Quality of Life Research最新文献

{"title":"Association of healthy eating behaviours and comorbidity on quality of life among adults with beta-thalassemia major: a moderation analysis.","authors":"Ha-Linh Quach, Thi Ngoc Anh Hoang","doi":"10.1007/s11136-025-04043-5","DOIUrl":"https://doi.org/10.1007/s11136-025-04043-5","url":null,"abstract":"<p><strong>Purpose: </strong>Adults with beta-thalassemia major (BTM) and comorbidities may experience poorer quality of life (QoL), while healthy diet are suggested to improve chronic disease management and health outcomes. The purpose of this study was to explore how healthy diet can impact QoL among adults with BTM, and whether healthy diet can buffer the impact of comorbidities on QoL of this population.</p><p><strong>Methods: </strong>Cross-sectional data of 317 adults (18 years old or older) with BTM in Vietnam was analysed. Healthy eating scores was measured by Healthy Eating Scores-5 scale. Four domains of QoL (physical health, psychological, social relationships, and environment) were assessed using the 26-item Quality of Life scale (WHOQOL-BREF). Multivariable linear regression was used to assess the association of interest and its moderation between healthy eating scores and comorbidity status (yes/no).</p><p><strong>Results: </strong>Individuals with BTM and comorbidity had significantly a lower QoL score in physical health and social relationships domain than those without comorbidity. This association was inversely moderated by healthy eating scores, specifically in physical health, psychological, and environment domain. As individuals had higher scores in healthy eating, the difference in QoL scores in the three domains above between individuals with and without comorbidities reduced.</p><p><strong>Conclusion: </strong>Individuals with BTM and comorbidities have a poorer quality of life. However, encouraging a healthy diet could mitigate this risk. Healthcare system should include dietitians and family caregivers in chronic care management for patients with BTM.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining quality of life by recovery status among college students with a history of substance use.","authors":"Fares Qeadan, Naya Lipkens, Benjamin Tingey","doi":"10.1007/s11136-025-04041-7","DOIUrl":"https://doi.org/10.1007/s11136-025-04041-7","url":null,"abstract":"<p><strong>Purpose: </strong>Quality of Life (QoL) is a vital measure for individuals with chronic health concerns, including those with a history of substance use. Limited research, however, focuses on QoL among college students with a history of substance use, while comparing those in recovery to those not in recovery. This study aims to address this gap.</p><p><strong>Methods: </strong>We analyzed secondary data from the American College Health Association National College Health Assessment (ACHA-NCHA) III (Fall 2019-Fall 2022) to evaluate QoL across physical, psychological, social, and environmental domains. Using adapted questions from the WHOQOL-BREF framework, we constructed domain-specific and overall QoL scores. Multivariate linear regression was used to assess the association between recovery status and QoL, adjusting for demographic and lifestyle factors.</p><p><strong>Results: </strong>Among 249,849 students, 2.2% (n = 5473) self-identified as in recovery. Students in recovery reported significantly lower QoL across all domains compared to those not in recovery, with the greatest difference in the psychological domain (mean difference: - 4.43, 95% CI [- 4.79, - 4.07]) and the smallest in the environmental domain (- 1.31, 95% CI [- 1.54, - 1.09]). Stratified analyses revealed that younger students, females, non-binary individuals, and NH Asian/Native Hawaiian Pacific Islander students exhibited the largest QoL disparities.</p><p><strong>Conclusions: </strong>College students in recovery face notable challenges in their QoL, especially in psychological and social domains. These findings highlight the need for targeted interventions, stigma reduction, and tailored support systems on college campuses to improve recovery outcomes and overall well-being.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144800046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in interpreting individual-level changes in health-related quality of life in patients with glioma using minimally important differences (MIDs) and a 4-point Likert scale.","authors":"Ogechukwu A Asogwa, Johan A F Koekkoek, Marthe C M Peeters, Hanneke Zwinkels, Maaike J Vos, Linda Dirven, Martin J B Taphoorn","doi":"10.1007/s11136-025-04029-3","DOIUrl":"https://doi.org/10.1007/s11136-025-04029-3","url":null,"abstract":"<p><strong>Purpose: </strong>Interpretation of changes on the individual level is often based on minimally important differences (MIDs) developed on the group level. We investigated the impact of applying different group-level MIDs (anchor-based and 10-point MIDs) to determine health-related quality of life (HRQoL) changes in glioma patients. We further explored directions and magnitudes of these changes and their relationship to response formats and types of scale.</p><p><strong>Methods: </strong>We included 92 glioma patients at least 18 years old from a previously conducted randomized prospective study. We calculated changes in HRQoL (EORTC QLQ-C30 and QLQ-BN20) at individual levels over a two-week period and used anchor-based and 10-point MIDs to estimate if change is clinically meaningful; thereafter, we explored the direction and magnitude of changes.</p><p><strong>Results: </strong>Between 8.8% and 66.3% of the patients had actual changes in estimated scales. While 16.3%-60.9% and 8.8%-59.8% of the patients changed to a clinically relevant extent using anchor-based and 10-point MIDs in any scale, respectively. Changes were mostly in the functional than symptom scales and mostly minor, i.e., changes between 'not at all' and 'a little' or 'a little' and 'quite a bit.'</p><p><strong>Conclusion: </strong>10-point compared to anchor-based MIDs underestimates clinically relevant changes. Therefore, the application of different MIDs to the same research question can lead to diverse result interpretations. As most changes were minor, it could be argued if these reflect actual relevant changes for an individual or that the current response scale lacks sufficient differentiating ability, warranting further research over the best method to evaluate individual-level changes.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity evidence for the use of the Pediatric Quality of Life Inventory, the Revised Children's Anxiety and Depression Scale-25, and the Columbia-Suicide Severity Rating Scale in measurement-based care in intensive outpatient child and adolescent mental health care.","authors":"Erin McCabe, Whitney Hindmarch, Bishnu Bajgain, Johanna Jacob, Paul D Arnold, Iliana Ortega, Michele Dyson, Deborah McNeil, Gina Dimitropoulos, Ryan Clements, Maria J Santana, Jennifer D Zwicker","doi":"10.1007/s11136-025-04037-3","DOIUrl":"https://doi.org/10.1007/s11136-025-04037-3","url":null,"abstract":"<p><strong>Purpose: </strong>We sought to evaluate the validity of the interpretations made on the scores from three patient-reported outcome measures (PROMs), the Pediatric Quality of Life Inventory (PedsQL), the Revised Children's Anxiety and Depression Scale-25 (RCADS-25), and Columbia-Suicide Severity Rating Scale-short form (C-SSRS), for use in measurement-based care (MBC) in intensive outpatient child and adolescent mental health services.</p><p><strong>Methods: </strong>A mixed-methods, secondary analysis of interview and survey data from an MBC implementation evaluation, as well as PROMs data collected through MBC in routine clinical practice, was performed. The setting was intensive outpatient mental health services for children 6-18 years of age. The Standards for Educational and Psychological Testing argument-based approach to validation was used combining qualitative and quantitative data to evaluate validity.</p><p><strong>Results: </strong>The PROMs appear to comprehensively cover key domains relevant to child and adolescent mental health intensive outpatient treatment. There is preliminary evidence that youth scores accurately reflect their symptoms and functioning and pick up change in these constructs, however, potential issues with response processes were identified with the C-SSRS, the school domain of PedsQL, and for caregiver proxy-reports on the PedsQL and RCADS-25, which warrant further investigation.</p><p><strong>Conclusion: </strong>There is evidence to support the use of these PROMs for MBC in child and adolescent mental health. However, further investigation is needed into response processes, internal structure, and to establish clinically meaningful thresholds to improve interpretability, and ensure the validity of their use.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depicting patient-reported outcome measures within directed acyclic graphs: practice and implications for causal reasoning.","authors":"Matthew Franklin, Tessa Peasgood, Peter W G Tennant","doi":"10.1007/s11136-025-04007-9","DOIUrl":"10.1007/s11136-025-04007-9","url":null,"abstract":"<p><strong>Purpose: </strong>Estimating causal effects of an exposure (e.g., health condition or treatment) on a patient-reported outcome measure (PROM) can have complications depending on the relationship between the PROM's indicators and construct(s). Using directed acyclic graphs (DAGs) as visual tools, we show how to represent a PROM's potential internal causal relationship between its indicators and latent construct(s), then explain the implications when also accounting for external variables when estimating causal effects within observational data.</p><p><strong>Methods: </strong>Measurement theory suggests a PROM's relationships between its items/indicators and latent construct(s) is reflective (construct causes the indicators) or formative (indicators cause the construct). We present DAGs under reflective and formative model assumptions when the PROM is unidimensional (e.g., Patient Health Questionnaire-9 [PHQ-9] representing depression severity) or multidimensional (e.g., EQ-5D representing health-related quality-of-life).</p><p><strong>Results: </strong>Unidimensional PROMs under a reflective model can be analysed like other unidimensional outcomes (e.g., mortality) to estimate causal effects, thus don't require additional consideration. In comparison, each indicator of a multidimensional construct under a formative model needs specific consideration to ensure relevant external variables are appropriately conditioned to estimate causal effects.</p><p><strong>Conclusion: </strong>Multidimensional outcome constructs formed under a formative model increases the complexity of causal analyses. Despite this, multidimensional measures may particularly aid with a variety of 'outcome-wide' studies when assessing exposures that may be beneficial for some outcomes but harmful for others. Thus, we have taken important steps to supporting such studies in observational settings by showing how PROMs can be incorporated into DAGs to inform such causal analyses.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2175-2187"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Customizing workflows for electronic patient-reported outcome (ePRO) symptom monitoring using the action, actor, context, target, time (AACTT) framework.","authors":"Julia Lai-Kwon, Claudia Rutherford, Michael Jefford, Iris Zhang, Catherine Devereux, Dishan Herath, Kate Burbury, Stephanie Best","doi":"10.1007/s11136-025-03995-y","DOIUrl":"10.1007/s11136-025-03995-y","url":null,"abstract":"<p><strong>Background: </strong>Real-time electronic patient-reported outcome (ePRO) symptom monitoring is a complex intervention with few examples of successful implementation at scale. A key challenge is designing a clear ePRO symptom monitoring workflow to support implementation into practice. We aimed to create an empirical and theory-informed site-specific workflow guided by the Action, Actor, Context, Target, Time (AACTT) implementation science framework.</p><p><strong>Methods: </strong>A five-step process was undertaken to customize a generic ePRO symptom monitoring workflow to create a site-specific version: (1) design a generic ePRO symptom monitoring workflow through a qualitative study with key stakeholders; (2) conduct co-design workshops to understand stakeholder preferences regarding a site-specific version; (3) code co-design workshop data using the AACTT framework to produce a provisional site-specific version; (4) conduct a final co-design workshop using the AACTT framework to finalize stakeholder preferences for a site-specific version; and (5) code co-design workshop data using the AACTT framework to produce a final site-specific version.</p><p><strong>Results: </strong>Participants (n = 27) included nine patients, four caregivers, four oncologists, four nurses, two pharmacists, two clinic administrators, and two Electronic Medical Record (EMR) analysts. Provisional and final site-specific workflows were generated outlining the key AACTT components for each step of ePRO symptom monitoring.</p><p><strong>Conclusion: </strong>We demonstrated the value in using the AACTT to guide the co-design of a site-specific workflow for ePRO symptom monitoring. By describing this process in detail, we will enable others to replicate this process for creating site-specific workflows not only for ePRO symptom monitoring, but for any complex clinical process.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2329-2343"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing and testing a patient-reported outcome measure for patients with sleep disturbances using EQ-5D and condition-specific bolt-ons: a mixed method study.","authors":"Ai-Ping Chua, Aureliano Paolo Finch, Shaffinaz Abd Rahman, Mary Anne Relimbo Dela Cruz, Emelita Naval Montaniel, Kaayathiri Ravichandran, Nan Luo","doi":"10.1007/s11136-025-03985-0","DOIUrl":"10.1007/s11136-025-03985-0","url":null,"abstract":"<p><strong>Objectives: </strong>The EQ-5D-5L may not adequately capture the health-related quality of life in patients with sleep disturbances. We examined the psychometric properties of a hybrid PROM comprising a module of four sleep-related bolt-ons and EQ-5D-5L.</p><p><strong>Methods: </strong>We employed a sequential exploratory mixed method by first qualitatively testing the face validity of \"sleep\", \"cognition\", \"tiredness\" and \"relationship\" and refining these bolt-ons through in-depth interviews with 23 patients and clinicians. We then quantitatively assessed their performance by administering the four bolt-ons, appended to EQ-5D-5L, and three condition-specific patient-reported outcome measures (cPROMs) during two clinical visits of patients with respiratory-related sleep disorders. We compared ceiling effects and construct validity of EQ-5D-5L with and without the bolt-ons by testing a priori hypotheses about the cPROMs and polysomnographic characteristics via correlation and areas under the curves (AUC) analyses, respectively. We examined their responsiveness among \"treated/improved\" participants using standardized response means (SRM) and AUC analysis, and reliability among \"untreated/no change\" participants using intra-class correlation coefficient (ICC) or Cohen's Kappa (k).</p><p><strong>Results: </strong>110 participants (mean [SD] age: 47[13]) were recruited and 90 returned for their review assessments (mean [SD] interval: 2.2 [2.1] months). The bolt-ons led to a reduction of 42.7% in ceiling effects. The bolt-ons were better correlated with cPROMs and exhibited higher discriminatory power and responsiveness, with comparable reliability to EQ-5D-5L. A combined module of the four bolt-ons provided better results than individual bolt-ons.</p><p><strong>Conclusions: </strong>A \"hybrid\" PROM of sleep bolt-ons module added to EQ-5D-5L improved its psychometric properties among patients with sleep disturbances.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2219-2231"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related quality of life trajectories in older adult long-term survivors of colorectal cancer.","authors":"Sherry A Burrell, Margaret M Brace, Gabrielle E Sasso, Meredith MacKenzie Greenle","doi":"10.1007/s11136-025-03986-z","DOIUrl":"10.1007/s11136-025-03986-z","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to examine factors affecting health-related quality of life (HRQOL) over time in older adult survivors of colorectal cancer (CRC) and determine demographic and clinical characteristics associated with declines in HRQOL.</p><p><strong>Methods: </strong>This secondary analysis utilized the Surveillance Epidemiology and End Results and Medicare Health Outcomes Survey and included CRC survivors aged 65 or older who completed at least one survey pre-diagnosis and two surveys within ten years post-diagnosis. HRQOL was captured by the Veterans Rand 12-item scale which provides mental and physical composite scores. Group-based trajectory modeling was employed to identify HRQOL trajectories. Multinomial logistic regression predicted group membership based on demographic and clinical characteristics.</p><p><strong>Results: </strong>The cohort (n = 649) was predominantly female (58%), white (70%), with an average age of 77 years. Most participants were diagnosed at Stage I disease (56%) and underwent surgery (63%). Three groups were identified based on trajectories of MCS: low increasing, medium decreasing, and high stable. Income and comorbidity number predicted MCS group membership. Five groups were identified based on trajectories of PCS: low decreasing, medium stable, steeply decreasing, high decreasing, and high stable. Older age at diagnosis, identifying as Hispanic, and comorbidity number predicted PCS group membership.</p><p><strong>Conclusions: </strong>Comorbidities, age at diagnosis, ethnicity, and income significantly impact the HRQOL of older adult survivors of CRC. The resources and needs of each patient should be considered in long-term survivorship plans.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2345-2361"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A qualitative study on the return to work experiences and views of young and middle-aged patient with chronic kidney disease.","authors":"Jiaxing Zhou, Yi Wen, Difei Duan, Wenqiao Li, Lian Xue, Dengyan Ma","doi":"10.1007/s11136-025-03994-z","DOIUrl":"10.1007/s11136-025-03994-z","url":null,"abstract":"<p><strong>Objective: </strong>Chronic kidney disease (CKD) significantly impacts the work life and social integration of young and middle-aged patients. This study explores their experiences and views on returning to work.</p><p><strong>Methods: </strong>Semi-structured interviews were conducted with 15 young and middle-aged CKD patients, including 9 who had returned to work and 6 who had stable employment before CKD but had not yet returned.</p><p><strong>Results: </strong>Four key themes emerged: (1) The necessity and motivation to return to work; (2) Obstacles to returning to work; (3) Changes in mindset after returning; (4) The demand for support.</p><p><strong>Conclusion: </strong>Returning to work offers young and middle-aged CKD patients new life meaning, though challenges remain, with both positive and negative emotions. Patients express a strong need for comprehensive support and health knowledge, which are crucial for facilitating return to work and stable employment. Hospitals and social organizations should address these needs to improve the psychological well-being and quality of life of CKD patients post-return.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2419-2426"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the origin and conceptual framework of the EQ VAS.","authors":"Ling-Hsiang Chuang, Paul Kind, Thomas Kohlmann, You-Shan Feng","doi":"10.1007/s11136-025-03947-6","DOIUrl":"10.1007/s11136-025-03947-6","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this paper is to report on the origin of the EQ VAS and current understanding of the EQ VAS conceptual framework via a literature search based on the snowball approach.</p><p><strong>Methods: </strong>A review was conducted in two steps: (1) a citation search and (2) a search of the EuroQol group's grey literature.</p><p><strong>Results: </strong>The findings indicate that the EQ VAS was originally designed as a warm-up task for valuing hypothetical health states. The characters of the EQ VAS reflect its valuation origin, such as drawing a line (the previous version), vertical orientation, and choice of end labels. None of these design elements of the EQ VAS were chosen for the purpose of measuring self-reported overall health. Despite this, the EQ VAS proves to be a valid self-reported health status measure with its psychometric properties demonstrated in various general and clinical populations. We found a dearth of literature addressing the conceptual framework of EQ VAS as a measure of self-rated overall health.</p><p><strong>Conclusion: </strong>With its potential as a powerful measure of overall health, further research into EQ VAS design, conceptual framework and empirical function is warranted.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2163-2173"},"PeriodicalIF":3.3,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}