Quality of Life Research最新文献

{"title":"Health-related quality of life and economic impacts in adults with transfusion-dependent β-thalassemia: findings from a prospective longitudinal real-world study.","authors":"Jennifer Drahos, Adriana Boateng-Kuffour, Melanie Calvert, Laurice Levine, Neelam Dongha, Nanxin Li, Zahra Pakbaz, Farrukh T Shah, Nick Ainsworth, Antony P Martin","doi":"10.1007/s11136-025-03961-8","DOIUrl":"https://doi.org/10.1007/s11136-025-03961-8","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize the health-related quality of life (HRQoL) and economic impacts of transfusion-dependent β-thalassemia (TDT).</p><p><strong>Methods: </strong>A prospective longitudinal real-world study was conducted in adults with TDT in the US and Europe (France, Germany, Italy, UK) over 6 months. Eligibility criteria included receiving ≥ 8 blood transfusions/year in each of the 2 years before enrollment. Study outcomes assessed at months 0, 3, and 6, included demographics, clinical characteristics, patient-reported outcome measures (EQ-VAS, FACT-G, FACIT-F, 11-point Numerical Rating Scale (NRS) of pain, TranQoL, and WPAI), and responses to bespoke questions on financial burden/distress.</p><p><strong>Results: </strong>Overall, 155 adults with TDT participated (mean age [standard deviation (SD)]: 38.5 [10.8] years; 65.8% female). Most participants resided in the US (53.5%) or UK (22.6%). EQ-VAS, FACT-G, and FACIT-F mean (SD) scores at month 0 were lower among participants than the US general population (67.1 [20.4] versus 80.4 [15.6], 70.1 [19.0] versus 77.0 [16.1], and 27.9 [13.7] versus 43.6 [9.4], respectively; all p < 0.001). Mean (SD) TranQoL total score was 53.9 (18.5) and overall level of pain was \"moderate\" (NRS mean [SD]: 3.5 [2.8]). Part- or full-time employed participants missed a mean of 5.9 h of work in the preceding 7 days with out-of-pocket expenses being a moderate-to-major burden for 55% of participants. The findings were consistent over time.</p><p><strong>Conclusions: </strong>Participants reported substantial humanistic and economic burdens associated with living with TDT. Our findings highlight the need for alternative treatment options that contribute to improvements in HRQoL and reduce economic burden in this patient population.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An international compendium of health state utilities in people with HIV: a systematic review.","authors":"Edith Poku, Matthew Franklin, Emma Simpson, Louise Falzon, Ian Jacob, Christina Donatti","doi":"10.1007/s11136-025-03966-3","DOIUrl":"https://doi.org/10.1007/s11136-025-03966-3","url":null,"abstract":"<p><strong>Purpose: </strong>Measuring health-related quality of life across different health states for people with HIV (PWH) using direct or indirect preference-based values can inform decision-analytic models evaluating cost-effectiveness of different care strategies. This systematic literature review collates comprehensive international evidence on health state utility values (HSUVs) in PWH to inform economic modelling of antiretroviral therapies (ARTs).</p><p><strong>Methods: </strong>This review aligns with PRISMA standards (PROSPERO: CRD42022346286). Searches from multiple sources (e.g. MEDLINE, EMBASE) identified HSUVs for PWH from 2000. We categorised HSUVs using ISPOR's Task Force criteria from low (high bias risk) to high (low bias risk) quality, alongside National Institute for Health and Care Excellence (NICE) suitability grading from Grade 3 (did not meet necessary criteria) to 1 (no concerns). Tabular and narrative syntheses were undertaken.</p><p><strong>Results: </strong>Overall, 53 studies from 22 countries were identified. Study sizes ranged from 32 to 4137 participants. HSUVs were from cross-sectional (n = 45) or longitudinal (n = 10) datasets, stratified by infection stage, CD4 count, viral load, and treatment status. EQ-5D three-level (n = 29) and five-level (n = 18) estimates were most common. Although 28 included studies were 'high' quality, most were Grade 3 for NICE suitability, mainly indicating that the HSUVs for these studies were not representative of a UK population. Extensive methodological and clinical heterogeneity precluded meta-analysis.</p><p><strong>Conclusions: </strong>Greater clarity in treatment regimens, preference-weighting methods, and different HIV clinical stages could improve interpretation and applicability of HSUVs in economic models. Despite this, our compendium and taxonomy of HSUVs can inform ART economic modelling within relevant populations and different jurisdictions.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The moderating effect of family socioeconomic status in the relationship between health-related behaviors and quality of life among the Hakka older adults in Fujian, China.","authors":"Rongrong Liu, Jinghong Huang, Longhua Cai, Wenji Qiu, Xiaojun Liu","doi":"10.1007/s11136-025-03973-4","DOIUrl":"https://doi.org/10.1007/s11136-025-03973-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined the moderating effect of family socioeconomic status (SES) in the relationship between health-related behaviors and quality of life (QOL) among Hakka older adults from three levels: specific behaviors, the number of healthy behaviors, and behavior patterns.</p><p><strong>Methods: </strong>A total of 1,262 participants aged 60 years or above were included in this study. The Chinese version of the World Health Organization Quality of Life Instrument-Older Adults Module (WHOQOL-OLD) with six domains was used to measure the QOL. Two-Step Cluster Analysis (TCA) was employed to determine the health-related behaviors patterns. The generalized linear regression models were utilized to reveal the relationship between specific behaviors, the number of healthy behaviors and behavior patterns, and QOL.</p><p><strong>Results: </strong>Sleep regularity (β = 2.70, 95%CI 1.68, 3.72), physical exercise (β = 5.61, 95%CI 4.50, 6.72) were associated with higher QOL. Moreover, the higher number of healthy behaviors (from 4 to 5) were more likely to experience higher QOL, the β (95%CI) ranges from 5.08 (3.52, 6.64) to 5.82 (4.07, 7.57). Compared with the moderate-health pattern, risk-selective pattern (β = 7.432, t = 2.343, P < 0.05) and family SES (β = 4.691, t = 6.356, P < 0.001) were positively related to QOL. And the family SES exclusively moderated the risk-selective pattern (β = - 2.552, t = - 2.378 P < 0.05) on QOL.</p><p><strong>Conclusion: </strong>Maintaining healthy behaviors is closely related to a better QOL. Potential benefits of the active management of healthy behavior may improve the QOL of Hakka older adults.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory analysis of electronic patient-reported outcomes collection: comparing online and in-clinic modalities in cancer care.","authors":"Eric Adjei Boakye, Mrudula Nair, Nada Al-Antary, Carl Wilson, Katelyn Kerr, Theresa M Zatirka, Kelly A Hirko, Farah Elsiss, Steven S Chang, Benjamin Movsas, Michael Ryan, Samantha Tam","doi":"10.1007/s11136-025-03975-2","DOIUrl":"https://doi.org/10.1007/s11136-025-03975-2","url":null,"abstract":"<p><strong>Purpose: </strong>Patient reported outcome measures (PROMs) have been shown to improve cancer survival but are generally underutilized in cancer care. It is unclear whether electronic-PROMS (ePROMs) modality (online vs. in-clinic) may address barriers to completion. We examined whether patient sociodemographic and clinical factors differed by completion modality.</p><p><strong>Methods: </strong>Patients with cancer who had an oncologic provider visit from January 2021 to March 2023 at a tertiary cancer center were assigned the National Institute of Health's computer adaptive technology Patient-Reported Outcomes Measurement Information System instruments. Patients completed ePROMs either through online patient portal (online) up to 7 days before the visit or used a tablet at the clinic visit (in-clinic) if not completed online. Multivariable logistic regression model estimated associations between patient sociodemographic and clinical factors and completion modality.</p><p><strong>Results: </strong>A total of 8556 patients completed ePROMs (43.3% completed in-clinic). Females were less likely than males to complete ePROMs in-clinic (aOR = 0.89, 0.84-0.93) as were patients with commercial insurance (aOR = 0.83, 0.77-0.89) vs. Medicare; or saw radiation oncologist (aOR = 0.89, 0.83-0.96) vs. medical oncologist. However, patients were more likely to complete ePROMs in-clinic if they identified as Black race (aOR = 1.41, 1.33-1.49) vs. White; were single (aOR = 1.21, 1.14-1.29) or divorced/separated/widowed (aOR = 1.11, 1.04-1.18) vs. married; or saw a provider located in rural (aOR = 1.33, 1.25-1.42) vs. urban area.</p><p><strong>Conclusions: </strong>Patients who were males, Blacks, unmarried, Medicare insured or saw providers located in rural area were more likely to complete ePROMs in-clinic. Given the preference for online completion before visits for real-time symptom monitoring, targeted efforts are needed to boost online PROMs completion.</p><p><strong>Plain message: </strong>This is a cross-sectional analysis of the associations between sociodemographic and clinical factors with two electronic patient reported outcome measures completion modalities. The results indicate that about half of patients completed online and half completed in-clinic, with males, Blacks, patients who were divorced/separated/widowed, had Medicare insurance and saw a medical oncologist completing electronic patient reported outcome measures in-clinic. We support offering both options while addressing barriers to either modality.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of early-life food deprivation on health-related quality of life among older people in China: evidence from CHARLS.","authors":"Jingwen Liu, Wenfeng Lu, Yue Wang, Yaqi Wang, Xueying Xu, Yuan He, Qingyun Lv, Hairong Chang, Yue Zhao, Xiaonan Zhang, Xiaoying Zang, Na Wei","doi":"10.1007/s11136-025-03978-z","DOIUrl":"https://doi.org/10.1007/s11136-025-03978-z","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to explore the impact of early-life food deprivation on health-related quality of life (HRQoL) among older people, providing a scientific basis for developing public health strategies to improve the quality of life for older people.</p><p><strong>Methods: </strong>Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS), focusing on participants aged ≥60 years. The study included 7,192 eligible participants, categorized based on their self-reported early-life food deprivation experiences. HRQoL was measured using a newly developed scale based on variables from the Short Form-36 (SF-36) scale and CHARLS questionnaires. Inverse probability of treatment weighting (IPTW) was used to control for baseline differences. Weighted linear regression models were employed to analyze the impact of early-life food deprivation levels on HRQoL.</p><p><strong>Results: </strong>Findings indicate that older people who experienced early-life food deprivation exhibit a lower HRQoL (β = -1.83; 95% CI: -2.59, -1.07). This effect is particularly pronounced in older people with extreme early-life food deprivation (β = -3.50; 95% CI: -4.53, -2.47). Specifically, they exhibited lower scores in physical functioning, bodily pain, general health, role emotional, vitality, and mental health.</p><p><strong>Conclusions: </strong>Early-life food deprivation has a lasting negative effect on the HRQoL among older people. The results highlight the importance of early identification and improvement in cases of early-life food deprivation, alongside the implementation of targeted interventions. These measures can help improve the HRQoL of older adults affected by early-life food deprivation.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life and access to treatment for patients with multiple sclerosis during economic crisis: the Lebanese experience.","authors":"Maya Zeineddine, Ghida Ismail, Malak Issa, Taghrid El-Hajj, Hassan Tfaily, Mohamad Dassouki, Elie Assaf, Halim Abboud, Pascale Salameh, Amal Al-Hajje, Farid Boumediene, Bassem Yamout","doi":"10.1007/s11136-025-03970-7","DOIUrl":"https://doi.org/10.1007/s11136-025-03970-7","url":null,"abstract":"<p><strong>Purpose: </strong>Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that can lead to lifelong disability, significantly impacting patient's quality of life (QOL). The current Lebanese economic crisis led to limited accessibility to MS therapies and had a major impact on QOL.The aim of this study was to assess QOL in a cohort of Lebanese MS patients, and its association with socio-demographic factors, disease characteristics, and treatment accessibility.</p><p><strong>Methods: </strong>A cross-sectional, survey-based study was conducted between June and September 2022 in Lebanese patients with confirmed MS diagnosis as per the 2017 McDonald criteria. Structured questionnaires were used to obtain (1) socio-demographic and medical information, (2) QOL assessment using the MS International QOL questionnaire (MusiQoL), and (3) information related to barriers in accessing MS therapies. All questionnaires were administered via telephone call.</p><p><strong>Results: </strong>A total of 350 MS patients were included in the study. Most participants (92.3%) were diagnosed with relapsing-remitting MS and were females (65.1%) with a mean age of 39.4 ± 11.4 years. The mean MusiQol global index was 69.2 ± 11.5. In the multivariate analysis, younger age, higher level of education, being employed, being married, living outside the capital Beirut, and having no physical disability were significantly associated with higher MusiQol global index scores. A total of 216 Lebanese MS patients (61.7%) had no access to MS treatments due to the economic crisis. Treatment discontinuation and lack of governmental or private insurance were significant predictors of lower MusiQol scores.</p><p><strong>Conclusion: </strong>The economic crisis and resultant recession in Lebanon had a significantly negative impacted on QOL and treatment accessibility of MS patients. Socio-demographic factors, disease characteristics and treatment accessibility were strong predictors of QOL.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The humanistic burden of focal segmental glomerulosclerosis on patients and care-partners in the United States.","authors":"Justyna Szklarzewicz, Ute Floege, Daniel Gallego, Keisha Gibson, Kamyar Kalantar-Zadeh, Kelly Helm, Dale Robinson, Bonnie Schneider, Philip Smith, Kjell Tullus, Ali Poyan-Mehr, Bruce Hendry, Bridget L Balkaran, Adam K Jauregui, Aolin Wang, Ian Nason, Nisha C Hazra, Chunyi Xu, Jingyi Liu, Zheng-Yi Zhou, Mark Bensink","doi":"10.1007/s11136-025-03951-w","DOIUrl":"https://doi.org/10.1007/s11136-025-03951-w","url":null,"abstract":"<p><strong>Purpose: </strong>This study cross-sectionally surveyed patients with primary focal segmental glomerulosclerosis (FSGS) and their caregivers/care-partners, in terms of physical and mental health-related quality of life (HRQoL) and work productivity.</p><p><strong>Methods: </strong>HRQoL instruments, including the KDQoL-36 (with SF-12 v2), PedsQL (v4.0, parent proxy for children/adolescents), GAD-7 (anxiety), PHQ-9 (depression), and WPAI: SHP (work productivity), were used in the study. Participant characteristics and scores were summarized and compared to an external, kidney disease-free cohort.</p><p><strong>Results: </strong>78 adults and 29 children/adolescents with FSGS, with their care-partners/caregivers, were included. The median ages of adults and children/adolescents with FSGS were 44.5 and 12.0 years, respectively; 74.4% and 58.6% were female. Mean physical and mental SF-12 scores for adult patients were 41.9 (SD: 12.1) and 44.8 (10.2), respectively. Both SF-12 components for adult patients, the SF-12 mental component for care-partners, and all PedsQL item scores were worse compared to US general population estimates. Among adult patients, 28.2% reported at least moderate anxiety; 37.3% reported at least moderate depression. Compared to external controls, patients experienced significantly higher severity of anxiety (6.1 vs. 5.0) and depression (7.6 vs. 5.9; both p < 0.0001). Additionally, 14-20% of care-partners and caregivers reported moderate to severe anxiety or depression. All employed groups reported high overall work impairment (15.0-30.6%), with adult patients and their care-partners reporting high FSGS-related activity impairment (37.8%; 17.3%, respectively), absenteeism (10.4%; 6.1%) and presenteeism (21.8%; 11.6%).</p><p><strong>Conclusion: </strong>Patients with FSGS and their care-partners experience impairments to mental/physical HRQoL and work productivity, underscoring the need for effective FSGS therapies and care-partner support.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review.","authors":"Siti Nur Akmal Ghazali, Hanani Abdul Manan, Caryn Mei Hsien Chan, Marfu'ah Nik Eezamuddeen, Noorazrul Yahya","doi":"10.1007/s11136-025-03933-y","DOIUrl":"https://doi.org/10.1007/s11136-025-03933-y","url":null,"abstract":"<p><strong>Purpose: </strong>The association between health-related quality of life (HQoL) and overall survival (OS) among head and neck cancer (HNC) patients remains an important yet complex topic. This study aims to comprehensively analyze the prognostic effects of HQoL indices and symptoms-specific outcomes on overall survival in HNC patients.</p><p><strong>Methods: </strong>A systematic literature search was conducted in PubMed, Web of Science and Scopus databases. The QUIPS tool was used to assess the risk of bias in the prognostic studies. The variables from the HQoL assessments included as predictors of OS were recorded. Different phases of measurements either pre or post-treatment (3 to > 12 months after completion) were also classified to observe the patterns. This review utilized a proposed best-evidence synthesis in which the consistency of significant results from multivariate analysis was observed. Each index that shows > 75% proportion of high-quality studies with same result is classified as strong evidence.</p><p><strong>Results: </strong>Following an extensive search yielding 440 articles, the rigorous screening process identified 32 studies involving 12,206 HNC patients. This review underscores the pivotal role of higher post-treatment physical functioning predicting OS, which is supported by strong evidence and consistent findings. Three indices showed moderate evidence which are pretreatment physical function, post-treatment general HQoL and post-treatment social function. Notably, the analysis revealed that specific general-cancer symptoms, including appetite loss and dyspnea, were reported in association with OS in seven out of 33 instances, following multivariate analysis. Furthermore, the study highlighted the significance of social eating and problems with swallowing as predictors of OS (≥ 5 times instances) compared to other HNC symptoms-specific outcomes.</p><p><strong>Conclusion: </strong>This study sheds light on the underexplored role of post-treatment physical function as predictors for OS, complementing the well-discussed pretreatment physical function. It identifies four specific symptoms significantly impacting OS, highlighting the need for effective management strategies.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a community-based health behaviour intervention on health-related quality of life in people with Type 2 diabetes in Nepal: a Cluster Randomized Controlled Trial.","authors":"Ashmita Karki, Corneel Vandelanotte, M Mamun Huda, Lal B Rawal","doi":"10.1007/s11136-025-03971-6","DOIUrl":"https://doi.org/10.1007/s11136-025-03971-6","url":null,"abstract":"<p><strong>Purpose: </strong>Little is known about the effectiveness of health behaviour intervention in improving health-related quality of life (HRQOL) despite HRQOL being an important outcome in Type 2 diabetes (T2DM) management. This study examined the effectiveness of a culturally appropriate health behavioural intervention in improving HRQOL of people with T2DM in Nepal.</p><p><strong>Methods: </strong>A cluster randomized controlled trial was conducted among 481 people with T2DM from 30 randomly selected healthcare facilities in Kavrepalanchok and Nuwakot districts. The intervention group received 12 culturally tailored and group-based intervention sessions for six months whereas, the control group received usual care. The primary outcomes of this study were changes in the EuroQOL (EQ5D-3L) index score and EuroQOL visual analogue scale (EQVAS) score between baseline and six-month post-intervention. The intervention effect was assessed using generalized estimating equation models.</p><p><strong>Results: </strong>At six-months post-intervention, there was a positive and statistically significant effect on EQVAS (β₁ = 3.61, 95%CI: 0.05, 7.17) in the intervention group compared to control group. No statistically significant effect was observed in EQ5D-3L index score. A statistically significant increase in EQVAS score of 0.5 was observed per session attended by the study participants (β₁ = 0.49, 95%CI: 0.01, 0.98).</p><p><strong>Conclusion: </strong>The health behaviour intervention led to improved HRQOL. An increase in the number of intervention sessions attended was significantly associated with higher EQVAS scores, emphasizing the need for longer-term and engaging interventions that are well adhered to. Longer term assessment of change in HRQOL outcomes are needed when actual changes in HRQOL are more likely to be observed.</p><p><strong>Trial registration: </strong>Australia and New Zealand Clinical Trial Registry (ACTRN12621000531819).</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A COSMIN systematic review of generic patient-reported outcome measures in Switzerland.","authors":"Thanh Elsener, Matthew Kerry, Nikola Biller-Andorno","doi":"10.1007/s11136-025-03942-x","DOIUrl":"https://doi.org/10.1007/s11136-025-03942-x","url":null,"abstract":"<p><strong>Purpose: </strong>To conduct a systematic review of the quality of generic patient-reported outcome measures (PROMs) for clinical or population research or practice using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology, and to derive recommendations for usage of generic PROMs within Switzerland.</p><p><strong>Methods: </strong>We searched six databases (PubMed, CINAHL, Web of Science, PsycINFO, EMBASE, Cochrane) and grey literature in Switzerland to identify studies reporting on the development or validation of any generic PROMs used in Switzerland. Methodological quality of each study was assessed with COSMIN's Risk of Bias Checklist. Measurement property evidence (content validity and psychometrics) was further evaluated according to COSMIN's criteria for good measurement properties. Overall evidence was synthesized according to COSMIN's modified GRADE approach to generate recommendations for future use or disuse of generic PROMs within Switzerland.</p><p><strong>Results: </strong>Data from k = 49 studies reporting on five PROMs (EQ-5D, SF-36, PROMIS-29, WHOQOL-BREF, WORQ) were included. Among these, the SF-36 can be recommended for use. The PROMIS-29, WHOQOL-BREF, and WORQ have the potential to be recommended for use, but require further validation. The EQ-5D is not recommendable for future use.</p><p><strong>Conclusion: </strong>With a limited number of content validity studies, WHOQOL-BREF showed sufficiency with moderate quality, while other PROMs showed mixed quality ranging from very low to moderate. Synthesizing all measurement property evidence, SF-36 was identified as recommendable. PROMIS-29, WHOQOL-BREF, and WORQ were identified as potentially recommendable pending further validation evidence. The EQ-5D was identified as unrecommendable for future use within Switzerland.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}