[各防护剂组ED50及治疗指标的意义]。

Radiobiologiia Pub Date : 1992-11-01
V I Kulinskiĭ, V Iu Kovtun, A D Klimova, V G Iashunskiĭ
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引用次数: 0

摘要

放射防护剂分为3组:(1)半胱胺、AET、半胱胺、γ -磷和硫-磷,ED50(最大保护作用的一半剂量)为10(3)-10(1.6)μ mol/kg,治疗指数K = LD50/ED50 = 10(0)-10(1.6);(2) 5-甲氧基色胺、苯肾上腺素、血清素和去甲肾上腺素,ED50 = 10(1)-10(0) mumol/kg, K = 10(1.8)-10(2,6);(3)可乐定和异丙肾上腺素,ED50 = 10(-0.5)-10(-0.8) μ mol/kg, K = 10(3)-10(4)。讨论了产生这些差异的可能原因以及低ED50和高K的优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Significance of ED50 and therapeutic indexes of various radiation-protective agent groups].

Radioprotective agents are divided in 3 groups: (1) cystamine, AET, cystaphos, gammaphos, and thiogammaphos with ED50 (the dose that gives a half of the maximal protective effect) of 10(3)-10(1.6) mumol/kg and therapeutic index K = LD50/ED50 = 10(0)-10(1.6); (2) 5-methoxytryptamine, phenylephrine, serotonin, and norepinephrine with ED50 = 10(1)-10(0) mumol/kg and K = 10(1.8)-10(2,6); (3) clonidine and isoprenaline with ED50 = 10(-0.5)-10(-0.8) mumol/kg and K = 10(3)-10(4). Possible causes of these differences and advantages of low ED50 and high K are discussed.

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