Quality of Life Research最新文献

{"title":"Selected abstracts from the 10th UK Patient Reported Outcome Measures (PROMs) Research Conference, Sheffield, 23rd June 2026.","authors":"","doi":"10.1007/s11136-026-04358-x","DOIUrl":"10.1007/s11136-026-04358-x","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 Suppl 2","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement validity: essential in principle, subordinated in practice.","authors":"Bruno D Zumbo","doi":"10.1007/s11136-026-04355-0","DOIUrl":"10.1007/s11136-026-04355-0","url":null,"abstract":"<p><p>Quality-of-life and health outcomes research relies on assessment instruments, such as self-report surveys and patient-reported outcome measures, to assess respondents' standing on latent psychological attributes and experiences, such as pain, fatigue, stress, emotional well-being, social participation, and perceived quality of life. Unlike physiological measures, which record bodily states through calibrated procedures, these instruments are used to infer respondents' standing on these attributes through respondents' interpretations of items, response options, and lived experience. Nevertheless, researchers often treat measurement validation of scores from these instruments as a routine psychometric step rather than as an argument for score-based interpretations and decisions. Motivated by recent papers by Hawkins et al. [1] and Gill et al. [2] in Quality of Life Research, it is argued that validity resides not in instruments themselves but in the evidential warrant for interpreting and using scores in specified contexts. Results of investigations of reliability, factor structure, and correlations can support this warrant. However, they cannot explain the meaning of the score or justify their use on their own. Argument-based validation requires researchers to specify interpretations, uses, assumptions, and relevant evidence, including consequences-especially when measures cross languages, cultures, populations, service systems, and policy contexts.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement properties of a patient-reported outcome scale for peptic ulcer: a validation study using classical test theory and generalizability theory.","authors":"Fang Xu, Na Luo, TianLe Fu, Yanxiang Gao, Qiaoyun Huang, Zaixue Mu, Xiran Xia, Jing Yang, Ying Chen","doi":"10.1007/s11136-026-04373-y","DOIUrl":"10.1007/s11136-026-04373-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the measurement properties of the Patient-Reported Outcome Scale for Peptic Ulcer (PROISCD-PU) and to examine its reliability, validity, responsiveness, and domain-level measurement precision using an integrated framework of Classical Test Theory (CTT) and Generalizability Theory (GT).</p><p><strong>Methods: </strong>A total of 300 patients with peptic ulcer were recruited from tertiary hospitals and completed the PROISCD-PU. Classical Test Theory was used to evaluate internal consistency, construct validity, clinical discriminant validity, and responsiveness. Generalizability Theory was applied to identify sources of measurement variance and estimate relative generalizability (Eρ²) and absolute dependability (Φ) coefficients under the observed and alternative item configurations. Because the GT analyses were conducted separately for each domain, the findings were interpreted as evidence of domain-level measurement precision.</p><p><strong>Results: </strong>The PROISCD-PU demonstrated acceptable internal consistency for most domains and satisfactory construct validity, supported by item-domain correlation analyses and structural equation modeling. Clinical discriminant validity was partially supported, with significant differences after Holm-Bonferroni correction observed in the spirituality/belief health domain, general module subtotal, and disease-specific domain. Significant improvements were observed following treatment across all domains and the total scale, with standardized response mean values indicating moderate to large responsiveness. Generalizability analyses showed that person-by-item interaction was the major source of measurement variance. Absolute dependability (Φ) was acceptable for the mental health, social health, and disease-specific domains, whereas comparatively lower Φ coefficients were observed for the physical health and spirituality/belief health domains, indicating priorities for future refinement.</p><p><strong>Conclusions: </strong>The PROISCD-PU demonstrated generally acceptable reliability, validity, responsiveness, and domain-level measurement precision for assessing patient-reported outcomes in peptic ulcer disease. The combined use of Classical Test Theory and Generalizability Theory provides complementary psychometric evidence supporting its application in clinical outcome evaluation and quality-of-life research. Future studies should evaluate longitudinal score stability in clinically stable patients and apply multivariate Generalizability Theory to optimize the reliability and scoring structure of the total composite score.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Quality of life dynamics in the gastric cancer dyad: an actor-partner interdependence model analysis guiding the development of a family-centered nursing framework\".","authors":"Anri Inumaru, Yohei Kishi, Yurika Saito","doi":"10.1007/s11136-026-04376-9","DOIUrl":"10.1007/s11136-026-04376-9","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perception of health-related quality of life in people with vestibular disorders: a phenomenological approach from lived experience and belief systems.","authors":"Patricia Oyarzún Díaz, Guillermo Valderrama Gaete, Jacqueline Urra Cisternas, Belén Santibáñez Inostroza, Myriam Espinoza Bahamondes, Camila Valenzuela Becerra","doi":"10.1007/s11136-026-04377-8","DOIUrl":"10.1007/s11136-026-04377-8","url":null,"abstract":"<p><strong>Background: </strong>Most studies on health-related quality of life in vestibular disorders rely on standardized symptom- and function-based assessments. However, these approaches may overlook the meanings individuals attribute to their experiences and the belief systems through which they interpret their condition.</p><p><strong>Aim: </strong>To analyze the self-perception of health-related quality of life in people with vestibular disorders, considering the belief systems and personal experiences through which they interpret their health condition.</p><p><strong>Methods: </strong>This qualitative phenomenological study conducted 16 semi-structured, in-person interviews with patients diagnosed with vestibular disorders (10 women and 6 men; mean age: 53.8 years) treated at a university clinic. Interviews were audio-recorded and transcribed for inductive interpretive thematic analysis. Rigor was ensured through triangulation, reflexivity, and adherence to COREQ guidelines.</p><p><strong>Results: </strong>The study identified 10 categories grouped into three interrelated dimensions: (1) physical-functional, characterized by persistent bodily instability and loss of automaticity; (2) behavioral-social, involving activity restriction and changes in social participation; and (3) emotional-symbolic, encompassing anxiety, uncertainty, and meaning-making processes. Interpretations related to the body, autonomy, risk, and dependence suggested the presence of belief-related frameworks through which participants understood their symptoms and adaptation to the condition.</p><p><strong>Conclusion: </strong>Health-related quality of life in people with vestibular disorders appears to be a dynamic and multidimensional construct that extends beyond symptom burden alone. The findings suggest that belief-related frameworks may influence how physical limitations, emotional responses, and everyday functioning are experienced and interpreted. These findings support the value of integrative clinical approaches that consider not only functional recovery but also the meanings individuals attribute to their condition.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The indirect effects of cognitive function in the association between stroke and quality of life among older adults in a rural community: A cross-sectional study.","authors":"Memory Lucy Mtambo, Tin Tin Su, Devi Mohan, Narelle Warren, Kia Fatt Quek","doi":"10.1007/s11136-026-04379-6","DOIUrl":"10.1007/s11136-026-04379-6","url":null,"abstract":"<p><strong>Purpose: </strong>We examined whether cognitive function statistically accounted for associations between stroke and quality of life (QOL).</p><p><strong>Methods: </strong>A cross-sectional survey included adults aged ≥ 60 years in Segamat, Malaysia. Cognition was assessed using the Identification and Intervention for Dementia in Elderly Africans instrument, and QOL was assessed using the WHOQOL-BREF. Stroke survivors were matched 1:3 with non-stroke participants by propensity scores based on age, sex, and education. Stroke status was the exposure, cognition the proposed statistical mediator, and four QOL domains, overall QOL, and overall health the outcomes. Models were adjusted for sociodemographic and vascular factors, accounted for matching and multiple testing, and p < 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Among 596 participants, 149 reported stroke; the mean age was 70.36 years (SD 6.81); 41.6% female; 58.4% male. An indirect association between stroke and physical QOL via cognition was observed (β = -0.67, 95% CI - 1.30 to - 0.18; BH-adjusted p = 0.018). A residual correlation of ρ = 0.16 between cognition and physical-QOL models would attenuate this association to the null. The indirect association did not differ by sex (index β = -0.49, 95% bootstrap CI - 1.48 to 0.18; p = 0.164). Item-level physical-QOL analysis identified an indirect association with greater pain interference through lower cognition (β = -0.051, 95% CI - 0.113 to - 0.009; BH-adjusted p = 0.028).</p><p><strong>Conclusion: </strong>Reduced cognition partly accounted for associations of stroke with reduced physical QOL and greater pain interference. Findings were sensitive to modest unmeasured confounding but require confirmation from longitudinal studies.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciding on thresholds for clinical relevance of PROMIS-upper extremity v2.0 in patients with upper extremity injury.","authors":"Suus G J van Bruggen, Lore E de Vreeze, Charlotte M Lameijer, Frank W Bloemers, Caroline B Terwee","doi":"10.1007/s11136-026-04367-w","DOIUrl":"10.1007/s11136-026-04367-w","url":null,"abstract":"<p><strong>Purpose: </strong>In this study we focused on gaining better interpretation of the PROMIS-Upper-Extremity v2.0 (PROMIS-UE v2.0) T-score scale for measuring upper extremity function in patients with upper extremity injuries (UEIs). This is fundamental in order to clearly understand the clinical relevance of these outcomes. The aim of this study was to identify interpretive thresholds for mild, moderate and severe upper extremity function problems for PROMIS-UE v2.0 T-scores, in patients with UEIs, by performing a vignettes study.</p><p><strong>Methods: </strong>A qualitative vignette study, based on the PROMIS-UE v2.0 and its item response theory model. Designed vignettes were tested in pilot expert- and patient focus groups. The vignettes were ranked by participants by functioning level and interpretive threshold values were proposed.</p><p><strong>Results: </strong>This resulted in consensus on the following interpretive thresholds: no problems-mild problems at T-score 45, mild problems-moderate problems at T-score 32.5 and moderate problems-severe problems at T-score 25. The thresholds provide additional information on interpretation of a larger range of the T-score scale, not only the evidently low or high T-scores.</p><p><strong>Conclusion: </strong>This study provides clinically meaningful interpretive thresholds for interpreting PROMIS-UE v2.0 T-scores in patients with UEI, supporting more patient-centred interpretation of treatment outcomes. We recommend using these interpretive thresholds in clinical practice to support the interpretation of patient-reported treatment outcomes and facilitate shared decision-making. Future research with regards to influencing factors on ranking of the vignettes should follow.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative performance of the EQ-5D-5L, EQ-HWB, and PROMIS-10 in screening for history of anxiety and depression in the general adult population in 15 countries.","authors":"Hilary Short, Fatima Al Sayah, Mathieu F Janssen, Erica Lubetkin, Rosalie Viney, Jeffrey A Johnson","doi":"10.1007/s11136-026-04359-w","DOIUrl":"10.1007/s11136-026-04359-w","url":null,"abstract":"<p><strong>Background: </strong>Generic patient-reported outcome measures (PROMs) are increasingly being implemented in health systems for routine outcome measurement. Their ability to screen for anxiety and depression could serve as an added benefit. This study aims to assess the screening ability of selected EQ-5D-5L, EQ-HWB, and PROMIS-10 items for anxiety and depression, using self-reported diagnostic history of these conditions, relative to established PHQ-2 and GAD-2 screeners, in general adult populations across 15 countries.</p><p><strong>Methods: </strong>Cross-sectional data from \"EuroQol Data for Assessment of Population Health Needs and Instrument Evaluation (EQ-DAPHNIE)\" project was used. The following countries were included in the analysis: Argentina, Australia, Brazil, Canada, Chile, China, France, Germany, Japan, Mexico, Netherlands, New Zealand, Spain, the United Kingdom (UK), and the United States (US). A sample size of 4500 was planned per country. Sample quotas for age, sex, income, and urban/rural area were based on census or national data in each country. The performance of specific mental health items of the EQ-5D-5L, EQ-Health and Wellbeing (EQ-HWB), Patient-Reported Outcomes Measurement Information System Scale v1.2 - Global Health (PROMIS-10), Generalized Anxiety Disorder 2-item questionnaire (GAD-2), and Patient Health Questionnaire 2-item version (PHQ-2) were compared to self-reported diagnostic history of anxiety or depression. Performance of EQ-5D-5L, EQ-HWB, PROMIS-10, GAD-2, and PHQ-2 in screening for anxiety and depression was evaluated using area under receiver operating curve (AUROC) analysis RESULTS: A total of 68,419 respondents from 15 countries completed surveys. Brazil had the highest percentage of self-reported anxiety diagnoses (29.6%). The US had the highest depression diagnoses (26.7%), anxiety or depression diagnoses (34.1%), and anxiety and depression diagnoses (20.9%). By contrast, China had the lowest percentage of diagnoses for depression (3.9%) and anxiety or depression (9.7%) and Japan the lowest for anxiety (3.7%) and anxiety and depression (2.1%). Across all countries, except China, the EQ-5D-5L anxiety/depression dimension performed the best in screening for all conditions (AUROC range: 0.76-0.88), followed by the PROMIS-10 emotional problems item (AUROC range: 0.75-0.84). All measures performed considerably lower in China (AUROC range: 0.65-0.75).</p><p><strong>Conclusion: </strong>Generic PROMs, like the EQ-5D-5L, EQ-HWB, and PROMIS-10 have potential added value as effective screening tools for anxiety and depression in the general adult population, as evidenced by their performance across multiple countries.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Problem Areas in Diabetes (PAID) and Diabetes Distress Scale (DDS) to the EQ-5D-5L in diabetes care.","authors":"Pablo Arija, Nicholas Durno, Jie Wang, Phillip Kittel, Paco Cerletti, Evan W Davies","doi":"10.1007/s11136-026-04361-2","DOIUrl":"10.1007/s11136-026-04361-2","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and validate mapping algorithms that estimate EQ-5D health state utility values (HSUVs) from two diabetes-specific patient-reported outcome measures, the Problem Areas in Diabetes (PAID) and Diabetes Distress Scale (DDS), to support economic evaluations when EQ-5D data are unavailable.</p><p><strong>Methods: </strong>Data from 662 adults with diabetes in Germany included PAID-20, DDS-17, and EQ-5D-5L responses. Direct mapping models predicted EQ-5D utilities using Tobit and censored least absolute deviation (CLAD) regressions, while indirect mapping models used proportional and partial proportional odds regressions to predict EQ-5D dimensions. Six model specifications were tested, incorporating PAID and DDS items with covariates (age, sex, diabetes type), with selection of predictors guided by item correlations and backward stepwise procedure to retain statistically relevant variables. Model performance was assessed using a selection of performance metrics including root mean square error (RMSE) and mean absolute error (MAE). Internal validation of the models employed 10-fold cross-validation.</p><p><strong>Results: </strong>The strongest-performing direct mapping models consisted of a model with a selection of PAID-20 items and covariates (Tobit regression; RMSE: 0.159; MAE: 0.117) and a model that incorporated PAID-20, DDS-17, and covariates (CLAD regression; RMSE: 0.146; MAE: 0.09), and a model based on DDS-17 items and covariates (Tobit regression; RMSE: 0.164; MAE: 0.121). Indirect mapping models demonstrated higher prediction errors overall (RMSE: 0.187-0.21; MAE: 0.124-0.141) than their counterparts.</p><p><strong>Conclusions: </strong>We present novel algorithms that enable estimation of EQ-5D utilities from PAID and DDS scores, facilitating economic evaluation in diabetes. Preferred models demonstrated predictive accuracy comparable to published mapping studies.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 10","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13526043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Impact of response shift on change in patient-reported outcomes: a systematic review.","authors":"Mathilde G E Verdam, Jae-Yung Kwon, Lara Russell, Véronique Sébille, Mirjam A G Sprangers, Richard Sawatzky","doi":"10.1007/s11136-026-04329-2","DOIUrl":"10.1007/s11136-026-04329-2","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":"35 9","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148831912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}