Psychiatry Research: Neuroimaging最新文献_第9页

Brain alterations in Cocaine Use Disorder: Does the route of use matter and does it relate to the treatment outcome? 可卡因使用障碍的大脑改变：使用途径是否重要，是否与治疗结果有关？

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-22 DOI: 10.1016/j.pscychresns.2024.111830

Margaux Poireau , Shailendra Segobin , Angéline Maillard , Virgile Clergue-Duval , Romain Icick , Julien Azuar , Emmanuelle Volle , Christine Delmaire , Vanessa Bloch , Anne-Lise Pitel , Florence Vorspan

{"title":"Brain alterations in Cocaine Use Disorder: Does the route of use matter and does it relate to the treatment outcome?","authors":"Margaux Poireau , Shailendra Segobin , Angéline Maillard , Virgile Clergue-Duval , Romain Icick , Julien Azuar , Emmanuelle Volle , Christine Delmaire , Vanessa Bloch , Anne-Lise Pitel , Florence Vorspan","doi":"10.1016/j.pscychresns.2024.111830","DOIUrl":"10.1016/j.pscychresns.2024.111830","url":null,"abstract":"<div><h3>Aims</h3><p>Cocaine Use Disorder (CUD) is an important health issue, associated with structural brain abnormalities. However, the impact of the route of administration and their predictive value for relapse remain unknown. Methods: We conducted an anatomical MRI study in 55 CUD patients (26 CUD-Crack and 29 CUD-Hydro) entering inpatient detoxification, and 38 matched healthy controls. In patients, a 3-months outpatient follow-up was carried out to specify the treatment outcome status (relapser when cocaine was consumed once or more during the past month). A Voxel-Based Morphometry approach was used.</p></div><div><h3>Results</h3><p>Compared with controls, CUD patients had widespread gray matter alterations, mostly in frontal and temporal cortices, but also in the cerebellum and several sub-cortical structures. We then compared CUD-Crack with CUD-Hydro patients and found that crack-cocaine use was associated with lower volume in the right inferior and middle temporal gyri, and the right fusiform gyrus. Cerebellar vermis was smaller during detoxification in subsequent relapsers compared to three-months abstainers.</p></div><div><h3>Conclusions</h3><p>Patients with CUD display widespread cortical and subcortical brain shrinkage. Patients with preferential crack-cocaine use and subsequent relapsers showed specific gray matter volume deficits, suggesting that different patterns of cocaine use and different clinical outcome are associated with different brain macrostructure.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"342 ","pages":"Article 111830"},"PeriodicalIF":2.3,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0925492724000532/pdfft?md5=d193e07209a747d5e2d5eb9c8ae36dc9&pid=1-s2.0-S0925492724000532-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141135793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of resting-state EEG functional connectivity in depression and obsessive-compulsive disorder 抑郁症和强迫症静息态脑电图功能连接的比较分析

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-22 DOI: 10.1016/j.pscychresns.2024.111828

Dina Mitiureva , Olga Sysoeva , Ekaterina Proshina , Galina Portnova , Guzal Khayrullina , Olga Martynova

{"title":"Comparative analysis of resting-state EEG functional connectivity in depression and obsessive-compulsive disorder","authors":"Dina Mitiureva , Olga Sysoeva , Ekaterina Proshina , Galina Portnova , Guzal Khayrullina , Olga Martynova","doi":"10.1016/j.pscychresns.2024.111828","DOIUrl":"10.1016/j.pscychresns.2024.111828","url":null,"abstract":"<div><p>Major depressive disorder (MDD) and obsessive-compulsive disorder (OCD) are psychiatric disorders that often co-occur. We aimed to investigate whether their high comorbidity could be traced not only by clinical manifestations, but also at the level of functional brain activity. In this paper, we examined the differences in functional connectivity (FC) at the whole-brain level and within the default mode network (DMN). Resting-state EEG was obtained from 43 controls, 26 OCD patients, and 34 MDD patients. FC was analyzed between 68 cortical sources, and between-group differences in the 4–30 Hz range were assessed via the Network Based Statistic method. The strength of DMN intra-connectivity was compared between groups in the theta, alpha and beta frequency bands. A cluster of 67 connections distinguished the OCD, MDD and control groups. The majority of the connections, 8 of which correlated with depressive symptom severity, were found to be weaker in the clinical groups. Only 3 connections differed between the clinical groups, and one of them correlated with OCD severity. The DMN strength was reduced in the clinical groups in the alpha and beta bands. It can be concluded that the high comorbidity of OCD and MDD can be traced at the level of FC.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"342 ","pages":"Article 111828"},"PeriodicalIF":2.3,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141138784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis support of major depressive disorder using event-related potentials during affective priming tasks 利用情感启动任务中的事件相关电位为重度抑郁障碍提供诊断支持

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-12 DOI: 10.1016/j.pscychresns.2024.111827

Fabiana B.H. Umezaki , Ysabelle P. Sousa , Tiago Duarte Pereira , Francisco J. Fraga

{"title":"Diagnosis support of major depressive disorder using event-related potentials during affective priming tasks","authors":"Fabiana B.H. Umezaki , Ysabelle P. Sousa , Tiago Duarte Pereira , Francisco J. Fraga","doi":"10.1016/j.pscychresns.2024.111827","DOIUrl":"10.1016/j.pscychresns.2024.111827","url":null,"abstract":"<div><p>Major Depressive Disorder (MDD) is a global problem. Currently, the most common diagnosis is based on criteria susceptible to the subjectivity of the patient and the clinician. A possible solution to this problem is to look for diagnostic biomarkers that can accurately and early detect this mental condition. Some researchers have focused on electroencephalogram (EEG) analysis to identify biomarkers. In this study we used a dataset composed of EEG recordings from 24 subjects with MDD and 29 healthy controls (HC), during the execution of affective priming tasks with three different emotional stimuli (images): fear, sadness, and happiness. We investigated abnormalities in depressed patients using a novel technique, by directly comparing Event-Related Potential (ERP) waveforms to find statistically significant differences between the MMD and HC groups. Compared to the control group (healthy subjects), we found out that for the emotions fear and happiness there is a decrease in cortical activity at temporal regions in MDD patients. Just the opposite, for the emotion sadness, an increase in MDD brain activity occurs in frontal and occipital regions. Our findings suggest that emotions regulate the attentional control of cognitive processing and are promising for clinical application in diagnosing patients with MDD more objectively.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"341 ","pages":"Article 111827"},"PeriodicalIF":2.3,"publicationDate":"2024-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141038860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Excessive left anterior hippocampal and caudate activation in schizophrenia underlie cognitive underperformance in a virtual navigation task 精神分裂症患者左前海马和尾状体过度激活是虚拟导航任务中认知表现不佳的基础

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-06 DOI: 10.1016/j.pscychresns.2024.111826

John A. Zawadzki , Todd A. Girard , James Samsom , George Foussias , Ishraq Siddiqui , Jason P. Lerch , Cheryl Grady , Albert H.C. Wong

{"title":"Excessive left anterior hippocampal and caudate activation in schizophrenia underlie cognitive underperformance in a virtual navigation task","authors":"John A. Zawadzki , Todd A. Girard , James Samsom , George Foussias , Ishraq Siddiqui , Jason P. Lerch , Cheryl Grady , Albert H.C. Wong","doi":"10.1016/j.pscychresns.2024.111826","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111826","url":null,"abstract":"<div><p>We used a virtual navigation paradigm in a city environment to assess neuroanatomical correlates of cognitive deficits in schizophrenia spectrum disorders (SSD). We studied a total of <em>N</em> = 36 subjects: 18 with SSD and 18 matched unaffected controls. Participants completed 10 rapid, single-trial navigation tasks within the virtual city while undergoing functional magnetic resonance imaging (fMRI). All trials tested ability to find different targets seen earlier, during the passive viewing of a path around different city blocks. SSD patients had difficulty finding previously-encountered targets, were less likely to find novel shortcuts to targets, and more likely to attempt retracing of the path observed during passive viewing. Based on <em>a priori</em> region-of-interest analyses, SSD participants had hyperactivation of the left hippocampus when passively viewing turns, hyperactivation of the left caudate when finding targets, and hypoactivation of a focal area of the dorsolateral prefrontal cortex when targets were initially shown during passive viewing. We propose that these brain-behaviour relations may bias or reinforce stimulus-response navigation approaches in SSD and underlie impaired performance when allocentric spatial memory is required, such as when forming efficient shortcuts. This pattern may extend to more general cognitive impairments in SSD that could be used to design remediation strategies.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"341 ","pages":"Article 111826"},"PeriodicalIF":2.3,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140906731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and functional neural patterns among sub-threshold bulimia nervosa: Abnormalities in dorsolateral prefrontal cortex and orbitofrontal cortex 阈值下神经性贪食症的结构和功能神经模式：背外侧前额叶皮层和眶额叶皮层异常

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-06 DOI: 10.1016/j.pscychresns.2024.111825

Lin Luo , Yijun Luo , Ximei Chen , Mingyue Xiao , Ziming Bian , Xuechen Leng , Wei Li , Junjie Wang , Yue Yang , Yong Liu , Hong Chen

{"title":"Structural and functional neural patterns among sub-threshold bulimia nervosa: Abnormalities in dorsolateral prefrontal cortex and orbitofrontal cortex","authors":"Lin Luo , Yijun Luo , Ximei Chen , Mingyue Xiao , Ziming Bian , Xuechen Leng , Wei Li , Junjie Wang , Yue Yang , Yong Liu , Hong Chen","doi":"10.1016/j.pscychresns.2024.111825","DOIUrl":"10.1016/j.pscychresns.2024.111825","url":null,"abstract":"<div><h3>Background</h3><p>Disordered eating behaviors are prevalent among youngsters and highly associated with dysfunction in neurocognitive systems. We aimed to identify the potential changes in individuals with bulimia symptoms (sub-BN) to generate insights to understand developmental pathophysiology of bulimia nervosa.</p></div><div><h3>Methods</h3><p>We investigated group differences in terms of degree centrality (DC) and gray matter volume (GMV) among 145 undergraduates with bulimia symptoms and 140 matched control undergraduates, with the secondary analysis of the whole brain connectivity in these regions of interest showing differences in static functional connectivity (FC).</p></div><div><h3>Results</h3><p>The sub-BN group exhibited abnormalities of the right dorsolateral prefrontal cortex and right orbitofrontal cortex in both GMV and DC, and displayed decreased FC between these regions and the precuneus. We also observed that sub-BN presented with reduced FC between the calcarine and superior temporal gyrus, middle temporal gyrus and inferior parietal gyrus. Additionally, brain-behavioral associations suggest a distinct relationship between these FCs and psychopathological symptoms in sub-BN group.</p></div><div><h3>Conclusions</h3><p>Our study demonstrated that individuals with bulimia symptoms present with aberrant neural patterns that mainly involved in cognitive control and reward processing, as well as attentional and self-referential processing, which could provide important insights into the pathology of BN.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"342 ","pages":"Article 111825"},"PeriodicalIF":2.3,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141027527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Test-retest reliability of resting-state cerebral blood flow quantification using pulsed Arterial Spin Labeling (PASL) over 3 weeks vs 8 weeks in healthy controls 在健康对照组中使用脉冲动脉自旋标记（PASL）进行静息态脑血流定量的测试-再测试可靠性（3 周与 8 周对比

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-04 DOI: 10.1016/j.pscychresns.2024.111823

Alexandra Kyrou , Elina Grünert , Florian Wüthrich , Niluja Nadesalingam , Victoria Chapellier , Melanie G Nuoffer , Anastasia Pavlidou , Stephanie Lefebvre , Sebastian Walther

{"title":"Test-retest reliability of resting-state cerebral blood flow quantification using pulsed Arterial Spin Labeling (PASL) over 3 weeks vs 8 weeks in healthy controls","authors":"Alexandra Kyrou , Elina Grünert , Florian Wüthrich , Niluja Nadesalingam , Victoria Chapellier , Melanie G Nuoffer , Anastasia Pavlidou , Stephanie Lefebvre , Sebastian Walther","doi":"10.1016/j.pscychresns.2024.111823","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111823","url":null,"abstract":"<div><p>Arterial Spin Labeling is a valuable functional imaging tool for both clinical and research purposes. However, little is known about the test-retest reliability of cerebral blood flow measurements over longer periods. In this study, we investigated the reliability of pulsed Arterial Spin Labeling in assessing cerebral blood flow over a 3 (<em>n</em> = 28) vs 8 (<em>n</em> = 19) weeks interscan interval in 47 healthy participants. As a measure of cerebral blood flow reliability, we calculated voxel-wise, whole-brain, and regions of interest intraclass correlation coefficients. The whole-brain mean resting-state cerebral blood flow showed good to excellent reliability over time for both periods (intraclass correlation coefficients = 0.85 for the 3-week delay, intraclass correlation coefficients = 0.53 for the 8-week delay). However, the voxel-wise and regions of interest intraclass correlation coefficients fluctuated at 8-week compared to the 3-week interval, especially within cortical areas. These results confirmed previous findings that Arterial Spin Labeling could be used as a reliable method to assess brain perfusion. However, as the reliability seemed to decrease over time, caution is warranted when performing correlations with other variables, especially in clinical populations.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"341 ","pages":"Article 111823"},"PeriodicalIF":2.3,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0925492724000465/pdfft?md5=1f5e5dde9eced5aface76362711aee1f&pid=1-s2.0-S0925492724000465-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140906732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoactivation of the language network during auditory imagery contributes to hallucinations in Schizophrenia 听觉想象过程中语言网络激活不足导致精神分裂症患者产生幻觉

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-05-03 DOI: 10.1016/j.pscychresns.2024.111824

Luca Besso , Sara Larivière , Meighen Roes , Nicole Sanford , Chantal Percival , Matteo Damascelli , Ava Momeni , Katie Lavigne , Mahesh Menon , André Aleman , Branislava Ćurčić-Blake , Todd S. Woodward

{"title":"Hypoactivation of the language network during auditory imagery contributes to hallucinations in Schizophrenia","authors":"Luca Besso , Sara Larivière , Meighen Roes , Nicole Sanford , Chantal Percival , Matteo Damascelli , Ava Momeni , Katie Lavigne , Mahesh Menon , André Aleman , Branislava Ćurčić-Blake , Todd S. Woodward","doi":"10.1016/j.pscychresns.2024.111824","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111824","url":null,"abstract":"<div><p>Auditory verbal hallucinations (AVHs) involve perceptions, often voices, in the absence of external stimuli, and rank among the most common symptoms of schizophrenia. Metrical stress evaluation requires determination of the stronger syllable in words, and therefore requires auditory imagery, of interest for investigation of hallucinations in schizophrenia. The current functional magnetic resonance imaging study provides an updated whole-brain network analysis of a previously published study on metrical stress, which showed reduced directed connections between Broca's and Wernicke's regions of interest (ROIs) for hallucinations. Three functional brain networks were extracted, with the language network (LN) showing an earlier and shallower blood-oxygen-level dependent (BOLD) response for hallucinating patients, in the auditory imagery condition only (the reduced activation for hallucinations observed in the original ROI-based results were not specific to the imagery condition). This suggests that hypoactivation of the LN during internal auditory imagery may contribute to the propensity to hallucinate. This accords with cognitive accounts holding that an impaired balance between internal and external linguistic processes (underactivity in networks involved in internal auditory imagery and overactivity in networks involved in speech perception) contributes to our understanding of the biological underpinnings of hallucinations.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"341 ","pages":"Article 111824"},"PeriodicalIF":2.3,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0925492724000477/pdfft?md5=71e3c4d53ae375bcf7c141de70451ecf&pid=1-s2.0-S0925492724000477-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140949988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting individual autistic symptoms for patients with autism spectrum disorder using interregional morphological connectivity 利用区域间形态连接预测自闭症谱系障碍患者的个体自闭症症状

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-04-19 DOI: 10.1016/j.pscychresns.2024.111822

Xun-Heng Wang, Peng Wu, Lihua Li

{"title":"Predicting individual autistic symptoms for patients with autism spectrum disorder using interregional morphological connectivity","authors":"Xun-Heng Wang, Peng Wu, Lihua Li","doi":"10.1016/j.pscychresns.2024.111822","DOIUrl":"10.1016/j.pscychresns.2024.111822","url":null,"abstract":"<div><p>Intelligent predictive models for autistic symptoms based on neuroimaging datasets were beneficial for the precise intervention of patients with ASD. The goals of this study were twofold: investigating predictive models for autistic symptoms and discovering the brain connectivity patterns for ASD-related behaviors. To achieve these goals, we obtained a cohort of patients with ASD from the ABIDE project. The autistic symptoms were measured using the Autism Diagnostic Observation Schedule (ADOS). The anatomical MRI datasets were preprocessed using the Freesurfer package, resulting in regional morphological features. For each individual, the interregional morphological network was constructed using a novel feature distance-based method. The predictive models for autistic symptoms were built using the support vector regression (SVR) algorithm with feature selection method. The predicted autistic symptoms (i.e., ADOS social score, ADOS behavior) were significantly correlated to the original measures. The most predictive features for ADOS social scores were located in the bilateral fusiform. The most predictive features for ADOS behavior scores were located in the temporal pole and the lingual gyrus. In summary, the autistic symptoms could be predicted using the interregional morphological connectivity and machine learning. The interregional morphological connectivity could be a potential biomarker for autistic symptoms.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"341 ","pages":"Article 111822"},"PeriodicalIF":2.3,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory P50 Sensory Gating Alterations in Major Depressive Disorder and their Relationship to Clinical Symptoms 重度抑郁症的听觉 P50 感觉门控改变及其与临床症状的关系

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-04-02 DOI: 10.1016/j.pscychresns.2024.111813

Sara de la Salle , Hayley Bowers , Meagan Birmingham , Jennifer L. Phillips , Pierre Blier , Verner Knott

{"title":"Auditory P50 Sensory Gating Alterations in Major Depressive Disorder and their Relationship to Clinical Symptoms","authors":"Sara de la Salle , Hayley Bowers , Meagan Birmingham , Jennifer L. Phillips , Pierre Blier , Verner Knott","doi":"10.1016/j.pscychresns.2024.111813","DOIUrl":"10.1016/j.pscychresns.2024.111813","url":null,"abstract":"<div><p>Cognitive deficits in depression are pervasive and include impairments in attention and higher-order functions but the degree to which low-level sensory processes are affected is unclear. The present work examined event-related potential (P50 and N100) features of auditory sensory gating (i.e., the ability to inhibit P50/N100 responses to redundant stimuli) and their relationship to depressive symptoms, including ruminations and dysfunctional attitudes. In 18 patients with major depressive disorder (MDD) and 18 healthy volunteers, auditory sensory gating was measured using a paired-stimulus paradigm yielding ratio (rP50, rN100) and difference (dP50, dN100) gating indices, which reflected amplitude reductions from first (S1) to second (S2) stimulus. Patients with MDD exhibited diminished rP50 and dP50 gating scores and delayed S1-N100 latencies compared to healthy volunteers. These measures were positively associated with ruminative thoughts, negative attitudes and degree of depression. Study findings implicate aberrant sensory processing in depressed patients that is related to severity of maladaptive thinking.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"341 ","pages":"Article 111813"},"PeriodicalIF":2.3,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140352635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral state-dependent associations between EEG temporal correlations and depressive symptoms 脑电图时空相关性与抑郁症状之间的行为状态相关性

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-27 DOI: 10.1016/j.pscychresns.2024.111811

Ruifang Cui , Xinyang Hao , Pei Huang , Mengling He , Weiyi Ma , Diankun Gong , Dezhong Yao

{"title":"Behavioral state-dependent associations between EEG temporal correlations and depressive symptoms","authors":"Ruifang Cui , Xinyang Hao , Pei Huang , Mengling He , Weiyi Ma , Diankun Gong , Dezhong Yao","doi":"10.1016/j.pscychresns.2024.111811","DOIUrl":"10.1016/j.pscychresns.2024.111811","url":null,"abstract":"<div><p>Previous studies have shown abnormal long-range temporal correlations in neuronal oscillations among individuals with Major Depressive Disorders, occurring during both resting states and transitions between resting and task states. However, the understanding of this effect in preclinical individuals with depression remains limited. This study investigated the association between temporal correlations of neuronal oscillations and depressive symptoms during resting and task states in preclinical individuals, specifically focusing on male action video gaming experts. Detrended fluctuation analysis (DFA), Lifetimes, and Waitingtimes were employed to explore temporal correlations across long-range and short-range scales. The results indicated widespread changes from the resting state to the task state across all frequency bands and temporal scales. Rest-task DFA changes in the alpha band exhibited a negative correlation with depressive scores at most electrodes. Significant positive correlations between DFA values and depressive scores were observed in the alpha band during the resting state but not in the task state. Similar patterns of results emerged concerning maladaptive negative emotion regulation strategies. Additionally, short-range temporal correlations in the alpha band echoed the DFA results. These findings underscore the state-dependent relationships between temporal correlations of neuronal oscillations and depressive symptoms, as well as maladaptive emotion regulation strategies, in preclinical individuals.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"341 ","pages":"Article 111811"},"PeriodicalIF":2.3,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0