Quality of Life Research最新文献

{"title":"Health related quality of life of patients with breast cancer in Malaysia: evidence from EQ-5D-5L and EORTC QLQ-C30.","authors":"Siew Chin Ong, Sook Pin Goh, Siew Wei Yeong, Chow Kyn Ng, Yi Jing Tan, Muhammad Daoud Butt, Kian Keong Kong, Sin Dee Cheah, Boon Seang Tan, Jen Ven Lee, Ros Suzanna Ahmad Bustamam, Wei Wern Khor, Liyana Ahamad Fouzi, Aina Shafiza Abd Aziz, Su Yiu Chieng, Sarahfarina Abd Rahim","doi":"10.1007/s11136-026-04334-5","DOIUrl":"10.1007/s11136-026-04334-5","url":null,"abstract":"<p><strong>Purpose: </strong>Health-related quality of life (HRQoL) data among patients with breast cancer (BC) in Malaysia remain limited. This study aimed to describe HRQoL and identify its key predictors to inform future health policy planning.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted between April 2023 and January 2025 among BC outpatients in eight public specialist hospitals in Malaysia. Sociodemographic and clinical data were collected alongside patient-reported outcome measures, including the EuroQol-5 Dimension 5-Level questionnaire (EQ-5D-5L), a preference-based health utility measure, and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30), a cancer-specific HRQoL questionnaire. Multivariable linear regression models were used to identify independent predictors of HRQoL for each instrument.</p><p><strong>Results: </strong>The mean (standard deviation) EQ-5D-5L health state utility value (HSUV) was 0.853 (0.179), the mean EQ-VAS score was 79.2 (19.1), and the mean (standard deviation) EORTC QLQ-C30 summary score was 83.3 (15.3). The EQ-5D-5L dimensions with the highest prevalence of reported problems were pain/discomfort and anxiety/depression. The EQ-5D-5L HSUV and VAS score demonstrated moderate to strong positive correlations with the EORTC QLQ-C30 summary score (ρ = 0.503 to 0.672, p < 0.001). In multivariable analysis, advanced cancer stage, Chinese ethnicity, and lower education were independently associated with poorer EQ-5D-5L HSUV. EQ-VAS scores were associated with Indian ethnicity and completion of the questionnaire in English. For EORTC QLQ-C30, advanced cancer stages and Chinese ethnicity remained significant predictors.</p><p><strong>Conclusion: </strong>HRQoL among patients with BC in Malaysia was primarily influenced by cancer stage, ethnicity, and education level. Advanced cancer stage was consistently associated with poorer patient-reported outcomes. The complementary use of EQ-5D-5L and EORTC QLQ-C30 provides more comprehensive estimates to inform survivorship care and future economic evaluations.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and cutpoints of the treatment-induced neuropathy assessment scale (TNAS) in Chinese cancer patients: a prospective cohort study.","authors":"Chenxi He, Wei Xu, Jing Li, Wenlin Wu, Shi Wang, Changjin Wu, Yubo Zhang, Yuxian Nie, Feng Gao, Qiuling Shi","doi":"10.1007/s11136-026-04338-1","DOIUrl":"10.1007/s11136-026-04338-1","url":null,"abstract":"<p><strong>Objective: </strong>Treatment-induced peripheral neuropathy (TIPN) significantly impairs patients' quality of life, compromises the treatment process, and adversely affects prognosis. The aim of this study was to evaluate the psychometric properties of the Treatment-induced Neuropathy Assessment Scale (TNAS) and establish cutpoints in Chinese patients with cancer.</p><p><strong>Methods: </strong>In a prospective cohort of 254 colorectal cancer patients receiving oxaliplatin, the TNAS was assessed for reliability and validity. Using patient-reported walking impairment and CTCAE grades as anchors, optimal cutpoints (CPs) for the numbness, sensory subscale, and interference subscale were derived. Group-Based Trajectory Modeling (GBTM) was subsequently used to examine the clinical utility of the cutpoints.</p><p><strong>Results: </strong>The TNAS showed internal consistency (α = 0.92) and repeatability (ICC = 0.85) in Chinese patients. The scale significantly discriminated between patients with and without CTCAE-defined events (1.87 ± 1.60 vs. 1.15 ± 1.72, effect size = 0.44; P < 0.001). Mild, moderate, and severe numbness strata were defined as < 3, 3-6, and ≥ 7 using the walking anchor, and as < 2, 2-4, and ≥ 5 using the CTCAE anchor. For the sensory subscale, the corresponding CPs were < 2.50, 2.50-5.49, and ≥ 5.50 per the walking anchor, versus < 0.83, 0.83-2.32, and ≥ 2.33 per the CTCAE anchor. For the interference subscale, stratification CPs were < 2.00, 2.00-4.66, and ≥ 4.67 based on the walking anchor, and < 1.67, 1.67-3.99, and ≥ 4.00 based on the CTCAE anchor. These subgroups displayed distinct longitudinal trajectories across the chemotherapy course.</p><p><strong>Conclusion: </strong>The Chinese version of the TNAS is a valid and sensitive tool for TIPN assessment. Its established cutpoints provide a quantitative basis for defining responders in clinical trials and triggering early toxicity management.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative health-related quality of life across four degenerative lumbar conditions in a multi-ethnic Southeast Asian surgical cohort: a cross-sectional SF-36 analysis.","authors":"Yu Heng Yeow, Siew Tiang Lau, Xun Li, Calvin Wei Jie Chern, Xin Zhang, Alex Quok An Teo, Hwee Weng Dennis Hey, Ling Jie Cheng","doi":"10.1007/s11136-026-04336-3","DOIUrl":"10.1007/s11136-026-04336-3","url":null,"abstract":"<p><strong>Purpose: </strong>The evidence base for preoperative health-related quality of life (HRQoL) in degenerative lumbar conditions derives predominantly from Western populations. This study characterised HRQoL across four degenerative lumbar conditions in a multi-ethnic Southeast Asian surgical cohort and identified factors associated with physical and mental health at composite and domain levels.</p><p><strong>Methods: </strong>Cross-sectional analysis of 1173 preoperative patients from a Singaporean spine surgery registry (2017-2022). SF-36 norm-based T-scores were computed for eight domains and two component summaries. Diagnosis-stratified stepwise multiple regression identified factors associated with the Physical Component Summary (PCS), Mental Component Summary (MCS), and domain scores. LASSO regression served as a sensitivity analysis.</p><p><strong>Results: </strong>Mean PCS was 35.6 (SD 8.9), 1.4 SD below the US normative mean, whereas MCS was 50.3 (SD 9.7), near normative levels. Physical functioning and role-physical were the most impaired domains. Scores differed across the four diagnoses on six of the ten SF-36 outcomes (one-way ANOVA, all p < 0.05; corroborated by Kruskal-Wallis tests), although effect sizes were small (eta-squared ≤ 0.02). Functional disability showed the strongest association with PCS across all four conditions (β range: - 0.32 to - 0.28; adjusted R² = 0.48-0.52). MCS models explained limited variance (adjusted R² = 0.09-0.22). At the domain level, physical functioning had the highest adjusted R² (0.57-0.67), exceeding even PCS. Indian ethnicity was independently associated with lower MCS in two conditions. LASSO sensitivity analyses corroborated the stepwise findings.</p><p><strong>Conclusion: </strong>Functional disability was most strongly associated with physical HRQoL, channelled through physical functioning limitations. Conventional variables explained limited mental HRQoL variance, suggesting unmeasured psychological and cultural factors play a substantial role. While functional disability's primacy was consistent with Western evidence, secondary patterns diverged from Western cohorts. These findings underscore the need to incorporate psychological and culturally adapted measures into preoperative assessment.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Factors associated with preoperative health-related quality of life in patients undergoing lumbar spine surgery: a multi-ethnic Asian cohort.","authors":"Xun Li, Calvin Wei Jie Chern, Alex Quok An Teo, Jiong Hao Jonathan Tan, Annushiah Vasan Thakumar, Nan Luo, Hwee Weng Dennis Hey, Ling Jie Cheng","doi":"10.1007/s11136-026-04304-x","DOIUrl":"10.1007/s11136-026-04304-x","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13364872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Needs and health-related quality of life domains relevant to people in Europe with advanced cancer in need of palliative care: a systematic review of qualitative research.","authors":"Catalina Lizano-Barrantes, Clara Amat-Fernandez, Olatz Garin, Ricardo Luer-Aguila, Yolanda Pardo, Leslye Rojas-Concha, Melissa S Y Thong, Giovanni Apolone, Cinzia Brunelli, Augusto Caraceni, Norbert Couespel, Nanne Bos, Mogens Groenvold, Stein Kaasa, Gennaro Ciliberto, Claudio Lombardo, Ricardo Pietrobon, Gabriella Pravettoni, Aude Sirven, Hugo Vachon, Alexandra Gilbert, Galina Velikova, Montse Ferrer","doi":"10.1007/s11136-026-04268-y","DOIUrl":"10.1007/s11136-026-04268-y","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13341814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148397564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement between the EQ-5D-5L anxiety/depression dimension and GAD-7/PHQ-9 for psychological distress assessment in patients with hematologic malignancies.","authors":"Fenfang Tong, Yue Zhang, Tingting Cheng, Shiyu Wang, Yan Chen, Wei Qin, Yajing Xu","doi":"10.1007/s11136-026-04330-9","DOIUrl":"10.1007/s11136-026-04330-9","url":null,"abstract":"<p><strong>Background: </strong>Patients with hematologic malignancies (HMs) often experience psychological distress, significantly impairing health-related quality of life (HRQoL) and deteriorating clinical prognosis. Although the widely used instrument EuroQol 5-Dimension 5-Level (EQ-5D-5L) has been validated in the general population for accurately identifying the psychological symptoms, its performance in HM patients remains unclear. We aimed to investigate whether the EQ-5D-5L questionnaire anxiety/depression (A/D) dimension, when already collected for HRQoL assessment, correlates with anxiety and depression symptoms and may potentially flag patients who may warrant further psychiatric evaluation.</p><p><strong>Methods: </strong>Enrolled HM patients were invited to complete the EQ-5D-5L questionnaire. The anxiety/depression symptoms were additionally assessed using the symptom-specific tools Generalized Anxiety Disorder 7-item scale (GAD-7) and Patient Health Questionnaire-9 (PHQ-9). Spearman correlation analysis was performed to examine the correlation between the EQ-5D-5L A/D dimension and GAD-7/PHQ-9. The sensitivity and specificity of the A/D dimension were evaluated using GAD-7/PHQ-9 as a comparative measure. The associations between patient characteristics and responses on the A/D dimension were explored.</p><p><strong>Results: </strong>The A/D dimension exhibited moderate-to-strong correlations with GAD-7 grade (r = 0.607, P < 0.001), PHQ-9 grade (r = 0.579, P < 0.001), and combined GAD-7/PHQ-9 grade (r = 0.603, P < 0.001). For identifying the presence of anxiety/depression, the A/D dimension showed high specificity (94.3-98.6%) but relatively low sensitivity (47.2-60.0%). A subset of patients classified as having anxiety or depression according to the GAD-7/PHQ-9 reported no emotional problems on the A/D dimension. Further analysis revealed that patients with higher education level tended to report lower symptom severity on the A/D dimension.</p><p><strong>Conclusions: </strong>The EQ-5D-5L A/D dimension showed moderate-to-strong correlation with GAD-7 and PHQ-9 among HM patients. Based on its limited sensitivity but high specificity, it may serve as a supplementary indicator within routine HRQoL assessments rather than a standalone screening tool. Due to the relatively small sample size and exploratory design of our study, further multicenter investigations with larger sample sizes are needed to validate our findings.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empirical comparison of health-related quality of life and subjective well-being measures in Australian adolescents.","authors":"Kaung Mon Winn, Maame Esi Woode, Gang Chen","doi":"10.1007/s11136-026-04331-8","DOIUrl":"10.1007/s11136-026-04331-8","url":null,"abstract":"<p><strong>Background: </strong>Health-related quality of life (HRQoL) and subjective well-being (SWB) are increasingly used to capture aspects of welfare beyond traditional health indicators; however, their conceptual distinction has not been fully resolved.</p><p><strong>Objective: </strong>This study examines the empirical relationships between HRQoL, measured using Child Health Utility 9D (CHU9D), EQ-5D-5L and EQ-5D-5L with psychosocial bolt-ons and SWB, measured using a 12-item Life Satisfaction Scale for Youth (LSS-Y) and the Disability Wellbeing Index (DWI), among Australian adolescents, and explores factors associated with these outcomes.</p><p><strong>Methods: </strong>A nationwide, quota-based online survey was administered to Australian adolescents aged 15-19 years. The survey included the above instruments and sociodemographic questions. Psychometric analyses, including Spearman's correlation, Kruskal-Wallis tests, and exploratory factor analyses (EFA), were conducted to examine interrelationships and latent structures. Regression analyses were used to identify factors associated with the outcome measures.</p><p><strong>Results: </strong>Data were collected from 1026 adolescents (44.5% female). Of these, 510 completed the CHU9D and 516 completed the EQ-5D-5L with psychosocial bolt-ons under a randomised design; all participants completed the LSS-Y and DWI. No HRQoL dimension showed strong correlations (Spearman's ρ > 0.60) with SWB dimensions, and EFA revealed limited overlap in latent constructs. Regression analyses identified general health, socioeconomic status, gender, migration status, and disability status as significant determinants of adolescents' health and well-being.</p><p><strong>Conclusion: </strong>HRQoL and SWB are not interchangeable but provide complementary insights. Using both measures may offer a more comprehensive understanding of adolescents' overall well-being.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life dynamics in the gastric cancer dyad: an actor-partner interdependence model analysis guiding the development of a family-centered nursing framework.","authors":"Ying-Ying Gu, Yan-Mei Chen, Yong-Qi Ye, Can Zhang, Hong-Yan Hu, Kaiwusaierjiang Keremu, Zheng-Yu Yang, Fang-Fang Xing, Jing Zhang, Chao-Zhu He","doi":"10.1007/s11136-026-04333-6","DOIUrl":"10.1007/s11136-026-04333-6","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the mechanisms linking quality of life (QoL) between postoperative GC patients and their family caregivers, and to construct a family-centered nursing framework.</p><p><strong>Methods: </strong>353 patient-caregiver dyads were recruited. Based on a validated theoretical framework, we analyzed factors influencing QoL and used the Actor-Partner Interdependence Model (APIM) to examine bidirectional pathways.</p><p><strong>Results: </strong>Patient and caregiver QoL were positively correlated (r = 0.287, p < 0.001). Actor effects: Patient QoL was positively predicted by patient health literacy, benefit finding, and positive coping, and negatively by patient negative coping and anxiety/depression. Caregiver QoL was positively predicted by caregiver health literacy and positive coping, and negatively by caregiver benefit finding, negative coping, and anxiety/depression. Partner effects: Caregiver health literacy and positive coping positively predicted patient QoL; caregiver self‑efficacy and benefit finding negatively predicted patient QoL. Patient positive coping positively predicted caregiver QoL, while patient social support negatively predicted caregiver QoL.</p><p><strong>Conclusions: </strong>This study reveals significant bidirectional interdependence of QoL within GC dyads, uncovers complex negative spillover mechanisms, and provides an empirical basis for identifying high-risk groups and developing balanced, de-burdening interventions. The findings support integrating the patient-caregiver dyad as a holistic unit into disease management frameworks. Gastric cancer and surgery can greatly change the lives of both patients and the family members who care for them. However, care after surgery often focuses mainly on the patient, while the caregiver's needs and influence may be overlooked. This study aimed to understand how quality of life is connected between patients after gastric cancer surgery and their family caregivers. We studied 353 patient-caregiver dyads and looked at how understanding health information, confidence in managing care, finding positive meaning, coping styles, emotional distress, and social support were related to their quality of life. We found that patients and caregivers affected each other. When caregivers had better health knowledge and used more positive ways to cope, patients tended to report better quality of life. When patients used positive coping, caregivers also tended to report better quality of life. However, some forms of support or personal effort were linked with lower quality of life for the other person, suggesting possible hidden burden. These findings show that patients and caregivers should be supported together, not separately.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Self-stigma and suicide risk mediates the associations of inattention/impulsivity symptoms with psychological distress and quality of life among people with schizophrenia.","authors":"Thao Thanh Thi Nguyen, Paolo Soraci, Hsiao-Wei Huang, Yun-Ling Chen, Yu-Ting Huang, Renato Pisanti, Kun-Chia Chang, Mark D Griffiths, Chung-Ying Lin","doi":"10.1007/s11136-026-04306-9","DOIUrl":"10.1007/s11136-026-04306-9","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A methodological overview of new measure development for the Limb Injury Measurement Battery for Quality of Life (LIMB-QOL).","authors":"Aaron J Boulton, Seung W Choi, Callie E Tyner, Jerry Slotkin, David S Tulsky","doi":"10.1007/s11136-026-04298-6","DOIUrl":"10.1007/s11136-026-04298-6","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the data analytic strategy used to develop new quality-of-life measures for the Limb Injury Measurement Battery for Quality of Life (LIMB-QOL).</p><p><strong>Methods: </strong>Several item pools were created and administered to a large sample of individuals with a history of major extremity injury or limb loss (n = 603). Item analyses adhered to modern psychometric standards (e.g., PROMIS®, COSMIN) and aimed to create several item response theory-based (IRT) item banks based on the graded response model. Items were removed iteratively based on pre-defined criteria and IRT model assumptions were met for the final item pools (monotonicity, unidimensionality, local item independence); differential item functioning, test-retest reliability, and convergent validity were then evaluated. Computer adaptive test and short-form versions of final item banks were created and examined using data simulation.</p><p><strong>Results: </strong>Item analyses led to the development of 8 new item banks and two fixed-length scales. These 10 new LIMB-QOL measures demonstrated initial evidence of reliability (α range = 0.94-0.98, test-retest ICC range: 0.68-0.91) and convergent validity for use in individuals with a history of major extremity injury or limb loss, and abbreviated formats of the full item banks exhibited comparable performance.</p><p><strong>Conclusion: </strong>The new LIMB-QOL measures demonstrated strong psychometric properties and can be used to collect patient-reported assessments of quality of life following major extremity injury and limb loss. The analytic strategy described herein exemplifies how the PROMIS methodology can be utilized to design IRT-based patient-reported outcome measures to fill measurement gaps for specific clinical populations.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 8","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}