Psychiatry Research: Neuroimaging最新文献

Brain functional network dynamics in women with alleged mediumship: a controlled study 所谓的灵媒女性的脑功能网络动态：一项对照研究。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2026-06-01 Epub Date: 2026-02-02 DOI: 10.1016/j.pscychresns.2026.112164

Jéssica Plácido , Marco Aurélio Vinhosa Bastos Jr. , Paulo Roberto Haidamus de Oliveira Bastos , Thaise G.L. de O. Toutain , José Garcia Vivas Miranda

{"title":"Brain functional network dynamics in women with alleged mediumship: a controlled study","authors":"Jéssica Plácido , Marco Aurélio Vinhosa Bastos Jr. , Paulo Roberto Haidamus de Oliveira Bastos , Thaise G.L. de O. Toutain , José Garcia Vivas Miranda","doi":"10.1016/j.pscychresns.2026.112164","DOIUrl":"10.1016/j.pscychresns.2026.112164","url":null,"abstract":"<div><h3>Introduction</h3><div>The Brain Functional Networks (BFN) approach integrates Electroencephalography, Graph Theory, and Motif Synchronization to identify brain regions that are functionally connected over time, even if spatially distant. This contrasts with previous studies on mediumship.</div></div><div><h3>Objective</h3><div>To analyze BFN topological indices during mediumistic trance.</div></div><div><h3>Method</h3><div>Secondary data collected in Campo Grande, Brazil, were analyzed. Twenty-eight women participated, divided into two groups: Mediums Group (MG, <em>n</em> = 14) and Control Group (CG, <em>n</em> = 14). Both groups performed a pre-trance task (resting condition). MG performed a mediumship trance task, while CG engaged in a prayer task (listening and praying). EEG data were processed to construct networks for Delta, Theta, Alpha, Beta, and all-frequency bands.</div></div><div><h3>Results</h3><div>Significant differences in brain connectivity indices were observed: MG showed changes in delta (<em>p</em> = 0.002), theta (<em>p</em> = 0.006), and alpha (<em>p</em> = 0.035) bands. CG showed changes in the beta band (<em>p</em> = 0.008).</div></div><div><h3>Discussion</h3><div>These results suggest that the tasks influenced brain activity patterns. Mediumistic trance appears to be an altered state of consciousness distinct from sleep.</div></div><div><h3>Conclusion</h3><div>The results reinforce the notion of mediumship as an altered, non-pathological brain state, distinct from schizophrenia and non-dominant temporal lobe syndrome.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"358 ","pages":"Article 112164"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the neuroanatomical underpinnings of complex PTSD in people with psychosis 研究精神病患者复杂创伤后应激障碍的神经解剖学基础。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2026-06-01 Epub Date: 2026-02-20 DOI: 10.1016/j.pscychresns.2026.112182

Peter Panayi , Filippo Varese , Emmanuelle Peters , Richard Bentall , Amy Hardy , Katherine Berry , William Sellwood , Raphael Underwood , Craig Steel , Liam Mason , Rebecca Elliott

{"title":"Investigating the neuroanatomical underpinnings of complex PTSD in people with psychosis","authors":"Peter Panayi , Filippo Varese , Emmanuelle Peters , Richard Bentall , Amy Hardy , Katherine Berry , William Sellwood , Raphael Underwood , Craig Steel , Liam Mason , Rebecca Elliott","doi":"10.1016/j.pscychresns.2026.112182","DOIUrl":"10.1016/j.pscychresns.2026.112182","url":null,"abstract":"<div><div>Childhood maltreatment and complex post-traumatic stress disorder (cPTSD) are common among people with psychosis. Traumatic life experiences may contribute to the neural substrates of psychosis. Affective pathways to psychosis outline the role of post-traumatic sequelae, but no studies have explored the neurobiological underpinnings of cPTSD in this population. We compared two groups meeting criteria for schizophrenia-spectrum disorders, with (<em>n</em> = 58) and without (<em>n</em> = 50) comorbid cPTSD. Region of interest (ROI) analysis was used to assess structural differences in ROIs identified by meta-analyses as overlapping between PTSD and psychosis. The cPTSD group showed enlarged limbic regions, including the bilateral anterior insula and left parahippocampus, and smaller prefrontal regions, including the left medial orbitofrontal cortex (mOFC). In the right mOFC, specific voxel volumes were larger, and others smaller, in the cPTSD group. All differences, aside from hippocampal volume, survived whole-brain analysis corrected for multiple comparisons. Post-hoc analyses indicated trends suggesting bilateral insula and mOFC volume correlated positively, whereas parahippocampal volume correlated negatively, with cPTSD symptom severity. To conclude, in people with comorbid cPTSD and psychosis, post-traumatic sequelae may be underpinned by anatomical differences in regions implicated in emotion regulation, especially the regulation of fear, supporting the neural characterisation of affective psychosis pathways.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"358 ","pages":"Article 112182"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147322090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into changes in glutaminergic metabolites in the anterior cingulate cortex: A systematic review and meta-analysis of magnetic resonance spectroscopy in schizophrenia 对前扣带皮层谷氨酰胺能代谢物变化的见解：精神分裂症磁共振波谱的系统回顾和荟萃分析。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2026-06-01 Epub Date: 2026-02-11 DOI: 10.1016/j.pscychresns.2026.112175

Mercedes Simh-Peh Chan, Pek-Yee Tang, Zhi-Kuan Chua, Wan-Ling Cheong, Siew-Ying Mok

{"title":"Insights into changes in glutaminergic metabolites in the anterior cingulate cortex: A systematic review and meta-analysis of magnetic resonance spectroscopy in schizophrenia","authors":"Mercedes Simh-Peh Chan, Pek-Yee Tang, Zhi-Kuan Chua, Wan-Ling Cheong, Siew-Ying Mok","doi":"10.1016/j.pscychresns.2026.112175","DOIUrl":"10.1016/j.pscychresns.2026.112175","url":null,"abstract":"<div><div>Dysregulation of glutamatergic metabolites—glutamate (GLU), glutamine (GLN), and the combined metabolite glutamine–glutamate (GLX)—has been implicated in schizophrenia, but interpreting these metabolites using magnetic resonance spectroscopy is challenging due to regional brain variation. This systematic review and meta-analysis investigate GLU, GLN, and GLX levels in the anterior cingulate cortex (ACC), a region critical for cognitive and emotional regulation. Database searches identified 51 case-control studies comparing schizophrenia patients to healthy controls. Data were analyzed using random-effects models, pooling Hedges' g effect sizes. Overall, no significant differences in glutamatergic metabolites were found between groups. However, after excluding one study in a leave-one-out analysis, a significant increase in GLX was observed. Subgroup analyses revealed that treatment-resistant schizophrenia (TRS) patients had higher GLU and GLX levels, indicating more pronounced glutamatergic dysregulation in TRS. Higher GLX levels were observed in medicated patients, and removal of the TRS cohort made GLX non-significant and reduced GLU, suggesting these variations were driven by TRS. Further meta-regression showed that GLX variation in TRS was linked to age of onset and disease severity, but not illness duration, pointing to a distinct neurochemical profile. These findings highlight the potential of targeting glutamatergic systems as a therapeutic strategy, particularly for treatment-resistant cases.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"358 ","pages":"Article 112175"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146214114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TMN: Learning multi-timescale functional connectivity for identifying brain disorders TMN：学习多时间尺度功能连接识别大脑疾病

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2026-06-01 Epub Date: 2026-01-30 DOI: 10.1016/j.pscychresns.2026.112156

Jinlong Hu , Jianmiao Luo , Jiatong Huang , Shoubin Dong , Bin Liao

{"title":"TMN: Learning multi-timescale functional connectivity for identifying brain disorders","authors":"Jinlong Hu , Jianmiao Luo , Jiatong Huang , Shoubin Dong , Bin Liao","doi":"10.1016/j.pscychresns.2026.112156","DOIUrl":"10.1016/j.pscychresns.2026.112156","url":null,"abstract":"<div><h3>Background</h3><div>Functional connectivity (FC) has been used to identify brain disorders. The present study aimed to identify brain disorders by FC across multiple timescales.</div></div><div><h3>Methods</h3><div>We first segmented the resting-state fMRI signals to construct multiple timescale functional connectivity (mFC) between brain regions. Next, we developed a deep multiple instance learning (MIL) approach, namely the Two-stage Multi-stream Network (TMN), to capture spatio-temporal patterns from the mFC. We evaluated the TMN in the ABIDE I dataset and the REST-Meta-MDD dataset. Furthermore, we proposed using the inputXgrad to explain the important features in the model.</div></div><div><h3>Results</h3><div>We achieved the best performance using the TMN model with mFC. Our findings indicated that mFC outperformed both static FC and the combination of static and dynamic FC in identification tasks. The model's explanation revealed that FC across all timescales contributed to the identification of brain disorders and highlighted the important FC that are strongly associated with these conditions.</div></div><div><h3>Limitations</h3><div>The techniques used for data preprocessing can influence the model's performance, and this study requires further validation with a larger patient cohort and a broader range of brain disorders.</div></div><div><h3>Conclusions</h3><div>The experimental results demonstrate that brain disorders can be effectively identified using the proposed TMN with mFC.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"358 ","pages":"Article 112156"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The time course of affective processing in anhedonia: Insights from event-related potentials 快感缺乏症中情感加工的时间过程：来自事件相关电位的见解。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2026-06-01 Epub Date: 2026-02-18 DOI: 10.1016/j.pscychresns.2026.112177

Valentina Mologni , Carola Dell'Acqua , Roza Mejza , Simone Messerotti Benvenuti

{"title":"The time course of affective processing in anhedonia: Insights from event-related potentials","authors":"Valentina Mologni , Carola Dell'Acqua , Roza Mejza , Simone Messerotti Benvenuti","doi":"10.1016/j.pscychresns.2026.112177","DOIUrl":"10.1016/j.pscychresns.2026.112177","url":null,"abstract":"<div><div>Anhedonia, defined as a diminished capacity to experience pleasure from appetitive stimuli, is a core symptom of depression and a predisposing factor for its development. Prior research links anhedonia with blunted emotional processing of appetitive stimuli. Yet, emotional processing encompasses multiple stages (cue engagement, affective anticipation, and elaboration), and how each stage relates to anhedonia remains unclear. This study examined these associations in a sample of university students (<em>n</em> = 45, 31 females) with varying levels of anhedonia. Participants underwent electroencephalography recording during an S1-S2 paradigm, in which a cue (S1) anticipated the valence (pleasant, neutral, unpleasant) of an upcoming emotional image (S2). Three event-related potentials (ERPs) were assessed: the Cue-P300 (reflecting cue evaluation and engagement), the Stimulus Preceding Negativity (SPN; reflecting affective anticipation), and the Late Positive Potential (LPP; reflecting affective elaboration). While the LPP was larger for emotional vs. neutral images, the Cue-P300 and the SPN were more pronounced for pleasant (but not unpleasant) vs. neutral stimuli. Notably, anhedonia, independent of other depressive symptoms, was associated with an increased SPN and a blunted LPP for pleasant stimuli. These findings suggest a complex pattern of emotional processing in anhedonia, marked by increased anticipation but reduced elaboration of appetitive stimuli.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"358 ","pages":"Article 112177"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146776584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers 酒精滥用和神经型饮酒者的负面情绪加工：行为和神经标记的性别差异

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2026-06-01 Epub Date: 2026-02-11 DOI: 10.1016/j.pscychresns.2026.112174

Shefali Chaudhary , Yu Chen , Hak Kei Wong , Herta H. Chao , Chiang-Shan R. Li

{"title":"Alcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers","authors":"Shefali Chaudhary , Yu Chen , Hak Kei Wong , Herta H. Chao , Chiang-Shan R. Li","doi":"10.1016/j.pscychresns.2026.112174","DOIUrl":"10.1016/j.pscychresns.2026.112174","url":null,"abstract":"<div><div>Negative emotion contributes to problem drinking. Men and women may differ in the mechanisms of negative emotion processing and the pathophysiology of alcohol misuse. However, few have investigated sex differences in the impact of alcohol misuse on negative emotion processing. We addressed this issue in a community sample of 148 drinkers (71 women) evaluated with Alcohol Use Disorder Identification Test (AUDIT; men/women 4.4 ± 5.4/4.2 ± 5.6, mean±SD) and functional imaging in a Hariri task. Men and women did not differ in reaction time (RT<sub>Neg-Neu</sub>) in matching negative vs. neutral images. Linear regression revealed significant sex differences, with men showing faster but women showing longer RT<sub>Neg-Neu</sub> in correlation with AUDIT score. Whole-brain regression identified bilateral middle frontal gyrus (MFG) with activities (β’s) each showing positive and negative correlation with AUDIT score, in men and women, respectively. We tested whether the MFG activity supports downstream motor or higher-level cognitive processes in relation to alcohol use driven by negative emotions, in models with RT<sub>Neg-Neu</sub> and the Inventory of Drinking Situations 42 Negative Emotions (IDS42-NE) score, respectively, as the dependent variable. The latter model showed a significant sex interaction, with the MFG β and IDS42-NE score negatively and positively correlated in women and in men, respectively. Together, these findings suggest sex differences in negative emotion processing in link with alcohol misuse. Women relative to men appeared more vulnerable to the interference of negative emotion, as reflected in higher RT<sub>Neg-Neu</sub>, and showed diminished prefrontal cortical activation in association with individual differences in the impact of negative emotion on problem drinking.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"358 ","pages":"Article 112174"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered resting-state functional connectivity in delusional patients with schizophrenia or schizoaffective disorder: An fMRI study using threshold-free cluster-enhancement 精神分裂症或分裂情感性障碍妄想患者静息状态功能连通性的改变：一项使用无阈值簇增强的fMRI研究。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2026-06-01 Epub Date: 2026-02-03 DOI: 10.1016/j.pscychresns.2026.112165

Samaneh Taghvatalab , S.Amir Hossein Batouli , Hamid Soltanian-Zadeh , Mohammad-Reza Zarrindast , Hamid Reza Naghavi

{"title":"Altered resting-state functional connectivity in delusional patients with schizophrenia or schizoaffective disorder: An fMRI study using threshold-free cluster-enhancement","authors":"Samaneh Taghvatalab , S.Amir Hossein Batouli , Hamid Soltanian-Zadeh , Mohammad-Reza Zarrindast , Hamid Reza Naghavi","doi":"10.1016/j.pscychresns.2026.112165","DOIUrl":"10.1016/j.pscychresns.2026.112165","url":null,"abstract":"<div><h3>Background</h3><div>Delusions are a core symptom of schizophrenia and schizoaffective disorder (SCZ/SZA), yet their neural mechanisms remain incompletely understood. Contemporary models emphasize dysfunctional network-level interactions, particularly between subcortical and cortical regions.</div></div><div><h3>Objective</h3><div>To characterize resting-state functional connectivity (rsFC) alterations specifically associated with prominent delusions in SCZ/SZA, with emphasis on cortico-subcortical and cerebellar networks.</div></div><div><h3>Methods</h3><div>High-resolution ROI-to-ROI rsFC analyses were conducted in 20 SCZ/SZA patients with prominent delusions and 20 matched healthy controls. Functional connectivity was calculated across 164 regions using the Harvard-Oxford atlas. Statistical significance was assessed with threshold-free cluster enhancement (TFCE) and family-wise error (FWE) correction at <em>p</em> < 0.05.</div></div><div><h3>Results</h3><div>Twenty significant connectivity clusters were identified, encompassing both hyper- and hypoconnectivity. Increased connectivity was observed between basal ganglia structures (putamen, pallidum) and cortical regions of the default mode network (DMN), frontal executive networks, and limbic areas, consistent with aberrant salience attribution and disrupted integration of internal and external signals.</div></div><div><h3>Conclusion</h3><div>Delusions in SCZ/SZA may stem from widespread dysconnectivity anchored in evolutionarily older subcortical and cerebellar regions, impairing sensorimotor, emotional, and cognitive integration. These findings support a network-based model of delusion formation and may inform potential targets for neuromodulatory intervention.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"358 ","pages":"Article 112165"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of impaired functional network of differential symptoms in depression–A meta-analysis of resting-state functional connectivity 识别抑郁症不同症状的功能网络受损——静息状态功能连通性的荟萃分析。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2026-06-01 Epub Date: 2026-02-15 DOI: 10.1016/j.pscychresns.2026.112176

Ru Hao , Chengfeng Chen , Xuanyu Zhang , Yubing Xu , Nan Fang , Huina Teng , Xin Luo , Ling Sun , Bin Zhang

{"title":"Identification of impaired functional network of differential symptoms in depression–A meta-analysis of resting-state functional connectivity","authors":"Ru Hao , Chengfeng Chen , Xuanyu Zhang , Yubing Xu , Nan Fang , Huina Teng , Xin Luo , Ling Sun , Bin Zhang","doi":"10.1016/j.pscychresns.2026.112176","DOIUrl":"10.1016/j.pscychresns.2026.112176","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a heterogeneous condition, manifesting with a range of clinical symptoms that may be linked to distinct brain circuits. However, the neural mechanisms underlying these associations remain unclear. In this meta-analysis, we systematically reviewed studies investigating brain network alterations in MDD through seed-based functional connectivity (FC) analysis. A total of 26 studies were included, with 18 contributing to the meta-analysis. Our findings revealed increased FC within the default mode network (DMN), and between the DMN and limbic network (LN), fronto-parietal network (FPN), while decreased FC between the DMN and ventral attention network (VAN) was associated with suicidal symptoms. For anxiety symptoms, we observed negative correlations with FC within the LN. Cognitive symptoms showed negative correlations with FC between the LN and FPN, and depressive symptoms were negatively correlated with FC between the LN and somatomotor network (SMN), and between the DMN and FPN. These findings highlight the relationship between various symptoms of MDD and their corresponding brain networks, enhancing our understanding of the neurobiological mechanisms that link brain network connectivity to depressive symptoms. Additionally, they provide theoretical basis for physical therapy interventions aimed at alleviating these symptoms.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"358 ","pages":"Article 112176"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing memory control in subthreshold depression: a tDCS study targeting right dorsal lateral prefrontal cortex 增强阈下抑郁的记忆控制：一项针对右背外侧前额叶皮层的tDCS研究。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2026-06-01 Epub Date: 2026-02-19 DOI: 10.1016/j.pscychresns.2026.112180

Yu-xiang Guo , Zi-li Wang , Teresa Boemo , Shao-shuai Zhang , Yan Zhang , Ming Peng , Xu Li

{"title":"Enhancing memory control in subthreshold depression: a tDCS study targeting right dorsal lateral prefrontal cortex","authors":"Yu-xiang Guo , Zi-li Wang , Teresa Boemo , Shao-shuai Zhang , Yan Zhang , Ming Peng , Xu Li","doi":"10.1016/j.pscychresns.2026.112180","DOIUrl":"10.1016/j.pscychresns.2026.112180","url":null,"abstract":"<div><h3>Background</h3><div>Evidence indicates that depression is associated with memory suppression deficits, which are linked to abnormal prefrontal engagement. Specifically, right dorsal lateral prefrontal cortex (rDLPFC) plays a crucial role in memory control. This study used anodal transcranial direct current stimulation (tDCS) to examine whether stimulating rDLPFC could enhance memory suppression performance in individuals with subthreshold depression.</div></div><div><h3>Materials and methods</h3><div>A total of 50 individuals with subthreshold depression received a single session of either active or sham tDCS before completing the Think/No-Think task. In this paradigm, participants were presented with neutral and negative stimuli and instructed to either retrieve or suppress the task materials.</div></div><div><h3>Results</h3><div>Results indicated a three-way interaction between group, valence, and memory instruction. Within the active tDCS group, memory accuracy was lower for both neutral and negative materials in the No-Think condition than in the baseline condition, indicating successful suppression. No such effect was found in the sham group. Further analysis showed a smaller suppression effect for negative relative to neutral materials within the active tDCS group.</div></div><div><h3>Conclusion</h3><div>The findings provide preliminary evidence that tDCS may facilitate memory suppression in individuals with subthreshold depression, suggesting potential relevance of non-invasive brain stimulation in addressing memory suppression deficits in depression.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"358 ","pages":"Article 112180"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding pulvinar dysfunction in parkinson's disease dementia: Linking brain networks and structural alterations to cognitive impairment 解读帕金森氏症痴呆的枕核功能障碍：将大脑网络和结构改变与认知障碍联系起来。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2026-06-01 Epub Date: 2026-02-19 DOI: 10.1016/j.pscychresns.2026.112179

Behcet Ayyildiz , Burak Yulug , Sevilay Ayyildiz , Bernis Sutcubasi , Ali Behram Salar , Ruhat Arslan , Ufuk Sakul , Seyda Cankaya , Lutfu Hanoglu , Halil Aziz Velioglu

{"title":"Decoding pulvinar dysfunction in parkinson's disease dementia: Linking brain networks and structural alterations to cognitive impairment","authors":"Behcet Ayyildiz , Burak Yulug , Sevilay Ayyildiz , Bernis Sutcubasi , Ali Behram Salar , Ruhat Arslan , Ufuk Sakul , Seyda Cankaya , Lutfu Hanoglu , Halil Aziz Velioglu","doi":"10.1016/j.pscychresns.2026.112179","DOIUrl":"10.1016/j.pscychresns.2026.112179","url":null,"abstract":"<div><div>This study aimed to examine functional connectivity and grey matter volume differences in the pulvinar sub-regions between healthy controls (HCs) and Parkinson's disease (PD) patients with dementia. Resting-state functional MRI (rs-fMRI) and T1-weighted images were collected from 20 HCs (10 males, 10 females; mean age 65.45±7.53) and 20 PD patients with dementia (9 males, 11 females; mean age 66.75±7.87). Functional data were pre-processed using SPM12 and CONN software. ROI-based rs-fMRI and grey matter volume analyses were conducted to compare functional connectivity and grey matter volume, respectively. After controlling for age, education, and gender, PD patients with dementia showed significantly lower functional connectivity of the right anterior pulvinar (PuA) to bilateral temporal regions (Cluster 1: <em>p</em> = 0.000919 and Cluster 2: <em>p</em> = 0.038627, FDR-corrected) and reduced right PuA volume compared to HCs (<em>p</em> = 0.044). These functional differences correlated with Unified Parkinson's Disease Rating Scale (UPDRS) scores (cluster 1 <em>r</em> = -0.641, <em>p</em> = 0.006), as well as with right PuA volume loss (cluster 1: <em>r</em> = 0387, <em>p</em> = 0.016 and cluster 2: <em>r</em> = 0.350, <em>p</em> = 0.031). The findings suggest that reduced functional connectivity and volume in the right anterior pulvinar are associated with cognitive symptoms in PD with dementia, highlighting the pulvinar’s role in cognitive deficits linked to neurodegeneration.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"358 ","pages":"Article 112179"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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