Psychiatry Research: Neuroimaging最新文献_第4页

Reduced gray matter volume in limbic and cortical areas is associated with anxiety and depression in alcohol use disorder patients 酒精使用障碍患者边缘和皮质区域灰质体积减少与焦虑和抑郁有关。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-01-07 DOI: 10.1016/j.pscychresns.2025.111946

Laís da Silva Pereira-Rufino , Denise Ribeiro Gobbo , Rafael Conte , Raissa Mazzer de Sino , Natan Nascimento de Oliveira , Thiago Marques Fidalgo , João Ricardo Sato , Henrique Carrete Junior , Maria Lucia Oliveira Souza-Formigoni , Zhenhao Shi , João Ricardo N. Vissoci , Corinde E. Wiers , Isabel Cristina Céspedes

{"title":"Reduced gray matter volume in limbic and cortical areas is associated with anxiety and depression in alcohol use disorder patients","authors":"Laís da Silva Pereira-Rufino , Denise Ribeiro Gobbo , Rafael Conte , Raissa Mazzer de Sino , Natan Nascimento de Oliveira , Thiago Marques Fidalgo , João Ricardo Sato , Henrique Carrete Junior , Maria Lucia Oliveira Souza-Formigoni , Zhenhao Shi , João Ricardo N. Vissoci , Corinde E. Wiers , Isabel Cristina Céspedes","doi":"10.1016/j.pscychresns.2025.111946","DOIUrl":"10.1016/j.pscychresns.2025.111946","url":null,"abstract":"<div><div>Alcohol use disorder (AUD) is a multifactorial disease closely related to neurodevelopment and environmental factors that influence behavior. This study explored the relationships between brain volume and behavior from an Exploratory Structural Equation Modeling (ESEM) based on the Research Domain Criteria. High-resolution magnetic resonance imaging scans were acquired from recent patients with AUD (<em>n</em> = 50) and healthy controls (HC=50). Group differences were assessed by means of voxel-based morphometry (VBM) and regions of interest (ROIs). Participants completed a battery of neurocognitive tasks and emotional tests. When controlling for age, education levels, and total intracranial volume, we found lower gray matter volume in cortical and limbic areas, as well as significant impairments in the AUD group on cognition and affective status. This study demonstrated the importance of multifactorial analysis and complex models in order to better understand substance use disorders. The brain losses may have been the result of neurodevelopmental impairments due to biological and environmental factors that predisposed to AUD or the result of drug abuse. The ESEM indicated that limbic areas indirectly affected the alcohol severity through emotional dysfunction. These results suggest a more relevant involvement of limbic regions for the severity of alcohol use, showing a more significant association between AUD and mood disorders.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"Article 111946"},"PeriodicalIF":2.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Left posterior superior temporal gyrus and its structural connectivity in schizophrenia 精神分裂症患者左侧颞后上回及其结构连通性。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-01-05 DOI: 10.1016/j.pscychresns.2025.111947

Hitoshi Sasaki , Manabu Kubota , Jun Miyata , Toshiya Murai

{"title":"Left posterior superior temporal gyrus and its structural connectivity in schizophrenia","authors":"Hitoshi Sasaki , Manabu Kubota , Jun Miyata , Toshiya Murai","doi":"10.1016/j.pscychresns.2025.111947","DOIUrl":"10.1016/j.pscychresns.2025.111947","url":null,"abstract":"<div><div>The left posterior superior temporal gyrus (pSTG) is thought to be involved in the pathophysiology and core symptoms of schizophrenia, although its structural connectivity has not yet been systematically investigated. Here, we aimed to evaluate its white matter (WM) connectivity with Broca's area, the thalamus, and the right pSTG. Eighty-three patients with schizophrenia and 141 healthy controls underwent diffusion-weighted imaging and T1-weighted three-dimensional magnetic resonance imaging. Probabilistic tractography was performed from the left pSTG to the Broca area, the left thalamus, and the right pSTG. Group comparison of WM fractional anisotropy (FA) in these pathways, as well as its correlations with the pSTG volume and clinical characteristics in the patient group, were examined. Patients showed significantly lower FA in the left pSTG-Broca and left-right pSTG pathways, but not in the left pSTG-thalamus pathway. Patients also revealed a trend toward a smaller left pSTG volume. Significant negative correlations were found in patients between FA in the left-right pSTG pathway and the left pSTG volume, and between FA in the left pSTG-Broca pathway and positive symptom severity. The present results suggest fiber-specific alterations in structural connectivity linked to the left pSTG, possibly supporting the “inner speech” and “interhemispheric disconnection” hypotheses of schizophrenia.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"Article 111947"},"PeriodicalIF":2.1,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142972054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A review of studies on constructing classification models to identify mental illness using brain effective connectivity 基于脑有效连通性构建精神疾病分类模型的研究综述

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-01-01 DOI: 10.1016/j.pscychresns.2024.111928

Fangfang Huang , Yuan Huang , Siying Guo , Xiaoyi Chang , Yuqi Chen , Mingzhu Wang , Yingfang Wang , Shuai Ren

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Machine learning based classification of excessive smartphone users via neuronal cue reactivity 基于机器学习，通过神经元线索反应对过度使用智能手机的用户进行分类。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-01-01 DOI: 10.1016/j.pscychresns.2024.111903

Jailan Oweda , Mike Michael Schmitgen , Gudrun M. Henemann , Marius Gerdes , Robert Christian Wolf

{"title":"Machine learning based classification of excessive smartphone users via neuronal cue reactivity","authors":"Jailan Oweda , Mike Michael Schmitgen , Gudrun M. Henemann , Marius Gerdes , Robert Christian Wolf","doi":"10.1016/j.pscychresns.2024.111903","DOIUrl":"10.1016/j.pscychresns.2024.111903","url":null,"abstract":"<div><div>Excessive Smartphone Use (ESU) poses a significant challenge in contemporary society, yet its recognition as a distinct disorder remains ambiguous. This study aims to address this gap by leveraging functional magnetic resonance imaging (fMRI) data and machine learning techniques to classify ESU and non-excessive smartphone users (n-ESU) based on their neural Cue-Reactivity (CR) signatures. By conducting a CR task and analyzing brain activation patterns, we identified spatial similarities between addictive smartphone use and established addictive disorders. Our approach involved employing Support Vector Machines (SVM) for classification, enhanced with feature selection methods such as Recursive Feature Elimination (RFE) and Model-based Selection and dimensionality reduction methods such as and Principal Component Analysis (PCA) to mitigate the challenges posed by limited dataset size and high dimensionality of fMRI data. The results demonstrate the effectiveness of our classification model, achieving accuracies of up to 79.9 %. Furthermore, we observed region-specific activations contributing significantly to classification accuracy, highlighting the potential biomarkers associated with ESU. External validation on longitudinal data revealed the necessity for larger training datasets to improve model generalizability. Additionally, feature selection techniques proved crucial for optimizing model performance, particularly in datasets with combined information from multiple sources. Our findings underscore the importance of incorporating more data to enhance model stability and generalizability, with implications for advancing the understanding and treatment of ESU and related disorders. Overall, our study demonstrates the promise of machine learning approaches in elucidating neural correlates of ESU and informing targeted interventions for affected individuals.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"346 ","pages":"Article 111903"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered brain network stability in OCD following rTMS intervention: Insights from structural balance theory rTMS干预后强迫症患者脑网络稳定性的改变：来自结构平衡理论的见解。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-01-01 DOI: 10.1016/j.pscychresns.2024.111927

Maryam Ansari Esfeh , Alireza Talesh Jafadideh , Asiyeh Rezaei Niyasar , Reza Rostami , Reza Khosrowabadi

{"title":"Altered brain network stability in OCD following rTMS intervention: Insights from structural balance theory","authors":"Maryam Ansari Esfeh , Alireza Talesh Jafadideh , Asiyeh Rezaei Niyasar , Reza Rostami , Reza Khosrowabadi","doi":"10.1016/j.pscychresns.2024.111927","DOIUrl":"10.1016/j.pscychresns.2024.111927","url":null,"abstract":"<div><div>Repetitive Transcranial Magnetic Stimulation (rTMS) is a promising intervention for Obsessive-Compulsive Disorder (OCD). However, understanding brain network changes following rTMS remains limited, despite its potential to enhance treatment efficacy. In this retrospective study, we investigated brain network reorganization in OCD patients after rTMS, using structural balance theory as a framework. We hypothesized that rTMS-induced functional plasticity would alter brain network topology, particularly affecting triadic associations, and leading to increased balance energy levels, indicative of a less stable network state. Brain functional networks were constructed from resting-state EEGs of OCD patients, with phase lag indexes calculated both before and after rTMS treatment. These networks were analyzed by comparing global parameters, including positive and negative links, triadic interactions (balanced/unbalanced), hub formation tendencies, and balance energy levels. We observed a significant decrease in weak-balanced triads and an increase in strong-unbalanced triads within the Beta І frequency band (12–15 Hz). Additionally, there was a notable reduction in the tendency of negative links to form hubs across certain frequency bands. These changes led to an increase in the network's balanced energy level, pushing it toward a less stable state. We hope these findings will refine rTMS strategies by facilitating brain network reorganization.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"346 ","pages":"Article 111927"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142780511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal imaging of the amygdala in non-clinical subjects with high vs. low autistic-like social skills traits 杏仁核多模态成像在自闭症类社交技能特征较高与较低的非临床受试者中的应用。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-01-01 DOI: 10.1016/j.pscychresns.2024.111910

Niccolò Zovetti , Tina Meller , Ulrika Evermann , Julia-Katharina Pfarr , Jonas Hoffmann , Andrea Federspiel , Sebastian Walther , Sarah Grezellschak , Andreas Jansen , Ahmad Abu-Akel , Igor Nenadić

{"title":"Multimodal imaging of the amygdala in non-clinical subjects with high vs. low autistic-like social skills traits","authors":"Niccolò Zovetti , Tina Meller , Ulrika Evermann , Julia-Katharina Pfarr , Jonas Hoffmann , Andrea Federspiel , Sebastian Walther , Sarah Grezellschak , Andreas Jansen , Ahmad Abu-Akel , Igor Nenadić","doi":"10.1016/j.pscychresns.2024.111910","DOIUrl":"10.1016/j.pscychresns.2024.111910","url":null,"abstract":"<div><div>Recent clinical and theoretical frameworks suggest that social skills and theory of mind impairments characteristic of autism spectrum disorder (ASD) are distributed in the general population on a continuum between healthy individuals and patients. The present multimodal study aimed at investigating the amygdala's function, perfusion, and volume in 56 non-clinical subjects from the general population with high (<em>n</em> = 28 High-SOC) or low (<em>n</em> = 28 Low-SOC) autistic-like social skills traits. Participants underwent magnetic resonance imaging to evaluate the amygdala's functional connectivity at rest, blood perfusion by means of arterial spin labelling, its activation during a face evaluation task and lastly grey matter volumes. The High-SOC group was characterised by higher blood perfusion in both amygdalae, lower volume of the left amygdala and higher activations of the right amygdala during processing of human faces with fearful value. Resting state analyses did not reveal any significant difference between the two groups. Overall, our results highlight the presence of overlapping morpho-functional alterations of the amygdala between healthy individuals and ASD patients confirming the importance of the amygdala in this disorder and in social and emotional processing. Our findings may help disentangle the neurobiological facets of ASD elucidating aetiology and the relationship between clinical symptomatology and neurobiology.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"346 ","pages":"Article 111910"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Neuroanatomical alterations in young boys and adolescents with Klinefelter syndrome 年轻男孩和青少年Klinefelter综合征的神经解剖学改变。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-01-01 DOI: 10.1016/j.pscychresns.2024.111929

Lara C. Foland-Ross , Tracy L. Jordan , Matthew J. Marzelli , Judith L. Ross , Allan L. Reiss

{"title":"Neuroanatomical alterations in young boys and adolescents with Klinefelter syndrome","authors":"Lara C. Foland-Ross , Tracy L. Jordan , Matthew J. Marzelli , Judith L. Ross , Allan L. Reiss","doi":"10.1016/j.pscychresns.2024.111929","DOIUrl":"10.1016/j.pscychresns.2024.111929","url":null,"abstract":"<div><div>Klinefelter syndrome (KS, 47,XXY) is a common sex chromosome aneuploidy in males that is characterized by pubertal developmental delays and a wide range of alterations in cognitive, social and emotional functioning. The neural bases of these behavioral symptoms, however, are unclear. A total of 130 boys and adolescents, including 67 males with KS (11.5 ± 2.8 years) and 63 typically developing (TD; control) males (10.6 ± 2.8 years) underwent MRI scanning and pubertal assessment. Group differences in regional gray matter volume was examined using voxel-based morphometry while controlling for age at scan and total gray matter volume. Thresholded statistical significance maps indicated widespread reductions in frontal and temporal and cerebellar gray matter in males with KS relative to TD males, as well as increases in parietal and occipital gray matter. Secondary analyses explored potential associations between GMV in these regions and pubertal development. Lower testicular volume was a significant predictor of reduced GMV in frontal, temporal and cerebellar subregions, even after accounting for group status (KS, TD). Taken together, these findings add support for a neuroanatomical phenotype of KS and provide initial evidence for a role of pubertal development in KS-associated differences in gray matter structure. Future studies that examine the influence of testosterone supplementation on GMV in males with KS are warranted.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"346 ","pages":"Article 111929"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Objective outcome prediction in depression through functional MRI brain network dynamics 通过功能性MRI脑网络动态预测抑郁症的客观预后。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-12-30 DOI: 10.1016/j.pscychresns.2024.111945

Jesper Pilmeyer , Stefan Rademakers , Rolf Lamerichs , Vivianne van Kranen-Mastenbroek , Jacobus FA Jansen , Marcel Breeuwer , Svitlana Zinger

{"title":"Objective outcome prediction in depression through functional MRI brain network dynamics","authors":"Jesper Pilmeyer , Stefan Rademakers , Rolf Lamerichs , Vivianne van Kranen-Mastenbroek , Jacobus FA Jansen , Marcel Breeuwer , Svitlana Zinger","doi":"10.1016/j.pscychresns.2024.111945","DOIUrl":"10.1016/j.pscychresns.2024.111945","url":null,"abstract":"<div><h3>Research purpose</h3><div>Subjective clinical decision-making in major depressive disorder (MDD) may result in low treatment effectiveness. This study aims to identify objective predictors of MDD outcome using resting-state functional MRI scans, acquired from 25 MDD patients at baseline. Over a year, patients were assessed every 3 months, labeled as positive or negative outcome (change in depression severity). Group independent component analysis (GICA) identified (sub)networks at different orders, from which static and dynamic (wavelet) fMRI features were extracted. Binary classifiers performed MDD outcome prediction at each follow-up.</div></div><div><h3>Principal Results</h3><div>The total coherence feature, reflecting network interactivity, yielded the highest performance (area under the curve (AUC) of 0.70). In the positive outcome group, total coherence between the default mode network and ventral salience network was increased at all follow-ups. Classification using this feature alone further demonstrated its discriminating capability (AUC of 0.76 ± 0.10 over all follow-ups). These results suggest that a higher switching capability between internal and external brain states predicts symptom improvement. Higher GICA orders, where major networks are divided into subnetworks, yielded optimal classification performance.</div></div><div><h3>Major Conclusions</h3><div>Total coherence, a dynamic fMRI measure, achieved the highest classification performance. These findings contribute to the identification of prognostic biomarkers in MDD.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"Article 111945"},"PeriodicalIF":2.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the changes in volumes of the limbic system and hypothalamic-subnuclei in patients with depression 研究抑郁症患者边缘系统和下丘脑亚核体积的变化。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-12-24 DOI: 10.1016/j.pscychresns.2024.111942

Daun Shin , Kyu-Man Han , Sun-Uk Lee , Byung-Jo Kim , Sung-Bom Pyun , Woo Suk Tae , Byung-Joo Ham

{"title":"Investigating the changes in volumes of the limbic system and hypothalamic-subnuclei in patients with depression","authors":"Daun Shin , Kyu-Man Han , Sun-Uk Lee , Byung-Jo Kim , Sung-Bom Pyun , Woo Suk Tae , Byung-Joo Ham","doi":"10.1016/j.pscychresns.2024.111942","DOIUrl":"10.1016/j.pscychresns.2024.111942","url":null,"abstract":"<div><h3>Background</h3><div>Depression is consistently linked to changes in the hypothalamus, HPA axis, and limbic system, though the specific substructures involved remain unclear. This study aims to explore the relationship between depression and the volumes of specific nuclei within these brain regions. Understanding these connections could provide deeper insights into the biological mechanisms underlying depression.</div></div><div><h3>Methods</h3><div>Seventy-three healthy individuals and 39 patients with depression were assessed using the Beck Depression Inventory or Hamilton Depression Rating Scale. All participants underwent 3.0T MRI, and the volumes of subnuclei in the hypothalamus and limbic system were measured.</div></div><div><h3>Results</h3><div>The results revealed increased volumes in both the inferior tubular areas of the hypothalamus and the left hypothalamus in the patient group with depression. Moreover, the left infTub volume initially increased during the first three years of depression, followed by a decrease, suggesting distinct structural changes between early and chronic stages of the illness.</div></div><div><h3>Conclusions</h3><div>Alterations in the left inferior tubular area volume suggest a connection between the hypothalamus and the chronicity of depressive symptoms. Further exploration of specific nuclei in the hypothalamus promises deeper insights into depression's biological mechanisms.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"Article 111942"},"PeriodicalIF":2.1,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143010504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered coupling relationships across resting-state functional connectivity measures in schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder 精神分裂症、双相情感障碍和注意缺陷/多动障碍静息状态功能连接测量中耦合关系的改变

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2024-12-18 DOI: 10.1016/j.pscychresns.2024.111943

Lu Ma , Shanshan Jiang , Wei Tang

{"title":"Altered coupling relationships across resting-state functional connectivity measures in schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder","authors":"Lu Ma , Shanshan Jiang , Wei Tang","doi":"10.1016/j.pscychresns.2024.111943","DOIUrl":"10.1016/j.pscychresns.2024.111943","url":null,"abstract":"<div><div>Resting-state functional connectivity (rsFC) measures have enjoyed significant success in discovering the neuropathological characteristics of schizophrenia (SZ), bipolar disorder (BD), and attention deficit/hyperactivity disorder (ADHD). However, it is unknown whether and how the spatial and temporal coupling relationships across rsFC measures would be altered in these psychiatric disorders. Here, resting-state fMRI data were obtained from a transdiagnostic sample of healthy controls (HC) and individuals with SZ, BD, and ADHD. We used Kendall's W to compute volume-wise and voxel-wise concordance across rsFC measures, followed by group comparisons. In terms of the spatial coupling, both SZ and BD individuals exhibited decreased volume-wise concordance compared with HC. Regarding the temporal coupling, SZ individuals showed decreased voxel-wise concordance in the right lateral occipital cortex relative to HC. BD individuals exhibited decreased voxel-wise concordance in the bilateral basal forebrain and bilateral superior/middle temporal gyrus compared to HC. Additionally, correlation analyses demonstrated positive associations of voxel-wise concordance in the left basal forebrain with negative symptoms including alogia and affective flattening in pooled SZ and BD individuals. Our findings of distinct patterns of spatial and temporal decoupling across rsFC measures among SZ, BD, and ADHD may provide unique insights into the neuropathological mechanisms of these psychiatric disorders.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"347 ","pages":"Article 111943"},"PeriodicalIF":2.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0