Psychiatry Research: Neuroimaging最新文献

{"title":"Resting state functional connectivity in adolescents with substance use disorder and their unaffected siblings","authors":"Hakan Kayış ,&nbsp;Betül Akyel Göven ,&nbsp;Zeki Yüncü ,&nbsp;Emre Bora ,&nbsp;Nabi Zorlu","doi":"10.1016/j.pscychresns.2024.111916","DOIUrl":"10.1016/j.pscychresns.2024.111916","url":null,"abstract":"<div><div>We aimed to examine resting-state functional connectivity (rsFC) in adolescents with substance use disorder (SUD) and their unaffected biological siblings (SIB), relative to typically-developing controls (TDC) in order to identify alterations in functional network organization that may be associated with the familial risk for SUD. Resting-state functional magnetic resonance imaging analysis included 20 adolescents with SUD, 20 SIB, and 18 TDC. Network‐based analysis revealed that adolescents with SUD had significantly both weaker and higher rsFC compared to TDC mainly within the default-mode network (DMN) and between the DMN, fronto-parietal (FPN) and salience networks. In addition, adolescents with SUD showed lower rsFC between the visual network and other functional networks. Although the SIB group did not differ from TDC in the whole brain analysis, they showed lower rsFC within DMN and also between the visual network and other large-scale networks as well as higher rsFC between DMN and FPN compared to TDC in connections found to be abnormal in SUD group. Our results suggest that lower rsFC within DMN and higher rsFC between the DMN with FPN which were evident both in SUD and in SIB groups, and might be related to the familial predisposition for SUD.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111916"},"PeriodicalIF":2.1,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between eye movement characteristics and cognitive function in adolescents with major depressive disorder","authors":"Yuanyuan Lu ,&nbsp;Lintong Song ,&nbsp;Chunxiang Huang,&nbsp;Tianqing Fan,&nbsp;Jinqiao Huang,&nbsp;Leyin Zhang,&nbsp;Xuerong Luo,&nbsp;Yanhua Li,&nbsp;Yanmei Shen","doi":"10.1016/j.pscychresns.2024.111914","DOIUrl":"10.1016/j.pscychresns.2024.111914","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to explore the relationship between eye movement characteristics and cognitive function in adolescents with major depressive disorder (MDD).</div></div><div><h3>Method</h3><div>EyeLink 1000 eye tracker was used to obtain eye movement data in free-viewing and smooth pursuit tasks. Chi-square test and Mann-Whitney test were used for inter-group comparison of demographic and clinical data. Spearman correlation was used to analyze the correlation between eye movement characteristics and cognitive function.</div></div><div><h3>Results</h3><div>Adolescents with MDD showed lower saccade amplitude in the free-viewing task and more fixations and saccades in the smooth pursuit task. In the free-viewing task, fixation count, saccade duration and saccade speed were found to be positively correlated with immediate memory and attention; fixation duration was negatively correlated with immediate memory. In the smooth pursuit task, saccade count was positively correlated with the faux pas test; fixation duration and saccade duration were significantly correlated with memory and attention.</div></div><div><h3>Conclusion</h3><div>Adolescents with MDD showed abnormalities in several indices of eye movement, and altered eye movement variables were also correlated with cognitive deficits. Eye-tracking technology helps illustrate the diverse cognitive strategies employed by individuals during cognitive tasks, allowing researchers to explore subtle differences in cognitive processes.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111914"},"PeriodicalIF":2.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter organization abnormalities in adults with 47,XXX: A 7 Tesla MRI study","authors":"Chaira Serrarens ,&nbsp;Sriranga Kashyap ,&nbsp;Maarten Otter ,&nbsp;Bea C.M. Campforts ,&nbsp;Constance T.R.M. Stumpel ,&nbsp;David E.J. Linden ,&nbsp;Thérèse A.M.J. van Amelsvoort ,&nbsp;Claudia Vingerhoets","doi":"10.1016/j.pscychresns.2024.111915","DOIUrl":"10.1016/j.pscychresns.2024.111915","url":null,"abstract":"<div><div>47,XXX (Triple X syndrome) is a sex chromosome aneuploidy characterized by the presence of a supernumerary X chromosome in affected females, and has been associated with a variable cognitive, behavioral, and psychiatric phenotype. Alterations in brain gray matter structure and function have been reported, but less is known about white matter (WM) organization in 47,XXX. Therefore, we conducted 7 T diffusion tensor imaging and characterized fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity of 22 adult women with 47,XXX and 22 age-matched typically developing females using tract-based spatial statistics. Relationships between phenotypic traits and WM organization characteristics in 47,XXX were also investigated. Adults with 47,XXX showed lower axial diffusivity in the body of the corpus callosum and the right superior longitudinal fasciculus. WM organization variability was not associated with IQ and social cognition and social functioning deficits in 47,XXX. Our findings indicate an effect of a supernumerary X chromosome in adult women on axonal integrity of the body of the corpus callosum and the right superior longitudinal fasciculus. These findings provide additional insight into the role of the X chromosome on WM organization. Future research is warranted to explore the clinical significant impact of altered WM organization in 47,XXX.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111915"},"PeriodicalIF":2.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardized weighted low-resolution electromagnetic tomography study of the amygdala activity in patients with comorbid major depressive disorder and anxiety symptoms","authors":"Cheng-Tzu Chou ,&nbsp;I-Mei Lin","doi":"10.1016/j.pscychresns.2024.111913","DOIUrl":"10.1016/j.pscychresns.2024.111913","url":null,"abstract":"<div><div>Major depressive disorder (MDD) often coexists with anxiety disorders or symptoms, as identified by previous functional magnetic resonance imaging (fMRI) studies. These studies have found abnormal amplitudes of low-frequency fluctuations (ALFF) in the amygdala, which serve as traits and state markers of MDD. This study used standardized weighted low-resolution electromagnetic tomography (swLORETA) technology to explore amygdala markers in patients with comorbid MDD and anxiety. Participants included patients with MDD comorbid with anxiety symptoms (MDD group) and healthy controls (HC group) who completed the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI). EEG data collected under resting state, happiness recall, and depressive recall tasks were converted into current-source density (CSD) values using swLORETA to assess amygdala activation. The results indicated higher beta2, beta3, and high beta levels in both the left and right amygdalae during the resting state in the MDD group than in the HC group. Similarly, elevated levels of beta2, beta3, and high beta were observed in the left and right amygdalae of the MDD group during happiness and depressive recall tasks. These findings support the presence of hyperactivity in the amygdala under resting state and emotional tasks in patients with comorbid MDD and anxiety symptoms.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111913"},"PeriodicalIF":2.1,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal imaging of the amygdala in non-clinical subjects with high vs. low autistic-like social skills traits.","authors":"Niccolò Zovetti, Tina Meller, Ulrika Evermann, Julia-Katharina Pfarr, Jonas Hoffmann, Andrea Federspiel, Sebastian Walther, Sarah Grezellschak, Andreas Jansen, Ahmad Abu-Akel, Igor Nenadić","doi":"10.1016/j.pscychresns.2024.111910","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111910","url":null,"abstract":"<p><p>Recent clinical and theoretical frameworks suggest that social skills and theory of mind impairments characteristic of autism spectrum disorder (ASD) are distributed in the general population on a continuum between healthy individuals and patients. The present multimodal study aimed at investigating the amygdala's function, perfusion, and volume in 56 non-clinical subjects from the general population with high (n = 28 High-SOC) or low (n = 28 Low-SOC) autistic-like social skills traits. Participants underwent magnetic resonance imaging to evaluate the amygdala's functional connectivity at rest, blood perfusion by means of arterial spin labelling, its activation during a face evaluation task and lastly grey matter volumes. The High-SOC group was characterised by higher blood perfusion in both amygdalae, lower volume of the left amygdala and higher activations of the right amygdala during processing of human faces with fearful value. Resting state analyses did not reveal any significant difference between the two groups. Overall, our results highlight the presence of overlapping morpho-functional alterations of the amygdala between healthy individuals and ASD patients confirming the importance of the amygdala in this disorder and in social and emotional processing. Our findings may help disentangle the neurobiological facets of ASD elucidating aetiology and the relationship between clinical symptomatology and neurobiology.</p>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":" ","pages":"111910"},"PeriodicalIF":2.1,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG oscillations in recent suicide attempters: Assessing responses to positive and negative future imagination tasks","authors":"Niloofar Fallahinia ,&nbsp;Seyed Kazem Malakouti ,&nbsp;Reza Khosrowabadi ,&nbsp;Nafee Rasouli ,&nbsp;Shadi Moradkhanie ,&nbsp;Firouzeh Mahjoubnavaz ,&nbsp;Masoumeh Bayat","doi":"10.1016/j.pscychresns.2024.111912","DOIUrl":"10.1016/j.pscychresns.2024.111912","url":null,"abstract":"<div><h3>Background</h3><div>Our goal is to uncover Electroencephalography (EEG) power spectrum patterns during imagination tasks in individuals who attempted suicide within the past 1–4 weeks, addressing gaps in understanding the neural correlates of future imagination in suicidal behavior.</div></div><div><h3>Methods</h3><div>This case-control study comprised a total of 60 participants, consisting of 47 females and 13 males. The sample comprised three groups: Attempted Suicide + Major Depressive Disorder (SA+MDD), Major Depressive Disorder (MDD), and Healthy Controls (HC). To assess participants' future imagination, a unique approach called the Positive and Negative Future Imagination Task was designed, which involved scenario visualization concurrent with EEG recording. Statistical analyses included ANOVA with post-hoc pairwise comparisons to compare EEG power spectrum between three groups.</div></div><div><h3>Results</h3><div>It was observed that the SA+MDD group experienced significantly increased theta frequency band in the right frontocentral regions when compared to the MDD group during both positive and negative imagination tasks (<em>P-value &lt; 0.05</em>). Furthermore, increased gamma activity was observed in the SA+MDD group compared to the HC group, predominantly in the right frontocentral areas during both imagination tasks.</div></div><div><h3>Conclusion</h3><div>The results of this study indicate that individuals who have recently attempted suicide exhibit heightened neural activity in the frontocentral regions of the right hemisphere of the brain, specifically in theta and gamma band frequencies, when contemplating both positive and negative aspects of the future. These findings, in the context of behavioral tasks may indicate a decrease in the ability to envision a positive future and an increase in visualizing a negative future.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111912"},"PeriodicalIF":2.1,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural alterations in a rumination-related network in patients with major depressive disorder","authors":"Paul Z. Cheng ,&nbsp;Hsin-Chien Lee ,&nbsp;Timothy J. Lane ,&nbsp;Tzu-Yu Hsu ,&nbsp;Niall W. Duncan","doi":"10.1016/j.pscychresns.2024.111911","DOIUrl":"10.1016/j.pscychresns.2024.111911","url":null,"abstract":"<div><div>Rumination is a common symptom in major depressive disorder (MDD). Previous work has connected individual differences in rumination to structural properties in various brain regions. Some of these, such as the dorsolateral prefrontal cortex (dlPFC), have also been highlighted as being altered in MDD, suggesting a connection between structural changes and ruminative symptoms. Although informative, such localised relations have limitations in the context of a network view of the brain. To further investigate rumination-related structural changes in depression, and to situate these within potential functional networks, we acquired T1-weighted structural MRI data from patients with MDD (<em>n</em> = 32) and controls (<em>n</em> = 69). Rumination was measured with the Rumination Response Scale. Surface-based, whole-brain analysis of cortical grey-matter identified group differences in the dlPFC that were, however, not related to rumination. Instead, rumination was correlated with grey-matter properties in the right precuneus. Using normative functional connectivity analysis on an independent sample (<em>n</em> = 100), we show these two regions to be interconnected. Further developing a network-based perspective, it was shown that the rumination-related precuneus region is connected with networks associated with processes such as executive function, autobiographical memory, and visual perception. Notably, these processes have been connected to rumination. These results suggest that rumination in depression may be linked to focal structural changes. The effects of these focal changes on rumination may then be connected to their influence on distributed functional networks.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111911"},"PeriodicalIF":2.1,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A coordinate-based meta-analysis of grey matter volume differences between adults with obsessive-compulsive disorder (OCD) and healthy controls","authors":"Antonio Del Casale ,&nbsp;Stefano Ferracuti ,&nbsp;Serena Mancino ,&nbsp;Jan Francesco Arena ,&nbsp;Irene Bilotta ,&nbsp;Alessandro Alcibiade ,&nbsp;Andrea Romano ,&nbsp;Alessandro Bozzao ,&nbsp;Maurizio Pompili","doi":"10.1016/j.pscychresns.2024.111908","DOIUrl":"10.1016/j.pscychresns.2024.111908","url":null,"abstract":"<div><div>According to the cortico-striato-thalamo-cortical (CSTC) model of obsessive-compulsive disorder (OCD), the striatum plays a primary role in its neuropathophysiology. Hypothesising that volumetric alterations are more pronounced in subcortical areas of patients within the CSTC circuit compared to healthy controls (HCs), we conducted a coordinate-based meta-analysis of magnetic resonance imaging (MRI) studies. We included 26 whole-brain MRI studies, comprising 3,010 subjects: 1,508 patients (788 men, 720 women; mean age: 30.26 years, SD = 8.16) and 1,502 HCs (801 men, 701 women; mean age: 29.47 years, SD = 7.88). This meta-analysis demonstrated significant grey matter volume increases in the bilateral putamen, lateral globus pallidus, left parietal cortex, right pulvinar, and left cerebellum in adults with OCD, alongside decreases in the right hippocampus/caudate, bilateral medial frontal gyri, and other cortical regions. Volume increases were predominantly observed in subcortical areas, with the exception of the left parietal cortex and cerebellar dentate, while volume decreases were primarily cortical, aside from the right hippocampus/caudate. Further exploration of these neuropathophysiological correlates could inform specific prevention and treatment strategies, advancing precision mental health in clinical applications.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111908"},"PeriodicalIF":2.1,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay of genetic and environmental factors on the morphology of the limbic cortex and hippocampal subfields: Insights from an MRI twin study","authors":"Arsalan Vessal ,&nbsp;Amirreza Alijanpourotaghsara ,&nbsp;David Strelnikov ,&nbsp;Aliz Persely ,&nbsp;Marton Piroska ,&nbsp;Amirmasoud Alijanpour ,&nbsp;Zsofia Jokkel ,&nbsp;Laszlo Szalontai ,&nbsp;Bianka Forgo ,&nbsp;Lajos Rudolf Kozak ,&nbsp;Adam Bekesy-Szabo ,&nbsp;Pal Maurovich-Horvat ,&nbsp;David Laszlo Tarnoki ,&nbsp;Adam Domonkos Tarnoki","doi":"10.1016/j.pscychresns.2024.111909","DOIUrl":"10.1016/j.pscychresns.2024.111909","url":null,"abstract":"<div><h3>Introduction</h3><div>The limbic system and the hippocampus are complex brain structures with key roles in memory, emotions, sexual stimulation and learning, with subregion abnormalities associated with a range of disorders and psychopathologies. Our study aimed to explore the heritability of specific subfield structures within the limbic system and hippocampus first in a Caucasian twin sample with volBrain pipeline.</div></div><div><h3>Materials and Methods</h3><div>59 healthy adult Caucasian twin pairs from the Hungarian Twin Registry without any history of previous neurodegenerative or cerebrovascular diseases underwent brain MRI on a 3.0 T scanner (43 monozygotic, MZ and 16 dizygotic, DZ pairs, with a median age of 50±+27 years). The volBrain automated volumetry pipeline was used to calculate the subcortical and general brain volumes from three-dimensional T1-weighted images. Based on age- and sex-adjusted MZ and DZ intra-pair correlations, the univariate ACE model was applied to calculate additive genetic, shared and unshared environmental influences.</div></div><div><h3>Results</h3><div>Adjusting for age and sex, moderate to strong heritability (A: 59.7 to 73.1 %) was found for most limbic cortex volumes, except for the volumes of entorhinal area and posterior cingulate gyrus where common environmental contribution was detected (C: 56.6 % and 65.0 %, respectively). A substantial heritability (A: 67.0 to 79.4 %) was estimated for the overall hippocampus and most subfield volumes, except for the CA2-CA3 region which was determinated by common environmental factors (C: 45.7 %). Unique environmental variance was a minor to moderate contributor across all variables (E: 20.6 to 54.3 %).</div></div><div><h3>Conclusions</h3><div>Albeit most limbic cortex, overall hippocampus and most subfield volumes are under substantial genetic influence in healthy adult twins, the volumes of entorhinal area, posterior cingulate gyrus and the CA2-CA3 region of the hippocampus are influenced common environmental factors. The findings underline the importance of unique environmental factors which may play a role in the prevention of disorders related to limbic cortex and hippocampus.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111909"},"PeriodicalIF":2.1,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning based classification of excessive smartphone users via neuronal cue reactivity.","authors":"Jailan Oweda, Mike Michael Schmitgen, Gudrun M Henemann, Marius Gerdes, Robert Christian Wolf","doi":"10.1016/j.pscychresns.2024.111903","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111903","url":null,"abstract":"<p><p>Excessive Smartphone Use (ESU) poses a significant challenge in contemporary society, yet its recognition as a distinct disorder remains ambiguous. This study aims to address this gap by leveraging functional magnetic resonance imaging (fMRI) data and machine learning techniques to classify ESU and non-excessive smartphone users (n-ESU) based on their neural Cue-Reactivity (CR) signatures. By conducting a CR task and analyzing brain activation patterns, we identified spatial similarities between addictive smartphone use and established addictive disorders. Our approach involved employing Support Vector Machines (SVM) for classification, enhanced with feature selection methods such as Recursive Feature Elimination (RFE) and Model-based Selection and dimensionality reduction methods such as and Principal Component Analysis (PCA) to mitigate the challenges posed by limited dataset size and high dimensionality of fMRI data. The results demonstrate the effectiveness of our classification model, achieving accuracies of up to 79.9 %. Furthermore, we observed region-specific activations contributing significantly to classification accuracy, highlighting the potential biomarkers associated with ESU. External validation on longitudinal data revealed the necessity for larger training datasets to improve model generalizability. Additionally, feature selection techniques proved crucial for optimizing model performance, particularly in datasets with combined information from multiple sources. Our findings underscore the importance of incorporating more data to enhance model stability and generalizability, with implications for advancing the understanding and treatment of ESU and related disorders. Overall, our study demonstrates the promise of machine learning approaches in elucidating neural correlates of ESU and informing targeted interventions for affected individuals.</p>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":" ","pages":"111903"},"PeriodicalIF":2.1,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}