发布求助
文献互助 智能选刊 最新文献

Radiobiologiia最新文献

筛选
英文 中文
[Expression of ORIGIN-like sequence in mammalian cells]. ORIGIN-like序列在哺乳动物细胞中的表达
Radiobiologiia Pub Date : 1992-11-01
L T Timchenko, V O Fomin, I V Pravosudov, L A Noskin
{"title":"[Expression of ORIGIN-like sequence in mammalian cells].","authors":"L T Timchenko,&nbsp;V O Fomin,&nbsp;I V Pravosudov,&nbsp;L A Noskin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There are some genes whose expression increases in non-proliferating hepatocytes after whole-body X-irradiation. We suppose that some of them participate in cell division regulation. To verify our postulate we have studied expression of autonomously replicating sequence pDARC1 in normal, irradiated and dividing rat hepatocytes. We have succeeded earlier in cloning the autonomously replicating sequence pDARC1 and have shown that it could be transcribed in X-irradiated hepatocytes. Here we report on the results of analysis of this sequence expression in dividing mammalian cells. Hybridization with the pDARC1 sequence reveals 4.0 kb mRNA in non-proliferating rat hepatocytes after X-irradiation: this mRNA is absent in normal hepatocytes. Induction of 4.0 kb mRNA is a function of radiation dose; 4.0 kb mRNA content is maximum 6-24 h following whole-body 6 Gy X-irradiation. The 4.0 kb mRNA is also found in dividing rat hepatocytes during the pre-replicative period.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12665066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cyclic nucleotides in rat tissues under long-term irradiation]. [长期照射下大鼠组织中的环核苷酸]。
Radiobiologiia Pub Date : 1992-11-01
E I Kisel'gof, V B Shorokhova
{"title":"[Cyclic nucleotides in rat tissues under long-term irradiation].","authors":"E I Kisel'gof,&nbsp;V B Shorokhova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Considerable changes in concentrations of cAMP and cGMP and in the CAMPOcGMP ratio were found in the thymus and blood plasma of rats subjected to long-term irradiation at cumulative doses of 10 to 20 Gy. This might be a manifestation of adaptation reactions that develop in response to the effect of ionizing radiation.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12510666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Significance of ED50 and therapeutic indexes of various radiation-protective agent groups]. [各防护剂组ED50及治疗指标的意义]。
Radiobiologiia Pub Date : 1992-11-01
V I Kulinskiĭ, V Iu Kovtun, A D Klimova, V G Iashunskiĭ
{"title":"[Significance of ED50 and therapeutic indexes of various radiation-protective agent groups].","authors":"V I Kulinskiĭ,&nbsp;V Iu Kovtun,&nbsp;A D Klimova,&nbsp;V G Iashunskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Radioprotective agents are divided in 3 groups: (1) cystamine, AET, cystaphos, gammaphos, and thiogammaphos with ED50 (the dose that gives a half of the maximal protective effect) of 10(3)-10(1.6) mumol/kg and therapeutic index K = LD50/ED50 = 10(0)-10(1.6); (2) 5-methoxytryptamine, phenylephrine, serotonin, and norepinephrine with ED50 = 10(1)-10(0) mumol/kg and K = 10(1.8)-10(2,6); (3) clonidine and isoprenaline with ED50 = 10(-0.5)-10(-0.8) mumol/kg and K = 10(3)-10(4). Possible causes of these differences and advantages of low ED50 and high K are discussed.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12509994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Early changes in intracellular ATP concentration after 5 Gy irradiation by routine regimen and regimen modified by low doses (0.1+4.9 Gy)]. [常规方案和低剂量方案(0.1+4.9 Gy) 5 Gy照射后细胞内ATP浓度的早期变化]。
Radiobiologiia Pub Date : 1992-11-01
V A Andrushkevich, G S Kalendo
{"title":"[Early changes in intracellular ATP concentration after 5 Gy irradiation by routine regimen and regimen modified by low doses (0.1+4.9 Gy)].","authors":"V A Andrushkevich,&nbsp;G S Kalendo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Comparative studies were made of immediate (within the first minutes) changes in intracellular ATP concentration after irradiation by different regimens. ATP concentration in cells at a stationary phase of growth increased immediately after irradiation with a dose of 5 Gy, reaching its maximum within 30-40 min. Irradiation with the same total dose, by the regimen of 0.1 + 4.9 Gy at a 3-minute interval between the doses, did not cause alterations in the ATP content in cells. It is concluded that the absence of the increase in the parameter under study (ATP) after irradiation by the latter regimen indicates that preirradiation at a dose of 0.1 Gy inhibits the adequate development of an early response to irradiation with a dose of 4.9 Gy.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Isoenzyme spectrum of lactate dehydrogenase, malate dehydrogenase, esterase and acid phosphatase of rat brain cells at different times after external 1 Gy gamma irradiation]. [外照射1 Gy γ后不同时间大鼠脑细胞乳酸脱氢酶、苹果酸脱氢酶、酯酶和酸性磷酸酶同工酶谱]。
Radiobiologiia Pub Date : 1992-11-01
P P Chaialo, A F Protas
{"title":"[Isoenzyme spectrum of lactate dehydrogenase, malate dehydrogenase, esterase and acid phosphatase of rat brain cells at different times after external 1 Gy gamma irradiation].","authors":"P P Chaialo,&nbsp;A F Protas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The influence of external single gamma-irradiation with a dose of 1 Gy on the isoenzyme composition of lactate dehydrogenase, malate dehydrogenase, esterase and acid phosphatase in the cytoplasm of rat brain cells has been investigated. Irradiation was shown to cause differently directed changes in the ratio of the isoenzymes under study at different times after exposure. The isoenzyme spectrum of lactate dehydrogenase and malate dehydrogenase was shown to be normalized on day 30 after irradiation, whereas the isoform composition of esterase and acid phosphatase was not stabilized at that time.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12665071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of chronic gamma irradiation on the activity of adenylate cyclase in rat lung tissue]. 慢性γ辐射对大鼠肺组织腺苷酸环化酶活性的影响。
Radiobiologiia Pub Date : 1992-11-01
L V Slozhenikina, V P Krymskaia, L A Fialkovskaia, A M Kuzin
{"title":"[Effects of chronic gamma irradiation on the activity of adenylate cyclase in rat lung tissue].","authors":"L V Slozhenikina,&nbsp;V P Krymskaia,&nbsp;L A Fialkovskaia,&nbsp;A M Kuzin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Different phase changes were observed in adenylate cyclase (AC) activity of pulmonary tissue plasma membranes under chronic gamma-irradiation of rats at a dose-rate of 12.9 cGy/day. Comparison of AC basal activity with the data reported earlier on changes in ornithine decarboxylase activity under similar radiation conditions showed unidirectional changes which indicated that cAMP-dependent processes were possibly involved in radiation modification of ornithine decarboxylase.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparative analysis of mechanisms of the modification of microorganism viability under the effect of UHF heating and hyperthermia]. [超高频加热与热疗作用下微生物活力改变机理的对比分析]。
Radiobiologiia Pub Date : 1992-11-01
T N Kuchma, E D Alipov, I I Samoĭlenko, V N Lystsov
{"title":"[Comparative analysis of mechanisms of the modification of microorganism viability under the effect of UHF heating and hyperthermia].","authors":"T N Kuchma,&nbsp;E D Alipov,&nbsp;I I Samoĭlenko,&nbsp;V N Lystsov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In experiments with models of isogenic Escherichia coli strains, a comparative study was made of the effect of SHF of electromagnetic field and hyperthermia. The survival rate of bacteria was determined and, simultaneously, injuries to genetic supramolecular structures were registered through measuring the anomalous time dependence of cell lysate viscosity. The combined effects of the mixture of these factors with H2O2 microconcentrations were studied. The differences observed in their realization were attributed to the different mechanisms of action of these factors on the repair enzyme systems of the studied cells. It has been found that the effect of microwaves on microorganisms causes much severer damages to DNA that hyperthermia does.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Characteristics of the effect of irradiation at different dose rates on survival, death kinetics and response of critical systems of the C57Bl/6 mice]. [不同剂量率辐照对C57Bl/6小鼠生存、死亡动力学及关键系统反应的影响特点]。
Radiobiologiia Pub Date : 1992-11-01
E I Tolstykh, V S Korytnyĭ
{"title":"[Characteristics of the effect of irradiation at different dose rates on survival, death kinetics and response of critical systems of the C57Bl/6 mice].","authors":"E I Tolstykh,&nbsp;V S Korytnyĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A comparison was made of the biological effect on mice of irradiation at different dose rates (70, 5.5 and 1.5 cGy/min) with equally effective, with respect to lethality, doses, or with physically equal doses within the range from 1/4 of LD50/30 to LD99-95/30. Equally effective, with respect to lethality, doses caused similar changes in the intestinal epithelium and in the haemopoietic system. The death rate kinetics was identical with doses of LD80-95/30 within the dose-rate range under study. The equally effective doses caused injuries, different in degrees, to critical systems, including CFUs.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12665068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Choice of quantitative characteristics of a radiation modifier affinity and the range of its pharmacological action (minireview)]. [选择辐射调节剂亲和力的定量特征及其药理作用范围(迷你综述)]。
Radiobiologiia Pub Date : 1992-11-01
V I Kulinskiĭ, V Iu Kovtun
{"title":"[Choice of quantitative characteristics of a radiation modifier affinity and the range of its pharmacological action (minireview)].","authors":"V I Kulinskiĭ,&nbsp;V Iu Kovtun","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>On the basis of the literature the necessity of using not only DMF and maximal protective or sensitizing effects, but also the affinity and the range of the pharmacological action of radiation modifiers is argued. The affinity is worth while to expressed as ED50 (the dose that produces a half of the maximal effect), and the range of the pharmacological action as a therapeutic index K = LD50/ED50.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Identification of a multihit model for nonhomogeneous cell population]. [非均匀细胞群的多命中模型的鉴定]。
Radiobiologiia Pub Date : 1992-11-01
L V Pavlova, L G Khanin, A Iu Iakovlev
{"title":"[Identification of a multihit model for nonhomogeneous cell population].","authors":"L V Pavlova,&nbsp;L G Khanin,&nbsp;A Iu Iakovlev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A generalized multihit-multitarget model for a nonhomogeneous, with respect to radiosensitivity, population of irradiated cells is presented. The least squares and the maximum likelihood estimation of the model parameters is given. The estimates quality is evaluated by the computer-based study. The results obtained show the possibility of the parametric identification of cell radiosensitivity distribution according to the \"dose-response\" data.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12665067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信