Quality of Life Research最新文献

{"title":"Item comprehension and content coverage of patient-reported outcome measures for long COVID: a qualitative study.","authors":"Christina K Zigler, Charis Yousefian, Rikki Mangrum, Maliyah Faulstich, Sean M O'Brien, Christine Maughan, Marta Cerda, Lucinda Bateman, Cyndya A Shibao, Barry Make, Leonard A Jason, Kevin P Weinfurt, Kanecia O Zimmerman","doi":"10.1007/s11136-026-04340-7","DOIUrl":"10.1007/s11136-026-04340-7","url":null,"abstract":"<p><strong>Purpose: </strong>Fit-for-purpose clinical outcome assessments are essential to inform medical product development, but outcome measures for Long COVID, a new and devastating phenomenon, have not yet been established. The objective of this study was to evaluate item comprehension and content coverage of four selected patient-reported outcome measures (PROMs) for use in a Long COVID clinical trial platform.</p><p><strong>Methods: </strong>A noninterventional, cross-sectional qualitative cognitive debriefing study of English-speaking adults with Long COVID was conducted, with interviews taking place virtually between August and November 2024. Recruitment was managed by a research firm. The main outcomes of the study were participant comprehension and relevance of the selected PROMs, including symptoms and functioning as measured by modified versions of the DePaul Symptom Questionnaire-Post-Exertional Malaise, Everyday Cognition Scale 2 questionnaire, Composite Autonomic Symptom Score-31, and Orthostatic Hypotension Questionnaire.</p><p><strong>Results: </strong>Participants were able to comprehend most items and indicated they were relevant to their experiences with Long COVID. Participants identified potential enhancements to the measures such as simplifying instructions, modifying item wording, and reducing PROM length. Interviewers observed cognitive burden during some of the interviews.</p><p><strong>Conclusions: </strong>Based on the overall support for comprehension and relevance of items within each measure, use of these measures within the Long COVID clinical trial platform was generally supported. Future work, including qualitative and quantitative studies, could improve the experience of PROM data collection in this context. Clinical trial protocols for Long COVID should carefully consider burden on participants when collecting PROMs.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet-related quality of life is associated with health-related quality of life: a nationwide online cohort study.","authors":"Yoshinari Matsumoto, Ataru Igarashi, Yasutake Tomata, Takahiro Tabuchi","doi":"10.1007/s11136-026-04356-z","DOIUrl":"10.1007/s11136-026-04356-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study focused on diet-related quality of life (DRQoL), a concept encompassing the enjoyment of meals, dietary satisfaction, environment, and variety, and examined its association with health-related quality of life (HRQoL) in Japan.</p><p><strong>Methods: </strong>This study analyzed the data from the nationwide 2021 and 2022 JACSIS study in Japan using cross-sectional and longitudinal data. DRQoL was assessed using a short version of the DRQoL Scale, and DRQoL scores were categorized into sex-specific quartiles. HRQoL was assessed using the EuroQol 5 dimensions 5-level. In the cross-sectional analysis, the association between DRQoL and the full HRQoL score was analyzed using multivariable logistic regression analysis. Longitudinal HRQoL changes were evaluated using the Paretian Classification of Health Change. Multinomial logistic regression analysis was performed with \"the same,\" \"worse,\" \"better,\" and \"mixed\" as outcomes. Stabilized calibration weights were applied to ensure representativeness.</p><p><strong>Results: </strong>The analysis included 19,482 participants. In the cross-sectional analysis, DRQoL Q2 [stabilized calibration weight-adjusted odds ratio (swOR): 1.21, 95% confidence interval (CI): 1.05, 1.41], Q3 (swOR: 1.43, 95% CI 1.23, 1.66), and Q4 (swOR: 2.04, 95% CI 1.77, 2.37) were significantly associated with a full HRQoL score. In the longitudinal analysis, Q4 status in DRQoL was significantly associated with lower odds of worse (swOR: 0.70, 95% CI 0.58, 0.83) and mixed HRQoL outcomes (swOR: 0.72, 95% CI 0.48, 0.99).</p><p><strong>Conclusion: </strong>Higher DRQoL was associated with higher HRQoL in both cross-sectional and longitudinal analyses, suggesting an association between DRQoL and HRQoL in the general Japanese population.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Association between child ADHD and caregivers' mental health and health-related quality of life: results from a population-based study\".","authors":"Anri Inumaru, Yurika Saito, Yohei Kishi","doi":"10.1007/s11136-026-04332-7","DOIUrl":"10.1007/s11136-026-04332-7","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eliciting health state utilities for open wounds in dystrophic epidermolysis bullosa.","authors":"Damian Lewis, Adam B Smith, Marjolijn van Keep, Anna E Martinez, Gabriela Petrof, Sagair Hussain, Sophie Jones, Sharmila Nikapota, Andria Joseph","doi":"10.1007/s11136-026-04322-9","DOIUrl":"10.1007/s11136-026-04322-9","url":null,"abstract":"<p><strong>Purpose: </strong>Qualitative accounts and studies employing disease-specific outcome measures have demonstrated that people with dystrophic epidermolysis bullosa (DEB) display impaired health-related quality of life (HRQoL) due to wound-related challenges. There is a paucity of utility data necessary to inform the health economic evaluation of emerging treatments for cutaneous open wounds.</p><p><strong>Methods: </strong>The objective was to implement a vignette study with a representative sample of the United Kingdom (UK) general population (N = 1139) and people with DEB (N = 44) to estimate utility values. Vignettes were defined by various attributes, including the number and area of wounds, pain, itch and hours spent managing wounds. Participants valued the vignettes from the perspective of a patient or a caregiver proxy using the EQ-5D-3L or EQ-5D-Y-3L, respectively.</p><p><strong>Results: </strong>The mean utilities elicited from the patient perspective ranged from 0.491 to - 0.448 and 0.457 to - 0.462 for the general population (N = 627) and DEB (N = 31) sample, respectively. The utilities elicited from the proxy perspective ranged from 0.443 to - 0.543 and 0.079 to - 0.550 in the general population (N = 512) and DEB (N = 13) sample, respectively.</p><p><strong>Conclusion: </strong>The findings join a limited evidence base indicating that the symptoms associated with the wounds experienced by people with DEB have a considerable detrimental effect on their HRQoL.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of social isolation and family structure on stroke-specific quality of life in a community-based study.","authors":"Josh Martins-Caulfield, Chen Chen, Lynda D Lisabeth, Guanghao Zhang, Madeline Kwicklis, Leanna M Delhey, Lewis B Morgenstern","doi":"10.1007/s11136-026-04337-2","DOIUrl":"10.1007/s11136-026-04337-2","url":null,"abstract":"<p><strong>Purpose: </strong>Quality of Life (QOL) is a critical patient-centered outcome for individuals who have experienced stroke. This study examined the association of social isolation and family structure with Stroke-Specific QOL (SSQOL).</p><p><strong>Methods: </strong>Participants were stroke survivors enrolled in the Brain Attack Surveillance in Corpus Christi (BASIC) study in Nueces County, Texas who completed 90-day post-stroke follow-up interviews between October 2019 and June 2023. Interviewers assessed QOL using the SSQOL scale, social isolation using the Patient-Reported Outcomes Measurement Information System (PROMIS) scale. Family structure was assessed based on marital status, family size, and whether adult children were living within 10 miles of the patient. Linear models were developed to analyze the relationship between social isolation and SSQOL with successive adjustment for demographic, clinical, socioeconomic, and familial variables from interviews and medical records.</p><p><strong>Results: </strong>Among 706 stroke survivors (median age = 64, 36% Non-Hispanic White and 64% Mexican American), median PROMIS social isolation score was 44 (IQR: 34.8-51.6) and median SSQOL was 3.67 (IQR: 2.75-4.50). The average family size was 2.18 people and 50% of participants were married while 60% had a child living within 10 miles of them. A consistent negative association between social isolation and SSQOL scores was observed across all adjusted models (fully adjusted [Formula: see text]0.77, 95% CI = (- 0.88, - 0.65), p < 0.01), while family structure was not associated with SSQOL.</p><p><strong>Conclusions: </strong>Social isolation was negatively associated with SSQOL. There was no association between family structure and SSQOL. This study highlights the significance of modifiable psychosocial factors, such as social isolation, as potential key elements in stroke recovery.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments raised by 'Do non-responders to a geriatric screening questionnaire face lower 1-year survival compared to responders? A retrospective cohort study'.","authors":"Yohei Kishi, Yurika Saito, Anri Inumaru","doi":"10.1007/s11136-026-04349-y","DOIUrl":"10.1007/s11136-026-04349-y","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the NEI-VFQ-25 scores to the EQ-5D-Y-3L and CHU-9D utility values among adolescents with myopia.","authors":"Chang Luo, Mingxing Liu, Rongjie Shao, Shitong Xie, Jing Wu","doi":"10.1007/s11136-026-04344-3","DOIUrl":"10.1007/s11136-026-04344-3","url":null,"abstract":"<p><strong>Purpose: </strong>To develop mapping algorithms for predicting EQ-5D-Y-3L and CHU-9D utility values from the National Eye Institute 25-Item Visual Function Questionnaire (NEI-VFQ-25) among adolescents with myopia to support economic evaluation.</p><p><strong>Methods: </strong>Data were collected from 2,198 adolescents with myopia in China. Conceptual overlap was assessed using Spearman's rank correlation. Six regression models, including ordinary least squares (OLS), Tobit, censored least absolute deviations (CLAD), generalized linear model (GLM), two-part model (TPM), and adjusted limited dependent variable mixture model (ALDVMM), were evaluated. The predictors included the NEI-VFQ-25 total score and the subscale scores. Model performance was assessed via five-fold cross-validation and random sample validation based on mean absolute error (MAE), root mean squared error (RMSE), Akaike information criterion (AIC), Bayesian information criterion (BIC), and the proportions of absolute error (AE) > 0.05. Sensitivity analyses of model validation were conducted.</p><p><strong>Results: </strong>The mean (SD) utility values were 0.962 (0.070) for the EQ-5D-Y-3L and 0.851 (0.160) for the CHU-9D. The NEI-VFQ-25 total score correlated moderately with the CHU-9D (r = 0.50) but weakly with the EQ-5D-Y-3L (r = 0.37). The OLS and GLM using stepwise-selected subscale scores demonstrated the best predictive performance for EQ-5D-Y-3 L (MAE = 0.045, RMSE = 0.061, AE > 0.05 [%] = 30.37%) and CHU-9D (MAE = 0.103, RMSE = 0.139, AE > 0.05 [%] = 61.50%), respectively. Sensitivity analyses generally supported the primary model-selection results.</p><p><strong>Conclusion: </strong>This study established algorithms for estimating EQ-5D-Y-3L and CHU-9D utility values based on NEI-VFQ-25 subscale scores for adolescents with myopia, thus facilitating future economic evaluation for myopia interventions. However, given the limited conceptual overlap between the NEI-VFQ-25 and EQ-5D-Y-3L, the EQ-5D-Y-3L algorithm should be applied with caution.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Humanistic and economic burden among caregivers of adults and children with sickle cell disease and recurrent vaso-occlusive crises.","authors":"Lauren Lilly, Duncan Brown, Nanxin Li, Jennifer Drahos, Melanie Calvert, Anthony Mason, Zahra Pakbaz, Farrukh Shah, Ashley Valentine, Bethany Franks, Idaira Rodriguez Santana","doi":"10.1007/s11136-026-04347-0","DOIUrl":"10.1007/s11136-026-04347-0","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the humanistic burden and economic impact among informal caregivers of individuals with sickle cell disease (SCD) and recurrent vaso-occlusive (VOCs) across North America and Europe.</p><p><strong>Methods: </strong>A mixed-methods study was conducted with qualitative interviews in the US and UK and an online survey in the US, Canada, UK, France, Germany, Italy, Spain, and the Netherlands. The survey included CarerQoL-7D, WPAI:CG, and explored time spent providing informal care, out-of-pocket expenses, and health inequity. Interviews were analyzed using the Framework Method and survey data with descriptive analyses. Monetary values were standardized to US dollars.</p><p><strong>Results: </strong>Interviews with 10 caregivers identified five key themes: (1) Need for a strong support network; (2) Providing constant care/attention; (3) Ensuring optimal care; (4) Major lifestyle adjustments; and (5) Impact on caregiver's emotional and physical wellbeing. 173 caregivers completed the survey. The CarerQoL indicated adverse impacts on health-related quality of life (HRQoL) with > 70% reporting problems due to mental health, difficulty combining caregiving with daily activities, and physical health. On average, US and European/Canadian caregivers spent 53.7 and 32.0 h per week providing care. WPAI:CG indicated overall work impairment of 52% and 42% among caregivers in the US and Europe/Canada. Average annual out-of-pocket expenses were $13,300 in the US and $4,050 in Europe/Canada.</p><p><strong>Conclusion: </strong>Caregivers of people with SCD with recurrent VOCs experience negative impacts on HRQoL, work productivity, and out-of-pocket expenses. Policies addressing caregiver challenges are urgently needed, and improved access to emerging therapies may ease the burden experienced by caregivers and patients.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intergenerational associations between maternal health and offspring mental wellbeing: evidence from a nationally representative longitudinal study.","authors":"Minnat Seema, Clifford Afoakwah, Joshua Byrnes","doi":"10.1007/s11136-026-04339-0","DOIUrl":"10.1007/s11136-026-04339-0","url":null,"abstract":"<p><strong>Background: </strong>Maternal mental health has been linked to a range of offspring outcomes; however, population-based evidence examining intergenerational associations across multiple health-related quality of life (HRQoL) domains over the life course remains limited. This study examines associations between maternal mental health and offspring HRQoL using nationally representative longitudinal data from Australia.</p><p><strong>Methods: </strong>We used data from the Household, Income and Labour Dynamics in Australia (HILDA) Survey. The analytic sample comprised 8,737 offspring linked to 4,966 mothers. Three offspring's HRQoL outcomes were examined: mental health and general health domain of the SF-36 instrument and the Kessler Psychological Distress Scale. Maternal mental health was measured using the SF-36 mental health domain. Associations were estimated using weighted linear regression models with standard errors clustered at the maternal level, adjusting for socioeconomic and demographic characteristics. Gender differences were examined using interaction terms.</p><p><strong>Results: </strong>Higher maternal mental health was significantly associated with better offspring mental health in fully adjusted models (β = 0.485 SD, p < 0.001). Higher maternal mental health was also associated with better offspring general health (β = 0.458 SD, p < 0.001). For psychological distress, higher maternal psychological distress was associated with higher offspring psychological distress (β = 0.419 SD, p < 0.001). Higher maternal mental health was also positively associated with offspring psychological distress (β = 0.216 SD, p < 0.001); however, this reflects differences in measurement constructs (higher distress scores indicate worse outcomes) and should be interpreted cautiously. Associations remained statistically significant after covariate adjustment and did not differ by offspring gender.</p><p><strong>Conclusions: </strong>Maternal mental health is associated with multiple dimensions of offspring HRQoL across the life course. These findings highlight maternal mental health as an important correlate of offspring health and underscore the relevance of family-centred, preventive strategies aimed at reducing intergenerational inequalities in mental health.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construct validity and responsiveness of EQ-5D-3L and EQ VAS in psoriatic arthritis: an evaluation based on the Swedish Rheumatology Quality Register.","authors":"Kinza Degerlund-Maldi, Malin Regardt, Camilla Nystrand Länsman, Lena Larsson, Ioannis Parodis, Emelie Heintz","doi":"10.1007/s11136-026-04323-8","DOIUrl":"10.1007/s11136-026-04323-8","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate construct validity and responsiveness of the health-related quality of life (HRQoL) instrument EQ-5D-3L (index, dimensions) and EQ VAS among patients with psoriatic arthritis (PsA).</p><p><strong>Methods: </strong>This retrospective, register-based study utilised data from the Swedish Rheumatology Quality Register. Known-groups validity was assessed by comparing EQ-5D-3L and EQ VAS results across groups with varying levels of physical function or disease activity. Convergent validity was assessed through correlations with comparator instruments. Responsiveness was assessed by analysing correlations between changes in EQ-5D-3L, EQ VAS, and comparator instruments, as well as by assessing the ability to discriminate between patients who improved and those who did not, using the area under the receiver operating characteristic curve (AUC). To confirm construct validity or responsiveness, ≥ 75% of hypotheses had to be supported.</p><p><strong>Results: </strong>The study included 13,105 patients with PsA. EQ-5D-3L and EQ VAS demonstrated moderate to strong correlations with comparator instruments and found expected differences between groups with varying physical function or disease activity. Over 75% of the hypotheses related to construct validity were supported. Regarding responsiveness, several hypotheses for the EQ-5D-3L were not supported, and none of the AUC-related hypotheses for EQ VAS were supported. Overall, less than 75% of the hypotheses related to responsiveness for EQ-5D-3L and EQ VAS were supported.</p><p><strong>Conclusion: </strong>The results from this observational study support construct validity of EQ-5D-3L and EQ VAS among patients with PsA. However, responsiveness was not supported for the EQ-5D-3L dimensions which suggests that the EQ-5D-3L may not fully capture changes in HRQoL from interventions impacting other dimensions than pain/discomfort.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}