Psychiatry Research: Neuroimaging最新文献

Test-retest reliability of functional near infrared spectroscopy during tasks of inhibitory control and working memory. 功能近红外光谱在抑制控制和工作记忆任务中的重测信度。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-04-18 DOI: 10.1016/j.pscychresns.2025.111993

Clara Nittel, Daniela Michelle Hohmann, Andreas Jansen, Jens Sommer, Ricarda Krauß, Max Völk, Inge Kamp-Becker, Stefanie Weber, Katja Becker, Sanna Stroth

{"title":"Test-retest reliability of functional near infrared spectroscopy during tasks of inhibitory control and working memory.","authors":"Clara Nittel, Daniela Michelle Hohmann, Andreas Jansen, Jens Sommer, Ricarda Krauß, Max Völk, Inge Kamp-Becker, Stefanie Weber, Katja Becker, Sanna Stroth","doi":"10.1016/j.pscychresns.2025.111993","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2025.111993","url":null,"abstract":"<p><p>Functional near-infrared spectroscopy (fNIRS) has become a well-established tool for neuroscience research and been suggested as a potential biomarker during clinical assessment in individuals with mental disorders. Biomarker need to be objective indications of biological processes which can be measured accurately and reproducibly. Despite various applications in clinical research, test-retest reliability of the fNIRS signal has not yet been evaluated sufficiently. To assess reliability of the fNIRS signal during tasks of executive functions, a group of 34 healthy subjects (13 male, 21 female) were tested twice for inhibitory control and working memory. On a group level results show a specific activation pattern throughout the two sessions, reflecting a task-related frontal network associated with the assessed cognitive functions. On the individual level the retest reliability of the activation patterns were considerably lower and differed strongly between participants. In conclusion, the interpretation of fNIRS signal on a single subject level is partially hampered by its low reliability. More studies are needed to optimize the retest reliability of fNIRS and to be applied on a routine basis in developmental research.</p>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":" ","pages":"111993"},"PeriodicalIF":2.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated multimodal analysis for high-accuracy anxiety disease subtype classification 高精度焦虑症亚型分类的综合多模态分析

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-04-15 DOI: 10.1016/j.pscychresns.2025.111991

Ying Chen , Yibin Tang , Qinghua Ni , Yuan Gao , Chun Wang

{"title":"Integrated multimodal analysis for high-accuracy anxiety disease subtype classification","authors":"Ying Chen , Yibin Tang , Qinghua Ni , Yuan Gao , Chun Wang","doi":"10.1016/j.pscychresns.2025.111991","DOIUrl":"10.1016/j.pscychresns.2025.111991","url":null,"abstract":"<div><div>In this study, we propose a classification method for identifying subtypes of anxiety disorders (AD). A large dataset is built with 108 healthy controls and 179 subjects from four primary AD subtypes: generalized anxiety disorder (GAD), social anxiety disorder (SAD), panic disorder (PD), and specific phobia (SP). We calculate diverse multimodal data, including amplitude of low-frequency fluctuations, regional homogeneity, and voxel-based morphometry, and create brain gradient data to provide a comprehensive representation of these data. For subtype classification, we develop a hierarchical binary hypothesis testing (H-BHT) framework with a two-stage scheme. In the first stage, we use a traditional BHT method to identify AD individuals. In the second stage, we categorize AD subjects into different subtypes under multi-class hypotheses. Our experiments demonstrate that the gradient data outperforms single-modal data in subtype classification, achieving an impressive 97.9% accuracy. When performing a multivariate analysis of variance on the brain regions associated with the discriminative gradient data, it reveals significant biomarkers among the subtypes, including the insula, amygdala, orbital inferior frontal, middle frontal and anterior cingulate gyri. These regions are strongly correlated with emotion control, providing substantial support for the pathogenesis of existing AD subtypes and confirming the validity of our method.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111991"},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different corpus callosum in panic disorder 惊恐障碍的不同胼胝体

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-04-05 DOI: 10.1016/j.pscychresns.2025.111990

Halim Ömer Kaşikci , Sema Baykara , Hale Nur Balci , Murat Baykara

{"title":"Different corpus callosum in panic disorder","authors":"Halim Ömer Kaşikci , Sema Baykara , Hale Nur Balci , Murat Baykara","doi":"10.1016/j.pscychresns.2025.111990","DOIUrl":"10.1016/j.pscychresns.2025.111990","url":null,"abstract":"<div><h3>Background</h3><div>Despite hypotheses regarding the neurobiology of panic disorder (PD), its neurobiological basis is still unknown. Study results support that the individual differences in corpus callosum (CC) properties could reflect trait based alterations that predispose individuals to higher anxiety sensitivity, and to disorders associated with stress such as PD. Neuroimaging studies with panic disorder have not been sufficient to explain the pathophysiology of the disease. The aim of this study is to provide additional information for studies examining the etiology of PD by comparing the corpus callosum, a region associated with attention, anxiety, and somatic complaints, on sagittal MRI images of PD patients with the corpus callosum of healthy individuals.</div></div><div><h3>Methods</h3><div>T2-weighted MRI images of 164 patients diagnosed with PD and 78 controls selected from Hospital Information System (HIS) and meeting the study criteria were evaluated by shape analysis method.</div></div><div><h3>Results</h3><div>There were differences between the shapes and areas of the CC in the mid-sagittal images of the PD patients and healthy controls.</div></div><div><h3>Conclusions</h3><div>This study findings highlighted the variable dimensional and subregional properties of CC in PD patients. This study could shed light on future studies about PD etiology, diagnosis and treatment.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111990"},"PeriodicalIF":2.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How psychostimulant treatment changes the brain morphometry in adults with ADHD: sMRI Comparison study to medication-naïve adults with ADHD 精神兴奋剂治疗如何改变成人多动症患者的大脑形态：sMRI 与药物治疗无效的成人多动症患者对比研究

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-04-04 DOI: 10.1016/j.pscychresns.2025.111992

Sherief Ghozy , Jennifer Meiza , Ahmed Morsy , Sadiq Naveed , Adam A. Dmytriw , Kevin Kallmas , Sara Morsy

{"title":"How psychostimulant treatment changes the brain morphometry in adults with ADHD: sMRI Comparison study to medication-naïve adults with ADHD","authors":"Sherief Ghozy , Jennifer Meiza , Ahmed Morsy , Sadiq Naveed , Adam A. Dmytriw , Kevin Kallmas , Sara Morsy","doi":"10.1016/j.pscychresns.2025.111992","DOIUrl":"10.1016/j.pscychresns.2025.111992","url":null,"abstract":"<div><div>ADHD is increasingly recognised as a cause of functional impairment in adults. Treatment guidelines recommend stimulants as the first-line treatment for adult ADHD, but concerns exist about long-term efficacy and potential tolerance. We investigated the long-term effect of stimulant therapy on brain morphometry in individuals with ADHD.</div><div>We obtained structural MRI data from the UCLA Consortium for Neuropsychiatric Phenomics for 26 adults with ADHD. We compared grey matter volume, cortical thickness, sulcal depth, gyrification index, and fractal dimension between individuals with ADHD who had received psychostimulant treatment and medication naïve. For clinical assessment, we also compared Barratt's impulsivity score, Dickman impulsivity inventory II, and Eysenck's impulsivity inventory and investigated how brain morphometry were associated with these scores</div><div>The treated group exhibited significantly higher values in surface-based metrics (<em>FWE-corrected p-value</em> < 0.05), including gyrification index, sulcal depth, and fractal dimension. There was an increased gyrification observed in the right Rolandic operculum, left supplementary motor area, left superior temporal gyrus, right fusiform gyrus, and left cuneus. Increased sulcal depth was detected in the inferior and superior orbitofrontal regions, while increased fractal dimension was also evident in the left superior orbitofrontal gyrus. Treated group venturesomeness scores positively correlated with the grey matter volume of the right anterior cingulate gyrus and negatively with the right superior occipital gyrus.</div><div>Our results suggest a limited treatment effect on ADHD scores and grey matter volume in adults. Despite significant surface-based metrics, these changes were not accompanied by improvements in the clinical scores.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111992"},"PeriodicalIF":2.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the efficacy and acceptability of non-invasive brain stimulation for generalized anxiety disorder: a systematic review and network meta-analysis 评估无创脑刺激治疗广泛性焦虑障碍的疗效和可接受性：一项系统综述和网络荟萃分析

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-04-04 DOI: 10.1016/j.pscychresns.2025.111989

Nanxue Duan , Yulin Zhang , Shaoyang Wang , Jian Guan , Yang Ji , Wanling Huang , Rui Qian , Hao Zheng , Tongjian Bai , Yanghua Tian

{"title":"Evaluating the efficacy and acceptability of non-invasive brain stimulation for generalized anxiety disorder: a systematic review and network meta-analysis","authors":"Nanxue Duan , Yulin Zhang , Shaoyang Wang , Jian Guan , Yang Ji , Wanling Huang , Rui Qian , Hao Zheng , Tongjian Bai , Yanghua Tian","doi":"10.1016/j.pscychresns.2025.111989","DOIUrl":"10.1016/j.pscychresns.2025.111989","url":null,"abstract":"<div><div>Non-invasive brain stimulation (NIBS) has the potential to treat generalized anxiety disorder (GAD). To assess the efficacy (response/remission/post-treatment continuous anxiety severity scores) and acceptability (failure to complete treatment for any reason) of NIBS, we searched PubMed, Web of Science, and the Cochrane Library (as of April 2024) for articles on NIBS for GAD and conducted a network meta-analysis of eight randomized trials (20 treatment arms, 405 participants). Data were pooled using standardized mean difference (SMD) and odds ratio (OR) with 95 % confidence interval (CI). Repetitive transcranial magnetic stimulation (rTMS) was the most widely studied treatment for GAD. The right dorsolateral prefrontal cortex (DLPFC) was the most common treatment target for GAD. High-frequency rTMS showed higher response rates (OR 291.40, 95 % CI 13.08 to 6490.21) and remission rates (OR 182.14, 95 % CI 8.72 to 3805.76) compared with other active therapies. Continuous theta burst stimulation (cTBS) greatly improved continuous post-treatment anxiety severity scores (SMD -2.56, 95 % CI -3.16 to -1.96). No significant differences in acceptability were found between the treatment strategies and the sham stimulation group. These findings provide evidence to consider NIBS techniques as alternative or adjunctive treatments for GAD.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111989"},"PeriodicalIF":2.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mediating role of the parietal-prefrontal white matter network between trauma experience and anxiety symptoms in individuals with borderline personality disorder: Findings from neuroimaging studies 边缘型人格障碍患者创伤经历和焦虑症状之间顶叶-前额叶白质网络的中介作用：来自神经影像学研究的发现

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-04-02 DOI: 10.1016/j.pscychresns.2025.111987

Piotr Podwalski , Bartosz Dawidowski , Kamil Lipiński , Łukasz Franczak , Patryk Wysocki , Marcin Jabłoński , Adam Jędrzejewski , Piotr Plichta , Ernest Tyburski , Łukasz Zwarzany , Monika Szewczuk-Bogusławska , Błażej Misiak , Wojciech Poncyljusz , Jerzy Samochowiec

{"title":"The mediating role of the parietal-prefrontal white matter network between trauma experience and anxiety symptoms in individuals with borderline personality disorder: Findings from neuroimaging studies","authors":"Piotr Podwalski , Bartosz Dawidowski , Kamil Lipiński , Łukasz Franczak , Patryk Wysocki , Marcin Jabłoński , Adam Jędrzejewski , Piotr Plichta , Ernest Tyburski , Łukasz Zwarzany , Monika Szewczuk-Bogusławska , Błażej Misiak , Wojciech Poncyljusz , Jerzy Samochowiec","doi":"10.1016/j.pscychresns.2025.111987","DOIUrl":"10.1016/j.pscychresns.2025.111987","url":null,"abstract":"<div><h3>Background</h3><div>Borderline personality disorder (BPD) is linked to impairments in white matter (WM) integrity, with traumatic experiences (TE) playing a key role in its development. As TE can affect brain structure, this study examined the parietal-prefrontal WM pathway, focusing on the superior longitudinal fasciculus (SLF), the longest association bundle, to explore WM integrity impairments and their link to BPD symptoms.</div></div><div><h3>Methodology</h3><div>The study included 90 women (47 with BPD, 43 healthy controls). Participants underwent psychopathology assessments and diffusion tensor imaging (DTI) to measure WM integrity. Mean fractional anisotropy (FA) values were calculated for SLF subdivisions (SLF I, II, III). BPD symptoms were evaluated using the Five-Factor Borderline Inventory.</div></div><div><h3>Results</h3><div>Healthy controls showed significantly higher FA in the left SLF I and a trend toward higher FA in the left SLF III compared to BPD. Left SLF I FA mediated the link between trauma (e.g., sexual harassment, emotional/physical abuse) and BPD symptoms (despondence, fragility). Left SLF III FA mediated the relationship between sexual harassment and anxious uncertainty.</div></div><div><h3>Conclusion</h3><div>The SLF mediates the impact of TE on anxiety and depression in BPD, highlighting neurobiological mechanisms and potential research directions.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111987"},"PeriodicalIF":2.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An ERP study on pre-attentive processing of emotional faces in individuals with high social anhedonia 高社交快感缺乏症个体情绪面孔前注意加工的ERP研究

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-03-31 DOI: 10.1016/j.pscychresns.2025.111988

Xin-wei Fu , Juan Yang , Xin-ran Yao , Ya-li Wang , Guo-hui Zhu , Jia-sen Geng , Xue Meng , Wen-ting Hu , Jie Gu , Yi Wang , Yan-yu Wang

{"title":"An ERP study on pre-attentive processing of emotional faces in individuals with high social anhedonia","authors":"Xin-wei Fu , Juan Yang , Xin-ran Yao , Ya-li Wang , Guo-hui Zhu , Jia-sen Geng , Xue Meng , Wen-ting Hu , Jie Gu , Yi Wang , Yan-yu Wang","doi":"10.1016/j.pscychresns.2025.111988","DOIUrl":"10.1016/j.pscychresns.2025.111988","url":null,"abstract":"<div><div>Expression-related visual mismatch negativity (EMMN) is encoded by prediction errors associated with facial emotion changes. Previous studies have shown that patients with psychiatric disorders (e.g., schizophrenia and major depressive disorder) exhibit significantly reduced EMMNs. However, although social anhedonia is recognized as a transdiagnostic feature across psychiatric disorders, it remains unclear whether individuals with high social anhedonia (HSA) also display similar deficits. The present study aimed to explore the pre-attentive processing characteristics of unexpected facial emotions in individuals with HSA. Thirty-one participants with HSA and 31 participants with low social anhedonia (LSA) were recruited. The EMMN components elicited by happy and sad expressions in an oddball-control paradigm were analysed under three different time windows (70–140 ms, 180–270 ms, 280–360 ms) over six regions of interest. In comparison with the LSA group, the EMMN amplitudes elicited by emotional faces were lower in the HSA group in the 280–360 ms time window. In addition, the results showed that the decreased EMMN amplitudes in the 280–360 ms time window were significantly correlated with social anhedonia. Our study indicated decreased EMMN and its close relationship with social anhedonia in individuals with HSA, which promotes a deeper understanding of the psychophysiological mechanism of emotional face processing in individuals with social anhedonia.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111988"},"PeriodicalIF":2.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain activity differences between difficulty in falling asleep and early awakening symptoms in major depressive disorder: A resting-state fMRI study 重度抑郁症入睡困难和早醒症状之间的脑活动差异：静息状态功能磁共振成像研究

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-03-25 DOI: 10.1016/j.pscychresns.2025.111986

Xiaoqin Wang , Rui Yan , Yinghong Huang , Hao Sun , Yi Xia , Zhijian Yao , Qing Lu

{"title":"Brain activity differences between difficulty in falling asleep and early awakening symptoms in major depressive disorder: A resting-state fMRI study","authors":"Xiaoqin Wang , Rui Yan , Yinghong Huang , Hao Sun , Yi Xia , Zhijian Yao , Qing Lu","doi":"10.1016/j.pscychresns.2025.111986","DOIUrl":"10.1016/j.pscychresns.2025.111986","url":null,"abstract":"<div><div>Numerous studies have revealed that patients with major depressive disorder (MDD) suffer from insomnia symptoms. However, the dysfunction pattern in specific insomnia symptoms in patients with MDD remains unclear. The present study aimed to examine the regional brain neuroimaging activity features of difficulty falling asleep (DFA) and early awakening (EA) in patients with MDD. The resting-fMRI by applying the amplitude of low-frequency fluctuation (ALFF) method was estimated in 50 MDD patients with DFA, 36 patients with EA, 46 patients without insomnia symptoms, and 60 matched healthy controls. The Pearson correlation analysis was used among the ALFF with significant difference brain regions, the 17-item Hamilton Depression Rating Scale factor scores, and the Pittsburgh Sleep Quality Index scores. Patients with DFA showed lower ALFF values in the left precentral gyrus than those with EA and higher ALFF values in the left insula than those without insomnia symptoms. Patients with EA showed higher ALFF values in the left precentral gyrus than those without insomnia symptoms. This study revealed distinct neural mechanisms underlying specific insomnia symptoms, identifying the left insula as a potential pathological region in DFA patients and the left precentral gyrus as a characteristic neuropathological region in EA patients.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111986"},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered white matter topological network and cognitive function in patients with major depressive disorder 重度抑郁症患者白质拓扑网络与认知功能的改变

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-03-19 DOI: 10.1016/j.pscychresns.2025.111984

Peiwei Xu , Jing Huang , Xiu Yan , Xueli Sun , Yingying Pan

{"title":"Altered white matter topological network and cognitive function in patients with major depressive disorder","authors":"Peiwei Xu , Jing Huang , Xiu Yan , Xueli Sun , Yingying Pan","doi":"10.1016/j.pscychresns.2025.111984","DOIUrl":"10.1016/j.pscychresns.2025.111984","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to explore the association between cognitive impairment and white matter topological networks in patients with major depressive disorder (MDD).</div></div><div><h3>Methods</h3><div>We enrolled 51 patients diagnosed with MDD and 57 healthy controls for this study. Cognitive function was evaluated using the MATRICS Consensus Cognitive Battery. Diffusion tensor imaging magnetic resonance scans were performed to construct white matter brain networks based on deterministic fiber tracts and we quantified the topological properties of these networks. Then, we investigated the potential association between changes in these network properties and cognitive dysfunction.</div></div><div><h3>Results</h3><div>MDD patients performed significantly worse in all cognitive domains, including speed of processing, attention/vigilance, working memory, verbal learning, visual learning, reasoning and problem solving, and social cognition. In MDD, there was a positive correlation between local efficiency and processing speed, as well as reasoning and problem solving. Additionally, the local efficiency of the right precuneus was positively correlated with verbal learning.</div></div><div><h3>Conclusion</h3><div>Cognitive symptoms in MDD patients may relate to dysfunction in white matter topological network.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111984"},"PeriodicalIF":2.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant information flow within resting-state triple network model in schizophrenia-An EEG effective connectivity study 精神分裂症静息状态三重网络模型中的异常信息流——脑电有效连通性研究

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-03-18 DOI: 10.1016/j.pscychresns.2025.111985

Przemysław Adamczyk , Wiktor Więcławski , Maja Wojcik , Sandra Frycz , Bartłomiej Panek , Martin Jáni , Miroslaw Wyczesany

{"title":"Aberrant information flow within resting-state triple network model in schizophrenia-An EEG effective connectivity study","authors":"Przemysław Adamczyk , Wiktor Więcławski , Maja Wojcik , Sandra Frycz , Bartłomiej Panek , Martin Jáni , Miroslaw Wyczesany","doi":"10.1016/j.pscychresns.2025.111985","DOIUrl":"10.1016/j.pscychresns.2025.111985","url":null,"abstract":"<div><div>Schizophrenia is a psychiatric disorder with heterogeneous clinical manifestations and complex aetiology. Notably, the triple-network model proposes an interesting framework for investigating abnormal neurocircuit activity at rest in schizophrenia.</div><div>The present study on 30 chronic schizophrenia individuals and 30 controls aimed to explore the differences in EEG resting state effective connectivity within a triple-network model using source-localization-based Directed Transfer Function.</div><div>Our findings revealed multiband effective connectivity disturbances within default mode (DMN), central executive (CEN), and salience (SN) networks in schizophrenia. The most significant difference was manifested in a global DMN hyperconnectivity, accompanied by low-band hyperconnectivity and high-band hypoconnectivity in CEN, along with the aberrant information flows in SN.</div><div>In conclusion, our study presents novel insights into schizophrenia neuropathology, with a particular emphasis on the reversed directionality in information flows between hubs of SN, DMN, and CEN. This may be suggested as a promising biomarker of schizophrenia.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111985"},"PeriodicalIF":2.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0