Psychiatry Research: Neuroimaging最新文献_第10页

Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity 精神分裂症的白质结构异常及其与神经认知能力和症状严重程度的关系

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-06-06 DOI: 10.1016/j.pscychresns.2024.111843

Alie G. Male , Esther Goudzwaard , Soichiro Nakahara , Jessica A. Turner , Vince D. Calhoun , Bryon A. Mueller , Kelvin O. Lim , Juan R. Bustillo , Aysenil Belger , James Voyvodic , Daniel O'Leary , Daniel H. Mathalon , Judith M. Ford , Steven G. Potkin , Adrian Preda , Theo G. M. van Erp

{"title":"Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity","authors":"Alie G. Male , Esther Goudzwaard , Soichiro Nakahara , Jessica A. Turner , Vince D. Calhoun , Bryon A. Mueller , Kelvin O. Lim , Juan R. Bustillo , Aysenil Belger , James Voyvodic , Daniel O'Leary , Daniel H. Mathalon , Judith M. Ford , Steven G. Potkin , Adrian Preda , Theo G. M. van Erp","doi":"10.1016/j.pscychresns.2024.111843","DOIUrl":"10.1016/j.pscychresns.2024.111843","url":null,"abstract":"<div><p>Schizophrenia is associated with robust white matter (WM) abnormalities but influences of potentially confounding variables and relationships with cognitive performance and symptom severity remain to be fully determined. This study was designed to evaluate WM abnormalities based on diffusion tensor imaging (DTI) in individuals with schizophrenia, and their relationships with cognitive performance and symptom severity. Data from individuals with schizophrenia (SZ; n=138, mean age<span><math><mo>±</mo></math></span>SD=39.02<span><math><mo>±</mo></math></span>11.82; 105 males) and healthy controls (HC; n=143, mean age<span><math><mo>±</mo></math></span>SD=37.07<span><math><mo>±</mo></math></span>10.84; 102 males) were collected as part of the Function Biomedical Informatics Research Network Phase 3 study. Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) were compared between individuals with schizophrenia and healthy controls, and their relationships with neurocognitive performance and symptomatology assessed. Individuals with SZ had significantly lower FA in forceps minor and the left inferior fronto-occipital fasciculus compared to HC. FA in several tracts were associated with speed of processing and attention/vigilance and the severity of the negative symptom alogia. This study suggests that regional WM abnormalities are fundamentally involved in the pathophysiology of schizophrenia and may contribute to cognitive performance deficits and symptom expression observed in schizophrenia.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"342 ","pages":"Article 111843"},"PeriodicalIF":2.3,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141412920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of antidepressants on brain structure and function in patients with obsessive-compulsive disorder: A review of neuroimaging studies 抗抑郁药对强迫症患者大脑结构和功能的影响：神经影像学研究综述。

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-06-06 DOI: 10.1016/j.pscychresns.2024.111842

Homa Seyedmirzaei , Nikoo Bayan , Mohammad Amin Dabbagh Ohadi , Giulia Cattarinussi , Fabio Sambataro

{"title":"Effects of antidepressants on brain structure and function in patients with obsessive-compulsive disorder: A review of neuroimaging studies","authors":"Homa Seyedmirzaei , Nikoo Bayan , Mohammad Amin Dabbagh Ohadi , Giulia Cattarinussi , Fabio Sambataro","doi":"10.1016/j.pscychresns.2024.111842","DOIUrl":"10.1016/j.pscychresns.2024.111842","url":null,"abstract":"<div><p>Obsessive-compulsive disorder (OCD) affects 2–3% of people worldwide. Although antidepressants are the standard pharmachological treatment of OCD, their effect on the brain of individuals with OCD has not yet been fully clarified. We conducted a systematic search on PubMed, Scopus, Embase, and Web of Science to explore the effects of antidepressants on neuroimaging findings in OCD. Thirteen neuroimaging investigations were included. After antidepressant treatment, structural magnetic resonance imaging studies suggested thalamic, amygdala, and pituitary volume changes in patients. In addition, the use of antidepressants was associated with alterations in diffusion tensor imaging metrics in the left striatum, the right midbrain, and the posterior thalamic radiation in the right parietal lobe. Finally, functional magnetic resonance imaging highlighted possible changes in the ventral striatum, frontal, and prefrontal cortex. The small number of included studies and sample sizes, short durations of follow-up, different antidepressants, variable regions of interest, and heterogeneous samples limit the robustness of the findings of the present review. In conclusion, our review suggests that antidepressant treatment is associated with brain changes in individuals with OCD, and these results may help to deepen our knowledge of the pathophysiology of OCD and the brain mechanisms underlying the effects of antidepressants.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"342 ","pages":"Article 111842"},"PeriodicalIF":2.3,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0925492724000659/pdfft?md5=723e123bc69901065e73cebf21ab4225&pid=1-s2.0-S0925492724000659-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141321467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Female sex and age-based advantage of simulated electric field in TMS to the prefrontal cortex in schizophrenia and mood disorders 精神分裂症和情绪障碍患者前额叶皮层经颅磁刺激模拟电场的女性性别和年龄优势

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-06-06 DOI: 10.1016/j.pscychresns.2024.111844

Atsushi Tamaki , Shinya Uenishi , Shinichi Yamada , Kasumi Yasuda , Natsuko Ikeda , Michiyo Tabata , Akira Kita , Yuki Mizutani-Tiebel , Daniel Keeser , Frank Padberg , Tomikimi Tsuji , Sohei Kimoto , Shun Takahashi

{"title":"Female sex and age-based advantage of simulated electric field in TMS to the prefrontal cortex in schizophrenia and mood disorders","authors":"Atsushi Tamaki , Shinya Uenishi , Shinichi Yamada , Kasumi Yasuda , Natsuko Ikeda , Michiyo Tabata , Akira Kita , Yuki Mizutani-Tiebel , Daniel Keeser , Frank Padberg , Tomikimi Tsuji , Sohei Kimoto , Shun Takahashi","doi":"10.1016/j.pscychresns.2024.111844","DOIUrl":"10.1016/j.pscychresns.2024.111844","url":null,"abstract":"<div><p>This study investigates computational models of electric field strength for transcranial magnetic stimulation (TMS) of the left dorsolateral prefrontal cortex (DLPFC) based on individual MRI data of patients with schizophrenia (SZ), major depressive disorder (MDD), bipolar disorder (BP), and healthy controls (HC). In addition, it explores the association of electric field intensities with age, gender and intracranial volume. The subjects were 23 SZ (12 male, mean age = 45.30), 24 MDD (16 male, mean age = 43.57), 23 BP (16 male, mean age = 39.29), 23 HC (13 male, mean age = 40.91). Based on individual MRI sequences, electric fields were computationally modeled by two independent investigators using SimNIBS ver. 2.1.1. There was no significant difference in electric field strength between the groups (HC vs SZ, HC vs MDD, HC vs BP, S<del>C</del>Z vs MDD, S<del>C</del>Z vs BP, MDD vs BP). Female subjects showed higher electric field intensities in widespread areas than males, and age was positively significantly associated with electric field strength in the left parahippocampal area as observed. Our results suggest differences in electric field strength of left DLPFC TMS for gender and age. It may open future avenues for individually modeling TMS based on structural MRI data.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"342 ","pages":"Article 111844"},"PeriodicalIF":2.3,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141414629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Susceptibility or resilience to childhood peer abuse can be explained by cortical thickness in brain regions involved in emotional regulation 参与情绪调节的大脑区域皮层厚度可解释对童年同伴虐待的易感性或复原力

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-23 DOI: 10.1016/j.pscychresns.2024.111829

Mengchun Yang , Zhengxinyue Wang , Xinyu Cao , Jianjun Zhu , Yuanyuan Chen

{"title":"Susceptibility or resilience to childhood peer abuse can be explained by cortical thickness in brain regions involved in emotional regulation","authors":"Mengchun Yang , Zhengxinyue Wang , Xinyu Cao , Jianjun Zhu , Yuanyuan Chen","doi":"10.1016/j.pscychresns.2024.111829","DOIUrl":"10.1016/j.pscychresns.2024.111829","url":null,"abstract":"<div><p>Experiencing peer abuse in childhood can damage mental health, but some people exhibit resilience against these negative outcomes. However, it remains uncertain which specific changes in brain structures are associated with this type of resilience. We categorized 217 participants into three groups: resilience group, susceptibility group, and healthy control group, based on their experiences of peer abuse and mental health problems. They underwent MRI scans to measure cortical thickness in various brain regions of the prefrontal cortex. We employed covariance analysis to compare cortical thickness among these groups. Individuals who resilient to anxiety exhibited smaller cortical thickness in the bilateral inferior frontal gyrus (IFG), and with larger thickness in the right medial orbitofrontal cortex (mOFC), while those resilient to stress was associated with smaller thickness in both the bilateral IFG and bilateral middle frontal gyrus (MFG). These findings deepen our understanding of the neural mechanisms underlying resilience and offer insight into improving individual resilience.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"342 ","pages":"Article 111829"},"PeriodicalIF":2.3,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141141782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain alterations in Cocaine Use Disorder: Does the route of use matter and does it relate to the treatment outcome? 可卡因使用障碍的大脑改变：使用途径是否重要，是否与治疗结果有关？

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-22 DOI: 10.1016/j.pscychresns.2024.111830

Margaux Poireau , Shailendra Segobin , Angéline Maillard , Virgile Clergue-Duval , Romain Icick , Julien Azuar , Emmanuelle Volle , Christine Delmaire , Vanessa Bloch , Anne-Lise Pitel , Florence Vorspan

{"title":"Brain alterations in Cocaine Use Disorder: Does the route of use matter and does it relate to the treatment outcome?","authors":"Margaux Poireau , Shailendra Segobin , Angéline Maillard , Virgile Clergue-Duval , Romain Icick , Julien Azuar , Emmanuelle Volle , Christine Delmaire , Vanessa Bloch , Anne-Lise Pitel , Florence Vorspan","doi":"10.1016/j.pscychresns.2024.111830","DOIUrl":"10.1016/j.pscychresns.2024.111830","url":null,"abstract":"<div><h3>Aims</h3><p>Cocaine Use Disorder (CUD) is an important health issue, associated with structural brain abnormalities. However, the impact of the route of administration and their predictive value for relapse remain unknown. Methods: We conducted an anatomical MRI study in 55 CUD patients (26 CUD-Crack and 29 CUD-Hydro) entering inpatient detoxification, and 38 matched healthy controls. In patients, a 3-months outpatient follow-up was carried out to specify the treatment outcome status (relapser when cocaine was consumed once or more during the past month). A Voxel-Based Morphometry approach was used.</p></div><div><h3>Results</h3><p>Compared with controls, CUD patients had widespread gray matter alterations, mostly in frontal and temporal cortices, but also in the cerebellum and several sub-cortical structures. We then compared CUD-Crack with CUD-Hydro patients and found that crack-cocaine use was associated with lower volume in the right inferior and middle temporal gyri, and the right fusiform gyrus. Cerebellar vermis was smaller during detoxification in subsequent relapsers compared to three-months abstainers.</p></div><div><h3>Conclusions</h3><p>Patients with CUD display widespread cortical and subcortical brain shrinkage. Patients with preferential crack-cocaine use and subsequent relapsers showed specific gray matter volume deficits, suggesting that different patterns of cocaine use and different clinical outcome are associated with different brain macrostructure.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"342 ","pages":"Article 111830"},"PeriodicalIF":2.3,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0925492724000532/pdfft?md5=d193e07209a747d5e2d5eb9c8ae36dc9&pid=1-s2.0-S0925492724000532-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141135793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of resting-state EEG functional connectivity in depression and obsessive-compulsive disorder 抑郁症和强迫症静息态脑电图功能连接的比较分析

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-22 DOI: 10.1016/j.pscychresns.2024.111828

Dina Mitiureva , Olga Sysoeva , Ekaterina Proshina , Galina Portnova , Guzal Khayrullina , Olga Martynova

{"title":"Comparative analysis of resting-state EEG functional connectivity in depression and obsessive-compulsive disorder","authors":"Dina Mitiureva , Olga Sysoeva , Ekaterina Proshina , Galina Portnova , Guzal Khayrullina , Olga Martynova","doi":"10.1016/j.pscychresns.2024.111828","DOIUrl":"10.1016/j.pscychresns.2024.111828","url":null,"abstract":"<div><p>Major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) are psychiatric disorders that often co-occur. We aimed to investigate whether their high comorbidity could be traced not only by clinical manifestations, but also at the level of functional brain activity. In this paper, we examined the differences in functional connectivity (FC) at the whole-brain level and within the default mode network (DMN). Resting-state EEG was obtained from 43 controls, 26 OCD patients, and 34 MDD patients. FC was analyzed between 68 cortical sources, and between-group differences in the 4–30 Hz range were assessed via the Network Based Statistic method. The strength of DMN intra-connectivity was compared between groups in the theta, alpha and beta frequency bands. A cluster of 67 connections distinguished the OCD, MDD and control groups. The majority of the connections, 8 of which correlated with depressive symptom severity, were found to be weaker in the clinical groups. Only 3 connections differed between the clinical groups, and one of them correlated with OCD severity. The DMN strength was reduced in the clinical groups in the alpha and beta bands. It can be concluded that the high comorbidity of OCD and MDD can be traced at the level of FC.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"342 ","pages":"Article 111828"},"PeriodicalIF":2.3,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141138784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis support of major depressive disorder using event-related potentials during affective priming tasks 利用情感启动任务中的事件相关电位为重度抑郁障碍提供诊断支持

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-12 DOI: 10.1016/j.pscychresns.2024.111827

Fabiana B.H. Umezaki , Ysabelle P. Sousa , Tiago Duarte Pereira , Francisco J. Fraga

{"title":"Diagnosis support of major depressive disorder using event-related potentials during affective priming tasks","authors":"Fabiana B.H. Umezaki , Ysabelle P. Sousa , Tiago Duarte Pereira , Francisco J. Fraga","doi":"10.1016/j.pscychresns.2024.111827","DOIUrl":"10.1016/j.pscychresns.2024.111827","url":null,"abstract":"<div><p>Major Depressive Disorder (MDD) is a global problem. Currently, the most common diagnosis is based on criteria susceptible to the subjectivity of the patient and the clinician. A possible solution to this problem is to look for diagnostic biomarkers that can accurately and early detect this mental condition. Some researchers have focused on electroencephalogram (EEG) analysis to identify biomarkers. In this study we used a dataset composed of EEG recordings from 24 subjects with MDD and 29 healthy controls (HC), during the execution of affective priming tasks with three different emotional stimuli (images): fear, sadness, and happiness. We investigated abnormalities in depressed patients using a novel technique, by directly comparing Event-Related Potential (ERP) waveforms to find statistically significant differences between the MMD and HC groups. Compared to the control group (healthy subjects), we found out that for the emotions fear and happiness there is a decrease in cortical activity at temporal regions in MDD patients. Just the opposite, for the emotion sadness, an increase in MDD brain activity occurs in frontal and occipital regions. Our findings suggest that emotions regulate the attentional control of cognitive processing and are promising for clinical application in diagnosing patients with MDD more objectively.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"341 ","pages":"Article 111827"},"PeriodicalIF":2.3,"publicationDate":"2024-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141038860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Excessive left anterior hippocampal and caudate activation in schizophrenia underlie cognitive underperformance in a virtual navigation task 精神分裂症患者左前海马和尾状体过度激活是虚拟导航任务中认知表现不佳的基础

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-06 DOI: 10.1016/j.pscychresns.2024.111826

John A. Zawadzki , Todd A. Girard , James Samsom , George Foussias , Ishraq Siddiqui , Jason P. Lerch , Cheryl Grady , Albert H.C. Wong

{"title":"Excessive left anterior hippocampal and caudate activation in schizophrenia underlie cognitive underperformance in a virtual navigation task","authors":"John A. Zawadzki , Todd A. Girard , James Samsom , George Foussias , Ishraq Siddiqui , Jason P. Lerch , Cheryl Grady , Albert H.C. Wong","doi":"10.1016/j.pscychresns.2024.111826","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111826","url":null,"abstract":"<div><p>We used a virtual navigation paradigm in a city environment to assess neuroanatomical correlates of cognitive deficits in schizophrenia spectrum disorders (SSD). We studied a total of <em>N</em> = 36 subjects: 18 with SSD and 18 matched unaffected controls. Participants completed 10 rapid, single-trial navigation tasks within the virtual city while undergoing functional magnetic resonance imaging (fMRI). All trials tested ability to find different targets seen earlier, during the passive viewing of a path around different city blocks. SSD patients had difficulty finding previously-encountered targets, were less likely to find novel shortcuts to targets, and more likely to attempt retracing of the path observed during passive viewing. Based on <em>a priori</em> region-of-interest analyses, SSD participants had hyperactivation of the left hippocampus when passively viewing turns, hyperactivation of the left caudate when finding targets, and hypoactivation of a focal area of the dorsolateral prefrontal cortex when targets were initially shown during passive viewing. We propose that these brain-behaviour relations may bias or reinforce stimulus-response navigation approaches in SSD and underlie impaired performance when allocentric spatial memory is required, such as when forming efficient shortcuts. This pattern may extend to more general cognitive impairments in SSD that could be used to design remediation strategies.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"341 ","pages":"Article 111826"},"PeriodicalIF":2.3,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140906731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and functional neural patterns among sub-threshold bulimia nervosa: Abnormalities in dorsolateral prefrontal cortex and orbitofrontal cortex 阈值下神经性贪食症的结构和功能神经模式：背外侧前额叶皮层和眶额叶皮层异常

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-06 DOI: 10.1016/j.pscychresns.2024.111825

Lin Luo , Yijun Luo , Ximei Chen , Mingyue Xiao , Ziming Bian , Xuechen Leng , Wei Li , Junjie Wang , Yue Yang , Yong Liu , Hong Chen

{"title":"Structural and functional neural patterns among sub-threshold bulimia nervosa: Abnormalities in dorsolateral prefrontal cortex and orbitofrontal cortex","authors":"Lin Luo , Yijun Luo , Ximei Chen , Mingyue Xiao , Ziming Bian , Xuechen Leng , Wei Li , Junjie Wang , Yue Yang , Yong Liu , Hong Chen","doi":"10.1016/j.pscychresns.2024.111825","DOIUrl":"10.1016/j.pscychresns.2024.111825","url":null,"abstract":"<div><h3>Background</h3><p>Disordered eating behaviors are prevalent among youngsters and highly associated with dysfunction in neurocognitive systems. We aimed to identify the potential changes in individuals with bulimia symptoms (sub-BN) to generate insights to understand developmental pathophysiology of bulimia nervosa.</p></div><div><h3>Methods</h3><p>We investigated group differences in terms of degree centrality (DC) and gray matter volume (GMV) among 145 undergraduates with bulimia symptoms and 140 matched control undergraduates, with the secondary analysis of the whole brain connectivity in these regions of interest showing differences in static functional connectivity (FC).</p></div><div><h3>Results</h3><p>The sub-BN group exhibited abnormalities of the right dorsolateral prefrontal cortex and right orbitofrontal cortex in both GMV and DC, and displayed decreased FC between these regions and the precuneus. We also observed that sub-BN presented with reduced FC between the calcarine and superior temporal gyrus, middle temporal gyrus and inferior parietal gyrus. Additionally, brain-behavioral associations suggest a distinct relationship between these FCs and psychopathological symptoms in sub-BN group.</p></div><div><h3>Conclusions</h3><p>Our study demonstrated that individuals with bulimia symptoms present with aberrant neural patterns that mainly involved in cognitive control and reward processing, as well as attentional and self-referential processing, which could provide important insights into the pathology of BN.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"342 ","pages":"Article 111825"},"PeriodicalIF":2.3,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141027527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Test-retest reliability of resting-state cerebral blood flow quantification using pulsed Arterial Spin Labeling (PASL) over 3 weeks vs 8 weeks in healthy controls 在健康对照组中使用脉冲动脉自旋标记（PASL）进行静息态脑血流定量的测试-再测试可靠性（3 周与 8 周对比

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-04 DOI: 10.1016/j.pscychresns.2024.111823

Alexandra Kyrou , Elina Grünert , Florian Wüthrich , Niluja Nadesalingam , Victoria Chapellier , Melanie G Nuoffer , Anastasia Pavlidou , Stephanie Lefebvre , Sebastian Walther

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