Psychiatry Research: Neuroimaging最新文献_第5页

Selection, visualization, and explanation of deep features from resting-state fMRI for Alzheimer’s disease diagnosis 静息状态fMRI对阿尔茨海默病诊断的深度特征的选择、可视化和解释

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-05-31 DOI: 10.1016/j.pscychresns.2025.112005

Mahda Nasrolahzadeh , Azizeh Akbari

{"title":"Selection, visualization, and explanation of deep features from resting-state fMRI for Alzheimer’s disease diagnosis","authors":"Mahda Nasrolahzadeh , Azizeh Akbari","doi":"10.1016/j.pscychresns.2025.112005","DOIUrl":"10.1016/j.pscychresns.2025.112005","url":null,"abstract":"<div><div>Despite the remarkable achievements of deep learning networks in analyzing neuroimaging data for various tasks linked to brain functions and disorders, the opaque nature of these models and their interpretability challenges pose significant barriers to their broader use in clinical settings. This research scrutinizes the visualization of deep features from resting-state functional magnetic resonance imaging (rs-fMRI) images to discriminate individuals who are cognitively normal from those with different stages of Alzheimer's disease. Rs-fMRI data are obtained from the ADNI database. This research indicates the presence of a specific subset of deep features capable of effectively identifying Alzheimer's, termed \"informative deep features.\" By visualizing the distinct deep features, we gain better insights into the pathological patterns present at each level of the entire rs-fMRI volume, despite the challenges posed by closely resembling patterns of brain atrophy and image intensities. These deep features were visualized across the whole slide image level using deep feature-specific heatmaps and activation maps. Furthermore, the findings imply that these significant deep features may hold diagnostic potential for other central nervous system disorders beyond Alzheimer's. This framework could act as a basis for assessing the interpretability of any deep learning model in the context of diagnostic decision-making.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"351 ","pages":"Article 112005"},"PeriodicalIF":2.1,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG vigilance and response to oral prolonged-release ketamine in treatment-resistant depression – A double-blind randomized validation study 难治性抑郁症患者口服延长释放氯胺酮的脑电图警觉性和反应-一项双盲随机验证研究

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-05-23 DOI: 10.1016/j.pscychresns.2025.112001

Anna Monn , Corinne Eicher , Annia Rüesch , Golo Kronenberg , Benjamin Offenhammer , Atalìa Adank , Mateo de Bardeci , Cheng-Teng Ip , Hanne Scherer , Linda Schaekel , Michael Colla , Annette B. Brühl , Erich Seifritz , Sebastian Olbrich

{"title":"EEG vigilance and response to oral prolonged-release ketamine in treatment-resistant depression – A double-blind randomized validation study","authors":"Anna Monn , Corinne Eicher , Annia Rüesch , Golo Kronenberg , Benjamin Offenhammer , Atalìa Adank , Mateo de Bardeci , Cheng-Teng Ip , Hanne Scherer , Linda Schaekel , Michael Colla , Annette B. Brühl , Erich Seifritz , Sebastian Olbrich","doi":"10.1016/j.pscychresns.2025.112001","DOIUrl":"10.1016/j.pscychresns.2025.112001","url":null,"abstract":"<div><div>Treatment-resistant depression (TRD) is associated with reduced quality of life and elevated mortality, posing a major challenge to psychiatric care. After non-response to conventional treatments, next-level interventions such as (es)ketamine are recommended, though remission rates remain variable. Identifying reliable markers of treatment response is therefore critical. Recent evidence suggests that a higher percentage of electroencephalography (EEG) vigilance stage A1 is associated with response to intravenous ketamine in major depression. We aimed to corroborate this finding in TRD patients from a recent phase-2 randomized controlled trial of oral prolonged-release ketamine. An algorithm classified vigilance stages in 21 10-minute resting-state EEG recordings. While no significant response <span><math><mo>×</mo></math></span> treatment interaction emerged for percentage of vigilance stage A1, a small-scale meta-analysis showed a significant pooled mean difference between ketamine responders and non-responders. Applying a previously proposed A1 cutoff (43 %) yielded chance-level prediction accuracy in the combined ketamine group, but 75 % accuracy in the 240 mg subgroup. Moreover, responders to 240 mg ketamine exhibited a significantly more stable vigilance over time compared to non-responders. Although further validation in a larger sample is warranted, these findings support the clinical value of EEG vigilance as a predictive biomarker for treatment outcomes in depression.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"350 ","pages":"Article 112001"},"PeriodicalIF":2.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical gyrification patterns associated with neuroticism in panic disorder and healthy individuals 与惊恐障碍和健康个体神经质相关的皮质旋回模式

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-05-21 DOI: 10.1016/j.pscychresns.2025.112002

Yeong-Geon Hwang , Geonseop Lee , Hyun-Ju Kim

{"title":"Cortical gyrification patterns associated with neuroticism in panic disorder and healthy individuals","authors":"Yeong-Geon Hwang , Geonseop Lee , Hyun-Ju Kim","doi":"10.1016/j.pscychresns.2025.112002","DOIUrl":"10.1016/j.pscychresns.2025.112002","url":null,"abstract":"<div><h3>Background</h3><div>Several studies have demonstrated an association between neuroticism and alterations in cortical folding. However, few studies have investigated the relation between neuroticism and gyrification in panic disorder (PD) patients and healthy controls (HC).</div></div><div><h3>Methods</h3><div>This study included 102 PD patients and 128 HC. Neuroticism, anxiety symptomatology, ways of coping strategies, and health-related quality of life was evaluated. Voxel-wise correlation analyses using FreeSurfer were conducted to determine the neural correlates of neuroticism related to cortical gyrification.</div></div><div><h3>Results</h3><div>As neuroticism increased, cortical gyrification of the lingual gyrus decreased significantly in HC, whereas postcentral gyrus gyrification increased while lingual gyrus gyrification decreased in PD patients. Although lingual gyrus gyrification in HC was significantly correlated with social phobia, interoception, and agoraphobia, lingual gyrus gyrification in PD patients revealed significant correlations with emotional coping, physical functioning, and emotional role. The gyrification patterns in the postcentral gyrus was significantly correlated with excessive worry scores.</div></div><div><h3>Conclusions</h3><div>Our study suggests that increased neuroticism is associated with decreased gyrification patterns in the lingual gyrus in both HC and PD group and increased postcentral gyrus gyrification only in PD group. These gyrification alterations may influence perceived quality of life as well as high levels of anxiety in PD patients.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"350 ","pages":"Article 112002"},"PeriodicalIF":2.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term resting-state electroencephalography fast activity is associated with cognitive decline in older adults: A population-based cross-sectional pilot study 短期静息状态脑电图快速活动与老年人认知能力下降有关：一项基于人群的横断面试点研究

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-05-21 DOI: 10.1016/j.pscychresns.2025.112004

Yoshikazu Nikaido , Takashi Kudo , Daiki Takekawa , Hirotaka Kinoshita , Tatsuya Mikami , Tetsuya Kushikata , Kazuyoshi Hirota

{"title":"Short-term resting-state electroencephalography fast activity is associated with cognitive decline in older adults: A population-based cross-sectional pilot study","authors":"Yoshikazu Nikaido , Takashi Kudo , Daiki Takekawa , Hirotaka Kinoshita , Tatsuya Mikami , Tetsuya Kushikata , Kazuyoshi Hirota","doi":"10.1016/j.pscychresns.2025.112004","DOIUrl":"10.1016/j.pscychresns.2025.112004","url":null,"abstract":"<div><div>Electroencephalography (EEG) slowing may help detect and prognosticate mild cognitive impairment (MCI). Whether slowed EEG activity is helpful for non-invasive MCI detection in a health checkup remains uncertain. This cross-sectional secondary study assessed the hypothesis that frontal EEG slowing in short-term resting-state is associated with MCI-suspicious participants over 65 in the Iwaki Health Promotion Project 2022. Participants who underwent the MCI screen test were matched by propensity score to minimize confounding (age and educational history) between the non-cognitive impairment (NCI, <em>n</em> = 14) and suspected-MCI (sMCI, <em>n</em> = 14) groups. The matched sMCI group had increased EEG β power, decreased δ power, θ/β power ratio (TBR), and frontal α asymmetry. No significant differences were found in imaginary coherence and debiased weighted phase lag index (dwPLI) between the groups. Spearman’s correlation showed a negative correlation between the MCI screen performance and β power and positive correlations between the performance and δ power, TBR, or α–γ dwPLI. Contrary to the hypothesis and previous findings, these results suggest that fast frontal EEG activity is negatively associated with cognitive performance in older adults. EEG measurements in health checkups may be useful for screening cognitive impairments that are less likely due to neurodegeneration.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"350 ","pages":"Article 112004"},"PeriodicalIF":2.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional brain connectivity changes following Masterson Psychotherapy in borderline personality disorder: a pilot study 马斯特森心理治疗治疗边缘型人格障碍后脑功能连通性的改变：一项初步研究

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-05-14 DOI: 10.1016/j.pscychresns.2025.112000

Meral Aydın , Shams Farhad , Barış Metin , Mehmet Kemal Arıkan , Nevzat Tarhan

引用次数: 0

Test–retest reliability of functional near infrared spectroscopy during tasks of inhibitory control and working memory 功能近红外光谱在抑制控制和工作记忆任务中的重测信度。

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-04-18 DOI: 10.1016/j.pscychresns.2025.111993

Clara Nittel , Daniela Michelle Hohmann , Andreas Jansen , Jens Sommer , Ricarda Krauß , Max Völk , Inge Kamp-Becker , Stefanie Weber , Katja Becker , Sanna Stroth

{"title":"Test–retest reliability of functional near infrared spectroscopy during tasks of inhibitory control and working memory","authors":"Clara Nittel , Daniela Michelle Hohmann , Andreas Jansen , Jens Sommer , Ricarda Krauß , Max Völk , Inge Kamp-Becker , Stefanie Weber , Katja Becker , Sanna Stroth","doi":"10.1016/j.pscychresns.2025.111993","DOIUrl":"10.1016/j.pscychresns.2025.111993","url":null,"abstract":"<div><div>Functional near-infrared spectroscopy (fNIRS) has become a well-established tool for neuroscience research and been suggested as a potential biomarker during clinical assessment in individuals with mental disorders. Biomarker need to be objective indications of biological processes which can be measured accurately and reproducibly. Despite various applications in clinical research, test-retest reliability of the fNIRS signal has not yet been evaluated sufficiently.</div><div>To assess reliability of the fNIRS signal during tasks of executive functions, a group of 34 healthy subjects (13 male, 21 female) were tested twice for inhibitory control and working memory.</div><div>On a group level results show a specific activation pattern throughout the two sessions, reflecting a task-related frontal network associated with the assessed cognitive functions. On the individual level the retest reliability of the activation patterns were considerably lower and differed strongly between participants.</div><div>In conclusion, the interpretation of fNIRS signal on a single subject level is partially hampered by its low reliability. More studies are needed to optimize the retest reliability of fNIRS and to be applied on a routine basis in developmental research.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"350 ","pages":"Article 111993"},"PeriodicalIF":2.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated multimodal analysis for high-accuracy anxiety disease subtype classification 高精度焦虑症亚型分类的综合多模态分析

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-04-15 DOI: 10.1016/j.pscychresns.2025.111991

Ying Chen , Yibin Tang , Qinghua Ni , Yuan Gao , Chun Wang

{"title":"Integrated multimodal analysis for high-accuracy anxiety disease subtype classification","authors":"Ying Chen , Yibin Tang , Qinghua Ni , Yuan Gao , Chun Wang","doi":"10.1016/j.pscychresns.2025.111991","DOIUrl":"10.1016/j.pscychresns.2025.111991","url":null,"abstract":"<div><div>In this study, we propose a classification method for identifying subtypes of anxiety disorders (AD). A large dataset is built with 108 healthy controls and 179 subjects from four primary AD subtypes: generalized anxiety disorder (GAD), social anxiety disorder (SAD), panic disorder (PD), and specific phobia (SP). We calculate diverse multimodal data, including amplitude of low-frequency fluctuations, regional homogeneity, and voxel-based morphometry, and create brain gradient data to provide a comprehensive representation of these data. For subtype classification, we develop a hierarchical binary hypothesis testing (H-BHT) framework with a two-stage scheme. In the first stage, we use a traditional BHT method to identify AD individuals. In the second stage, we categorize AD subjects into different subtypes under multi-class hypotheses. Our experiments demonstrate that the gradient data outperforms single-modal data in subtype classification, achieving an impressive 97.9% accuracy. When performing a multivariate analysis of variance on the brain regions associated with the discriminative gradient data, it reveals significant biomarkers among the subtypes, including the insula, amygdala, orbital inferior frontal, middle frontal and anterior cingulate gyri. These regions are strongly correlated with emotion control, providing substantial support for the pathogenesis of existing AD subtypes and confirming the validity of our method.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111991"},"PeriodicalIF":2.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different corpus callosum in panic disorder 惊恐障碍的不同胼胝体

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-04-05 DOI: 10.1016/j.pscychresns.2025.111990

Halim Ömer Kaşikci , Sema Baykara , Hale Nur Balci , Murat Baykara

{"title":"Different corpus callosum in panic disorder","authors":"Halim Ömer Kaşikci , Sema Baykara , Hale Nur Balci , Murat Baykara","doi":"10.1016/j.pscychresns.2025.111990","DOIUrl":"10.1016/j.pscychresns.2025.111990","url":null,"abstract":"<div><h3>Background</h3><div>Despite hypotheses regarding the neurobiology of panic disorder (PD), its neurobiological basis is still unknown. Study results support that the individual differences in corpus callosum (CC) properties could reflect trait based alterations that predispose individuals to higher anxiety sensitivity, and to disorders associated with stress such as PD. Neuroimaging studies with panic disorder have not been sufficient to explain the pathophysiology of the disease. The aim of this study is to provide additional information for studies examining the etiology of PD by comparing the corpus callosum, a region associated with attention, anxiety, and somatic complaints, on sagittal MRI images of PD patients with the corpus callosum of healthy individuals.</div></div><div><h3>Methods</h3><div>T2-weighted MRI images of 164 patients diagnosed with PD and 78 controls selected from Hospital Information System (HIS) and meeting the study criteria were evaluated by shape analysis method.</div></div><div><h3>Results</h3><div>There were differences between the shapes and areas of the CC in the mid-sagittal images of the PD patients and healthy controls.</div></div><div><h3>Conclusions</h3><div>This study findings highlighted the variable dimensional and subregional properties of CC in PD patients. This study could shed light on future studies about PD etiology, diagnosis and treatment.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111990"},"PeriodicalIF":2.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How psychostimulant treatment changes the brain morphometry in adults with ADHD: sMRI Comparison study to medication-naïve adults with ADHD 精神兴奋剂治疗如何改变成人多动症患者的大脑形态：sMRI 与药物治疗无效的成人多动症患者对比研究

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-04-04 DOI: 10.1016/j.pscychresns.2025.111992

Sherief Ghozy , Jennifer Meiza , Ahmed Morsy , Sadiq Naveed , Adam A. Dmytriw , Kevin Kallmas , Sara Morsy

{"title":"How psychostimulant treatment changes the brain morphometry in adults with ADHD: sMRI Comparison study to medication-naïve adults with ADHD","authors":"Sherief Ghozy , Jennifer Meiza , Ahmed Morsy , Sadiq Naveed , Adam A. Dmytriw , Kevin Kallmas , Sara Morsy","doi":"10.1016/j.pscychresns.2025.111992","DOIUrl":"10.1016/j.pscychresns.2025.111992","url":null,"abstract":"<div><div>ADHD is increasingly recognised as a cause of functional impairment in adults. Treatment guidelines recommend stimulants as the first-line treatment for adult ADHD, but concerns exist about long-term efficacy and potential tolerance. We investigated the long-term effect of stimulant therapy on brain morphometry in individuals with ADHD.</div><div>We obtained structural MRI data from the UCLA Consortium for Neuropsychiatric Phenomics for 26 adults with ADHD. We compared grey matter volume, cortical thickness, sulcal depth, gyrification index, and fractal dimension between individuals with ADHD who had received psychostimulant treatment and medication naïve. For clinical assessment, we also compared Barratt's impulsivity score, Dickman impulsivity inventory II, and Eysenck's impulsivity inventory and investigated how brain morphometry were associated with these scores</div><div>The treated group exhibited significantly higher values in surface-based metrics (<em>FWE-corrected p-value</em> < 0.05), including gyrification index, sulcal depth, and fractal dimension. There was an increased gyrification observed in the right Rolandic operculum, left supplementary motor area, left superior temporal gyrus, right fusiform gyrus, and left cuneus. Increased sulcal depth was detected in the inferior and superior orbitofrontal regions, while increased fractal dimension was also evident in the left superior orbitofrontal gyrus. Treated group venturesomeness scores positively correlated with the grey matter volume of the right anterior cingulate gyrus and negatively with the right superior occipital gyrus.</div><div>Our results suggest a limited treatment effect on ADHD scores and grey matter volume in adults. Despite significant surface-based metrics, these changes were not accompanied by improvements in the clinical scores.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111992"},"PeriodicalIF":2.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the efficacy and acceptability of non-invasive brain stimulation for generalized anxiety disorder: a systematic review and network meta-analysis 评估无创脑刺激治疗广泛性焦虑障碍的疗效和可接受性：一项系统综述和网络荟萃分析

IF 2.1 4区医学

Psychiatry Research: Neuroimaging Pub Date : 2025-04-04 DOI: 10.1016/j.pscychresns.2025.111989

Nanxue Duan , Yulin Zhang , Shaoyang Wang , Jian Guan , Yang Ji , Wanling Huang , Rui Qian , Hao Zheng , Tongjian Bai , Yanghua Tian

{"title":"Evaluating the efficacy and acceptability of non-invasive brain stimulation for generalized anxiety disorder: a systematic review and network meta-analysis","authors":"Nanxue Duan , Yulin Zhang , Shaoyang Wang , Jian Guan , Yang Ji , Wanling Huang , Rui Qian , Hao Zheng , Tongjian Bai , Yanghua Tian","doi":"10.1016/j.pscychresns.2025.111989","DOIUrl":"10.1016/j.pscychresns.2025.111989","url":null,"abstract":"<div><div>Non-invasive brain stimulation (NIBS) has the potential to treat generalized anxiety disorder (GAD). To assess the efficacy (response/remission/post-treatment continuous anxiety severity scores) and acceptability (failure to complete treatment for any reason) of NIBS, we searched PubMed, Web of Science, and the Cochrane Library (as of April 2024) for articles on NIBS for GAD and conducted a network meta-analysis of eight randomized trials (20 treatment arms, 405 participants). Data were pooled using standardized mean difference (SMD) and odds ratio (OR) with 95 % confidence interval (CI). Repetitive transcranial magnetic stimulation (rTMS) was the most widely studied treatment for GAD. The right dorsolateral prefrontal cortex (DLPFC) was the most common treatment target for GAD. High-frequency rTMS showed higher response rates (OR 291.40, 95 % CI 13.08 to 6490.21) and remission rates (OR 182.14, 95 % CI 8.72 to 3805.76) compared with other active therapies. Continuous theta burst stimulation (cTBS) greatly improved continuous post-treatment anxiety severity scores (SMD -2.56, 95 % CI -3.16 to -1.96). No significant differences in acceptability were found between the treatment strategies and the sham stimulation group. These findings provide evidence to consider NIBS techniques as alternative or adjunctive treatments for GAD.</div></div>","PeriodicalId":20776,"journal":{"name":"Psychiatry Research: Neuroimaging","volume":"349 ","pages":"Article 111989"},"PeriodicalIF":2.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0