Quality of Life Research最新文献

{"title":"Association between sarcopenic obesity, obesity, sarcopenia and quality of life in middle-aged and older Chinese: the Guangzhou Biobank Cohort Study.","authors":"Jing Yi Chen, Jiao Wang, Ya Li Jin, Kar Keung Cheng, Tai Hing Lam, Wei Sen Zhang, Lin Xu","doi":"10.1007/s11136-025-03960-9","DOIUrl":"https://doi.org/10.1007/s11136-025-03960-9","url":null,"abstract":"<p><strong>Purpose: </strong>Sarcopenic obesity (SO) is increasing globally, especially in aging populations. This study aims to analyze whether SO is more strongly associated with poorer quality of life (QoL) than obesity or sarcopenia alone.</p><p><strong>Methods: </strong>SO was defined as the coexistence of probable sarcopenia combined with obesity. Obesity was defined by body mass index and waist circumference, and probable sarcopenia was identified using the Asian Working Group for Sarcopenia criteria 2019. QoL was assessed using the Short-Form 12 Health Survey Version 2. Linear regression was used to analyze the association between SO with QoL composite and domain scores.</p><p><strong>Results: </strong>Of 6,332 participants aged 50 years or older, 21.9% had SO, 10.6% had obesity only, and 38.7% had probable sarcopenia only. Compared to participants without obesity or sarcopenia, those with SO showed a significant negative association with physical health-related QoL (all P < 0.05), which remained significant when obesity or sarcopenia alone was used as the reference. The adjusted beta (95% CI) for the Physical Component Summary, General Health, Physical Functioning, Role Physical, and Bodily Pain for the SO group was -1.23 (-1.68, -0.79), -0.86 (-1.51, -0.21), -1.28 (-1.77, -0.80), -0.51 (-0.95, -0.07), and -0.77 (-1.37, -0.18), respectively. Non-significant association of SO with the Mental Component Summary, Vitality, Role Limitation due to Emotional Problem, and Mental Health was found (all P > 0.05). The results were consistent across different SO criteria and by sex (P for sex-interaction from 0.21 to 0.99).</p><p><strong>Conclusion: </strong>SO was associated with lower physical health-related QoL compared to obesity or sarcopenia alone, but non-significantly associated with mental health-related QoL.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Evaluating the content validity of the EQ-5D-Y for Chinese children and adolescents.","authors":"Yifan Ding, Guangjie Zhang, Zhihao Yang, Yue Sun, Anle Shen, Zhuxin Mao, Pei Wang, Jan Busschbach","doi":"10.1007/s11136-025-03968-1","DOIUrl":"10.1007/s11136-025-03968-1","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood ammonia and eye-hand coordination negatively affect health-related quality of life in women with minimal hepatic encephalopathy.","authors":"Daniela Batallas, Juan José Gallego, Franc Casanova-Ferrer, Alessandra Fiorillo, Pablo Rivas-Diaz, Adrià López-Gramaje, Yaiza M Arenas, Luis Aparicio, Desamparados Escudero-García, Lucía Durbán, María-Pilar Rios, Salvador Benlloch, Amparo Urios, Vanesa Hidalgo, Carmina Montoliu, Alicia Salvador","doi":"10.1007/s11136-025-03920-3","DOIUrl":"https://doi.org/10.1007/s11136-025-03920-3","url":null,"abstract":"<p><strong>Purpose: </strong>Minimal hepatic encephalopathy (MHE) is common in cirrhosis, leading to cognitive impairment and eye-hand coordination (EHC) alterations. Hyperammonemia plays a key role in MHE, contributing to motor and cognitive deficits. Elevated blood ammonia levels and impaired EHC correlate with neuropsychiatric dysfunction, yet their direct impact on health-related quality of life (HRQoL) is complex. This study examines the associations between blood ammonia, EHC, and HRQoL, and the moderating influence of sex on these associations.</p><p><strong>Methods: </strong>Eighty-seven cirrhotic patients (67 male) and 23 healthy volunteers (11 male), aged 44-80 years, performed the Psychometric Hepatic Encephalopathy Score (PHES) for MHE diagnosis, the Vienna Test System, bimanual and visuomotor tests, and completed the SF-36 questionnaire to measure HRQoL. Blood samples were taken to test ammonia levels.</p><p><strong>Results: </strong>Results indicated a significant association between elevated blood ammonia and impaired EHC among cirrhotic patients. However, increased blood ammonia and EHC did not directly predict HRQoL. Moderated moderation analysis revealed that women with MHE showed greater sensitivity to hyperammonemia and EHC deficits in tasks requiring fine motor control and stability skills (aiming, tapping, and bimanual coordination), which were linked to lower HRQoL in both physical and mental domains. In women without MHE, alterations in linear tracking were linked to worse HRQoL. These effects were not observed in men.</p><p><strong>Conclusions: </strong>The findings underscore the sex-specific impacts of MHE, with women disproportionately affected by ammonia-related motor impairments and their subsequent influence on HRQoL. These results could contribute to developing targeted strategies to improve outcomes in this vulnerable population.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life and cost-utility analysis in patients with femoral neck fracture: a propensity score matching study comparing monopolar hemiarthroplasty and total hip arthroplasty.","authors":"Juan Miguel Gómez-Palomo, Ana Martínez-Crespo, Julieta Passini-Sánchez, Nikita Ignatyev-Simonov, Plácido Zamora-Navas, Enrique Guerado","doi":"10.1007/s11136-025-03965-4","DOIUrl":"https://doi.org/10.1007/s11136-025-03965-4","url":null,"abstract":"<p><strong>Introduction: </strong>Femoral neck fracture impacts patients' quality of life. Patients treated with a total hip arthroplasty (THA) versus a hemiarthroplasty (HA) may have higher quality of life scores after the intervention. This work aims to analyze and compare quality of life among patients with femoral neck fracture treated with THA versus monopolar HA and to perform a cost-utility analysis (CUA) on the procedures.</p><p><strong>Materials and methods: </strong>A prospective, comparative study was conducted on 424 patients with femoral neck fractures, 268 treated with monopolar HA and 156 with THA. To ensure comparability between the groups, Propensity Score Matching (PSM) was performed based on variables such as age and the Charlson Comorbidity Index. The index accounted for comorbidities including cardiovascular disease, diabetes, chronic pulmonary disease, renal disease, and malignancy. After PSM, 156 matched pairs were analyzed. Follow-up data, including quality of life (QoL) assessed via the EQ-5D scale, were collected at 1 year.</p><p><strong>Results: </strong>Twelve months after the procedure, patients treated with THA had significantly higher EuroQol-5D (EQ-5D) index values than those treated with monopolar HA (0.83 vs. 0.68; p = 0.001), with a large effect size (Cohen's d = 0.92), however, both procedures presented similar results on the EQ-5D visual analog scale (VAS) (86.59 vs. 87.11; p = 0.255). THA led to a gain of 0.15 quality-adjusted life years (QALY) compared to monopolar HA (0.83 QALY vs. 0.68 QALY) and demonstrated greater cost-effectiveness, particularly in patients younger than 80 years and those with fewer comorbidities.</p><p><strong>Conclusions: </strong>Patients with femoral neck fracture treated with THA may have higher quality of life levels than those treated with monopolar HA. Likewise, the greatest gain in QALY with THA versus monopolar HA was observed in patients younger than 80 years of age and those who had less comorbidity.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of WeChat-based EPIC training on health-related quality of life, attribution and life attitude in women newly diagnosed with breast cancer: a clinical randomized controlled trial.","authors":"Kaina Zhou, Xiao Wang, Yan Wang, Ailan Liu","doi":"10.1007/s11136-025-03959-2","DOIUrl":"https://doi.org/10.1007/s11136-025-03959-2","url":null,"abstract":"<p><strong>Purpose: </strong>When confronted with healthy functional impairments, the attribution of disease-induced distress plays a key role in the prognosis of health outcomes. This study examined the effects of an attribution-related intervention, namely WeChat-based EPIC (enter, practice, intensify, consolidate) training, on health-related quality of life (HRQoL), attribution, and life attitude in women newly diagnosed with breast cancer.</p><p><strong>Methods: </strong>Eligible patients were recruited using convenience sampling and randomly assigned to the intervention or control group via stratified block randomization. The former received WeChat-based EPIC training plus routine nursing care for 6 months. The latter received only routine nursing care. HRQoL (primary indicator), attribution and life attitude (secondary indicators) were measured using the Functional Assessment of Cancer Therapy-Breast version 4.0 (FACT-Bv4.0), Attributional Style Questionnaire (ASQ) and Life Attitude Self-rating Questionnaire for Breast Cancer (LASQ-BC), respectively. A linear mixed model was used to examine the score fluctuations at the 1-, 3-, and 6-month intervals relative to the baseline.</p><p><strong>Results: </strong>After 6 months, the intervention group (n = 84) showed statistically significant higher total scores in the FACT-Bv4.0 [mean difference: - 15.01; 95% confidence interval: - 17.96, - 12.07; p < 0.001], ASQ [- 4.16 (- 4.45, - 3.86); p < 0.001], and LASQ-BC [- 6.77 (- 8.27, - 5.27); p < 0.001] than that of the control group (n = 82). The total scores of the three indicators also showed significant group, time, and group-by-time interaction effects (p < 0.001).</p><p><strong>Conclusion: </strong>The WeChat-based EPIC training was an effective intervention for improving HRQoL and psychological health in women newly diagnosed with breast cancer.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry www.chictr.org.cn , prospectively registered on 11 April 2020, ChiCTR2000031827.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COSMIN reporting guideline for studies on measurement properties of patient‑reported outcome measures: version 2.0.","authors":"Joel J Gagnier, Guilherme Tavares de Arruda, Caroline B Terwee, Lidwine B Mokkink","doi":"10.1007/s11136-025-03950-x","DOIUrl":"https://doi.org/10.1007/s11136-025-03950-x","url":null,"abstract":"<p><strong>Purpose: </strong>In 2021 a set of consensus-based and empirically informed reporting recommendations were developed for primary studies of the measurement properties of patient‑reported outcome measures (PROMs). With their use, we determined that certain reporting items were redundant, some required revisions, and additional items were needed. The aim of this study was to update the COSMIN reporting guideline and develop version 2.0 for studies on measurement properties of PROMs.</p><p><strong>Methods: </strong>There were seven phases to this update: 1. Identification of relevant experts for the meeting; 2. Solicitation of written feedback on the existing reporting recommendations checklist; 3. Development of the Explanation & Elaboration document; 4. A face-to-face consensus meeting; 5. Post-meeting revisions of the checklist and Explanation & Elaboration document; 6. Circulation of the resultant manuscripts to experts for solicitation of final feedback, and 7. Completion of the final documents and resultant manuscripts, distribution to all members for approval, and finalization.</p><p><strong>Results: </strong>Overall, the revised recommendations for version 2.0 consists of 31 general items and 37 specific items. Of the general items, 15 were revised or reordered and one item was added. Of the specific items, 15 were revised or reordered and two new items were added.</p><p><strong>Conclusion: </strong>We recommend that the earlier version of this guidance (version 1.0) no longer be used. These revised reporting recommendations (version 2.0) will help to guide those reporting or reading these investigations on the essential information that is recommended to be included.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties, and cultural appropriateness, of patient reported outcome measures for use in primary healthcare: a scoping review.","authors":"Christopher M Doran, Jamie Bryant, Erika Langham, Roxanne Bainbridge, Anthony Shakeshaft, Breanne Hobden, Sara Farnbach, Megan Freund","doi":"10.1007/s11136-025-03956-5","DOIUrl":"https://doi.org/10.1007/s11136-025-03956-5","url":null,"abstract":"<p><strong>Purpose: </strong>To critically appraise the psychometric properties and cultural appropriateness of self-reported generic patient-reported outcome measures (PROMs) applicable for use in the primary healthcare setting using the Consensus Based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines.</p><p><strong>Methods: </strong>PROMs were identified via a published systematic review and searches of relevant websites. PROMs were included if they were generic (i.e., outcome measures that assessed general aspects of health); had a maximum of 30 items; were applicable for use by all adult primary care patients; and were validated in English. Data was extracted regarding the characteristics of each PROM and the characteristics of included validation studies. The COSMIN risk of bias checklist was used to assess methodological quality and the revised COSMIN criteria was used to assess measurement properties. An evidence synthesis was conducted across studies using the guidelines from the modified Grading of Recommendations Assessment, Development and Evaluation approach for systematic reviews of clinical trials.</p><p><strong>Results: </strong>399 PROMs were identified and 19 met inclusion criteria. The included PROMs measured general health related quality of life (n = 8), outcomes or impact of care (n = 3), patient enablement, activation, and empowerment (n = 3), quality of care (n = 3), health and disability (n = 1), and functional status (n = 1). Six PROMs met the recommended COSMIN threshold for implementation.</p><p><strong>Conclusion: </strong>Although six PROMs can be recommended for use in primary care, further psychometric testing is still required to strengthen evidence related to internal consistency, responsiveness and cross-cultural validity/measurement invariance. Selection of a PROM for routine clinical use in primary care also needs to be guided by the patient population.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting the meaningfulness of treatment effects estimated in parallel groups designs: comment on Trigg et al.","authors":"Kevin Weinfurt","doi":"10.1007/s11136-025-03952-9","DOIUrl":"https://doi.org/10.1007/s11136-025-03952-9","url":null,"abstract":"<p><p>Draft guidance from the U.S. Food and Drug Administration states that one can interpret a treatment effect on a clinical outcome assessment-based endpoint when expressed as some difference between group means. Recently, Trigg et al. examined different approaches for deriving thresholds for interpreting such between-group differences. In this commentary, I make several observations to advance further discussion around this issue. Some key points are (1) rather than \"between-group difference,\" specify the level at which you wish to infer a treatment effect: population or individual; (2) points of reference may be different for interpreting individual- and population-level treatment effect estimates; (3) who provides input and what types of anchor variables are used to generate points of reference might differ for interpreting individual- versus population-level estimates of treatment effect; and (4) in a parallel groups design, meaningful within-patient change is not especially relevant for understanding the meaningfulness of a treatment effect.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life after spontaneous subarachnoid hemorrhage - a prospective cohort study.","authors":"Verena Rass, Anna Berek, Klaus Altmann, Elisabeth Goettfried, Philipp Kindl, Raimund Helbok, Alois Schiefecker, Bettina Pfausler, Laura Zamarian, Ronny Beer","doi":"10.1007/s11136-025-03955-6","DOIUrl":"https://doi.org/10.1007/s11136-025-03955-6","url":null,"abstract":"<p><strong>Purpose: </strong>Reduced health-related quality of life (HR-QoL) is common after spontaneous subarachnoid hemorrhage (SAH). Here, we aimed to describe the prevalence of HR-QoL impairment one year after SAH and to identify associated factors.</p><p><strong>Methods: </strong>In this prospective cohort study, HR-QoL was assessed in 183 patients one year after SAH. We used the Short-Form-36 (SF-36) questionnaire, which consists of eight health domains that can be subdivided into mental and physical health components. Participants responded to scales on subjective attention deficit, mental health symptoms, and fatigue. Functional outcome was assessed with the modified Rankin Scale (mRS). Multivariable regression analysis was used to identify factors associated with reduced HR-QoL (MCS or PCS < 40).</p><p><strong>Results: </strong>Patients were 53 years of age (IQR, 46-61) and presented with a median Hunt&Hess score of 2 (2-3). HR-QoL was reduced in 66/183 patients (36%) with the highest abnormality in physical and emotional role. A lower Hunt&Hess score (p = 0.036), female sex (p = 0.017), self-reported depression (p = 0.001), fatigue (p < 0.001), and reduction of drive (p = 0.019) were associated with overall reduced HR-QoL and explained 68.9% of the observed variance. 26% (n = 48) scored below the normal range on the MCS, and independent associations emerged for self-reported anxiety and depression, fatigue, and reduction of drive. A reduction in the PCS was reported by 35 (19%) patients and independent associations were found for worse three-month functional outcome and fatigue.</p><p><strong>Conclusion: </strong>One in three patients reported a reduction in HR-QoL one year after SAH. Mental health problems and fatigue had a significant impact on HR-QoL.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring the health outcomes of Chinese ischemic stroke patients based on the data from a longitudinal multi-center study.","authors":"Luying Wang, Xin Guan, Jiting Zhou, Hongfei Hu, Wei Liu, Qiran Wei, Yining Huang, Weiping Sun, Xuejing Jin, Hongchao Li","doi":"10.1007/s11136-025-03957-4","DOIUrl":"https://doi.org/10.1007/s11136-025-03957-4","url":null,"abstract":"<p><strong>Purpose: </strong>Faced with scarcity of large-scale health measurement study in China, the study aims to provide health outcomes evidence from ischemic stroke patients.</p><p><strong>Methods: </strong>Data were collected from a prospective multi-center real-world study held from March 2015 to December 2018. Health-related quality of life (HRQoL) was assessed at admission, hospital discharge, 90 ± 14 days after medication treatment, and 360 ± 28 days after medication treatment. Baseline characteristics of patients were summarized. Mean values and standard deviation (SD) of EQ-5D utility index scores, VAS values, and NIHSS scores were reported. Rank-sum test was applied to analyze the differences of HRQoL among patient groups. Mix-effects regression was used to investigate the impact factors.</p><p><strong>Results: </strong>At the baseline visit, a total of 9978 patients with a mean age of 64.0 years were included. The mean utility index scores recorded at admission, discharge, 90 ± 14 days after therapy initiated, and 360 ± 28 days after therapy initiated were 0.546 (SD = 0.327), 0.709 (SD = 0.306), 0.801 (SD = 0.259), and 0.846 (SD = 0.237), respectively. Differences among sex and TOAST classification subgroups were observed. The mean utility index scores stratified by mRS levels ranged from 0.983 (SD = 0.076) to 0.058 (SD = 0.167) for level 0 to level 5. The mean NIHSS scores were 5.3 (SD = 4.98) and 3.6 (SD = 4.24) at admission and discharge.</p><p><strong>Conclusion: </strong>The impact of ischemic stroke on patient's HRQoL is significant, particularly during the acute phase. Results from the study are well representative and can be utilized in health policy making, economic evaluations and other comparison studies. The study was registered with ClinicalTrials.gov (NCT02470624) in October 2015.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}