Psychiatry Research: Neuroimaging最新文献_第9页

Behavioral state-dependent associations between EEG temporal correlations and depressive symptoms 脑电图时空相关性与抑郁症状之间的行为状态相关性

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-27 DOI: 10.1016/j.pscychresns.2024.111811

Ruifang Cui , Xinyang Hao , Pei Huang , Mengling He , Weiyi Ma , Diankun Gong , Dezhong Yao

{"title":"Behavioral state-dependent associations between EEG temporal correlations and depressive symptoms","authors":"Ruifang Cui , Xinyang Hao , Pei Huang , Mengling He , Weiyi Ma , Diankun Gong , Dezhong Yao","doi":"10.1016/j.pscychresns.2024.111811","DOIUrl":"10.1016/j.pscychresns.2024.111811","url":null,"abstract":"<div><p>Previous studies have shown abnormal long-range temporal correlations in neuronal oscillations among individuals with Major Depressive Disorders, occurring during both resting states and transitions between resting and task states. However, the understanding of this effect in preclinical individuals with depression remains limited. This study investigated the association between temporal correlations of neuronal oscillations and depressive symptoms during resting and task states in preclinical individuals, specifically focusing on male action video gaming experts. Detrended fluctuation analysis (DFA), Lifetimes, and Waitingtimes were employed to explore temporal correlations across long-range and short-range scales. The results indicated widespread changes from the resting state to the task state across all frequency bands and temporal scales. Rest-task DFA changes in the alpha band exhibited a negative correlation with depressive scores at most electrodes. Significant positive correlations between DFA values and depressive scores were observed in the alpha band during the resting state but not in the task state. Similar patterns of results emerged concerning maladaptive negative emotion regulation strategies. Additionally, short-range temporal correlations in the alpha band echoed the DFA results. These findings underscore the state-dependent relationships between temporal correlations of neuronal oscillations and depressive symptoms, as well as maladaptive emotion regulation strategies, in preclinical individuals.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"341 ","pages":"Article 111811"},"PeriodicalIF":2.3,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobiological correlates of religious coping among older adults with and without mood disorders: An exploratory study 患有和未患有情绪障碍的老年人宗教应对的神经生物学相关性：一项探索性研究

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-26 DOI: 10.1016/j.pscychresns.2024.111812

David H. Rosmarin , Poornima Kumar , Caroline C. Kaufman , Mia Drury , David Harper , Brent P. Forester

引用次数: 0

A scoping review of functional near-infrared spectroscopy biomarkers in late-life depression: Depressive symptoms, cognitive functioning, and social functioning 晚年抑郁症的功能性近红外光谱生物标志物范围综述：抑郁症状、认知功能和社会功能

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-26 DOI: 10.1016/j.pscychresns.2024.111810

Yujie Tong , Qiwei Wang , Xiao Wang , Yuxian Xiang , Long Cheng , Xiaodong Hu , Yun Chen , Luyao Huo , Yong Xu , Sha Liu

{"title":"A scoping review of functional near-infrared spectroscopy biomarkers in late-life depression: Depressive symptoms, cognitive functioning, and social functioning","authors":"Yujie Tong , Qiwei Wang , Xiao Wang , Yuxian Xiang , Long Cheng , Xiaodong Hu , Yun Chen , Luyao Huo , Yong Xu , Sha Liu","doi":"10.1016/j.pscychresns.2024.111810","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111810","url":null,"abstract":"<div><p>Late-life depression is one of the most damaging mental illnesses, disrupting the normal lives of older people by causing chronic illness and cognitive impairment. Patients with late-life depression, accompanied by changes in appetite, insomnia, fatigue and guilt, are more likely to experience irritability, anxiety and somatic symptoms. It increases the risk of suicide and dementia and is a major challenge for the public health systems. The current clinical assessment, identification and effectiveness assessment of late-life depression are primarily based on history taking, mental status examination and scale scoring, which lack subjectivity and precision. Functional near-infrared spectroscopy is a rapidly developing optical imaging technology that objectively reflects the oxygenation of hemoglobin in different cerebral regions during different tasks and assesses the functional status of the cerebral cortex. This article presents a comprehensive review of the assessment of functional near-infrared spectroscopy technology in assessing depressive symptoms, social functioning, and cognitive functioning in patients with late-life depression. The use of functional near-infrared spectroscopy provides greater insight into the neurobiological mechanisms underlying depression and helps to assess these three aspects of functionality in depressed patients. In addition, the study discusses the limitations of previous research and explores potential advances in the field.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"341 ","pages":"Article 111810"},"PeriodicalIF":2.3,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140330792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural correlates of increased alcohol demand following alcohol cue exposure in adult heavy drinkers 成年酗酒者接触酒精线索后酒精需求增加的神经相关性

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-23 DOI: 10.1016/j.pscychresns.2024.111809

Michael Amlung , Emma Marsden , Tegan Hargreaves , Lawrence H. Sweet , James G. Murphy , James MacKillop

{"title":"Neural correlates of increased alcohol demand following alcohol cue exposure in adult heavy drinkers","authors":"Michael Amlung , Emma Marsden , Tegan Hargreaves , Lawrence H. Sweet , James G. Murphy , James MacKillop","doi":"10.1016/j.pscychresns.2024.111809","DOIUrl":"10.1016/j.pscychresns.2024.111809","url":null,"abstract":"<div><p>Alcohol use disorder is associated with overvaluation of alcohol relative to other rewards, in part due to dynamic increases in value in response to alcohol-related cues. In a neuroeconomic framework, alcohol cues increase behavioral economic demand for alcohol, but the neural correlates these cue effects are unknown. This functional magnetic resonance imaging study combined a neuroeconomic alcohol purchase task with an alcohol cue exposure in 72 heavy drinkers with established sensitivity to alcohol cues (51 % female; mean age=33.74). Participants reported how many drinks they would consume from $0-$80/drink following exposure to neutral and alcohol images in a fixed order. Participants purchased significantly more drinks in the alcohol compared to the neutral condition, which was also evident for demand indices (i.e., intensity, breakpoint, Omax, elasticity; <em>p</em>s<0.001; <em>d</em>s=0.46–0.92). Alcohol purchase decisions were associated with activation in rostral middle and medial frontal gyri, anterior insula, posterior parietal cortex, and dorsal striatum, among other regions. Activation was lower across regions in the alcohol relative to neutral cue condition, potentially due to greater automaticity of choices in the presence of alcohol cues or attenuation of responses due to fixed cue order. These results contribute to growing literature using neuroeconomics to understand alcohol misuse and provide a foundation for future research investigating decision-making effects of environmental alcohol triggers.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111809"},"PeriodicalIF":2.3,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations of the amplitude of low-frequency fluctuation induced by repetitive transcranial magnetic stimulation combined with antidepressants treatment for major depressive disorder 重复经颅磁刺激结合抗抑郁药物治疗重度抑郁障碍所诱发的低频波动幅度的改变

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-13 DOI: 10.1016/j.pscychresns.2024.111792

Jing Qiu , Weiguo Gu , Yuan Zhang , Lei Wang , Junkang Shen

{"title":"Alterations of the amplitude of low-frequency fluctuation induced by repetitive transcranial magnetic stimulation combined with antidepressants treatment for major depressive disorder","authors":"Jing Qiu , Weiguo Gu , Yuan Zhang , Lei Wang , Junkang Shen","doi":"10.1016/j.pscychresns.2024.111792","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111792","url":null,"abstract":"<div><p>We investigated the neuroimaging changes and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with antidepressants in major depressive disorder (MDD) patients. We scanned 35 patients with MDD and 27 healthy controls (HC) with resting-state functional magnetic resonance imaging (fMRI) before and after treatment. We analyzed amplitude of low-frequency fluctuation (ALFF) and the correlation with clinical variables. The rate of significant efficacy after treatment was higher in the combination treatment group than in the antidepressant group, although not statistically significant. At baseline, ALFF increased in the left middle temporal, brain stem, and left cerebellum and decreased in the right anterior cingulate (ACC), right orbital frontal cortex (OFC), and right caudate. ALFF increased in the left fusiform and decreased in the right lingual gyrus, left middle occipital gyrus, and left superior occipital gyrus after antidepressants. ALFF increased in the right ACC, right OFC, and right rectus after combination treatment. ALFF changes in the right ACC/OFC were negatively correlated with HAMD changes. After treatment, abnormal activity in some brain regions normalized, but these regions differed between the two treatment groups. rTMS combined with antidepressants therapy may improve MDD symptoms by improving neuronal activity levels in the right ACC and right OFC.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111792"},"PeriodicalIF":2.3,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140113982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amygdala functional connectivity in borderline personality disorder 边缘型人格障碍的杏仁核功能连接

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-11 DOI: 10.1016/j.pscychresns.2024.111808

Laila Noor , Jonas Hoffmann , Tina Meller , Christian Gaser , Igor Nenadić

{"title":"Amygdala functional connectivity in borderline personality disorder","authors":"Laila Noor , Jonas Hoffmann , Tina Meller , Christian Gaser , Igor Nenadić","doi":"10.1016/j.pscychresns.2024.111808","DOIUrl":"10.1016/j.pscychresns.2024.111808","url":null,"abstract":"<div><p>Borderline personality disorder (BPD) is characterised by structural and functional brain alterations. Yet, there is little data on functional connectivity (FC) across different levels of brain networks and parameters. In this study, we applied a multi-level approach to analyse abnormal functional connectivity. We analysed resting-state functional magnetic resonance imaging (fMRI) data sets of 69 subjects: 17 female BPD patients and 51 age-matched psychiatrically healthy female controls. fMRI was analysed using CONN toolbox including: a) seed-based FC analysis of amygdala connectivity, b) independent component analysis (ICA) based network analysis of intra- and inter-network FC of selected resting-state networks (DMN, SN, FPN), as well as c) graph-theory based measures of network-level characteristics. We show group-level seed FC differences with higher amygdala to contralateral (superior) occipital cortex connectivity in BPD, which correlated with schema-therapy derived measures of symptoms/traits across the entire cohort. While there was no significant group effect on DMN, SN, or FPN intra-network or inter-network FC, we show a significant group difference for local efficiency and cluster coefficient for a DMN-linked cerebellum cluster. Our findings demonstrate BPD-linked changes in FC across multiple levels of observation, which supports a multi-level analysis for future studies to consider different aspects of functional connectome alterations.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111808"},"PeriodicalIF":2.3,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0925492724000313/pdfft?md5=aff0d19967b4bfdd0095174959193822&pid=1-s2.0-S0925492724000313-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140126368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subcortical-cortical white matter connectivity in adults with autism spectrum disorder and schizophrenia patients 自闭症谱系障碍成人和精神分裂症患者的皮层下-皮层白质连通性。

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-07 DOI: 10.1016/j.pscychresns.2024.111806

Akila Weerasekera , Adrian Ion-Mărgineanu , Garry P. Nolan , Maria Mody

{"title":"Subcortical-cortical white matter connectivity in adults with autism spectrum disorder and schizophrenia patients","authors":"Akila Weerasekera , Adrian Ion-Mărgineanu , Garry P. Nolan , Maria Mody","doi":"10.1016/j.pscychresns.2024.111806","DOIUrl":"10.1016/j.pscychresns.2024.111806","url":null,"abstract":"<div><p>Autism spectrum disorder (ASD) and schizophrenia (SZ) are neuropsychiatric disorders that overlap in symptoms associated with social-cognitive impairment. Alterations of the cingulate cortex, subcortical, medial-temporal, and orbitofrontal structures are frequently reported in both disorders. In this study, we examined white-matter connectivity between these structures in adults with ASD and SZ patients compared with their respective neurotypical controls and indirectly with each other, using probabilistic and local DTI tractography. This exploratory study utilized publicly available neuroimaging databases, of adults with ASD (ABIDE II; <em>n</em> = 28) and SZ (COBRE; <em>n</em> = 38), age-gender matched neurotypicals (NT) and associated phenotypic data. Tractography was performed using Freesurfer and MRtrix software, and diffusion metrics of white-matter tracts between cingulate-, orbitofrontal- cortices, subcortical structures, parahippocampal, entorhinal cortex were assessed. In ASD, atypical diffusivity parameters were found in the isthmus cingulate and parahippocampal connectivity to subcortical and rostral-anterior cingulate, which were also associated with IQ and social skills (SRS). In contrast, atypical diffusivity parameters were observed between the medial-orbitofrontal cortex and subcortical structures in SZ, and were associated with executive function (i.e., IQ, processing speed) and emotional regulation. Overall, the results suggest that defects in the isthmus cingulate, medial-orbitofrontal, and striato-limbic white matter connectivity may help unravel the neural underpinnings of executive and social-emotional dysfunction at the core of neuropsychiatric disorders.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111806"},"PeriodicalIF":2.3,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0925492724000295/pdfft?md5=fc1b608922a1164fef799a797ac86983&pid=1-s2.0-S0925492724000295-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased extra-neurite conductivity of brain in patients with Alzheimer's disease: A pilot study 阿尔茨海默病患者大脑神经元外传导性增加：一项试点研究

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-05 DOI: 10.1016/j.pscychresns.2024.111807

Seowon Hong , Yunjeong Choi , Mun Bae Lee , Hak Young Rhee , Soonchan Park , Chang-Woo Ryu , Ah Rang Cho , Oh In Kwon , Geon-Ho Jahng

{"title":"Increased extra-neurite conductivity of brain in patients with Alzheimer's disease: A pilot study","authors":"Seowon Hong , Yunjeong Choi , Mun Bae Lee , Hak Young Rhee , Soonchan Park , Chang-Woo Ryu , Ah Rang Cho , Oh In Kwon , Geon-Ho Jahng","doi":"10.1016/j.pscychresns.2024.111807","DOIUrl":"10.1016/j.pscychresns.2024.111807","url":null,"abstract":"<div><p>The objectives of this study were to investigate how the extra-neurite conductivity (EC) and intra-neurite conductivity (IC) were reflected in Alzheimer's disease (AD) patients compared with old cognitively normal (CN) people and patients with amnestic mild cognitive impairment (MCI) and to evaluate the association between those conductivity values and cognitive decline. To do this, high-frequency conductivity (HFC) at the Larmor frequency was obtained using MRI-based electrical property tomography (MREPT) and was decomposed into EC and IC using information of multi-shell multi-gradient direction diffusion tensor images. This prospective single-center study included 20 patients with mild or moderate AD, 25 patients with amnestic MCI, and 21 old CN participants. After decomposing EC and IC from HFC for all participants, we performed voxel-based and regions-of-interest analyses to compare conductivity between the three participant groups and to evaluate the association with either age or the Mini-Mental State Examination (MMSE) scores. We found increased EC in AD compared to CN and MCI. EC was significantly negatively associated with MMSE scores in the insula, and middle temporal gyrus. EC might be used as an imaging biomarker for helping to monitor cognitive function.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111807"},"PeriodicalIF":2.3,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0925492724000301/pdfft?md5=518d5f0aa2af288abb6519d574447a97&pid=1-s2.0-S0925492724000301-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140079303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childhood adversity modulates structural brain changes in borderline personality but not in major depression disorder 童年逆境能调节边缘型人格的大脑结构变化，但不能调节重度抑郁症的大脑结构变化

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-03-01 DOI: 10.1016/j.pscychresns.2024.111803

Vicente Camacho-Téllez , Mariana N. Castro , Agustina E. Wainsztein , Ximena Goldberg , Gabriela De Pino , Elsa Y. Costanzo , Narcís Cardoner , José M. Menchón , Carles Soriano-Mas , Salvador M. Guinjoan , Mirta F. Villarreal

{"title":"Childhood adversity modulates structural brain changes in borderline personality but not in major depression disorder","authors":"Vicente Camacho-Téllez , Mariana N. Castro , Agustina E. Wainsztein , Ximena Goldberg , Gabriela De Pino , Elsa Y. Costanzo , Narcís Cardoner , José M. Menchón , Carles Soriano-Mas , Salvador M. Guinjoan , Mirta F. Villarreal","doi":"10.1016/j.pscychresns.2024.111803","DOIUrl":"10.1016/j.pscychresns.2024.111803","url":null,"abstract":"<div><p>Adverse childhood experiences (ACEs) negatively affect the function and structure of emotion brain circuits, increasing the risk of various psychiatric disorders. It is unclear if ACEs show disorder specificity with respect to their effects on brain structure. We aimed to investigate whether the structural brain effects of ACEs differ between patients with major depression (MDD) and borderline personality disorder (BPD). These disorders share many symptoms but likely have different etiologies. To achieve our goal, we obtained structural 3T-MRI images from 20 healthy controls (HC), 19 MDD patients, and 18 BPD patients, and measured cortical thickness and subcortical gray matter volumes. We utilized the Adverse Childhood Experiences (ACE) questionnaire to quantify self-reported exposure to childhood trauma. Our findings suggest that individuals with MDD exhibit a smaller cortical thickness when compared to those with BPD. However, ACEs showed a significantly affected relationship with cortical thickness in BPD but not in MDD. ACEs were found to be associated with thinning in cortical regions involved in emotional behavior in BPD, whereas HC showed an opposite association. Our results suggest a potential mechanism of ACE effects on psychopathology involving changes in brain structure. These findings highlight the importance of early detection and intervention strategies.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111803"},"PeriodicalIF":2.3,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140056716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The importance of covert memory consolidation in schizophrenia: Dysfunctional network profiles of the hippocampus and the dorsolateral prefrontal cortex 精神分裂症患者隐蔽记忆巩固的重要性：海马和前额叶皮层背外侧的功能障碍网络概况

IF 2.3 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-02-29 DOI: 10.1016/j.pscychresns.2024.111805

Elias A. Samona, Asadur Chowdury, John Kopchick, Patricia Thomas, Usha Rajan, Dalal Khatib, Caroline Zajac-Benitez, Alireza Amirsadri, Luay Haddad, Jeffrey A. Stanley, Vaibhav A. Diwadkar

{"title":"The importance of covert memory consolidation in schizophrenia: Dysfunctional network profiles of the hippocampus and the dorsolateral prefrontal cortex","authors":"Elias A. Samona, Asadur Chowdury, John Kopchick, Patricia Thomas, Usha Rajan, Dalal Khatib, Caroline Zajac-Benitez, Alireza Amirsadri, Luay Haddad, Jeffrey A. Stanley, Vaibhav A. Diwadkar","doi":"10.1016/j.pscychresns.2024.111805","DOIUrl":"https://doi.org/10.1016/j.pscychresns.2024.111805","url":null,"abstract":"<div><p>Altered brain network profiles in schizophrenia (SCZ) during memory consolidation are typically observed during task-<em>active</em> periods such as encoding or retrieval. However active processes are also sub served by <em>covert</em> periods of memory consolidation. These periods <em>are</em> active in that they allow memories to be recapitulated even in the absence of overt sensorimotor processing. It is plausible that regions central to memory formation like the dlPFC and the hippocampus, exert network signatures during covert periods. Are these signatures altered in patients? The question is clinically relevant because real world learning and memory is facilitated by covert processing, and may be impaired in schizophrenia. Here, we compared network signatures of the dlPFC and the hippocampus during covert periods of a learning and memory task. Because behavioral proficiency increased non-linearly, functional connectivity of the dlPFC and hippocampus [psychophysiological interaction (PPI)] was estimated for each of the Early (linear increases in performance) and Late (asymptotic performance) covert periods. During Early periods, we observed hypo-modulation by the hippocampus but hyper-modulation by dlPFC. Conversely, during Late periods, we observed hypo-modulation by <em>both</em> the dlPFC and the hippocampus. We stitch these results into a conceptual model of network deficits during covert periods of memory consolidation.</p></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"340 ","pages":"Article 111805"},"PeriodicalIF":2.3,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0