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[Effects of single gamma-irradiation on the activity of ornithine decarboxylase in the thymus and pulmonary tissue]. [单次γ辐照对胸腺和肺组织鸟氨酸脱羧酶活性的影响]。
Radiobiologiia Pub Date : 1992-11-01
L V Slozhenikina, L A Fialkovskaia
{"title":"[Effects of single gamma-irradiation on the activity of ornithine decarboxylase in the thymus and pulmonary tissue].","authors":"L V Slozhenikina,&nbsp;L A Fialkovskaia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In studying the dose (0.1-6 Gy) and time (2 h to 180 days) dependence of ornithine decarboxylase activity, it was found that deviations from the control were more pronounced in the thymus than in the pulmonary tissue. The radiation effect was a function of dose and time after irradiation. A nonmonotonous type of the dose-response curve was observed 7 days after irradiation: the radiation effect with a low dose (0.1 Gy) was opposite to that with sublethal doses (1-6 Gy).</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12665069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Radiosensitivity of cells-precursors of hemopoietic stroma (CFU-F) in the rat bone marrow under the effect of 60Co gamma irradiation in various conditions]. [不同条件下60Co γ射线照射下大鼠骨髓造血基质细胞前体(CFU-F)的放射敏感性]。
Radiobiologiia Pub Date : 1992-11-01
A I Kolesnikova, S Sh Kal'sina, A G Konopliannikov, L A Lepekhina
{"title":"[Radiosensitivity of cells-precursors of hemopoietic stroma (CFU-F) in the rat bone marrow under the effect of 60Co gamma irradiation in various conditions].","authors":"A I Kolesnikova,&nbsp;S Sh Kal'sina,&nbsp;A G Konopliannikov,&nbsp;L A Lepekhina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Conditions have been developed for cloning cells-precursors of rat bone marrow haemopoietic stroma, that form in culture dense and sparse fibroblast colonies (CFU-F) at a plating efficiency of 10(-4). Radiosensitivity of rat bone marrow CFU-F, with 60Co-gamma-irradiation in vitro, is characterized by the values of Do and n of 1.87 Gy and 1.4 respectively for all clones; 0.65 Gy and 6.7 for dense clones, and 4.27 Gy and 1.0 for sparse clones. This confirms the observed heterogeneity of CFU-F population consisting of highly radiosensitive and radioresistant subpopulations. The parameters of rat bone marrow CFU-F are nearly the same with irradiation both in vivo and in vitro; with in situ irradiation, the oxygen effect comes into play in a radiosensitive subpopulation of CFU-F; the OER values are 1.6, 2.6 and 0.9 for all, dense and sparse clones respectively.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of a medium pH on the ability of Chinese hamster cells to repair radiation injuries]. [培养基pH对中国仓鼠细胞修复辐射损伤能力的影响]。
Radiobiologiia Pub Date : 1992-11-01
N L Shmakova, T A Fadeeva, T E Fomenkova
{"title":"[Effects of a medium pH on the ability of Chinese hamster cells to repair radiation injuries].","authors":"N L Shmakova,&nbsp;T A Fadeeva,&nbsp;T E Fomenkova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In experiments with Chinese hamster cells at exponential and stationary growth phases, it has been shown that the postirradiation incubation of irradiated cells in a medium with low pH (up to 6.0) promotes the recovery of cells from potentially lethal damages; it has also been found that the recovery from sublethal radiation damages does not depend on the medium pH. The long-term incubation of nonirradiated cells with low pHc causes death of part of cells.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Does ionizing radiation induce an adaptive response in mouse L5178Y lymphoma cells?]. 电离辐射能否诱导小鼠L5178Y淋巴瘤细胞的适应性反应?
Radiobiologiia Pub Date : 1992-11-01
G G Afanas'ev, S Zagurski, I Burachevska, I Shumel'
{"title":"[Does ionizing radiation induce an adaptive response in mouse L5178Y lymphoma cells?].","authors":"G G Afanas'ev,&nbsp;S Zagurski,&nbsp;I Burachevska,&nbsp;I Shumel'","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Growth kinetics of LY-S and LY-R cells (radiosensitive and radioresistant sublines of murine lymphoma L5178Y) has been investigated after beta-irradiation at cumulative doses of 1.5 to 20 cGy and dose rates of 0.8-10 mGy/h. It has been found that after 48 h culture in a complete medium the number of cells differed 5 times, whereas after X- and gamma-irradiation, Do values differed 1.62 times. Using the growth rate as the end point in evaluating the combined effect of beta-irradiation (10 cGy) and subsequent X-irradiation with lethal doses, we observed an increased relative cell number, in comparison to that after X-irradiation alone (an \"adaptive response\", using this criterion), in LY-S cells irradiated with a dose of 2 Gy. In contrast, when reproductive death of LY-S and LY-R cells the end-point analyzed, the lethal effect of consecutive beta- and X-irradiation in LY-S cells was higher than that expected for X-radiation alone (the synergistic effect).</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Postradiation recovery of hemopoietic and stromal precursor cells in mice preinjected with prodigiozan]. [注射神童肽后小鼠造血细胞和间质前体细胞的恢复]。
Radiobiologiia Pub Date : 1992-11-01
B B Moroz, V G Lebedev, O O Romashko, N A Levina
{"title":"[Postradiation recovery of hemopoietic and stromal precursor cells in mice preinjected with prodigiozan].","authors":"B B Moroz,&nbsp;V G Lebedev,&nbsp;O O Romashko,&nbsp;N A Levina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Injection of prodigiozan to mice 24 h before irradiation caused, by the time of the radiation effect, a decrease in the number of haemopoietic cells-precursors (CFUs and CFU-HM) in the bone marrow and an increase in the functional activity of stromal cell-precursors--the haemopoietic microenvironment of transfer units (HMTU); in the spleen, the number of CFUs decreased, but the number of CFU-HM increased considerably. During the postirradiation period, the haemopoietic and stromal precursors were damaged to a lesser extent, and CFUs, CFU-HM and HMTU recovered more readily in prodigiozan-protected animals than in unprotected mice; the HMTU restoration preceded the increase in CFUs and CFU-HM levels.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of dalargin on reparative processes in skin and muscle wounds of irradiated animals]. [dalargin对辐照动物皮肤和肌肉损伤修复过程的影响]。
Radiobiologiia Pub Date : 1992-11-01
V I Legeza, L I Konovalova, S N Marochkin
{"title":"[Effects of dalargin on reparative processes in skin and muscle wounds of irradiated animals].","authors":"V I Legeza,&nbsp;L I Konovalova,&nbsp;S N Marochkin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of fungal mycelium extracts on 137Cs accumulation in human embryo cells]. [真菌菌丝提取物对人胚胎细胞137Cs积累的影响]。
Radiobiologiia Pub Date : 1992-11-01
Iu M Leont'ev, A N Kapich, E F Konoplia
{"title":"[Effects of fungal mycelium extracts on 137Cs accumulation in human embryo cells].","authors":"Iu M Leont'ev,&nbsp;A N Kapich,&nbsp;E F Konoplia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The method is proposed for primary evaluation of the ability of drugs of various genesis to affect the accumulation of radionuclides in cells. Extracts of mycelium of wood-rotting Basidiomycetes were shown to prevent 137Cs accumulation in cultures of human embryo fibroblast.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Incidence of the development of 90Sr-induced osteosarcomas depending on the age of the animals]. [90sr诱发骨肉瘤的发病率与动物年龄的关系]。
Radiobiologiia Pub Date : 1992-11-01
V L Shvedov, N V Startsev
{"title":"[Incidence of the development of 90Sr-induced osteosarcomas depending on the age of the animals].","authors":"V L Shvedov,&nbsp;N V Startsev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In experiments with albino male rats, a study was made of the influence of age on the incidence of osteosarcomas induced by 90Sr. It was shown that the incidence of tumors decreases exponentially with age.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Individual immunological parameters in clean-up team members and patients with sequelae of acute radiation sickness 5 years after the effects of the Chernobyl accident]. [切尔诺贝利事故影响5年后清理小组成员和急性辐射病后遗症患者的个体免疫参数]。
Radiobiologiia Pub Date : 1992-11-01
A A Iarilin, I M Beliakov, I M Nadezhina, A V Simonova
{"title":"[Individual immunological parameters in clean-up team members and patients with sequelae of acute radiation sickness 5 years after the effects of the Chernobyl accident].","authors":"A A Iarilin,&nbsp;I M Beliakov,&nbsp;I M Nadezhina,&nbsp;A V Simonova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A study was made of deviations, beyond 1 sigma and 1.5 sigma of a mean value (M) of a donor group, in individual immunological parameters (for instance, the number of CD5+, CD2+, CD4+, CD8+, CD25+ and B-cells; alpha 1-thymosin concentration; and autoantibody titers to antigens of epithelial reticulum cell cytoplasm) in patients suffered acute radiation sickness (ARS) and liquidators of Chernobyl NPP accident. The radiation damage to the immune system was reliably detected in the affected subjects examined: they exhibited a decrease in the alpha 1-thymosin level below M = -1.5 sigma and in absolute B cellularity below M = -1 sigma; and increase in the number of CD25+ cells and in the level of serum autoantibodies to antigens of thymus epithelial reticulum cell cytoplasm. When several parameters selected were examined simultaneously the frequency of recording the deviations in merely one of them markedly increased.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12665065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The mechanism of action of low doses of gamma radiation connected with the development of human cell resistance to mutagens]. [低剂量伽马辐射与人类细胞对诱变剂产生抗性的作用机制]。
Radiobiologiia Pub Date : 1992-11-01
T A Sinel'shchikova, G D Zasukhina
{"title":"[The mechanism of action of low doses of gamma radiation connected with the development of human cell resistance to mutagens].","authors":"T A Sinel'shchikova,&nbsp;G D Zasukhina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The human fibroblasts were gamma-irradiated with low doses (0.07-0.21 Gy). After a short time interval (3 h), a study was made of the postirradiation viability of cells (by the trypan blue dye exclusion method); post-N-methyl-N'-nitro-nitrosoguanidine-DNA synthesis (by 3H-thymidine incorporation immediately after the mutagen treatment) and postirradiation induction of DNA single-strand breaks (by alkaline elution of cells lysed on the membrane filters). The preirradiation of cells with low doses of gamma-rays was shown to render the cells resistance to induction of DNA breaks by the following exposure to gamma-radiation. The survival rate increased; DNA synthesis was resistant to alkylation damage in these cells, as compared to nonirradiated cells.</p>","PeriodicalId":20808,"journal":{"name":"Radiobiologiia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12663505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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