[选择辐射调节剂亲和力的定量特征及其药理作用范围(迷你综述)]。

Radiobiologiia Pub Date : 1992-11-01
V I Kulinskiĭ, V Iu Kovtun
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引用次数: 0

摘要

在文献的基础上,讨论了使用DMF和最大保护或致敏作用的必要性,以及辐射调节剂的亲和力和药理作用范围。亲和性值得用ED50(产生最大作用的一半的剂量)表示,药理学作用范围作为治疗指标K = LD50/ED50。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Choice of quantitative characteristics of a radiation modifier affinity and the range of its pharmacological action (minireview)].

On the basis of the literature the necessity of using not only DMF and maximal protective or sensitizing effects, but also the affinity and the range of the pharmacological action of radiation modifiers is argued. The affinity is worth while to expressed as ED50 (the dose that produces a half of the maximal effect), and the range of the pharmacological action as a therapeutic index K = LD50/ED50.

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