-based study'.","authors":"Ailing Chen, Ningxu Li","doi":"10.1080/0886022X.2025.2508292","DOIUrl":"10.1080/0886022X.2025.2508292","url":null,"abstract":"","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2508292"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of acute kidney injury in Mexico; a systematic review and meta-analysis of pre-pandemic reports.","authors":"Jose J Zaragoza, Jonathan S Chavez-Iñiguez, Armando Vazquez-Rangel","doi":"10.1080/0886022X.2024.2449573","DOIUrl":"10.1080/0886022X.2024.2449573","url":null,"abstract":"<p><strong>Background: </strong>Acute Kidney Injury (AKI) is a health problem worldwide, accounting for high hospital morbidity and mortality. There is little available information regarding the characteristics and incidence of AKI in Latin America (LA), especially in Mexico.</p><p><strong>Objectives: </strong>Systematically search the literature and perform a meta-analysis of the epidemiology of AKI in Mexico, to provide data on AKI and kidney replacement therapy (KRT) that would contribute to general knowledge in this matter.</p><p><strong>Methods: </strong>We performed a systematic search for articles in pediatric and adult patients admitted to the general ward, Emergency Room or Intensive Care Unit published between January 1, 2000, and September 30, 2024. MEDLINE LILIACS, EMBASE and SciELO were searched, as additional reports from supplements, abstracts, and conference sessions. We performed a random-effects meta-analysis for clinically and methodologically comparable studies to estimate the frequency of AKI and KRT. We calculated pooled estimates stratified by age group, year of publication, and setting.</p><p><strong>Results: </strong>83 full-text articles were included. The percentage of AKI was calculated at 35% (95% CI, 28-42). Mortality for AKI adult patients was 36% (95% CI, 28-45). An overall KRT rate was 7% (95% CI, 6-9), all-cause mortality for AKI requiring KRT was 49% (95% CI, 42-56), with a global Ι2 estimated in 99.87% (<i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>AKI is common in Mexico and remains a main public health problem that needs to be addressed at every level of care. Efforts should be made to reinitiate AKI research and control in Mexico and LA.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2449573"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent hyperparathyroidism after kidney transplantation in children.","authors":"Peong Gang Park, Ahram Han, Yo Han Ahn, Sangil Min, Jongwon Ha, Hee Gyung Kang, Hyun Kyung Lee","doi":"10.1080/0886022X.2025.2511279","DOIUrl":"10.1080/0886022X.2025.2511279","url":null,"abstract":"<p><strong>Background: </strong>Persistent hyperparathyroidism after kidney transplantation (KT) has been reported in up to 50% of adult recipients, but pediatric data remain limited. We evaluated the prevalence, skeletal manifestations, and risk factors for persistent hyperparathyroidism in children following KT.</p><p><strong>Methods: </strong>In this retrospective cohort study, 107 pediatric KT recipients (58% male; median age 10.3 years) transplanted between 2004 and 2019 were analyzed. Persistent hyperparathyroidism was defined as a median parathyroid hormone (PTH) > 65 pg/mL between 3 and 12 months post-KT. Risk factors for persistent hyperparathyroidism, post KT clinical features, and treatment status were analyzed.</p><p><strong>Results: </strong>Thirty-six patients (33.6%) had persistent hyperparathyroidism after KT. On univariable analysis, dialysis duration of 24 months or longer (<i>p</i> = 0.028) and pretransplant hyperphosphatemia (<i>p</i> = 0.026) were significantly associated with persistent hyperparathyroidism. The multivariable model identified pretransplant hyperphosphatemia as an independent predictor (OR 2.70, 95% CI 1.10-6.87; <i>p</i> = 0.030). There was no significant difference in height Z score change between patients with and without persistent hyperparathyroidism (<i>p</i> = 0.97). However, persistent hyperparathyroidism was associated with poorer graft survival (log-rank <i>p</i> = 0.049). Six patients received cinacalcet and one underwent subtotal parathyroidectomy for refractory hypercalcemia.</p><p><strong>Conclusions: </strong>Persistent hyperparathyroidism is relatively common in pediatric KT recipients, affecting one-third of patients by one-year post-transplant. Prolonged dialysis and pre-existing hyperphosphatemia before KT may be risk factors. These findings underscore the importance of optimizing chronic kidney disease-mineral bone disease management and routine PTH monitoring before and after transplant in children.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2511279"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Lyn tyrosine kinase and renal injury in patients with systemic lupus erythematosus.","authors":"Jian Sun, Yihong Gu, Wei Lin, Linjuan Luo, Wei Li, Jinrong He, Zishun Zhan, Juan Tang","doi":"10.1080/0886022X.2025.2515532","DOIUrl":"10.1080/0886022X.2025.2515532","url":null,"abstract":"<p><strong>Background: </strong>To investigate protein kinase Lyn expression in patients with systemic lupus erythematosus (SLE) or lupus nephritis (LN) and its association with clinical markers.</p><p><strong>Methods: </strong>Sixty-one inpatients with SLE were categorized into low SLE Disease Activity Index (SLEDAI) group (SLEDAI < 6, <i>n</i> = 32) and high SLEDAI group (SLEDAI ≥ 6, <i>n</i> = 29). Thirty volunteers served as healthy controls (HC). SLE patients were further divided into non-LN (<i>n</i> = 31) and LN (<i>n</i> = 30) groups. Lyn mRNA and protein levels in peripheral blood mononuclear cells (PBMCs) were analyzed and correlations between Lyn expression and SLEDAI, clinical parameters were examined. Renal biopsies from LN (<i>n</i> = 24) were collected for immunohistochemical analysis of Lyn level.</p><p><strong>Results: </strong>Compared to the HC group, SLE patients exhibited a decline in both Lyn mRNA and protein expression in PBMCs, with significant downregulation in the high SLEDAI group versus the low SLEDAI group and a notable reduction in the LN group relative to the non-LN group. Lyn levels negatively correlated with SLEDAI and 24-hour urine protein (24h-U-pro) while positively correlated with serum C3, C4, hemoglobin, and albumin. Multiple linear regression indicated an independent association between Lyn mRNA and SLEDAI. ROC curve analysis suggested Lyn as a reliable predictor for SLE, LN, and lupus activity, with histopathological examination revealing that decreased Lyn expression correlated negatively with the renal pathology index (<i>r</i> = -0.8016, <i>p</i> = 0.0016).</p><p><strong>Conclusions: </strong>The protein kinase Lyn was inversely associated with disease activity, albuminuria level and renal pathology activity in SLE and may be a promising biomarker for assessing LN disease activity.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2515532"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smurf2 knockdown attenuates the progression of diabetic nephropathy by inhibiting mesangial cell proliferation and fibrosis through suppressing EYA2 ubiquitination.","authors":"Lizhen Chen, Yuqing Chen, Fei Liu, Yinhao Liu","doi":"10.1080/0886022X.2025.2520904","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2520904","url":null,"abstract":"<p><p>Diabetic nephropathy (DN) is a serious microvascular complication of diabetes and the main cause of end-stage renal disease. Smurf2 is a member of ubiquitin ligases. In this study, we aimed to investigate the mechanism by which Smurf2 mediated the development of DN. C57BL/6 mice were intraperitoneally injected into streptozotocin to construct a DN mouse model, and mouse mesangial cells (MCs) were treated with high glucose (HG) to establish a cell model. A cell counting kit 8, EDU staining and Western blot assay were performed to assess cell proliferation and fibrosis. The interaction between Smurf2 and EYA2 was identified by immunoprecipitation, and the ubiquitination of EYA2 was detected by Western blot. In addition, the kidney injury of DN mice was evaluated by hematoxylin-eosin and Masson staining and the detection of biochemical parameters. Results suggested that Smurf2 expression was increased in DN mouse model and HG-treated MCs; Smurf2 knockdown inhibited cell proliferation and fibrosis in HG-treated MCs. Mechanically, Smurf2 knockdown inhibited the ubiquitination on EYA2, leading to the suppression of EYA2 degradation and an upregulation in EYA2 protein levels. Moreover, EYA2 knockdown restored cell proliferation and fibrosis in HG-treated MCs inhibited by Smurf2 knockdown. Additionally, Smurf2 knockdown inhibited kidney injury and fibrosis in DN mouse model. In conclusion, we demonstrated that Smurf2 knockdown attenuated the progression of DN by inhibiting MCs proliferation and fibrosis through suppressing EYA2 ubiquitination, which may provide a novel insight into the pathogenesis of DN.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2520904"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationships between gut microbiota and IgA nephropathy: evidence from Mendelian randomization and microbiome validation.","authors":"Xin Wang, Jiong Liu, Wuda Huoshen, Jing Liu, Xue Qiao, Hong Zhang, Xu-Jie Zhou","doi":"10.1080/0886022X.2025.2522979","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2522979","url":null,"abstract":"<p><strong>Background: </strong>Emerging evidence links gut microbiota strongly with IgA Nephropathy (IgAN). However, the causal role of specific gut microbiota in IgAN remains unclear. This study used a two-sample Mendelian randomization (MR) approach, validated with 16S rRNA datasets, to identify these causal relationships.</p><p><strong>Methods: </strong>We performed MR analysis using genetic instruments for 412 gut microbiota taxa from genome-wide association studies (GWAS) as exposures and IgAN GWAS data as outcomes. The inverse-variance weighted method was used as the primary analysis, supplemented by MR-Egger regression, weighted median methods, and Cochran's Q test to assess pleiotropy and heterogeneity. Significant findings were validated using reverse, multivariable, and mediation MR analyses. Results were validated using genus-level 16S rRNA datasets with batch correction (ConQuR), and microbial function was inferred <i>via</i> PICRUSt2.</p><p><strong>Results: </strong>Three gut microbiota species were protective against IgAN: <i>s_Alistipes_senegalensis</i> (OR = 0.64, <i>p</i> = .002), <i>s_Ruminococcus_bromii</i> (OR = 0.75, <i>p</i> = .040), and <i>s_Bilophila_unclassified</i> (OR = 0.68, <i>p</i> = .040). Six species were associated with increased IgAN risk, including <i>g_Barnesiella</i> (OR = 1.32, <i>p</i> = .030) and <i>s_Rothia_mucilaginosa</i> (OR = 1.52, <i>p</i> = .040). After multiple-testing correction, significant associations persisted for <i>s_Alistipes_senegalensis</i> (<i>p</i> = .043), <i>s_Bacteroides_clarus</i> (<i>p</i> = .035), and <i>s_Bilophila_unclassified</i> (<i>p</i> = .002). Sensitivity analyses confirmed robust results without pleiotropy or heterogeneity. Genus-level validation confirmed consistent microbial shifts. Functional predictions showed upregulation of carbohydrate/fatty acid metabolism and downregulation of the urea cycle.</p><p><strong>Conclusions: </strong>This study reveals specific gut microbes and metabolic pathways potentially driving IgAN, offering novel biomarkers and therapeutic targets for microbiome-based interventions.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2522979"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variations in acute kidney injury incidence and outcomes: a multicenter prospective observational study highlighting socioeconomic disparities.","authors":"Ali AlSahow, Omar Alkandari, Naser AlSabti, Bassam AlHelal, Anas AlYousef, Heba AlRajab, Ahmed AlQallaf, Yousif Bahbahani, Monther AlSharekh, Abdulrahman AlKandari, Gamal Nessim, Bassem Mashal, Ahmad Mazroue, Alaa Abdelmoteleb, Mohamed Saad, Ali Abdelzaher, Emad Abdallah, Mohamed Abdellatif, Ziad ElHusseini, Ahmed Abdelrady","doi":"10.1080/0886022X.2025.2520421","DOIUrl":"https://doi.org/10.1080/0886022X.2025.2520421","url":null,"abstract":"<p><strong>Background: </strong>Kuwait experiences cool winters and hot summers. We evaluated the impact of ambient temperature in these two seasons on acute kidney injury (AKI) incidence and outcomes, and assessed difference between Kuwaitis and non-Kuwaitis.</p><p><strong>Method: </strong>Clinical and 30-day outcome data from AKI patients who were admitted to seven public hospitals during winter and summer of 2021 were prospectively collected.</p><p><strong>Results: </strong>Total number of AKI cases during both seasons was 1,493. Incidence was same in both seasons (50.0% each). Kuwaitis accounted for 56.7% of cases. Most AKI cases for Kuwaitis occurred in winter (52.4%), while most for non-Kuwaitis occurred in summer (53.2%). AKI patients in winter were significantly older (64.8 vs. 62.0 years, <i>p</i> = 0.001), had lower baseline eGFR (57.7 vs. 69.4 mL/min/1.73 m², <i>p</i> < 0.001), and had more cardiovascular (60.1% vs. 50.6%, <i>p</i> < 0.001), and chronic kidney diseases (59.3% vs. 43.6%, <i>p</i> < 0.001). Fluid utilization was higher in summer (83.1% vs. 75.3%, <i>p</i> < 0.001). No difference in mechanical ventilation and dialysis reported. Dialysis utilized slightly more frequently in summer (24.8% vs. 27.3%, <i>p</i> = 0.6), with significantly higher dialysis utilization for non-Kuwaitis in summer (30.6% vs. 23.0% for Kuwaitis, <i>p</i> < 0.001). Mortality rate was 26.1%, and complete kidney recovery occurred in 56.1% of cases with no difference between groups.</p><p><strong>Conclusion: </strong>No seasonal variations in AKI incidence, dialysis need, or mortality rate. In winter, AKI occurred more in older with more comorbidities among Kuwaitis but better socioeconomically, while in summer, AKI occurred more in younger, healthier non-Kuwaitis but socioeconomically disadvantaged.</p>","PeriodicalId":20839,"journal":{"name":"Renal Failure","volume":"47 1","pages":"2520421"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}