Psychiatry Research: Neuroimaging最新文献_第2页

Optimized attention-enhanced U-Net for autism detection and region localization in MRI 优化的注意力增强U-Net用于自闭症MRI检测和区域定位

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-03-14 DOI: 10.1016/j.pscychresns.2025.111970

Venkata Ratna Prabha K. , Chinni Hima Bindu , K. Rama Devi

{"title":"Optimized attention-enhanced U-Net for autism detection and region localization in MRI","authors":"Venkata Ratna Prabha K. , Chinni Hima Bindu , K. Rama Devi","doi":"10.1016/j.pscychresns.2025.111970","DOIUrl":"10.1016/j.pscychresns.2025.111970","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) is a neurodevelopmental condition that affects a child’s cognitive and social skills, often diagnosed only after symptoms appear around age 2. Leveraging MRI for early ASD detection can improve intervention outcomes. This study proposes a framework for autism detection and region localization using an optimized deep learning approach with attention mechanisms. The pipeline includes MRI image collection, pre-processing (bias field correction, histogram equalization, artifact removal, and non-local mean filtering), and autism classification with a Symmetric Structured MobileNet with Attention Mechanism (SSM-AM). Enhanced by Refreshing Awareness-aided Election-Based Optimization (RA-EBO), SSM-AM achieves robust classification. Abnormality region localization utilizes a Multiscale Dilated Attention-based Adaptive U-Net (MDA-AUnet) further optimized by RA-EBO. Experimental results demonstrate that our proposed model outperforms existing methods, achieving an accuracy of 97.29%, sensitivity of 97.27%, specificity of 97.36%, and precision of 98.98%, significantly improving classification and localization performance. These results highlight the potential of our approach for early ASD diagnosis and targeted interventions. The datasets utilized for this work are publicly available at <span><span>https://fcon_1000.projects.nitrc.org/indi/abide/</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111970"},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the significance of the frontal lobe for diagnosis of schizophrenia using explainable artificial intelligence and group level analysis 利用可解释的人工智能和群体水平分析探讨额叶对精神分裂症诊断的意义

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-03-13 DOI: 10.1016/j.pscychresns.2025.111969

S.A. Varaprasad, Tripti Goel

{"title":"Exploring the significance of the frontal lobe for diagnosis of schizophrenia using explainable artificial intelligence and group level analysis","authors":"S.A. Varaprasad, Tripti Goel","doi":"10.1016/j.pscychresns.2025.111969","DOIUrl":"10.1016/j.pscychresns.2025.111969","url":null,"abstract":"<div><div>Schizophrenia (SZ) is a complex mental disorder characterized by a profound disruption in cognition and emotion, often resulting in a distorted perception of reality. Magnetic resonance imaging (MRI) is an essential tool for diagnosing SZ which helps to understand the organization of the brain. Functional MRI (fMRI) is a specialized imaging technique to measure and map brain activity by detecting changes in blood flow and oxygenation. The proposed paper correlates the results using an explainable deep learning approach to identify the significant regions of SZ patients using group-level analysis for both structural MRI (sMRI) and fMRI data. The study found that the heat maps for Grad-CAM show clear visualization in the frontal lobe for the classification of SZ and CN with a 97.33% accuracy. The group difference analysis reveals that sMRI data shows intense voxel activity in the right superior frontal gyrus of the frontal lobe in SZ patients. Also, the group difference between SZ and CN during <span><math><mi>n</mi></math></span>-back tasks of fMRI data indicates significant voxel activation in the frontal cortex of the frontal lobe. These findings suggest that the frontal lobe plays a crucial role in the diagnosis of SZ, aiding clinicians in planning the treatment.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111969"},"PeriodicalIF":2.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotion recognition in individuals with elevated internet addiction scores: An event-related potential study 高网络成瘾个体的情绪识别：事件相关电位研究

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-03-11 DOI: 10.1016/j.pscychresns.2025.111982

Dalia Arafat , Jafar Jamal , Anna Sachs , Boris Suchan , Georg Juckel , Patrizia Thoma

{"title":"Emotion recognition in individuals with elevated internet addiction scores: An event-related potential study","authors":"Dalia Arafat , Jafar Jamal , Anna Sachs , Boris Suchan , Georg Juckel , Patrizia Thoma","doi":"10.1016/j.pscychresns.2025.111982","DOIUrl":"10.1016/j.pscychresns.2025.111982","url":null,"abstract":"<div><div>The current study aims to elucidate the electrophysiological correlates of performance patterns in an emotion recognition task among individuals with higher internet addiction (HIA) scores compared to those with lower internet addiction (LIA) scores. Forty participants, with twenty in the HIA group and twenty in the LIA group, completed an emotion recognition task, involving five facial expressions: anger, fear, disgust, neutral, and sadness. Additionally, cognitive flexibility and working memory were assessed to examine their link to emotion recognition abilities. No significant differences in accuracy or reaction times (RTs) were observed between the groups in the emotion recognition task. However, the HIA group showed reduced P150 amplitudes, but increased N250 amplitudes relative to the LIA group. There was a positive correlation between the RTs and cognitive flexibility, only in the LIA group. Although the groups demonstrated comparable behavioral performance, the stages of stimuli processing differed. The LIA group appeared to process the stimuli more efficiently in the early stage, while the HIA group required greater effort in decoding the stimuli at a later stage. This suggests that the HIA group may rely on over-processing at a later stage due to reduced early processing efficiency, potentially suggesting an early vulnerability marker.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111982"},"PeriodicalIF":2.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional dysconnectivity of the triple network in women with premenstrual syndrome 经前综合征女性三联神经网络功能障碍

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-03-09 DOI: 10.1016/j.pscychresns.2025.111973

Shihuan Lin , Yan Zhang , Jinli Huang , YinQi Lai , Qingping Zhang , Ya Chen , Ziyan Lai , Yuanyuan Ou , Haixia Qin , Gaoxiong Duan , Ruijing Sun , Shanshan Li , Kaixuan Zhou , Yuejuan Wu , Zhen Liu , Lingyan Liang , Demao Deng

{"title":"Functional dysconnectivity of the triple network in women with premenstrual syndrome","authors":"Shihuan Lin , Yan Zhang , Jinli Huang , YinQi Lai , Qingping Zhang , Ya Chen , Ziyan Lai , Yuanyuan Ou , Haixia Qin , Gaoxiong Duan , Ruijing Sun , Shanshan Li , Kaixuan Zhou , Yuejuan Wu , Zhen Liu , Lingyan Liang , Demao Deng","doi":"10.1016/j.pscychresns.2025.111973","DOIUrl":"10.1016/j.pscychresns.2025.111973","url":null,"abstract":"<div><h3>Objective</h3><div>Premenstrual syndrome (PMS) is a risk factor for female depression, linked to neural circuit dysfunction. This study investigates PMS-related brain network patterns, focusing on the triple network's integration and segregation.</div></div><div><h3>Materials & Methods</h3><div>The study enrolled 56 PMS patients and 67 healthy controls (HCs), assessed via the Daily Record of Severity of Problems (DRSP). Functional MRI (fMRI) was analyzed using independent component analysis (ICA) to calculate functional connectivity (FC) and functional network connectivity (FNC) within and between brain networks. Correlation analysis examined links between imaging metrics and DRSP scores.</div></div><div><h3>Results</h3><div>Compared with HCs, PMS patients showed increased FC in the left inferior frontal gyrus of the salience network (SN). Additionally, there was increased FNC between the dorsal default mode network (dDMN), while a decrease was observed between the right execution network (RECN) and SN. Conversely, the FNC between RECN and dDMN was enhanced. Significant correlations were found between the FC values within the SN and DRSP scores. Similarly, the abnormal FNC pattern also correlated significantly with DRSP scores.</div></div><div><h3>Conclusion</h3><div>Triple-network dysconnectivity may serve as a biomarker for PMS, offering insights into its pathophysiology and potential targets for network-based neuromodulation therapies.</div></div><div><h3>Clinical Relevance Statement</h3><div>Identifying network dysconnectivities in PMS offers potential biomarkers for diagnosis and targets for neuromodulation therapy, ultimately improving symptom management and patient outcomes.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111973"},"PeriodicalIF":2.1,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MRI-based cortical gray/white matter contrast in young adults who endorse psychotic experiences or are at genetic risk for psychosis 支持精神病经历或有精神病遗传风险的年轻人的mri皮质灰质/白质对比

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-03-07 DOI: 10.1016/j.pscychresns.2025.111981

Nasimeh Naseri , Dani Beck , Lia Ferschmann , Eira R. Aksnes , Alexandra Havdahl , Maria Jalbrzikowski , Linn B. Norbom , Christian K. Tamnes

{"title":"MRI-based cortical gray/white matter contrast in young adults who endorse psychotic experiences or are at genetic risk for psychosis","authors":"Nasimeh Naseri , Dani Beck , Lia Ferschmann , Eira R. Aksnes , Alexandra Havdahl , Maria Jalbrzikowski , Linn B. Norbom , Christian K. Tamnes","doi":"10.1016/j.pscychresns.2025.111981","DOIUrl":"10.1016/j.pscychresns.2025.111981","url":null,"abstract":"<div><div>Research has reported group-level differences in cortical grey/white matter contrast (GWC) in individuals with psychotic disorders. However, no studies to date have explored GWC in individuals at elevated risk for psychosis. In this study, we examined brain microstructure differences between young adults with psychotic-like experiences or a high genetic risk for psychosis and unaffected individuals. Moreover, we investigated the association between GWC and the number of and experiences of psychosis-like symptoms. The sample was obtained from the Avon Longitudinal Study of Parents and Children (ALSPAC): the psychotic experiences study, consisting of young adults with psychotic-like symptoms (<em>n</em> = 119) and unaffected individuals (<em>n</em> = 117), and the schizophrenia recall-by-genotype study, consisting of individuals with a high genetic risk for psychosis (<em>n</em> = 95) and those with low genetic risk for psychosis (<em>n</em> = 95). Statistical analyses were performed using FSL's Permutation Analysis of Linear Models (PALM), controlling for age and sex. The results showed no statistically significant differences in GWC between any of the groups and no significant associations between GWC and the number and experiences of psychosis-like symptoms. In conclusion, the results indicate there are no differences in GWC in individuals with high, low or no risk for psychosis.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111981"},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical coherence tomography in patients with schizophrenia: An exploratory study 精神分裂症患者的光学相干断层扫描：一项探索性研究

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-03-05 DOI: 10.1016/j.pscychresns.2025.111972

Shashidhara Munivenkatappa , Pratyusha Ganne , Muralidhar Parri , Swathi U , Vijaya Chandra Reddy Avula

{"title":"Optical coherence tomography in patients with schizophrenia: An exploratory study","authors":"Shashidhara Munivenkatappa , Pratyusha Ganne , Muralidhar Parri , Swathi U , Vijaya Chandra Reddy Avula","doi":"10.1016/j.pscychresns.2025.111972","DOIUrl":"10.1016/j.pscychresns.2025.111972","url":null,"abstract":"<div><h3>Background</h3><div>Neurodegeneration plays an important role in the pathophysiology of schizophrenia. Conventional imaging has limited sensitivity in identifying early degenerative changes in the brain. Optical Coherence Tomography (OCT) is a noninvasive method for assessing retinal changes, providing a window into the central nervous system.</div></div><div><h3>Methodology</h3><div>Thirty-six schizophrenia patients and 31 healthy controls aged 18–45 were included. OCT was used to measure macular thickness and volume across nine retinal regions. Comparative analyses were conducted using <em>t</em>-tests, and the association between retinal changes and clinical characteristics was explored.</div></div><div><h3>Results</h3><div>Patients exhibited increased macular thickness in the central subfield (right: <em>p</em> = 0.006; left <em>p</em> = 0.009) and outer superior quadrant (left <em>p</em> < 0.001). Significant thinning was observed in the right outer temporal(<em>p</em> < 0.001) and right inner temporal(<em>p</em> = 0.024), left inner inferior(<em>p</em> = 0.013) and left outer nasal quadrants (<em>p</em> ≤ 0.001). Macular volume was lower in the patients but not statistically significant.</div></div><div><h3>Conclusions</h3><div>Schizophrenia can present with a mixed pattern of changes in the structure of the macula. This pattern could suggest inflammatory changes in the macular structures. Future studies need to focus on the etiopathogenesis of these inflammatory changes, which will help in a better understanding of schizophrenia.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111972"},"PeriodicalIF":2.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Executive function and underlying brain network distinctions for callous-unemotional traits and conduct problems in adolescents 青少年冷酷无情特质和行为问题的执行功能和潜在脑网络差异

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-03-04 DOI: 10.1016/j.pscychresns.2025.111971

Drew E. Winters , Jules R Dugré , Joseph T. Sakai , R.McKell Carter

{"title":"Executive function and underlying brain network distinctions for callous-unemotional traits and conduct problems in adolescents","authors":"Drew E. Winters , Jules R Dugré , Joseph T. Sakai , R.McKell Carter","doi":"10.1016/j.pscychresns.2025.111971","DOIUrl":"10.1016/j.pscychresns.2025.111971","url":null,"abstract":"<div><div>The complexity of executive function (EF) impairments in youth antisocial phenotypes of callous-unemotional (CU) traits and conduct problems (CP) challenge identifying phenotypic specific EF deficits. We can redress these challenges by (1) accounting for EF measurement error and (2) testing distinct functional brain properties accounting for differences in EF. Thus, we employed a latent modeling approach for EFs (inhibition, shifting, fluency, common EF) and extracted connection density from matching contemporary EF brain models with a sample of 112 adolescents (ages 13–17, 42 % female). Path analysis indicated CU traits associated with lower inhibition. Inhibition network density positively associated with inhibition, but this association was strengthened by CU and attenuated by CP. Common EF associated with three-way interactions between density*CP by CU for the inhibition and shifting networks. This suggests those higher in CU require their brain to work harder for lower inhibition, whereas those higher in CP have difficulty engaging inhibitory brain responses. Additionally, those with CP interacting with CU show distinct brain patterns for a more general EF capacity. Importantly, modeling cross-network connection density in contemporary EF models to test EF involvement in core impairments in CU and CP may accelerate our understanding of EF in these phenotypes.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111971"},"PeriodicalIF":2.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143621157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depressive symptoms are associated with hippocampal volume in the oldest-old: The LifeAfter90 study 老年抑郁症状与海马体积相关：90后生活研究

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-02-19 DOI: 10.1016/j.pscychresns.2025.111967

Alexander Ivan B. Posis , L. Paloma Rojas-Saunero , Yi Lor , Kristen M. George , Paola Gilsanz , Pauline Maillard , Maria M. Corrada , Rachel A. Whitmer

{"title":"Depressive symptoms are associated with hippocampal volume in the oldest-old: The LifeAfter90 study","authors":"Alexander Ivan B. Posis , L. Paloma Rojas-Saunero , Yi Lor , Kristen M. George , Paola Gilsanz , Pauline Maillard , Maria M. Corrada , Rachel A. Whitmer","doi":"10.1016/j.pscychresns.2025.111967","DOIUrl":"10.1016/j.pscychresns.2025.111967","url":null,"abstract":"<div><div>Depressive symptoms are prevalent among those aged 90 and above, the oldest old, but studies examining associations with neuroimaging markers of brain health are sparse. Therefore, we tested the association between depressive symptoms and neuroimaging outcomes, and assessed whether these associations differ by gender. This cross-sectional study used data from 225 participants with imaging data from the <em>LifeAfter90</em> study (mean [SD] age=93.1 [2.2] years, 56 % female, 22 % African American/Black, 25 % Asian, 18 % Hispanic/Latino, 28 % White, 7 % multiracial/other). Depressive symptoms were measured using the 15-item Geriatric Depression Scale (GDS), and neuroimaging markers were collected via 3T magnetic resonance imaging and amyloid positron emission tomography (PET) scans. Average GDS score was 2.6 ± 2.3. Greater GDS scores were associated with lower total (β=-0.06; 95 % CI -0.12,>-0.01; <em>p</em> = 0.04) and right (β=-0.07; 95 % CI -0.13,-0.01; <em>p</em> = 0.02) hippocampal volumes. While GDS-by-gender interactions were not significant (p's interaction>0.05), estimates of GDS with lower total and right hippocampal volume were stronger among women compared with men in gender-stratified models. GDS was not associated with other measures of cortical volume, amyloid PET, nor white matter integrity. In a racially and ethnically diverse cohort<strong>,</strong> greater depressive symptoms were cross-sectionally associated with lower hippocampal volume among participants aged 90+.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"348 ","pages":"Article 111967"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of anticholinergic burden with hippocampal subfields volume in first-episode psychosis 首发精神病患者抗胆碱能负荷与海马亚区容量的关系

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-02-17 DOI: 10.1016/j.pscychresns.2025.111968

Agnès Belkacem , Katie M. Lavigne , Delphine Raucher-Chéné , Carolina Makowski , Mallar Chakravarty , Ridha Joober , Ashok Malla , Jai Shah , Martin Lepage

{"title":"Association of anticholinergic burden with hippocampal subfields volume in first-episode psychosis","authors":"Agnès Belkacem , Katie M. Lavigne , Delphine Raucher-Chéné , Carolina Makowski , Mallar Chakravarty , Ridha Joober , Ashok Malla , Jai Shah , Martin Lepage","doi":"10.1016/j.pscychresns.2025.111968","DOIUrl":"10.1016/j.pscychresns.2025.111968","url":null,"abstract":"<div><div>Polypharmacy is relatively common in early psychosis, but little attention has been paid to the anticholinergic burden of medication use (the cumulative effect of medications that block the cholinergic system). Evidence suggests that anticholinergic burden is associated with cognitive deficits and that hippocampal dysfunction may be involved in those impairments. We aimed to examine this association in a cohort of patients with first-episode psychosis. We hypothesized that patients with the highest burden would experience a more significant reduction in hippocampal volume compared to those with low burden and healthy controls, both at baseline (3 months) and at month 12. Patients (<em>n</em> = 82; low burden [<em>n</em> = 64] and high burden [<em>n</em> = 18], defined by a Drug Burden Index cut-off of 1) followed at the PEPP-Montreal clinic, and controls (<em>n</em> = 55) completed a 3T MRI at both timepoints. After controlling for antipsychotic dosage at both timepoints, results at baseline and over time revealed a greater reduction in left fimbria volumes in high-burden patients compared to low-burden patients and controls. Overall, the associations observed between high anticholinergic burden and hippocampal volume provide further evidence for considering this dimension when prescribing medication in early psychosis.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"348 ","pages":"Article 111968"},"PeriodicalIF":2.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between EEG theta/beta ratio and response inhibition in autogenous and reactive obsessions 自发性和反应性强迫的脑电图θ / β比值与反应抑制的关系

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-02-15 DOI: 10.1016/j.pscychresns.2025.111966

Zachary T. Gemelli, Maryam Ayazi, Han-Joo Lee

{"title":"The relationship between EEG theta/beta ratio and response inhibition in autogenous and reactive obsessions","authors":"Zachary T. Gemelli, Maryam Ayazi, Han-Joo Lee","doi":"10.1016/j.pscychresns.2025.111966","DOIUrl":"10.1016/j.pscychresns.2025.111966","url":null,"abstract":"<div><div>Obsessive-Compulsive Disorder (OCD) is a diverse mental health condition that leads to substantial impairment and currently has limited success in treatment outcomes. The aim of the current study was to examine the ratio of electroencephalographic (EEG) band power within the Autogenous-Reactive (AO-RO) taxonomy of OCD during inhibition to improve our understanding of the disorder. Inhibition was measured broadly using interference and action cancellation tasks while EEG data was recorded from 61 undergraduate students. EEG band power was computed from frontal-central electrodes Fz and Cz for theta and beta frequency bands. Event-related spectral perturbations (ERSPs) were used to measure EEG band power during inhibitory task performance to calculate the Theta/Beta ratio (TBR). The relationship between AO-RO severity and the TBR at each electrode was statistically analyzed using two hierarchical linear regressions. TBR at electrode Fz during the stop-signal task was the only significant EEG predictor of AO severity. TBR predictors were not significant for RO severity. These results suggest that AO is more strongly associated with a neural correlate of inefficient and excessive cognitive and attentional control than RO. Further research is required for determining the utility of TBR for characterizing the heterogeneity within OCD.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"348 ","pages":"Article 111966"},"PeriodicalIF":2.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0