Psychiatry Research: Neuroimaging最新文献

{"title":"The association between eye movement characteristics and cognitive function in adolescents with major depressive disorder","authors":"Yuanyuan Lu ,&nbsp;Lintong Song ,&nbsp;Chunxiang Huang,&nbsp;Tianqing Fan,&nbsp;Jinqiao Huang,&nbsp;Leyin Zhang,&nbsp;Xuerong Luo,&nbsp;Yanhua Li,&nbsp;Yanmei Shen","doi":"10.1016/j.pscychresns.2024.111914","DOIUrl":"10.1016/j.pscychresns.2024.111914","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to explore the relationship between eye movement characteristics and cognitive function in adolescents with major depressive disorder (MDD).</div></div><div><h3>Method</h3><div>EyeLink 1000 eye tracker was used to obtain eye movement data in free-viewing and smooth pursuit tasks. Chi-square test and Mann-Whitney test were used for inter-group comparison of demographic and clinical data. Spearman correlation was used to analyze the correlation between eye movement characteristics and cognitive function.</div></div><div><h3>Results</h3><div>Adolescents with MDD showed lower saccade amplitude in the free-viewing task and more fixations and saccades in the smooth pursuit task. In the free-viewing task, fixation count, saccade duration and saccade speed were found to be positively correlated with immediate memory and attention; fixation duration was negatively correlated with immediate memory. In the smooth pursuit task, saccade count was positively correlated with the faux pas test; fixation duration and saccade duration were significantly correlated with memory and attention.</div></div><div><h3>Conclusion</h3><div>Adolescents with MDD showed abnormalities in several indices of eye movement, and altered eye movement variables were also correlated with cognitive deficits. Eye-tracking technology helps illustrate the diverse cognitive strategies employed by individuals during cognitive tasks, allowing researchers to explore subtle differences in cognitive processes.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111914"},"PeriodicalIF":2.1,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White matter organization abnormalities in adults with 47,XXX: A 7 Tesla MRI study","authors":"Chaira Serrarens ,&nbsp;Sriranga Kashyap ,&nbsp;Maarten Otter ,&nbsp;Bea C.M. Campforts ,&nbsp;Constance T.R.M. Stumpel ,&nbsp;David E.J. Linden ,&nbsp;Thérèse A.M.J. van Amelsvoort ,&nbsp;Claudia Vingerhoets","doi":"10.1016/j.pscychresns.2024.111915","DOIUrl":"10.1016/j.pscychresns.2024.111915","url":null,"abstract":"<div><div>47,XXX (Triple X syndrome) is a sex chromosome aneuploidy characterized by the presence of a supernumerary X chromosome in affected females, and has been associated with a variable cognitive, behavioral, and psychiatric phenotype. Alterations in brain gray matter structure and function have been reported, but less is known about white matter (WM) organization in 47,XXX. Therefore, we conducted 7 T diffusion tensor imaging and characterized fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity of 22 adult women with 47,XXX and 22 age-matched typically developing females using tract-based spatial statistics. Relationships between phenotypic traits and WM organization characteristics in 47,XXX were also investigated. Adults with 47,XXX showed lower axial diffusivity in the body of the corpus callosum and the right superior longitudinal fasciculus. WM organization variability was not associated with IQ and social cognition and social functioning deficits in 47,XXX. Our findings indicate an effect of a supernumerary X chromosome in adult women on axonal integrity of the body of the corpus callosum and the right superior longitudinal fasciculus. These findings provide additional insight into the role of the X chromosome on WM organization. Future research is warranted to explore the clinical significant impact of altered WM organization in 47,XXX.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111915"},"PeriodicalIF":2.1,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardized weighted low-resolution electromagnetic tomography study of the amygdala activity in patients with comorbid major depressive disorder and anxiety symptoms","authors":"Cheng-Tzu Chou ,&nbsp;I-Mei Lin","doi":"10.1016/j.pscychresns.2024.111913","DOIUrl":"10.1016/j.pscychresns.2024.111913","url":null,"abstract":"<div><div>Major depressive disorder (MDD) often coexists with anxiety disorders or symptoms, as identified by previous functional magnetic resonance imaging (fMRI) studies. These studies have found abnormal amplitudes of low-frequency fluctuations (ALFF) in the amygdala, which serve as traits and state markers of MDD. This study used standardized weighted low-resolution electromagnetic tomography (swLORETA) technology to explore amygdala markers in patients with comorbid MDD and anxiety. Participants included patients with MDD comorbid with anxiety symptoms (MDD group) and healthy controls (HC group) who completed the Beck Depression Inventory-II (BDI-II) and the Beck Anxiety Inventory (BAI). EEG data collected under resting state, happiness recall, and depressive recall tasks were converted into current-source density (CSD) values using swLORETA to assess amygdala activation. The results indicated higher beta2, beta3, and high beta levels in both the left and right amygdalae during the resting state in the MDD group than in the HC group. Similarly, elevated levels of beta2, beta3, and high beta were observed in the left and right amygdalae of the MDD group during happiness and depressive recall tasks. These findings support the presence of hyperactivity in the amygdala under resting state and emotional tasks in patients with comorbid MDD and anxiety symptoms.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111913"},"PeriodicalIF":2.1,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG oscillations in recent suicide attempters: Assessing responses to positive and negative future imagination tasks","authors":"Niloofar Fallahinia ,&nbsp;Seyed Kazem Malakouti ,&nbsp;Reza Khosrowabadi ,&nbsp;Nafee Rasouli ,&nbsp;Shadi Moradkhanie ,&nbsp;Firouzeh Mahjoubnavaz ,&nbsp;Masoumeh Bayat","doi":"10.1016/j.pscychresns.2024.111912","DOIUrl":"10.1016/j.pscychresns.2024.111912","url":null,"abstract":"<div><h3>Background</h3><div>Our goal is to uncover Electroencephalography (EEG) power spectrum patterns during imagination tasks in individuals who attempted suicide within the past 1–4 weeks, addressing gaps in understanding the neural correlates of future imagination in suicidal behavior.</div></div><div><h3>Methods</h3><div>This case-control study comprised a total of 60 participants, consisting of 47 females and 13 males. The sample comprised three groups: Attempted Suicide + Major Depressive Disorder (SA+MDD), Major Depressive Disorder (MDD), and Healthy Controls (HC). To assess participants' future imagination, a unique approach called the Positive and Negative Future Imagination Task was designed, which involved scenario visualization concurrent with EEG recording. Statistical analyses included ANOVA with post-hoc pairwise comparisons to compare EEG power spectrum between three groups.</div></div><div><h3>Results</h3><div>It was observed that the SA+MDD group experienced significantly increased theta frequency band in the right frontocentral regions when compared to the MDD group during both positive and negative imagination tasks (<em>P-value &lt; 0.05</em>). Furthermore, increased gamma activity was observed in the SA+MDD group compared to the HC group, predominantly in the right frontocentral areas during both imagination tasks.</div></div><div><h3>Conclusion</h3><div>The results of this study indicate that individuals who have recently attempted suicide exhibit heightened neural activity in the frontocentral regions of the right hemisphere of the brain, specifically in theta and gamma band frequencies, when contemplating both positive and negative aspects of the future. These findings, in the context of behavioral tasks may indicate a decrease in the ability to envision a positive future and an increase in visualizing a negative future.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111912"},"PeriodicalIF":2.1,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural alterations in a rumination-related network in patients with major depressive disorder","authors":"Paul Z. Cheng ,&nbsp;Hsin-Chien Lee ,&nbsp;Timothy J. Lane ,&nbsp;Tzu-Yu Hsu ,&nbsp;Niall W. Duncan","doi":"10.1016/j.pscychresns.2024.111911","DOIUrl":"10.1016/j.pscychresns.2024.111911","url":null,"abstract":"<div><div>Rumination is a common symptom in major depressive disorder (MDD). Previous work has connected individual differences in rumination to structural properties in various brain regions. Some of these, such as the dorsolateral prefrontal cortex (dlPFC), have also been highlighted as being altered in MDD, suggesting a connection between structural changes and ruminative symptoms. Although informative, such localised relations have limitations in the context of a network view of the brain. To further investigate rumination-related structural changes in depression, and to situate these within potential functional networks, we acquired T1-weighted structural MRI data from patients with MDD (<em>n</em> = 32) and controls (<em>n</em> = 69). Rumination was measured with the Rumination Response Scale. Surface-based, whole-brain analysis of cortical grey-matter identified group differences in the dlPFC that were, however, not related to rumination. Instead, rumination was correlated with grey-matter properties in the right precuneus. Using normative functional connectivity analysis on an independent sample (<em>n</em> = 100), we show these two regions to be interconnected. Further developing a network-based perspective, it was shown that the rumination-related precuneus region is connected with networks associated with processes such as executive function, autobiographical memory, and visual perception. Notably, these processes have been connected to rumination. These results suggest that rumination in depression may be linked to focal structural changes. The effects of these focal changes on rumination may then be connected to their influence on distributed functional networks.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111911"},"PeriodicalIF":2.1,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A coordinate-based meta-analysis of grey matter volume differences between adults with obsessive-compulsive disorder (OCD) and healthy controls","authors":"Antonio Del Casale ,&nbsp;Stefano Ferracuti ,&nbsp;Serena Mancino ,&nbsp;Jan Francesco Arena ,&nbsp;Irene Bilotta ,&nbsp;Alessandro Alcibiade ,&nbsp;Andrea Romano ,&nbsp;Alessandro Bozzao ,&nbsp;Maurizio Pompili","doi":"10.1016/j.pscychresns.2024.111908","DOIUrl":"10.1016/j.pscychresns.2024.111908","url":null,"abstract":"<div><div>According to the cortico-striato-thalamo-cortical (CSTC) model of obsessive-compulsive disorder (OCD), the striatum plays a primary role in its neuropathophysiology. Hypothesising that volumetric alterations are more pronounced in subcortical areas of patients within the CSTC circuit compared to healthy controls (HCs), we conducted a coordinate-based meta-analysis of magnetic resonance imaging (MRI) studies. We included 26 whole-brain MRI studies, comprising 3,010 subjects: 1,508 patients (788 men, 720 women; mean age: 30.26 years, SD = 8.16) and 1,502 HCs (801 men, 701 women; mean age: 29.47 years, SD = 7.88). This meta-analysis demonstrated significant grey matter volume increases in the bilateral putamen, lateral globus pallidus, left parietal cortex, right pulvinar, and left cerebellum in adults with OCD, alongside decreases in the right hippocampus/caudate, bilateral medial frontal gyri, and other cortical regions. Volume increases were predominantly observed in subcortical areas, with the exception of the left parietal cortex and cerebellar dentate, while volume decreases were primarily cortical, aside from the right hippocampus/caudate. Further exploration of these neuropathophysiological correlates could inform specific prevention and treatment strategies, advancing precision mental health in clinical applications.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111908"},"PeriodicalIF":2.1,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interplay of genetic and environmental factors on the morphology of the limbic cortex and hippocampal subfields: Insights from an MRI twin study","authors":"Arsalan Vessal ,&nbsp;Amirreza Alijanpourotaghsara ,&nbsp;David Strelnikov ,&nbsp;Aliz Persely ,&nbsp;Marton Piroska ,&nbsp;Amirmasoud Alijanpour ,&nbsp;Zsofia Jokkel ,&nbsp;Laszlo Szalontai ,&nbsp;Bianka Forgo ,&nbsp;Lajos Rudolf Kozak ,&nbsp;Adam Bekesy-Szabo ,&nbsp;Pal Maurovich-Horvat ,&nbsp;David Laszlo Tarnoki ,&nbsp;Adam Domonkos Tarnoki","doi":"10.1016/j.pscychresns.2024.111909","DOIUrl":"10.1016/j.pscychresns.2024.111909","url":null,"abstract":"<div><h3>Introduction</h3><div>The limbic system and the hippocampus are complex brain structures with key roles in memory, emotions, sexual stimulation and learning, with subregion abnormalities associated with a range of disorders and psychopathologies. Our study aimed to explore the heritability of specific subfield structures within the limbic system and hippocampus first in a Caucasian twin sample with volBrain pipeline.</div></div><div><h3>Materials and Methods</h3><div>59 healthy adult Caucasian twin pairs from the Hungarian Twin Registry without any history of previous neurodegenerative or cerebrovascular diseases underwent brain MRI on a 3.0 T scanner (43 monozygotic, MZ and 16 dizygotic, DZ pairs, with a median age of 50±+27 years). The volBrain automated volumetry pipeline was used to calculate the subcortical and general brain volumes from three-dimensional T1-weighted images. Based on age- and sex-adjusted MZ and DZ intra-pair correlations, the univariate ACE model was applied to calculate additive genetic, shared and unshared environmental influences.</div></div><div><h3>Results</h3><div>Adjusting for age and sex, moderate to strong heritability (A: 59.7 to 73.1 %) was found for most limbic cortex volumes, except for the volumes of entorhinal area and posterior cingulate gyrus where common environmental contribution was detected (C: 56.6 % and 65.0 %, respectively). A substantial heritability (A: 67.0 to 79.4 %) was estimated for the overall hippocampus and most subfield volumes, except for the CA2-CA3 region which was determinated by common environmental factors (C: 45.7 %). Unique environmental variance was a minor to moderate contributor across all variables (E: 20.6 to 54.3 %).</div></div><div><h3>Conclusions</h3><div>Albeit most limbic cortex, overall hippocampus and most subfield volumes are under substantial genetic influence in healthy adult twins, the volumes of entorhinal area, posterior cingulate gyrus and the CA2-CA3 region of the hippocampus are influenced common environmental factors. The findings underline the importance of unique environmental factors which may play a role in the prevention of disorders related to limbic cortex and hippocampus.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111909"},"PeriodicalIF":2.1,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-based deep learning for differentiating between bipolar and major depressive disorders","authors":"Ruipeng Li ,&nbsp;Yueqi Huang ,&nbsp;Yanbin Wang ,&nbsp;Chen Song ,&nbsp;Xiaobo Lai","doi":"10.1016/j.pscychresns.2024.111907","DOIUrl":"10.1016/j.pscychresns.2024.111907","url":null,"abstract":"<div><div>Mood disorders, particularly bipolar disorder (BD) and major depressive disorder (MDD), manifest changes in brain structure that can be detected using structural magnetic resonance imaging (MRI). Although structural MRI is a promising diagnostic tool, prevailing diagnostic criteria for BD and MDD are predominantly subjective, sometimes leading to misdiagnosis. This challenge is compounded by a limited understanding of the underlying causes of these disorders. In response, we present SE-ResNet, a Residual Network (ResNet)-based framework designed to discriminate between BD, MDD, and healthy controls (HC) using structural MRI data. Our approach extends the traditional Squeeze-and-Excitation (SE) layer by incorporating a dedicated branch for spatial attention map generation, equipped with soft-pooling, a 7 × 7 convolution, and a sigmoid function, intended to detect complex spatial patterns. The fusion of channel and spatial attention maps through element-wise addition aims to enhance the model's ability to discriminate features. Unlike conventional methods that use max-pooling for downsampling, our methodology employs soft-pooling, which aims to preserve a richer representation of input features and reduce data loss. When evaluated on a proprietary dataset comprising 303 subjects, the SE-ResNet achieved an accuracy of 85.8 %, a recall of 85.7 %, a precision of 85.9 %, and an F1 score of 85.8 %. These performance metrics suggest that the SE-ResNet framework has potential as a tool for detecting psychiatric disorders using structural MRI data.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111907"},"PeriodicalIF":2.1,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(Interfering) Cortical mechanisms of standing balance and cognition in old-age depression: A functional near-infrared spectroscopy (fNIRS) study","authors":"Pia Thönnessen ,&nbsp;L.Cornelius Bollheimer ,&nbsp;Michael Luehrs ,&nbsp;Ute Habel ,&nbsp;Bettina Sorger ,&nbsp;Charlotte Huppertz","doi":"10.1016/j.pscychresns.2024.111905","DOIUrl":"10.1016/j.pscychresns.2024.111905","url":null,"abstract":"<div><div>Major depressive disorder in old age can cause changes in the cerebral cortex that might lead to postural imbalance and thus increase fall risk. We aim to examine cortical activation during standing balance in depressed older patients compared to healthy controls and to determine how an additional cognitive task affects this activation. Eleven older patients (age ≥65 years) diagnosed with major depressive disorder and sixteen age-matched healthy controls participated in the study. Functional near-infrared spectroscopy (fNIRS) was used to assess cortical activation of the prefrontal (PFC) and motor (MC) cortex during standing balance with eyes closed under single and dual task (counting backwards). The present study generally revealed tendencies in the MC – and partly the PFC too – for more activation whilst balancing compared to baseline. Also, in the MC, patients tended to show more cortical activation compared to controls and dual task tended to elicit more activation. The results suggest that depressed older patients, to compensate for their illness, may require increased cortical activation to perform motor and cognitive tasks than healthy controls. The absence of PFC activation in the main analyses may be related to the small participant number and possibly to too simple task conditions.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111905"},"PeriodicalIF":2.1,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal changes in neural responses to fearful faces in adolescents with anorexia nervosa – A fMRI study","authors":"Lukas Stanetzky ,&nbsp;Arne Hartz ,&nbsp;Kimberly Buettgen ,&nbsp;Brigitte Dahmen ,&nbsp;Beate Herpertz-Dahlmann ,&nbsp;Kerstin Konrad ,&nbsp;Jochen Seitz","doi":"10.1016/j.pscychresns.2024.111904","DOIUrl":"10.1016/j.pscychresns.2024.111904","url":null,"abstract":"<div><h3>Objective</h3><div>Although proven neuronal changes are correlated with anorexia nervosa (AN), where these changes occur and how they change during the course of this disease are often unclear; this is especially true regarding emotion processing, e.g., of anxiety, despite a growing body of literature on its importance for the pathophysiology and clinical course of patients with AN.</div></div><div><h3>Methods</h3><div>Twenty-two female adolescent patients with AN were scanned during acute starvation and after short-term weight recovery and were compared to 27 healthy controls. A well-established face-matching paradigm involving individuals with different emotions was used during fMRI.</div></div><div><h3>Results</h3><div>Patients with AN selectively showed significantly increasing neural activation in the somatomotor cortex when viewing fearful faces following short-term weight recovery. No differences were found compared to healthy controls or for neutral, angry or surprised faces. Neural activation in response to fearful faces during acute starvation was associated with lower BMI-SDS and greater illness burden.</div></div><div><h3>Conclusion</h3><div>Higher somatomotor activity could represent anxiety-induced preparations for motor reactions (e.g., fight or flight) that are more pronounced in more affected patients. These results align with recent models of AN that increasingly incorporate anxiety into the pathophysiological and prognostic model of AN and help elucidate its underlying neurological mechanisms.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"345 ","pages":"Article 111904"},"PeriodicalIF":2.1,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}