Psychiatry Research: Neuroimaging最新文献

{"title":"Occipital structure is linked to vagal tone in borderline personality but not in major depressive disorder","authors":"Vicente Camacho-Téllez ,&nbsp;Mariana N. Castro ,&nbsp;Gabriela De Pino ,&nbsp;Bárbara Duarte-Abritta ,&nbsp;Agustina E. Wainsztein ,&nbsp;Delfina Lahitou Herlyn ,&nbsp;Ximena Goldberg ,&nbsp;Elsa Y. Costanzo ,&nbsp;Narcís Cardoner ,&nbsp;José M. Menchón ,&nbsp;Carles Soriano-Mas ,&nbsp;Salvador M. Guinjoan ,&nbsp;Mirta F. Villarreal","doi":"10.1016/j.pscychresns.2025.112044","DOIUrl":"10.1016/j.pscychresns.2025.112044","url":null,"abstract":"<div><div>Major depressive (MDD) and borderline personality disorders (BPD) are highly prevalent and frequently comorbid psychiatric conditions, both characterized by emotion dysregulation yet likely arising from distinct etiologies. Nonetheless, the specific features of autonomic central-peripheral relationships in these disorders remain poorly understood. We investigated the association between brain structure and vagal activity, and explored the resting-state functional connectivity of brain regions found to be associated with vagal tone, in 19 MDD, 18 BPD and 20 healthy controls (HC). We found that the cortical thinning in the right lateral occipital region was associated with increased parasympathetic tone in BPD, a relationship not observed in MDD. Moreover, in BPD, this region was functionally connected to the anterior insula and prefrontal areas, linked to the central autonomic system and emotion regulation processes. Accordingly, this region was also linked to emotion dysregulation in BPD. Our findings highlight distinct central–peripheral autonomic integration in these disorders and emphasize the occipital region's structural and functional involvement in emotional and autonomic regulation in BPD. Further research is needed to clarify how occipital structure and function, well as vagal activity, may contribute as potential biomarkers for BPD.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"352 ","pages":"Article 112044"},"PeriodicalIF":2.1,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing schizophrenia diagnosis efficiency with EEGNet: a simplified recognition model based on γ band features","authors":"Shuai Hao ,&nbsp;Zhi-jie Zhang ,&nbsp;Xu Wang ,&nbsp;Pan Zhang ,&nbsp;Hui-peng Ren ,&nbsp;Wei-cong Ren","doi":"10.1016/j.pscychresns.2025.112047","DOIUrl":"10.1016/j.pscychresns.2025.112047","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to develop an objective and efficient diagnostic model for schizophrenia (SCZ) by integrating electroencephalogram (EEG) signals with deep learning techniques. Building on previous research, γ wave activity is selected as a potential biomarker to achieve high recognition accuracy while significantly reducing model complexity and enhancing training efficiency.</div></div><div><h3>Methods</h3><div>We implemented an EEGNet architecture optimized for simplified feature engineering, targeting γ band features extracted from resting-state EEG recordings. The model was trained and evaluated using Leave-One-Subject-Out Cross-Validation (LOSOCV) to ensure robustness in distinguishing SCZ patients from healthy controls (HC).</div></div><div><h3>Results</h3><div>The γ band feature model achieved average recognition accuracies of 98.19 % for the SCZ group and 97.24 % for the HC group. Additionally, the model significantly reduced training time, indicating an efficient classification process that is more conducive to training on large datasets.</div></div><div><h3>Conclusion</h3><div>The findings highlight the effectiveness of γ band features for EEG-based SCZ diagnostics, with the proposed model offering both high accuracy and improved training efficiency. This study underscores the potential clinical utility of γ band-focused EEG analysis as an objective diagnostic tool for SCZ.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"352 ","pages":"Article 112047"},"PeriodicalIF":2.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the feasibility and acceptability of using fMRI to measure pain responses in women with and without postpartum depression","authors":"Sandraluz Lara-Cinisomo ,&nbsp;Michelle M. Nutlis ,&nbsp;Andrea Ramirez Olarte ,&nbsp;Bradley P. Sutton ,&nbsp;Ryan J. Larsen ,&nbsp;Hillary Schwarb","doi":"10.1016/j.pscychresns.2025.112042","DOIUrl":"10.1016/j.pscychresns.2025.112042","url":null,"abstract":"<div><div>Little is known about differences in pain perception among depressed versus non-depressed postpartum women. This novel study aimed to determine the feasibility and acceptability of enrolling non-depressed and depressed postpartum women in a laboratory-induced pain study using fMRI. Eleven non-depressed and two depressed postpartum women participated in a cold pain-induced experiment using fMRI. Feasibility and acceptability were assessed. Brain activation of the pain-associated regions of interest was measured. Participants provided subjective pain ratings (i.e., intensity and unpleasantness). The results indicated that enrolling postpartum women in a laboratory-induced pain study using fMRI is feasible. Participants found the study acceptable. The findings showed that the study’s pain device activated the amygdala and insula in the non-depressed group, with activation in the anterior cingulate cortex being marginally significant. Exploratory analyses of differences in brain activation by depression status were not statistically significant. There was a significant and positive association between depressive symptoms and pain unpleasantness. Subjective pain ratings differed by depression status but were not statistically significant. This study showed that conducting a pain experiment using fMRI with postpartum women is feasible and acceptable. Future research should include a larger sample to confirm findings and investigate the impact of depression on pain responses.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"353 ","pages":"Article 112042"},"PeriodicalIF":2.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial direct current stimulation may enhance attention performance in a difficult task among patients with Graves’ disease practicing mindfulness intervention","authors":"Shih-Hsien Lin ,&nbsp;Shih-Ming Huang ,&nbsp;Yen Kuang Yang","doi":"10.1016/j.pscychresns.2025.112045","DOIUrl":"10.1016/j.pscychresns.2025.112045","url":null,"abstract":"<div><div>This study investigated the effect of transcranial direct current stimulation (tDCS) on sustained attention performance following a mindfulness intervention in seventeen patients with Graves’ Disease. Significant improvements in the performance of the masked continuous performance test were observed among patients who received 2 weeks of active tDCS (10 sessions). These findings reaffirm that tDCS may enhance cognitive function.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"352 ","pages":"Article 112045"},"PeriodicalIF":2.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144860602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heartbeat evoked potential and spectral analysis in patients with panic disorder during resting state","authors":"Ziheng Gao ,&nbsp;Zhiwan Xiong ,&nbsp;Xiaoshuang Wang ,&nbsp;Yi Chang ,&nbsp;Tommi Kärkkäinen ,&nbsp;Fengyu Cong","doi":"10.1016/j.pscychresns.2025.112039","DOIUrl":"10.1016/j.pscychresns.2025.112039","url":null,"abstract":"<div><div>Panic disorder (PD) involves recurrent panic attacks and anticipatory anxiety, with interoceptive dysfunction potentially contributing to its pathophysiology. This study analyzed differences in heartbeat evoked potential (HEP) and spectral power between 19 PD patients and 21 HCs during eyes-closed (EC) and eyes-open (EO) conditions to assess interoceptive processing and cortical arousal patterns. Key findings showed: (1) Compared to healthy controls, panic disorder patients exhibited higher interoceptive attention scores (BPQ-VSF: <em>t</em> = -4.944, <em>p</em> &lt; .001; noticing: <em>t</em> = -1.156, <em>p</em> = .255), greater interaction between interoception and emotion (not-worrying: <em>t</em> = 4.487, <em>p</em> &lt; .001; emotional awareness: Z = 2.009, <em>p</em> = .004), greater difficulty in regulating attention to maladaptive interoceptive signals (not distracting: <em>t</em> = 2.504, <em>p</em> = .017), and lower sense of safety and trust in the body (trusting: <em>t</em> = -2.858, <em>p</em> = .004); (2) PD patients exhibited reduced HEP amplitudes in left parieto-occipital regions during EC compared to HCs; (3) Spectral analysis revealed increased beta-band power in PD patients during EC (<em>t</em> = -0.804, <em>p</em> &lt; .05), further elevated during EO (<em>t</em> = -0.553, <em>p</em> &lt; .001) - a pattern absent in HCs. These results demonstrate impaired interoceptive regulation (diminished HEP modulation) and cortical hyperarousal (elevated beta oscillations) in PD. The study provides novel electrophysiological evidence for PD's neuropathology, identifying interoception-arousal dysregulation as a potential treatment target.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"352 ","pages":"Article 112039"},"PeriodicalIF":2.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of functional connectivity differences in Schizophrenia groups characterized by M1 receptor polymorphism during the N-Back task with fNIRS","authors":"Ece Çağlayan ,&nbsp;Yağmur Kır ,&nbsp;Murat Perit Çakır ,&nbsp;Bora Baskak","doi":"10.1016/j.pscychresns.2025.112041","DOIUrl":"10.1016/j.pscychresns.2025.112041","url":null,"abstract":"<div><div>This study focuses on the impact of M1-receptor polymorphism (rs2067477) on functional connectivity patterns of patients with schizophrenia receiving clozapine monotherapy. Although previous work suggested a relationship between M1-receptor polymorphism and cognitive function in schizophrenia, there are contradictory findings. In earlier work, we conducted an fNIRS experiment with treatment resistant schizophrenia patients and observed that the M1-receptor polymorphism did not have an effect on N-back performance; however, significant differences in cortical activity were observed at regions associated with working memory. The current study investigates whether there are differences in the functional connectivity patterns of these patient groups. Wavelet Transform Coherence method was utilized to observe overall and task-level differences in the connectivity profiles of patient groups. The results revealed that wild-type individuals exhibit higher brain activation in task related cortical regions in the prefrontal and premotor cortex, but lower functional connectivity in the fronto-temporal network compared to non-wild-types. These differences indicate the possible role of genetic variations in shaping the neural response to clozapine, with wild-type individuals displaying more efficient neural strategies, whereas non-wild-type individuals rely on broader, less efficient compensatory processes to sustain cognitive performance.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"352 ","pages":"Article 112041"},"PeriodicalIF":2.1,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous neural activity mediates the effect of adverse childhood experiences on negative cognitive styles in mood disorders: a multivariate approach","authors":"Tommaso Cazzella ,&nbsp;Michele Acconcia ,&nbsp;Federica Colombo ,&nbsp;Federico Calesella ,&nbsp;Lidia Fortaner-Uyà ,&nbsp;Camilla Monopoli ,&nbsp;Greta D’Orsi ,&nbsp;Bianca Maria Benatti ,&nbsp;Sara Poletti ,&nbsp;Raffaella Zanardi ,&nbsp;Cristina Colombo ,&nbsp;Francesco Benedetti ,&nbsp;Benedetta Vai","doi":"10.1016/j.pscychresns.2025.112038","DOIUrl":"10.1016/j.pscychresns.2025.112038","url":null,"abstract":"<div><div>Negative cognitive styles and spontaneous neural activity can reveal cognitive and neurobiological underpinnings of depression, related to poor clinical outcomes and worsened by Adverse Childhood Experiences (ACEs). This study examined the associations between ACEs, fractional Amplitude of Low Frequency Fluctuations (fALFF), and negative cognitive styles in Major Depressive Disorder (MDD) and Bipolar Disorder (BD). In a sample of 94 patients (48 MDD; 46 BD) and 35 matched HC, Canonical Correlation Analysis was used to assess the multivariate association between fALFF and ACEs, rated with the Childhood Trauma Questionnaire. A mediation model tested the role of fALFF in mediating the effect of ACEs on negative cognitive styles, assessed with the Cognitions Questionnaire. In depressed patients, negative cognitive styles were worsened by with ACEs. Cognitive biases were also associated with an ACEs-related spontaneous neural activity pattern, involving the bilateral precuneus and posterior cingulate gyrus, left dorsolateral insula, and right superior temporal gyrus. Moreover, the identified fALFF pattern mediated the effect of ACEs on the perceived uncontrollability of negative events. No significant results were found in HC. These findings highlight fALFF as a promising endophenotype linking ACEs and negative cognitive styles, offering valuable insight into the neurobiological mechanisms underlying mood disorders symptomatology.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"352 ","pages":"Article 112038"},"PeriodicalIF":2.1,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between α4β2-nicotinic acetylcholine receptor availability and brain arousal regulation as assessed by 2-[18F]F-A85380 PET and EEG following nicotine cessation in male individuals with nicotine dependence","authors":"Jue Huang ,&nbsp;Philipp M. Meyer ,&nbsp;Ivonne Burgos Guerrero ,&nbsp;Georg A. Becker ,&nbsp;Michael Rullmann ,&nbsp;Nicole Mauche ,&nbsp;Bernhard Sattler ,&nbsp;Swen Hesse ,&nbsp;Franziska R. Zientek ,&nbsp;Ulrich Hegerl ,&nbsp;Maria Strauß ,&nbsp;Osama Sabri","doi":"10.1016/j.pscychresns.2025.112035","DOIUrl":"10.1016/j.pscychresns.2025.112035","url":null,"abstract":"<div><h3>Background</h3><div>While α4β2-nicotinic-acetylcholine-receptor (α4β2-nAChR) density has been linked to cognitive performance, it remains unclear whether nicotine’s cognitive-enhancing effect are mediated primarily through direct receptor action. An alternative view suggests that nicotine exerts its influence by stabilizing brain arousal, which can be assessed using electroencephalography (EEG). This study examines the relationship between changes in α4β2-nAChR availability and brain arousal regulation following nicotine cessation in nicotine-dependent males.</div></div><div><h3>Methods</h3><div>Ten nicotine-dependent male participants underwent assessments during continued smoking, 24-h, and 7-day nicotine cessation in counterbalanced sequences. The α4β2-nAChR availability was measured using positron emission tomography (PET) under continued smoking and after 7-day nicotine cessation. EEG-based algorithm assessed changes in brain arousal regulation.</div></div><div><h3>Results</h3><div>A 7-day nicotine cessation led to higher availability of α4β2-nAChR in male participants. Despite higher availability of α4β2-nAChR, nicotine cessation showed no significant effect on arousal stability score and EEG-vigilance score. The findings of exploratory analyses suggested a potential non-linear relationship between α4β2-nAChR availability and arousal regulation.</div></div><div><h3>Conclusion</h3><div>The findings may suggest that the brain arousal regulation in some of the male participants may become more instable following a 7-day smoking cessation despite increased α4β2-nAChR binding. However, this sample limits the generalizability, and further studies with larger cohorts are needed.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"352 ","pages":"Article 112035"},"PeriodicalIF":2.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lorcaserin modulation of semantic drug cue-elicited effective brain connectivity in persons with cocaine and opioid use disorders","authors":"Liangsuo Ma ,&nbsp;Joel L. Steinberg ,&nbsp;James M. Bjork ,&nbsp;Kyle Woisard ,&nbsp;Edward Zuniga ,&nbsp;Kathryn A. Cunningham ,&nbsp;F. Gerard Moeller","doi":"10.1016/j.pscychresns.2025.112034","DOIUrl":"10.1016/j.pscychresns.2025.112034","url":null,"abstract":"<div><div>Understanding the neural mechanisms of drug cue reactivity may improve understanding of therapeutic targets for substance use disorders (SUDs). Preclinical studies indicate that the serotonin (5-HT) 5-HT_2A receptor (5-HT_2AR) and 5-HT_2CR systems considerably but oppositely impact relapse vulnerability. Specifically, 5-HT_2AR antagonists and 5-HT_2CR agonists reduce drug-seeking behavior and reactivity to drug cues. Our previous neuroimaging study showed that mirtazapine (a non-selective 5-HT_2AR antagonist) can reduce the effective connectivity (EC) of the pathway from the anterior cingulate cortex (ACC) to the hippocampus. The EC of this pathway has been consistently found to be associated with attentional bias towards drug cues in individuals with SUDs. To extend this finding, we investigated the effect of lorcaserin (a 5-HT_2CR agonist) on the EC linked to attentional bias elicited by drug-related cues by employing dynamic causal modeling on functional magnetic resonance imaging data acquired during a drug-word Stroop task performed by 45 individuals diagnosed with SUDs. We observed a marginally positive correlation between the ACC → hippocampus EC and drug cue-related attentional bias at the pretreatment baseline. Furthermore, compared to the placebo condition, 7-day administration of lorcaserin reduced the ACC → hippocampus EC. Notably, these EC outcomes remained unaffected by factors such as handedness, presence of drug metabolites in urine, pretreatment urine drug screen, and the type of substance used. This study contributes further evidence of serotonergic regulation of the ACC → hippocampus EC, and the potential for this EC to be an early signal of target engagement for medication to treat SUDs.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"352 ","pages":"Article 112034"},"PeriodicalIF":2.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gap between neurology and psychiatry in body integrity identity disorder","authors":"Maryam ,&nbsp;Hadia ,&nbsp;Filza Haq Nawaz","doi":"10.1016/j.pscychresns.2025.112036","DOIUrl":"10.1016/j.pscychresns.2025.112036","url":null,"abstract":"","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"352 ","pages":"Article 112036"},"PeriodicalIF":2.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}