探讨首发精神病和精神分裂症青少年的视网膜厚度变化：与健康兄弟姐妹和对照组的比较研究

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2025-06-30 DOI:10.1016/j.pscychresns.2025.112020

Kardelen Akbal Bağcı , Pınar Nalçacıoğlu Memiş , Mustafa Akhoroz , Beyza Nur Top Karakılınç , Esra Çöp

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引用次数: 0

摘要

视网膜提供了一种间接评估大脑炎症和变性的方法。最近，科学家们把重点放在视网膜上，把它作为了解大脑结构和功能的一个有价值的工具。本研究旨在利用光学相干断层扫描（OCT）比较首发精神病和精神分裂症患者、精神分裂症患者的健康兄弟姐妹和健康对照组的青少年视网膜层厚度。方法研究对象为18例首发精神病患者和22例精神分裂症患者，29例精神分裂症患者的健康兄弟姐妹和31例健康对照。由临床医生填写社会人口学资料表、阴性症状评估量表（SANS）、阳性症状评估量表（SAPS）、临床总体印象量表（CGI）。采用OCT自动测量黄斑总厚度、黄斑视网膜神经纤维层（RNFL）、视网膜内层包括神经节细胞层（GCL）、内丛状层（IPL），并比较四组间的差异。结果精神分裂症患者和健康兄弟姐妹的IPL内上亚段、内下亚段和GCL内颞亚段均较健康对照组变薄。此外，FEP患者的平均GCL、内sreco、内鼻部RNFL厚度均大于健康兄弟姐妹和对照组。结论精神分裂症患者和健康同胞的视网膜变薄可能是精神分裂症神经退行性变的结果。此外，在健康的兄弟姐妹中变薄可能是一种内表型候选者。FEP组的增厚可能是由于疾病急性期发生的神经炎症和水肿。

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Exploring retinal thickness variations in adolescents with first episode psychosis and schizophrenia: A comparative study with healthy siblings and controls

Background

The retina offers a way to indirectly evaluate inflammation and degeneration in the brain. Recently, scientists are focusing on the retina as a valuable tool to understand brain structure and function. This study aims to compare retinal layer thicknesses of adolescents by using Optical coherence tomography (OCT), between first episode psychosis and schizophrenia patients, healthy siblings of schizophrenia patients and healthy control groups.

Methods

The study included 18 first episode psychosis (FEP) and 22 schizophrenia patients, 29 healthy siblings of schizophrenia patients and 31 healthy controls.The sociodemographic data form, Scale for the Assesment of Negative Symptoms(SANS), Scale for the Assessment of Positive Symptoms (SAPS), Clinical Global Impression (CGI) scale were completed by the clinician. The total macular thickness, macular retinal nerve fiber layer (RNFL), inner retinal layers including, ganglion cell layer (GCL), inner plexiform layer (IPL) were automatically measured by using OCT and compared between the four groups.

Results

The inner süperior and inner inferior subsegments of IPL and inner temporal subsegments of GCL were found thinner in schizophrenia patients and healthy siblings than healthy controls. Also, average GCL, inner süperior, inner nasal of RNFL thickness was greater in FEP patients than in healthy siblings and controls.

Conclusion

Retinal thinning in schizophrenia patients and healthy siblings might be the result of the neurodegeneration seen at schizophrenia. Also thinning in healthy siblings might be an endophenotype candidate. And the thickening in the FEP group could be due to neuroinflammation and edema occurring in the acute phase of the illness.

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.