Psychiatry Research: Neuroimaging最新文献_第2页

Altered coupling relationships across resting-state functional connectivity measures in schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder. 精神分裂症、双相情感障碍和注意缺陷/多动障碍静息状态功能连接测量中耦合关系的改变

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-12-18 DOI: 10.1016/j.pscychresns.2024.111943

Lu Ma, Shanshan Jiang, Wei Tang

{"title":"Altered coupling relationships across resting-state functional connectivity measures in schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder.","authors":"Lu Ma, Shanshan Jiang, Wei Tang","doi":"10.1016/j.pscychresns.2024.111943","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111943","url":null,"abstract":"<p><p>Resting-state functional connectivity (rsFC) measures have enjoyed significant success in discovering the neuropathological characteristics of schizophrenia (SZ), bipolar disorder (BD), and attention deficit/hyperactivity disorder (ADHD). However, it is unknown whether and how the spatial and temporal coupling relationships across rsFC measures would be altered in these psychiatric disorders. Here, resting-state fMRI data were obtained from a transdiagnostic sample of healthy controls (HC) and individuals with SZ, BD, and ADHD. We used Kendall's W to compute volume-wise and voxel-wise concordance across rsFC measures, followed by group comparisons. In terms of the spatial coupling, both SZ and BD individuals exhibited decreased volume-wise concordance compared with HC. Regarding the temporal coupling, SZ individuals showed decreased voxel-wise concordance in the right lateral occipital cortex relative to HC. BD individuals exhibited decreased voxel-wise concordance in the bilateral basal forebrain and bilateral superior/middle temporal gyrus compared to HC. Additionally, correlation analyses demonstrated positive associations of voxel-wise concordance in the left basal forebrain with negative symptoms including alogia and affective flattening in pooled SZ and BD individuals. Our findings of distinct patterns of spatial and temporal decoupling across rsFC measures among SZ, BD, and ADHD may provide unique insights into the neuropathological mechanisms of these psychiatric disorders.</p>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"111943"},"PeriodicalIF":2.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotion regulation in self-injurious youth: A tale of two circuits. 自我伤害青少年的情绪调节：两个回路的故事。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-12-18 DOI: 10.1016/j.pscychresns.2024.111944

Carmen Santana-Gonzalez, Janani Ranatunga, Giang Nguyen, Brianna Greiskalns, Natasha Das, Evan Lattimer, Matthew Maurice, Gina Yi, Anna-Lena Zietlow, Monika Eckstein, Anna Zilverstand, Karina Quevedo

{"title":"Emotion regulation in self-injurious youth: A tale of two circuits.","authors":"Carmen Santana-Gonzalez, Janani Ranatunga, Giang Nguyen, Brianna Greiskalns, Natasha Das, Evan Lattimer, Matthew Maurice, Gina Yi, Anna-Lena Zietlow, Monika Eckstein, Anna Zilverstand, Karina Quevedo","doi":"10.1016/j.pscychresns.2024.111944","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111944","url":null,"abstract":"<p><p>Two emotion regulation (ER) networks, the amygdala and ventral striatum (VS) circuits underpin defensive and reward processes related to non-suicidal self-injury (NSSI). Youth who engaged in non-suicidal self-injury behavior (NSSIB) and healthy controls either watched images passively (passive condition) or increased their positive affect during positive/neutral images and decreased their negative affect during negative and self-harm images (regulate condition) in the scanner. NSSI youth showed higher amygdala to precuneus and inferior parietal lobe (IPL) connectivity while regulating emotions during self-harm images, a pattern which was associated with higher self-injury frequency. NSSI youth showed higher VS connectivity to the fusiform gyrus and parahippocampus while regulating emotions elicited by self-harm and positive images, which was in turn linked to higher self-harm frequency and relief after NSSI. Higher amygdala-precuneus and IPL connectivity in NSSI youth suggest greater self-identification with, or difficulty regulating negative affect elicited by, self-injury images. High VS-fusiform gyrus and parahippocampus connectivity during positive and self-harm images implies reward anomalies and/or greater effort to regulate positive affect. VS circuit's' links to relief and NSSIB frequency suggest VS reward-based learning as biomarker of NSSIB endurance. We discovered ER mechanisms in adolescents with NSSIB and promising targets for effective NSSIB treatment.</p>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"111944"},"PeriodicalIF":2.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural regulation of pain anticipation is associated with mindful behavior change in patients with anxiety or depression: A pilot study. 疼痛预期的神经调节与焦虑或抑郁患者的正念行为改变有关：一项初步研究。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-12-11 DOI: 10.1016/j.pscychresns.2024.111941

Michael Datko, Jacqueline Lutz, Richa Gawande, Alexandra Comeau, Jenny Gan, My Ngoc To, Gaelle Desbordes, Todd Griswold, Jean King, Eric Loucks, Vitaly Napadow, Zev Schuman-Olivier

{"title":"Neural regulation of pain anticipation is associated with mindful behavior change in patients with anxiety or depression: A pilot study.","authors":"Michael Datko, Jacqueline Lutz, Richa Gawande, Alexandra Comeau, Jenny Gan, My Ngoc To, Gaelle Desbordes, Todd Griswold, Jean King, Eric Loucks, Vitaly Napadow, Zev Schuman-Olivier","doi":"10.1016/j.pscychresns.2024.111941","DOIUrl":"10.1016/j.pscychresns.2024.111941","url":null,"abstract":"<p><p>Behavior change often requires overcoming discomfort or difficult emotions. Emotional dysregulation associated with anxiety or depression may prevent behavior change initiation among people managing chronic illness. Mindfulness training may catalyze chronic disease self-management by reducing experiential avoidance of aversive experiences that act as barriers to change initiation. Using a fMRI evoked pain task, we examined the effects of 8 weeks of Mindfulness Training for Primary Care (MTPC) on brain response to the anticipation of a noxious event (i.e., pain) among patients with anxiety and/or depression. We modeled the association between post-MTPC changes in brain response to pain anticipation and post-MTPC Action Plan Initiation (API), a measure of successful initiation of health behavior change. Greater post-MTPC increase in response to pain anticipation in the dorsal medial prefrontal cortex (dmPFC) was associated with higher levels of API (r=0.77, p<0.001). This increase in dmPFC response correlated with post-MTPC self-reported increase in emotion regulation skills related to goal-directed behaviors (r=-0.52, p=0.002). This suggests that mindfulness training increases the capacity to maintain goal-directed behavior in the face of aversive experiences by strengthening neural mechanisms of emotion- and self-regulation supporting successful health behavior change initiation in patients struggling with anxiety and/or depression.</p>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"111941"},"PeriodicalIF":2.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobiological response to trauma-related and general negative words in men firefighters with post-traumatic stress disorder, compared to trauma-exposed and trauma non-exposed controls: A pilot study. 与创伤暴露和非创伤暴露对照组相比，创伤后应激障碍男性消防员对创伤相关和一般负面词汇的神经生物学反应：一项初步研究。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-12-07 DOI: 10.1016/j.pscychresns.2024.111940

Ji Sun Hong, Da Young Lee, Minyoung Sim, Doug Hyun Han

{"title":"Neurobiological response to trauma-related and general negative words in men firefighters with post-traumatic stress disorder, compared to trauma-exposed and trauma non-exposed controls: A pilot study.","authors":"Ji Sun Hong, Da Young Lee, Minyoung Sim, Doug Hyun Han","doi":"10.1016/j.pscychresns.2024.111940","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111940","url":null,"abstract":"<p><p>Although firefighters frequently encounter various traumatic incidents, few develop posttraumatic stress disorder (PTSD). In this pilot study, we aimed to examine trauma-specific neurobiological alterations in firefighters with PTSD, distinguishing these characteristics from those of trauma-exposed controls. Twenty-two firefighters (11 firefighters with PTSD and 11 trauma-exposed controls) and 25 trauma non-exposed controls completed psychiatric questionnaires and functional magnetic resonance imaging while engaging in a trauma-specific emotional counting Stroop task for firefighters. In response to general negative words, the firefighter group exhibited increased brain activity in the left and right superior parietal lobes, left cingulate gyrus, and right medial frontal gyrus compared to the trauma non-exposed control group. In response to trauma-related words, the firefighter group displayed increased brain activity in the left and right superior parietal lobes, left and right middle temporal gyri, and precuneus compared to the trauma non-exposed control group. In response to general negative words, firefighters with PTSD exhibited increased brain activity in the right and left middle temporal gyri compared to trauma-exposed controls. In response to trauma-related words, firefighters with PTSD displayed decreased brain activity in the right and left middle frontal gyri compared to trauma-exposed controls. Among firefighters with PTSD, brain activity in the left middle frontal gyrus in response to trauma-related words negatively correlated with the Clinician-Administered PTSD Scale total score. Collectively, firefighters with PTSD demonstrate reduced brain activation within the middle frontal gyrus in response to trauma-related words, indicating a compromised top-down control mechanism.</p>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"111940"},"PeriodicalIF":2.1,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional connectivity density of postcentral gyrus predicts rumination and major depressive disorders in males. 中脑后回功能连接密度预测男性反刍和重度抑郁症。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-12-06 DOI: 10.1016/j.pscychresns.2024.111939

Qiuyao Fan, Haobo Zhang

{"title":"Functional connectivity density of postcentral gyrus predicts rumination and major depressive disorders in males.","authors":"Qiuyao Fan, Haobo Zhang","doi":"10.1016/j.pscychresns.2024.111939","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111939","url":null,"abstract":"<p><p>Major depressive disorder (MDD) is characterized by persistent sadness and loss of interest. Recent evidence suggested that abnormal functional connectivity (FC) may be linked to the development of MDD, and gender differences existed in FC patterns. In this study, we utilized resting-state functional magnetic resonance imaging (RS-fMRI) data from 41 healthy participants to identify FC patterns that correlate with levels of rumination in both genders. A 2-sample t-test showed no gender differences in rumination levels. A functional connectivity density (FCD) analysis was then conducted using DPABI. It was revealed that in males, the FCD of the postcentral gyrus (PCG) was negatively correlated with the levels of rumination and brooding (Pearson's r > 0.25), while not with reflection. No FCD in females was related to rumination or its subtypes. Further FC analysis revealed that the FC between the PCG and several regions, predominantly from the default mode network (DMN), were negatively correlated with rumination levels (Pearson's r > 0.25). This link was assumed to be a risk factor for rumination and MDD in males. In conclusion, our findings indicate that the PCG-DMN connectivity is a potential risk factor for MDD in males, while no FC risk factors were found in females.</p>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"111939"},"PeriodicalIF":2.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimaging findings of adolescent depression: A review by the Research Domain Criteria (RDoC) framework. 青少年抑郁症的神经影像学发现：研究领域标准（RDoC）框架的回顾。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-12-05 DOI: 10.1016/j.pscychresns.2024.111917

Harim Jeong, Tianqi Luo, Minjoo Kang, William Frederick Garvey, George Blankenau, Ji-Woo Suk, Mohadese Tarzaben, Soonjo Hwang

{"title":"Neuroimaging findings of adolescent depression: A review by the Research Domain Criteria (RDoC) framework.","authors":"Harim Jeong, Tianqi Luo, Minjoo Kang, William Frederick Garvey, George Blankenau, Ji-Woo Suk, Mohadese Tarzaben, Soonjo Hwang","doi":"10.1016/j.pscychresns.2024.111917","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111917","url":null,"abstract":"<p><p>This review examines neuroimaging studies on adolescent depression (AD) within the Research Domain Criteria (RDoC) framework, focusing on fMRI, DTI, and EEG findings. The research highlights disrupted connectivity in several neural networks-such as the affective, reward processing, cognitive control, and default mode networks-that underpin emotional and cognitive dysfunctions in AD. Notably, hypoconnectivity in the affective and cognitive control networks correlates with deficits in emotional processing and executive functioning, while hyperactivity in the default mode network relates to excessive self-referential thoughts. Additionally, blunted reward responses and frontal-striatal connectivity are discussed alongside the therapeutic potential of cognitive behavioral therapy (CBT) to modulate these dysfunctional circuits. Despite these insights, variability in findings due to small sample sizes and diverse methodologies suggests a need for further research to validate neuroimaging biomarkers for treatment efficacy and to explore less studied treatments like ECT and TMS in this population. This review underscores the importance of integrating neuroimaging findings to enhance understanding and treatment of AD.</p>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"111917"},"PeriodicalIF":2.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutamate concentrations and cognitive deficits in ultra-treatment-resistant schizophrenia: An exploratory and comparative ¹H-MRS study. 谷氨酸浓度和超治疗抵抗性精神分裂症的认知缺陷：一项探索性和比较1H-MRS研究。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-11-28 DOI: 10.1016/j.pscychresns.2024.111926

Jamie J Lopes, Caroline D Rae, Denny Meyer, Caitlin Yolland, Erica Neill, David Castle, Brian Dean, Susan L Rossell

{"title":"Glutamate concentrations and cognitive deficits in ultra-treatment-resistant schizophrenia: An exploratory and comparative <sup>1</sup>H-MRS study.","authors":"Jamie J Lopes, Caroline D Rae, Denny Meyer, Caitlin Yolland, Erica Neill, David Castle, Brian Dean, Susan L Rossell","doi":"10.1016/j.pscychresns.2024.111926","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111926","url":null,"abstract":"<p><strong>Background and aims: </strong>Glutamate plays a crucial role in cognition, learning, and mood regulation, with studies suggesting glutamatergic dysfunction in chronic schizophrenia. This study explored glutamate levels in the occipital cortex (OCC) and cognitive function in ultra-treatment resistant schizophrenia (uTRS) compared to healthy controls.</p><p><strong>Methods: </strong>Fifteen uTRS participants and 19 healthy controls underwent 3T proton magnetic resonance spectroscopy (<sup>1</sup>H-MRS) to measure glutamate levels in the OCC. Cognitive performance was assessed using the MATRICS Consensus Cognitive Battery (MCCB).</p><p><strong>Results: </strong>No significant differences in OCC glutamate levels were found between uTRS participants and healthy controls. uTRS participants performed significantly worse on the MCCB compared to healthy controls, with a large effect size (η² = 0.72). Although no significant direct relationships were observed between Glu levels and cognitive performance, significant regression models for certain cognitive domains suggest a modest association between Glu levels and cognitive outcomes.</p><p><strong>Conclusion: </strong>Participants with uTRS exhibited significant cognitive deficits compared to healthy controls, though no significant differences in OCC Glu levels were found. While no clear linear or quadratic relationships emerged, Glu explained a small portion of the variance in cognitive performance, indicating a more complex role for Glu in cognition that warrants further investigation.</p>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"111926"},"PeriodicalIF":2.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reward functioning in posttraumatic stress disorder, metabolic syndrome, and psychological resilience 创伤后应激障碍、代谢综合征和心理弹性中的奖励功能

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-11-22 DOI: 10.1016/j.pscychresns.2024.111918

Leigh Luella van den Heuvel , Laila Asmal , Stefan du Plessis , Chanellé Juanita Hendrikse , Soraya Seedat

{"title":"Reward functioning in posttraumatic stress disorder, metabolic syndrome, and psychological resilience","authors":"Leigh Luella van den Heuvel , Laila Asmal , Stefan du Plessis , Chanellé Juanita Hendrikse , Soraya Seedat","doi":"10.1016/j.pscychresns.2024.111918","DOIUrl":"10.1016/j.pscychresns.2024.111918","url":null,"abstract":"<div><h3>Background</h3><div>Reward system dysfunction may play a role in the comorbidity of metabolic syndrome (MetS) in posttraumatic stress disorder (PTSD). Psychological resilience, through its effects on the reward system, may modulate outcomes in PTSD. Utilising a monetary incentive delay task during functional magnetic resonance imaging in a case-control study (PTSD, <em>n</em> = 88, trauma-exposed controls [TEC], <em>n</em> = 85), we aimed to investigate reward system function in relation to PTSD, MetS, and psychological resilience.</div></div><div><h3>Methods</h3><div>Using repeated measures analysis of variance, we assessed change in activation in the ventral striatum (VS) during reward anticipation and in the orbitofrontal cortex (OFC) during reward outcome, in relation to PTSD, MetS, and psychological resilience, controlling for possible confounders including depression severity, childhood trauma and trauma load.</div></div><div><h3>Results</h3><div>Activation in the VS and OFC didn't differ in relation to PTSD and MetS. When we controlled for depression severity, PTSD cases had significantly lower activation in the VS and a greater increase in activation in the OFC compared to TEC. Psychological resilience was significantly associated with decreased change in activation in the VS and increased change in activation in the OFC. We also observed a greater increase in activation during reward outcome in the OFC in those with greater childhood trauma exposure and those with exposure to fewer lifetime traumatic events.</div></div><div><h3>Conclusions</h3><div>The effects of depression and psychological resilience on reward system function in PTSD can be utilised towards developing interventions targeted at altering positive valence systems in PTSD.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"346 ","pages":"Article 111918"},"PeriodicalIF":2.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in inter-temporal decision making and cortical thickness of the orbitofrontal and insula in young adult cannabis users: Evidence from 1111 subjects 年轻成年大麻使用者在时际决策以及眶额叶和岛叶皮层厚度方面的性别差异：来自 1111 名受试者的证据

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-11-22 DOI: 10.1016/j.pscychresns.2024.111919

Alan N. Francis , Joan A. Camprodon , Francesca Filbey

{"title":"Sex differences in inter-temporal decision making and cortical thickness of the orbitofrontal and insula in young adult cannabis users: Evidence from 1111 subjects","authors":"Alan N. Francis , Joan A. Camprodon , Francesca Filbey","doi":"10.1016/j.pscychresns.2024.111919","DOIUrl":"10.1016/j.pscychresns.2024.111919","url":null,"abstract":"<div><div>To test for sex differences in the impact of cannabis use on decision-making and brain correlates, we employed cortical thickness (CT) analysis of brain regions involved in intertemporal decision-making namely bilateral orbitofrontal cortex(OFC) and insula in young adult nondependent cannabis-users(CU) and non-users(NU) and their scores on delay discounting task.</div><div>Neuroimaging analyzes of previously collected data were performed on 608CU and 503NU. CT analysis was performed on MRI images. OFC and insula thickness, scores on the delay discounting test were compared between groups and correlated.</div><div>Controlling alcohol-use and intra-cranial-volume, CU exhibited sex differences in CT. The bilateral insula was significantly thinner in male CU. OFC was thinner in females relative to controls. Female CU had thinner Right-medial OFC, Left-lateral-OFC. While male CU scored significantly lower on items within delay discounting task, female CU delay-discounting scores were within normal range.</div><div>Our results demonstrate that cannabis-use differentially affects decision-making across sexes. Cortical morphology mirrors this dimorphism. CU subjects did not show a correlation between CT of OFC or insula and delay discounting, implying that thinner cortices and lower DD scores in males may be independent alterations which may be premorbid to cannabis use and may lead to cognitive deficits in later years.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"346 ","pages":"Article 111919"},"PeriodicalIF":2.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resting state functional connectivity in adolescents with substance use disorder and their unaffected siblings 患有药物使用障碍的青少年及其未受影响的兄弟姐妹的静息状态功能连接。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-11-19 DOI: 10.1016/j.pscychresns.2024.111916

Hakan Kayış , Betül Akyel Göven , Zeki Yüncü , Emre Bora , Nabi Zorlu

{"title":"Resting state functional connectivity in adolescents with substance use disorder and their unaffected siblings","authors":"Hakan Kayış , Betül Akyel Göven , Zeki Yüncü , Emre Bora , Nabi Zorlu","doi":"10.1016/j.pscychresns.2024.111916","DOIUrl":"10.1016/j.pscychresns.2024.111916","url":null,"abstract":"<div><div>We aimed to examine resting-state functional connectivity (rsFC) in adolescents with substance use disorder (SUD) and their unaffected biological siblings (SIB), relative to typically-developing controls (TDC) in order to identify alterations in functional network organization that may be associated with the familial risk for SUD. Resting-state functional magnetic resonance imaging analysis included 20 adolescents with SUD, 20 SIB, and 18 TDC. Network‐based analysis revealed that adolescents with SUD had significantly both weaker and higher rsFC compared to TDC mainly within the default-mode network (DMN) and between the DMN, fronto-parietal (FPN) and salience networks. In addition, adolescents with SUD showed lower rsFC between the visual network and other functional networks. Although the SIB group did not differ from TDC in the whole brain analysis, they showed lower rsFC within DMN and also between the visual network and other large-scale networks as well as higher rsFC between DMN and FPN compared to TDC in connections found to be abnormal in SUD group. Our results suggest that lower rsFC within DMN and higher rsFC between the DMN with FPN which were evident both in SUD and in SIB groups, and might be related to the familial predisposition for SUD.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111916"},"PeriodicalIF":2.1,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0