Quality of Life Research最新文献

{"title":"Are the EQ-5D-5L and EQ-HWB-9 valid instruments for measuring informal carer outcomes for use in economic evaluations?","authors":"Jan Faller, Valeriia Sokolova, Maja Kuharic, Fatima Al Sayah, Gang Chen, Cathrine Mihalopoulos, Brendan Mulhern, Lidia Engel","doi":"10.1007/s11136-026-04410-w","DOIUrl":"10.1007/s11136-026-04410-w","url":null,"abstract":"<p><strong>Objectives: </strong>Despite growing interest in incorporating informal carer outcomes into economic evaluations, evidence on the performance of utility measures for informal carers remains limited. This study assesses the psychometric performance of the EQ‑5D‑5L and EQ‑HWB‑9 in capturing informal carer outcomes for economic evaluations.</p><p><strong>Methods: </strong>This study utilized cross-sectional EQ-DAPHNIE survey data from English‑speaking countries (Australia, Canada, New Zealand, UK, and US) to evaluate the EQ‑HWB‑9 (UK pilot value set) and EQ‑5D‑5L (country‑specific value sets), assessing distributional (i.e., acceptability, distribution, floor and ceiling effects) and construct validity (i.e., convergent and known-group) properties, with subgroup analyses by age and financial situation.</p><p><strong>Results: </strong>There were 6,743 informal carers across Australia (n = 1447), Canada (n = 1265), New Zealand (n = 1435), UK (n = 1337), and US (n = 1259). The EQ-5D-5L showed a ceiling effect (19%), but not the EQ-HWB-9 (5%). Most respondents reported problems (level 2-5) on the EQ-5D-5L pain/discomfort (67%) and anxiety/depression (60%), with anxiety/depression showing the highest proportion with worst (level 5) responses (5%). For the EQ-HWB-9, ≥ 50% reported problems (level 2-5) across all domains except mobility, with ≥ 5% reporting the worst (level 5) responses in exhaustion, loneliness, cognition, sad/depressed, anxious, and control. Both instruments moderately correlated with the WHO-5, PROMIS-10 (physical and mental t-scores), ASCOT-SCT4, OPQOL-brief, PHQ-2, and GAD-2, and demonstrated known-group validity across groups relating to self-reported physical and mental disability, chronic conditions, sleep, social support, impact of caring, psychological wellbeing, and self-reported quality-of-life. Results were consistent in subgroup analyses.</p><p><strong>Conclusion: </strong>This study provides evidence supporting the acceptability and construct validity of the EQ-5D-5L and EQ-HWB-9 in measuring informal carer outcomes for use in economic evaluations. Responsiveness evidence remains limited and warrants further research.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life in patients with epilepsy in the context of socioeconomic challenges in Lebanon.","authors":"Samar Younes, Chadia Haddad, Jalal Dahham, Andre Slim, Nisreen Mourad, Pascale Salameh, Pierre-Marie Preux","doi":"10.1007/s11136-026-04405-7","DOIUrl":"10.1007/s11136-026-04405-7","url":null,"abstract":"<p><strong>Purpose: </strong>Epilepsy significantly impairs health-related quality of life (HRQoL), yet evidence from Lebanon; a country experiencing one of the most severe economic crises since the mid-nineteenth century, remains limited. This study examined multidimensional quality of life (QoL) among adults with epilepsy in Lebanon and identified its clinical, socioeconomic, and crisis-related determinants.</p><p><strong>Methods: </strong>A multicenter cross-sectional study was conducted between June and October 2025, recruiting 578 adults with confirmed epilepsy from community pharmacies and neurology outpatient clinics across all Lebanese governorates. Three validated instruments were administered: the Quality of Life in Epilepsy Inventory-10 (QOLIE-10), the EuroQol Five-Dimension Five-Level (EQ-5D-5 L), and the ICEpop CAPability measure for Adults (ICECAP-A). Bivariate analyses and multivariable linear regression models (Enter method) identified independent determinants of each QoL outcome.</p><p><strong>Results: </strong>Mean scores indicated meaningful impairment across all domains (QOLIE-10: 2.39 ± 0.78; EQ-5D-5 L utility index: 0.79 ± 0.24; ICECAP-A: 0.81 ± 0.21). Nearly half of participants were unemployed (48.3%) and faced antiseizure medication (ASM) shortages (50.5%). Adverse ASM effects had the largest independent effect on QoL across all three instruments (standardized β = 0.25-0.42), representing a small-to-moderate effect and exceeding all other predictors. Poorer medication adherence showed smaller but consistent independent effects on worse outcomes in the QOLIE-10 and ICECAP-A models (β = 0.08-0.12, negligible-to-small), while greater household crowding was independently associated with worse QOLIE-10 scores only (β = 0.08, negligible). Higher health literacy showed small independent effects on better QoL across all three instruments (β = 0.16-0.19).</p><p><strong>Conclusion: </strong>Adults with epilepsy in Lebanon experience substantial QoL impairment across epilepsy-specific, generic, and capability-based domains, associated with treatment burden, socioeconomic vulnerability, and crisis-related barriers to care. Integrated strategies addressing medication tolerability, adherence, health literacy, and structural determinants of health are needed to improve outcomes in this population.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EORTC QLQ-C30 symptom components and their functional correlates during adjuvant chemotherapy for early breast cancer: a multivariate analysis. Data from GEICAM/2003-02 study.","authors":"Andrea Blasco, Roberto Pastor-Barriuso, Pilar Zamora-Auñón, Miguel Martín, Javier Salvador Bofill, Cristina Reboredo, María Marín, Agustín Barnadas, Mireia Margeli, José Manuel López-Vega, Ainhara Lahuerta, Angel Guerrero, Sonia Servitja, Isabel Alvarez, Enrique Aranda, Eduardo Martínez de Dueñas, Francisco Carabantes, Virginia Lope","doi":"10.1007/s11136-026-04412-8","DOIUrl":"https://doi.org/10.1007/s11136-026-04412-8","url":null,"abstract":"<p><strong>Purpose: </strong>Understanding how multiple symptoms jointly impact functioning is essential for interpreting patient-reported outcomes (PROs) in oncology. We aimed to characterize the main dimensions underlying change-from-baseline (CFB) in symptom scores during adjuvant chemotherapy for early breast cancer, and to examine their associations with functional outcomes.</p><p><strong>Patients and methods: </strong>We analyzed EORTC QLQ-C30 CFB scores from 820 patients enrolled in the GEICAM/2003-02 trial. Principal component analysis (PCA) was used to summarize correlated symptom changes into a smaller number of components, and graphical LASSO network modelling was applied to explore relationships among Health-Related Quality of Life (HRQoL) domains. Associations between components and functional scales and global health status were assessed using Spearman correlations.</p><p><strong>Results: </strong>Three components were identified in the pooled sample, explaining 53.6% of the variance: a dominant general symptom burden component, a gastrointestinal component, and a diarrhea-specific component. The general component, primarily defined by fatigue, pain, appetite loss, insomnia, nausea/vomiting and dyspnea, showed consistent negative correlations with all functional scales and global health status. Similar patterns were observed across treatment arms, although gastrointestinal-related components differed. Graphical LASSO identified fatigue as the symptom most strongly connected to functional impairment.</p><p><strong>Conclusion: </strong>Symptom changes during chemotherapy are not independent, but follow a multivariate structured pattern in which a general symptom burden, anchored by fatigue, plays a central role in functional decline. These findings suggest that multivariate approaches may provide a complementary exploratory framework for summarizing correlated patterns of treatment-related burden and generating hypotheses regarding PROs. Trial registration number ClinTrials.gov: GEICAM/2003-02: NCT00129389.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimorbidity profiles and global quality of life: a population-based latent class and structural equation modeling study.","authors":"Diego Manríquez-Robles, Scarlett Roa-Castillo, Melisa Aedo, Felipe Henríquez-Valenzuela, Rubén Alvarado","doi":"10.1007/s11136-026-04411-9","DOIUrl":"https://doi.org/10.1007/s11136-026-04411-9","url":null,"abstract":"<p><strong>Purpose: </strong>To examine whether clustered configurations of multimorbidity, functional limitation, physical activity, formal social participation, and alcohol risk are associated with global quality of life (QoL), and to evaluate the hierarchical structure of the World Health Organization Quality of Life-BREF (WHOQOL-BREF) using data from anationally representative Chilean survey.</p><p><strong>Methods: </strong>Cross-sectional data were drawn from the 2023-2024 Chilean National Survey on Quality of Life and Health. Latent class analysis identified health-functional profiles using five categorical indicators (n = 16,469). Confirmatory factor analysis evaluated correlated four-factor and hierarchical second-order representations of the WHOQOL-BREF (n = 13,451). Structural equation modeling examined associations between profile membership, sociodemographic characteristics, and global QoL (n = 13,016). Analyses incorporated calibrated sampling weights, with design-basedinference accounting for the stratified and clustered survey design.</p><p><strong>Results: </strong>A three-class solution comprising lower-burden, intermediate-burden, and higher-burden profiles was retained. Profiles were most clearly differentiated by multimorbidity and functional limitation, whereas physical activity, social participation, and alcohol risk showed weaker or nonmonotonic differentiation. The hierarchical WHOQOL-BREF model showed comparable approximate fit to the correlated four-factor model, with strong secondorder loadings across all four QoL domains. Relative to the lower-burden profile, global QoL was lower in theintermediate-burden profile (β = -.132, p < .001) and substantially lower in the higher-burden profile (β = -.341, p < .001). Posterior pseudo-class sensitivity analyses preserved the direction and ordering of these associations. Educational attainment (β = .142, p < .001) and household income (β = .139, p < .001) were positively associated with global QoL.</p><p><strong>Conclusion: </strong>Global QoL was associated with graded health-functional burden and socioeconomic position. Combining person-centered health profiles with a hierarchical representation of QoL may provide a useful framework for characterizing population heterogeneity in health, functioning, and subjective quality of life.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dyadic death-preparedness concordance states and bereaved caregivers' health-related quality of life and psychological outcomes: a longitudinal study.","authors":"Fur-Hsing Wen, Chia-Hsun Hsieh, Wen-Chi Chou, Jen-Shi Chen, Wen-Cheng Chang, Siew Tzuh Tang","doi":"10.1007/s11136-026-04409-3","DOIUrl":"https://doi.org/10.1007/s11136-026-04409-3","url":null,"abstract":"<p><strong>Purpose: </strong>Health-related quality of life (HRQOL), psychological distress, anticipatory grief, and death preparedness are interdependent within patient-caregiver dyads. This study described caregivers' bereavement outcomes over two years across preloss patient-caregiver concordance states in multidimensional death preparedness and exploratorily examined adjusted differences across these states, addressing reliance on caregiver-only, retrospective designs, single-item preparedness measures, and limited outcome assessment.</p><p><strong>Methods: </strong>This cohort study followed 496 family caregivers of cancer patients. In exploratory analyses, multivariate hierarchical linear modeling estimated adjusted differences in four bereavement outcomes-physical and mental HRQOL, depressive symptoms, and prolonged grief (PG) symptoms-across preloss dyadic death-preparedness concordance states (unprepared, cognitive [prognostic understanding], emotional [acceptance of approaching death], and sufficient [both] concordant vs. discordant).</p><p><strong>Results: </strong>Over two years, mental HRQOL improved, physical HRQOL remained stable, and depressive and PG symptoms declined. Descriptively, sufficient-concordant dyads showed the most favorable mental HRQOL and lowest depressive and PG symptoms, but no statistically significant adjusted differences from discordant dyads. Exploratory adjusted estimates suggested poorer mental HRQOL and higher depressive symptoms in emotional-concordant dyads (n = 4) and better physical HRQOL in unprepared-concordant dyads (n = 3). Caregivers in cognitive-concordant dyads had higher estimated PG symptoms than those in discordant dyads (β = 1.283, 95% CI [- 0.026, 2.592]; p = 0.055).</p><p><strong>Conclusions: </strong>Bereavement outcomes showed differing patterns across dyadic death-preparedness concordance states. Adjusted estimates for the sparsely represented unprepared- and emotional-concordant groups are exploratory and hypothesis-generating. These findings highlight the value of examining cognitive and emotional dimensions of dyadic death preparedness jointly while underscoring the need for replication in larger samples.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 11","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of child loss on parents' health-related quality of life: evidence from the china health and retirement longitudinal study.","authors":"Qing Su, Keshan Liu","doi":"10.1007/s11136-026-04408-4","DOIUrl":"10.1007/s11136-026-04408-4","url":null,"abstract":"<p><strong>Purpose: </strong>Given the profound impact of adverse life events on later-life health, this study examined how the occurrence, timing, and number of child losses were associated with trajectories of health-related quality of life (HRQoL) among middle-aged and older adults in China. It further explored potential mediating mechanisms and heterogeneity by gender and residence.</p><p><strong>Methods: </strong>Using data from four waves (2011-2018) of the China Health and Retirement Longitudinal Study (CHARLS), this study included 13,161 individuals. HRQoL was assessed using the 36-Item Short Form Health Survey (SF-36). Linear mixed models were used to estimate longitudinal HRQoL trajectories, and the Karlson-Holm-Breen method was applied to examine potential mediating pathways.</p><p><strong>Results: </strong>Bereaved parents exhibited lower HRQoL than non-bereaved parents. The association between child loss and HRQoL varied by the timing of the loss and followed a dose-response pattern. Mediation analyses identified intergenerational support and social engagement as potential pathways. Moreover, mothers experienced a steeper decline in HRQoL over time than fathers following child loss.</p><p><strong>Conclusion: </strong>These findings suggest that child loss has a persistent and graded negative association with HRQoL, with important variation by timing and gender. The results highlight the need for targeted support and interventions to mitigate long-term health consequences among bereaved older adults.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement invariance of the Pediatric Quality of life index in a child and adolescent mental health population.","authors":"Bashir Bello, Okan Bulut, Whitney Hindmarch, Erin McCabe","doi":"10.1007/s11136-026-04403-9","DOIUrl":"10.1007/s11136-026-04403-9","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the measurement invariance of the Pediatric Quality of Life Index (PedsQL) in a population of children and adolescents participating in mental health treatment.</p><p><strong>Methods: </strong>We analyzed PedsQL data from three child and adolescent mental health service (CAMHS) services (walk-in, day hospital, intensive community treatment). We fit ordered-categorical confirmatory factor analysis (CFA) to the canonical four-domain model and a theory-refined variant with targeted cross-loadings. We then examined multi-group measurement invariance (configural, metric, scalar) across service streams, diagnosis, gender, race/ethnicity (White vs. racialised).) Finally, we assessed item-level bias (i.e., differential item functioning; DIF) with an ordinal logistic approach using an observed-score nested model sequence.</p><p><strong>Results: </strong>For the CFA, we found that the four-domain structure fit well and that allowing two theory-guided cross-loadings-Physical items 7 and 8 onto the Emotional domain yielded a strong fit. We found full scalar invariance across all groups tested. For DIF testing, no items exhibited meaningful uniform or non-uniform DIF.</p><p><strong>Conclusions: </strong>PedsQL domain scores demonstrate evidence of structural validity and preliminary evidence of measurement invariance across the CAMHS subgroups evaluated. This provides support for the use of PedsQL scores in CAMHS.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors independently associated with in-hospital HRQoL in adults treated at a high-complexity institution in a middle-income country.","authors":"Maricel Licht-Ardila, Alexandra Hurtado-Ortiz, Gladys Castro-Pinto, Luis Alejandro Olarte-Licht, Anderson Bermon, Edgar Fabián Manrique-Hernández","doi":"10.1007/s11136-026-04397-4","DOIUrl":"10.1007/s11136-026-04397-4","url":null,"abstract":"<p><strong>Introduction: </strong>Health systems are increasingly oriented toward value-based care, emphasizing patient-centered outcomes such as health-related quality of life (HRQoL). During hospitalization, HRQoL reflects the interplay of sociodemographic, geographic, and clinical factors, which may be particularly influential in middle-income settings where structural inequities can affect patient-reported outcomes.</p><p><strong>Objective: </strong>To identify factors independently associated with HRQoL measured during hospitalization in adults treated at a high-complexity institution in a middle-income country.</p><p><strong>Methods: </strong>We conducted a cross-sectional analytical study nested within an institutional prospective cohort (2023-2025). We included hospitalized adults with a complete in-hospital HRQoL assessment using the EQ-5D-3L descriptive system and the EQ visual analogue scale (EQ VAS). The EQ VAS score was analyzed as the primary continuous outcome. Associations were evaluated using bivariate analyses and multivariable linear regression.</p><p><strong>Results: </strong>A total of 46,083 patients were included, with a median EQ-VAS score of 70 (IQR, 60-80). Functional impairment was most commonly reported in usual activities (62.46%). In the multivariable linear regression model, lower EQ-VAS scores were independently associated with increasing age (β = - 0.150 per year) and ICU admission (β = - 1.661), whereas professional education (β = 2.364) and surgical admission (β = 1.672) were associated with higher scores. Across diagnostic groups, mental and behavioural disorders (β = - 2.949) and respiratory diseases (β = - 2.036) showed the strongest negative associations, while pregnancy-related conditions were associated with the highest scores (β = 3.982).</p><p><strong>Conclusion: </strong>EQ VAS scores measured during hospitalization were independently associated with sociodemographic and clinical factors, underscoring the multifactorial determinants of self-rated health in acute hospital settings.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping EORTC-QLQ-C30 scores to EQ-5D-5L utility values for gynecological cancer survivors in follow-up care.","authors":"Thom Åbyholm, Ingvild Vistad, Sveinung Berntsen, Torbjørn Wisløff","doi":"10.1007/s11136-026-04399-2","DOIUrl":"10.1007/s11136-026-04399-2","url":null,"abstract":"<p><strong>Purpose: </strong>To develop mapping algorithms from the EORTC-QLQ-C30 to EQ-5D-5L utilities for gynecological cancer survivors in follow-up care, enabling cost-effectiveness analyses when EQ-5D-5L utilities are unavailable.</p><p><strong>Methods: </strong>We used data from a Norwegian multicentre longitudinal study of gynecological cancer survivors in post-treatment follow-up (LETSGO), including 663 patients with 2,624 observations. Ten model types were estimated for three EQ-5D-5L value sets (Norwegian, UK, US): ordinary least squares, Tobit, beta and fractional logistic regression, linear mixed models, an adjusted limited dependent variable mixture model, and two-part models combining logistic regression for the probability of perfect health with OLS, mixed, beta or fractional logistic regression for utilities below 1. Each was fitted with three prespecified covariate sets comprising all EORTC-QLQ-C30 scales, with and without age, comorbidities and treatment type. Stratified five-fold cross-validation at the patient level was used for internal validation. Performance was assessed using mean absolute error (MAE), root mean squared error (RMSE), proportion of predictions with absolute error (AE) ≤ 0.05 and Lin's concordance correlation coefficient (CCC) and summarized using an average ranking value.</p><p><strong>Results: </strong>A two-part fractional logistic model with all covariates ranked highest, with MAE 0.0539-0.0660, RMSE 0.0806-0.0960, AE ≤ 0.05 for 54.8-67.1% of observations and CCC 0.7559-0.8034. Differences between the best-performing specifications were small. Accuracy declined at low utility levels, though overall mean bias was minimal.</p><p><strong>Conclusions: </strong>The algorithm enables estimation of EQ-5D-5L utilities from EORTC-QLQ-C30 scores in populations with severity profiles similar to the LETSGO cohort. Accuracy is reduced in poor health states.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric evaluation of the Disability Wellbeing Index (DWI) against the Adult Social Care Outcomes Toolkit (ASCOT) among people with disability.","authors":"Gozde Aydin, Samia Badji, Dennis Petrie, Anthony Harris, Gang Chen","doi":"10.1007/s11136-026-04406-6","DOIUrl":"10.1007/s11136-026-04406-6","url":null,"abstract":"<p><strong>Purpose: </strong>The Disability Wellbeing Index (DWI) is a preference-based wellbeing measure developed among people with disabilities. This study examined the psychometric properties of the DWI in both its Standard and Easy English versions and compared them with two Adult Social Care Outcomes Toolkit (ASCOT) instruments, the ASCOT-SCT4 and ASCOT-ER.</p><p><strong>Methods: </strong>We conducted an online survey among National Disability Insurance Scheme (NDIS) participants aged ≥ 15 years in 2024. DWI was scored using an Australian preference-based algorithm, and ASCOT was scored using UK preference weights. Convergent validity was assessed using Spearman's correlations between total utility scores and corresponding domain items. We examined underlying constructs between DWI and ASCOT using exploratory factor analyses (EFAs), and known-groups validity using regression analyses comparing scores across groups based on self-rated health, self-advocacy, participation in meaningful leisure activities, and autonomy in decision-making.</p><p><strong>Results: </strong>A total of 1871 participants were studied; among them, 39% completed the Easy English/Read version, and 30% were aged 15-24 years. Correlations between DWI and ASCOT were moderate for young people (ρ = 0.62, Easy English/Read; ρ = 0.66, Standard) and strong for adults (ρ = 0.74, Easy English/Read; ρ = 0.75, Standard). Convergence was strongest for safety items, whereas convergence was weaker for dignity items. EFA indicated partial overlap in underlying constructs. Known-groups validity was supported for both measures.</p><p><strong>Conclusions: </strong>The findings support the construct validity of DWI. DWI and ASCOT focus on different but overlapping aspects. The DWI places a stronger emphasis on general wellbeing, while the ASCOT focuses on social care related quality of life.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149070102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}