Psychiatry Research: Neuroimaging最新文献_第8页

Increased extra-neurite conductivity of brain in patients with Alzheimer's disease: A pilot study 阿尔茨海默病患者大脑神经元外传导性增加：一项试点研究

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-05 DOI: 10.1016/j.pscychresns.2024.111807

Seowon Hong , Yunjeong Choi , Mun Bae Lee , Hak Young Rhee , Soonchan Park , Chang-Woo Ryu , Ah Rang Cho , Oh In Kwon , Geon-Ho Jahng

{"title":"Increased extra-neurite conductivity of brain in patients with Alzheimer's disease: A pilot study","authors":"Seowon Hong , Yunjeong Choi , Mun Bae Lee , Hak Young Rhee , Soonchan Park , Chang-Woo Ryu , Ah Rang Cho , Oh In Kwon , Geon-Ho Jahng","doi":"10.1016/j.pscychresns.2024.111807","DOIUrl":"10.1016/j.pscychresns.2024.111807","url":null,"abstract":"<div><p>The objectives of this study were to investigate how the extra-neurite conductivity (EC) and intra-neurite conductivity (IC) were reflected in Alzheimer's disease (AD) patients compared with old cognitively normal (CN) people and patients with amnestic mild cognitive impairment (MCI) and to evaluate the association between those conductivity values and cognitive decline. To do this, high-frequency conductivity (HFC) at the Larmor frequency was obtained using MRI-based electrical property tomography (MREPT) and was decomposed into EC and IC using information of multi-shell multi-gradient direction diffusion tensor images. This prospective single-center study included 20 patients with mild or moderate AD, 25 patients with amnestic MCI, and 21 old CN participants. After decomposing EC and IC from HFC for all participants, we performed voxel-based and regions-of-interest analyses to compare conductivity between the three participant groups and to evaluate the association with either age or the Mini-Mental State Examination (MMSE) scores. We found increased EC in AD compared to CN and MCI. EC was significantly negatively associated with MMSE scores in the insula, and middle temporal gyrus. EC might be used as an imaging biomarker for helping to monitor cognitive function.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111807"},"PeriodicalIF":2.3,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0925492724000301/pdfft?md5=518d5f0aa2af288abb6519d574447a97&pid=1-s2.0-S0925492724000301-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140079303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood adversity modulates structural brain changes in borderline personality but not in major depression disorder 童年逆境能调节边缘型人格的大脑结构变化，但不能调节重度抑郁症的大脑结构变化

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-01 DOI: 10.1016/j.pscychresns.2024.111803

Vicente Camacho-Téllez , Mariana N. Castro , Agustina E. Wainsztein , Ximena Goldberg , Gabriela De Pino , Elsa Y. Costanzo , Narcís Cardoner , José M. Menchón , Carles Soriano-Mas , Salvador M. Guinjoan , Mirta F. Villarreal

{"title":"Childhood adversity modulates structural brain changes in borderline personality but not in major depression disorder","authors":"Vicente Camacho-Téllez , Mariana N. Castro , Agustina E. Wainsztein , Ximena Goldberg , Gabriela De Pino , Elsa Y. Costanzo , Narcís Cardoner , José M. Menchón , Carles Soriano-Mas , Salvador M. Guinjoan , Mirta F. Villarreal","doi":"10.1016/j.pscychresns.2024.111803","DOIUrl":"10.1016/j.pscychresns.2024.111803","url":null,"abstract":"<div><p>Adverse childhood experiences (ACEs) negatively affect the function and structure of emotion brain circuits, increasing the risk of various psychiatric disorders. It is unclear if ACEs show disorder specificity with respect to their effects on brain structure. We aimed to investigate whether the structural brain effects of ACEs differ between patients with major depression (MDD) and borderline personality disorder (BPD). These disorders share many symptoms but likely have different etiologies. To achieve our goal, we obtained structural 3T-MRI images from 20 healthy controls (HC), 19 MDD patients, and 18 BPD patients, and measured cortical thickness and subcortical gray matter volumes. We utilized the Adverse Childhood Experiences (ACE) questionnaire to quantify self-reported exposure to childhood trauma. Our findings suggest that individuals with MDD exhibit a smaller cortical thickness when compared to those with BPD. However, ACEs showed a significantly affected relationship with cortical thickness in BPD but not in MDD. ACEs were found to be associated with thinning in cortical regions involved in emotional behavior in BPD, whereas HC showed an opposite association. Our results suggest a potential mechanism of ACE effects on psychopathology involving changes in brain structure. These findings highlight the importance of early detection and intervention strategies.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111803"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140056716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The importance of covert memory consolidation in schizophrenia: Dysfunctional network profiles of the hippocampus and the dorsolateral prefrontal cortex 精神分裂症患者隐蔽记忆巩固的重要性：海马和前额叶皮层背外侧的功能障碍网络概况

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-02-29 DOI: 10.1016/j.pscychresns.2024.111805

Elias A. Samona, Asadur Chowdury, John Kopchick, Patricia Thomas, Usha Rajan, Dalal Khatib, Caroline Zajac-Benitez, Alireza Amirsadri, Luay Haddad, Jeffrey A. Stanley, Vaibhav A. Diwadkar

{"title":"The importance of covert memory consolidation in schizophrenia: Dysfunctional network profiles of the hippocampus and the dorsolateral prefrontal cortex","authors":"Elias A. Samona, Asadur Chowdury, John Kopchick, Patricia Thomas, Usha Rajan, Dalal Khatib, Caroline Zajac-Benitez, Alireza Amirsadri, Luay Haddad, Jeffrey A. Stanley, Vaibhav A. Diwadkar","doi":"10.1016/j.pscychresns.2024.111805","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111805","url":null,"abstract":"<div><p>Altered brain network profiles in schizophrenia (SCZ) during memory consolidation are typically observed during task-<em>active</em> periods such as encoding or retrieval. However active processes are also sub served by <em>covert</em> periods of memory consolidation. These periods <em>are</em> active in that they allow memories to be recapitulated even in the absence of overt sensorimotor processing. It is plausible that regions central to memory formation like the dlPFC and the hippocampus, exert network signatures during covert periods. Are these signatures altered in patients? The question is clinically relevant because real world learning and memory is facilitated by covert processing, and may be impaired in schizophrenia. Here, we compared network signatures of the dlPFC and the hippocampus during covert periods of a learning and memory task. Because behavioral proficiency increased non-linearly, functional connectivity of the dlPFC and hippocampus [psychophysiological interaction (PPI)] was estimated for each of the Early (linear increases in performance) and Late (asymptotic performance) covert periods. During Early periods, we observed hypo-modulation by the hippocampus but hyper-modulation by dlPFC. Conversely, during Late periods, we observed hypo-modulation by <em>both</em> the dlPFC and the hippocampus. We stitch these results into a conceptual model of network deficits during covert periods of memory consolidation.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111805"},"PeriodicalIF":2.3,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in cortical thickness of frontoparietal regions in patients with social anxiety disorder 社交焦虑症患者顶叶前部皮层厚度的变化

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-02-27 DOI: 10.1016/j.pscychresns.2024.111804

Dasom Lee , Ye-Ha Jung , Suhyun Kim , Yoonji Irene Lee , Jeonghun Ku , Uicheul Yoon , Soo-Hee Choi

{"title":"Alterations in cortical thickness of frontoparietal regions in patients with social anxiety disorder","authors":"Dasom Lee , Ye-Ha Jung , Suhyun Kim , Yoonji Irene Lee , Jeonghun Ku , Uicheul Yoon , Soo-Hee Choi","doi":"10.1016/j.pscychresns.2024.111804","DOIUrl":"10.1016/j.pscychresns.2024.111804","url":null,"abstract":"<div><p>Although functional changes of the frontal and (para)limbic area for emotional hyper-reactivity and emotional dysregulation are well documented in social anxiety disorder (SAD), prior studies on structural changes have shown mixed results. This study aimed to identify differences in cortical thickness between SAD and healthy controls (CON). Thirty-five patients with SAD and forty-two matched CON underwent structural magnetic resonance imaging. A vertex-based whole brain and regional analyses were conducted for between-group comparison. The whole-brain analysis revealed increased cortical thickness in the left insula, left superior parietal lobule, left superior temporal gyrus, and left frontopolar cortex in patients with SAD compared to CON, as well as decreased thickness in the left superior/middle frontal gyrus and left fusiform gyrus in patients (after multiple-correction). The results from the ROI analysis did not align with these findings at the statistically significant level after multiple corrections. Changes in cortical thickness were not correlated with social anxiety symptoms. While consistent results were not obtained from different analysis methods, the results from the whole-brain analysis suggest that patients with SAD exhibit distinct neural deficits in areas involved in salience, attention, and socioemotional processing.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111804"},"PeriodicalIF":2.3,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0925492724000271/pdfft?md5=ab9b0776d30778436fce5d637a1a5b7c&pid=1-s2.0-S0925492724000271-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140003347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal functional connectivity of the intrinsic networks in adolescent bipolar I versus bipolar II disorder 青少年双相情感障碍 I 与双相情感障碍 II 的内在网络功能连接异常

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-02-23 DOI: 10.1016/j.pscychresns.2024.111802

Qian Xiao , Gui Zhang , Yuan Zhong

{"title":"Abnormal functional connectivity of the intrinsic networks in adolescent bipolar I versus bipolar II disorder","authors":"Qian Xiao , Gui Zhang , Yuan Zhong","doi":"10.1016/j.pscychresns.2024.111802","DOIUrl":"10.1016/j.pscychresns.2024.111802","url":null,"abstract":"<div><h3>Background</h3><p>The symptoms of pediatric bipolar disorder (PBD)-I and PBD-II differ, but accurate identification at an early stage is difficult and may prevent effective treatment of this disorder. Therefore, it is urgent to elucidate a biological marker based on objective imaging indicators to help distinguish the two. Therefore, this research aims to compare the functional connectivity between PBD-I patient and PBD-II patient in different brain networks.</p></div><div><h3>Methods</h3><p>Our study enrolled 31 PBD-I and 23 PBD-II patients from 12 to 17 years of age. They were analyzed by resting state-functional connectivity through Independent component analysis (ICA).</p></div><div><h3>Results</h3><p>We found differences between PBD-I and PBD-II in functional connectivity of the default network, frontoparietal network, salience network and limbic system. In addition, the clinical features, cognitive functions are associated with the functional connectivity of the intrinsic networks in PBD-I and PBD-II separately.</p></div><div><h3>Conclusion</h3><p>This research is the first to find differences in functional connectivity between PBD-I and PBD-II, suggesting that abnormality of the functional connectivity within large networks may be biomarkers that help differentiate PBD-I from PBD-II in the future.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111802"},"PeriodicalIF":2.3,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139957558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in DTI studies for diagnoses and treatment of obsessive-compulsive disorder 用于诊断和治疗强迫症的 DTI 研究进展

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-02-15 DOI: 10.1016/j.pscychresns.2024.111794

Sadegh Masjoodi , MajidReza Farrokhi , Behrouz Vejdani Afkham , Javad Sheikhi Koohsar

{"title":"Advances in DTI studies for diagnoses and treatment of obsessive-compulsive disorder","authors":"Sadegh Masjoodi , MajidReza Farrokhi , Behrouz Vejdani Afkham , Javad Sheikhi Koohsar","doi":"10.1016/j.pscychresns.2024.111794","DOIUrl":"10.1016/j.pscychresns.2024.111794","url":null,"abstract":"<div><p>This review summarizes the current state of neuroimaging research on obsessive-compulsive disorder (OCD) using diffusion tensor imaging (DTI), which allows for the examination of white matter abnormalities in the brain. DTI studies on individuals with obsessive-compulsive disorder (OCD) consistently demonstrate widespread reductions in white matter integrity in various regions of the brain, including the corpus callosum, anterior and posterior cingulate cortex, and prefrontal cortex, which are involved in emotion regulation, decision-making, and cognitive control. However, the reviewed studies often have small sample sizes, and findings vary between studies, highlighting the need for larger and more standardized studies. Furthermore, discerning between causal and consequential effects of OCD on white matter integrity poses a challenge. Addressing this issue may be facilitated through longitudinal studies, including those evaluating the impact of treatment interventions, to enhance the accuracy of DTI data acquisition and processing, thereby improving the validity and comparability of study outcomes. In summary, DTI studies provide valuable insights into the neural circuits and connectivity disruptions in OCD, and future studies may benefit from standardized data analysis and larger sample sizes to determine whether structural abnormalities could be potential biomarkers for early identification and treatment of OCD.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111794"},"PeriodicalIF":2.3,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139817412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of depression and perceived physical fatigability with white matter integrity in older adults 抑郁和体力疲劳感与老年人白质完整性的关系

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-02-10 DOI: 10.1016/j.pscychresns.2024.111793

Chemin Lin , Fang‐Cheng Yeh , Nancy W. Glynn , Theresa Gmelin , Yi-Chia Wei , Yao-Liang Chen , Chih-Mao Huang , Yu-Chiau Shyu , Chih-Ken Chen

{"title":"Associations of depression and perceived physical fatigability with white matter integrity in older adults","authors":"Chemin Lin , Fang‐Cheng Yeh , Nancy W. Glynn , Theresa Gmelin , Yi-Chia Wei , Yao-Liang Chen , Chih-Mao Huang , Yu-Chiau Shyu , Chih-Ken Chen","doi":"10.1016/j.pscychresns.2024.111793","DOIUrl":"10.1016/j.pscychresns.2024.111793","url":null,"abstract":"<div><h3>Backgrounds</h3><p>Fatigability is prevalent in older adults. However, it is often associated with depressed mood. We aim to investigate these two psychobehavioral constructs by examining their underpinning of white matter structures in the brain and their associations with different medical conditions.</p></div><div><h3>Methods</h3><p>Twenty-seven older adults with late-life depression (LLD) and 34 cognitively normal controls (CN) underwent multi-shell diffusion MRI. Fatigability was measured with the Pittsburgh Fatigability Scale. We examined white matter integrity by measuring the quantitative anisotropy (QA), a fiber tracking parameter with better accuracy than the traditional imaging technique.</p></div><div><h3>Results</h3><p>We found those with LLD had lower QA in the 2nd branch of the left superior longitudinal fasciculus (SLF-II), and those with more physical fatigability had lower QA in more widespread brain regions. In tracts associated with more physical fatigability, the lower QA in left acoustic radiation and left superior thalamic radiation correlated with higher blood glucose (<em>r</em> = - 0.46 and - 0.49). In tracts associated with depression, lower QA in left SLF-II correlated with higher bilirubin level (<em>r</em> = - 0.58).</p></div><div><h3>Discussion</h3><p>Depression and fatigability were associated with various white matter integrity changes, which correlated with biochemistry biomarkers all related to inflammation.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111793"},"PeriodicalIF":2.3,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139883482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transdiagnostic symptom of depression and anxiety associated with reduced gray matter volume in prefrontal cortex 抑郁和焦虑的跨诊断症状与前额叶皮层灰质体积减少有关

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-02-10 DOI: 10.1016/j.pscychresns.2024.111791

Anna C. Cichocki , Richard E. Zinbarg , Michelle G. Craske , Iris K.-Y. Chat , Katherine S. Young , Susan Y. Bookheimer , Robin Nusslock

{"title":"Transdiagnostic symptom of depression and anxiety associated with reduced gray matter volume in prefrontal cortex","authors":"Anna C. Cichocki , Richard E. Zinbarg , Michelle G. Craske , Iris K.-Y. Chat , Katherine S. Young , Susan Y. Bookheimer , Robin Nusslock","doi":"10.1016/j.pscychresns.2024.111791","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111791","url":null,"abstract":"<div><p>Dimensional models of psychopathology may provide insight into mechanisms underlying comorbid depression and anxiety and improve specificity and sensitivity of neuroanatomical findings. The present study is the first to examine neural structure alterations using the empirically derived Tri-level Model. Depression and anxiety symptoms of 269 young adults were assessed using the Tri-level Model dimensions: General Distress (transdiagnostic depression and anxiety symptoms), Anhedonia-Apprehension (relatively specific depression symptoms), and Fears (specific anxiety symptoms). Using structural MRI, gray matter volumes were extracted for emotion generation (amygdala, nucleus accumbens) and regulation (orbitofrontal, ventrolateral, and dorsolateral prefrontal cortex) regions, often implicated in depression and anxiety. Each Tri-level symptom was regressed onto each region of interest, separately, adjusting for relevant covariates. General Distress was significantly associated with smaller gray matter volumes in bilateral orbitofrontal cortex and ventrolateral prefrontal cortex, independent of Anhedonia-Apprehension and Fears symptom dimensions. These results suggests that prefrontal alterations are associated with transdiagnostic dysphoric mood common across depression and anxiety, rather than unique symptoms of these disorders. Additionally, no regions of interest were associated with Anhedonia-Apprehension or Fears, highlighting the importance of studying transdiagnostic features of depression and anxiety. This has implications for understanding mechanisms of and interventions for depression and anxiety.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"339 ","pages":"Article 111791"},"PeriodicalIF":2.3,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139732509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroanatomical comparison of treatment-resistant and treatment-responsive schizophrenia patients using the cloud-based brain magnetic resonance image segmentation and parcellation system: An MRIcloud study 使用基于云的脑磁共振图像分割和解析系统对治疗耐受型和治疗应答型精神分裂症患者进行神经解剖学比较：磁共振成像云研究

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-01-30 DOI: 10.1016/j.pscychresns.2024.111789

Esra Porgalı Zayman , Mehmet Fatih Erbay

{"title":"Neuroanatomical comparison of treatment-resistant and treatment-responsive schizophrenia patients using the cloud-based brain magnetic resonance image segmentation and parcellation system: An MRIcloud study","authors":"Esra Porgalı Zayman , Mehmet Fatih Erbay","doi":"10.1016/j.pscychresns.2024.111789","DOIUrl":"10.1016/j.pscychresns.2024.111789","url":null,"abstract":"<div><p>Recent developments in neuroimaging have improved our understanding of the biological mechanisms underlying schizophrenia. However, neuroimaging findings in treatment-resistant schizophrenia (TRS) remain unclear. In the present study, we aimed to explore potential neuroanatomical regions that may be associated with treatment resistance in schizophrenia patients by comparing neuroanatomical regions of TRS and non-TRS patients using the MRICloud method. A total of 33 schizophrenia patients (meeting DSM 5 diagnostic criteria for schizophrenia) were included in the study. Patients were dichotomized into TRS (<em>n</em> = 18) and non-TRS (<em>n</em> = 15) groups, and all patients underwent MRI. Neuroanatomical regions of TRS and non-TRS patients were compared using the MRICloud method. Disease severity was measured using the Positive and Negative Syndrome Scale (PANSS). Interestingly, a statistically significant greater left Corpus Collosum (CC) thickness was found in TRS patients compared to non-TRS patients. It is clear that further studies comparing TRS patients with non-TRS patients are needed, and these studies should focus on the circuits in the corpus callosum that are thought to play a role in treatment resistance. Further longitudinal studies are also needed to complement the cross-sectional studies, using a multimodal imaging approach in the patients with clearly defined TRS criteria.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"339 ","pages":"Article 111789"},"PeriodicalIF":2.3,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139649044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The contribution of first-episode illness characteristics and cumulative antipsychotic usage to progressive structural brain changes over a long-term follow-up in schizophrenia 精神分裂症患者首次发病特征和累计使用抗精神病药物对长期随访期间大脑结构渐进性变化的影响

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-01-29 DOI: 10.1016/j.pscychresns.2024.111790

Tuomas Konttajärvi , Marianne Haapea , Sanna Huhtaniska , Lassi Björnholm , Jouko Miettunen , Matti Isohanni , Matti Penttilä , Graham K. Murray , Hannu Koponen , Anthony C. Vernon , Erika Jääskeläinen , Johannes Lieslehto

{"title":"The contribution of first-episode illness characteristics and cumulative antipsychotic usage to progressive structural brain changes over a long-term follow-up in schizophrenia","authors":"Tuomas Konttajärvi , Marianne Haapea , Sanna Huhtaniska , Lassi Björnholm , Jouko Miettunen , Matti Isohanni , Matti Penttilä , Graham K. Murray , Hannu Koponen , Anthony C. Vernon , Erika Jääskeläinen , Johannes Lieslehto","doi":"10.1016/j.pscychresns.2024.111790","DOIUrl":"10.1016/j.pscychresns.2024.111790","url":null,"abstract":"<div><p>Exposure to antipsychotics as well as certain first-episode illness characteristics have been associated with greater gray matter (GM) deficits in the early phase of schizophrenia. Whether the first-episode illness characteristics affect the long-term progression of the structural brain changes remain unexplored. We therefore assessed the role of first-episode illness characteristics and life-time antipsychotic use in relation to long-term structural brain GM changes in schizophrenia. Individuals with schizophrenia (SZ, <em>n</em> = 29) and non-psychotic controls (<em>n</em> = 61) from the Northern Finland Birth Cohort 1966 underwent structural MRI at the ages of 34 (baseline) and 43 (follow-up) years. At follow-up, the average duration of illness was 19.8 years. Voxel-based morphometry was used to assess the effects of predictors on longitudinal GM changes in schizophrenia-relevant brain areas. Younger age of onset (AoO), higher cumulative antipsychotic dose and severity of symptoms were associated with greater GM deficits in the SZ group at follow-up. None of the first-episode illness characteristics were associated with longitudinal GM changes during 9-year follow-up period. We conclude that a younger AoO and high life-time antipsychotic use may contribute to progression of structural brain changes in schizophrenia. Apart from AoO, other first-episode illness characteristics may not contribute to longitudinal GM changes in midlife.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"339 ","pages":"Article 111790"},"PeriodicalIF":2.3,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0925492724000131/pdfft?md5=3c1e1df09126ec0211aa8e6e44b2170a&pid=1-s2.0-S0925492724000131-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139592000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0