Quality of Life Research最新文献

{"title":"Profiles of quality of life among US young adult cancer survivors and their associations with potential psychosocial intervention targets of hope and psychological flexibility.","authors":"Carla J Berg, Laura C Schubel, Darcey M McCready, Sheena Shajan, Palash Bhanot, Campbell Dopke, Afrah Howlader, Pamela S Hinds, Jennifer Levine, Maureen E Lyon, Pavani Chalasani, Hannah Arem","doi":"10.1007/s11136-025-04010-0","DOIUrl":"10.1007/s11136-025-04010-0","url":null,"abstract":"<p><strong>Purpose: </strong>Given the growing population of young adult (YA) cancer survivors, understanding their different quality of life (QOL) profiles is important for informing interventions to promote QOL, which may target constructs like hope or psychological flexibility. This study assessed YA survivors' QOL profiles and their associations with these 2 constructs.</p><p><strong>Methods: </strong>Latent class analysis (LCA) was conducted on PROMIS QOL measures (physical functioning, social functioning, fatigue, sleep disturbance, pain interference, anxiety, depression) among 155 YA survivors (ages 18-39; M_age = 32.89, 87.7% female, 8.4% Hispanic, 22.6% racial minority) within 3 years post-treatment. Multivariable regressions assessed sociodemographic and cancer-related factors in relation to class (multinomial logistic), and class in relation to scores on Snyder's Hope Scale and the Acceptance and Action Questionnaire-II assessing psychological inflexibility (linear).</p><p><strong>Results: </strong>LCA identified 4 classes: (1) low physical/social functioning with high symptoms (i.e., fatigue, sleep disturbance, pain interference, anxiety, depression; 43.2%); (2) high physical/social functioning with high symptoms (23.9%); (3) high physical/social functioning with low symptoms (17.4%); and (4) low physical functioning, moderate social functioning and physical symptoms, and low mental health symptoms (15.5%). Compared to class 3 (referent), classes 1 and 4 more likely had chemotherapy (aOR = 6.54, CI 1.22-34.48; aOR = 12.82, CI 1.05-28.67), and class 2 had higher monthly income (≥ vs. < $4,200: aOR = 1.16, CI 1.02-1.54). Additionally, classes 1 and 2 had lower hope (B = -10.95, CI -14.42, -7.48; B = -5.50, CI -9.28, -1.71) and higher psychological inflexibility (B = 12.41, CI 9.06, 15.76; B = 8.21, CI 4.57, 11.86).</p><p><strong>Conclusions: </strong>YA survivors demonstrated varied QOL profiles, often with considerable symptoms. Interventions targeting hope and/or psychological flexibility may promote QOL.</p><p><strong>Trial registration: </strong>NCT05905250.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2677-2688"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Predictors of survival among head and neck cancer patients after radiotherapy based on health-related quality of life indices and symptoms-specific outcomes: a systematic review\".","authors":"Efsun Somay, Erkan Topkan, Ugur Selek","doi":"10.1007/s11136-025-04000-2","DOIUrl":"10.1007/s11136-025-04000-2","url":null,"abstract":"<p><p>We read with great interest the systematic review by Ghazali et al., which rigorously synthesizes data from 32 longitudinal studies involving 12,206 patients to explore the prognostic significance of health-related quality of life (HRQoL) and symptom-specific outcomes in patients with head and neck cancer (HNC) undergoing radiotherapy (RT). The authors employed best-evidence synthesis methodology and highlighted post-treatment physical function as a robust predictor of overall survival (OS). Moreover, the study underscores the prognostic impact of several clinical variables, such as dysphagia, social eating challenges, and loss of appetite, all of which merit further attention in designing personalized treatment approaches for HNC survivors. While the review makes a timely and essential contribution to the literature, we respectfully suggest several areas where further clarification and expanded analysis may strengthen the interpretation and future applicability of the findings.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2547-2548"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Development and initial validation of the health-related quality of life pictorial inventory for children (HEALTH-PIC).","authors":"Tracy C W Tang, Mun Wong, Jian-Bin Li, Derwin K C Chan","doi":"10.1007/s11136-025-04020-y","DOIUrl":"10.1007/s11136-025-04020-y","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2575"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12431867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The social determinants of health-related quality of life among people with chronic disease: a systematic literature review.","authors":"Terhi Kangas, Sara-Lynn Milis, Katrien Vanthomme, Hadewijch Vandenheede","doi":"10.1007/s11136-025-03976-1","DOIUrl":"10.1007/s11136-025-03976-1","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review investigates the relationship between Social Determinants of Health (SDoH) and Health-Related Quality of Life (HRQoL) among individuals with chronic diseases. SDoH refer to the conditions in which people live, work, and interact, which are associated with health outcomes and inequalities. Understanding these determinants in the context of chronic diseases is essential for developing targeted interventions to improve their HRQoL.</p><p><strong>Methods: </strong>We conducted a systematic review following PRISMA guidelines, searching PubMed, Web of Science, and Embase for original research articles published in English during the last 10 years. Studies included quantitative assessments of the relationship between SDoH and HRQoL in chronic disease populations. 38 studies met the eligibility criteria and were included in the analysis.</p><p><strong>Results: </strong>Significant bivariate associations between SDoH and HRQoL were observed. Younger age, male gender, higher social support, being married, higher education level, employment, higher income, and urban living were generally linked to better HRQoL. Multivariate analyses identified higher education and income as consistent predictors of better HRQoL when considered alongside other SDoH. Urbanization, age, and gender showed some mixed associations with HRQoL, highlighting the need for context-specific interventions.</p><p><strong>Conclusion: </strong>The findings underscore the critical role of SDoH in HRQoL among chronic disease populations. Policies aimed at improving HRQoL should consider multiple SDoH, particularly focusing on patients with low educational attainment living in low-income areas. However, variability in sample sizes and HRQoL measures complicate comparison. The predominance of cross-sectional studies limits the understanding of time-related effects, thus, future research should prioritize longitudinal studies.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2501-2511"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12431912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recreational physical activity and health-related quality of life among breast cancer survivors: a systematic review.","authors":"Emma Tian, Oliver W A Wilson, Kaitlyn M Wojcik, Gisela Butera, Jacob Schneider, Laura Q Rogers, Wendy Demark-Wahnefried, Jinani Jayasekera","doi":"10.1007/s11136-025-03992-1","DOIUrl":"10.1007/s11136-025-03992-1","url":null,"abstract":"<p><strong>Purpose: </strong>Breast cancer survivors are at increased risk of poor health-related quality of life (HRQOL). Clinical trials suggest physical activity interventions may improve HRQOL, however, evidence on whether these benefits extend to physical activity in real-world settings is limited. We aimed to evaluate the association between post-diagnosis recreational physical activity and HRQOL among breast cancer survivors in the observational literature and compare findings with clinical trial data.</p><p><strong>Methods: </strong>A systematic review was conducted, searching seven databases for studies published between January 2003 and October 2024. Study characteristics and adjusted analyses of the association between recreational physical activity and HRQOL were extracted. A qualitative synthesis categorized HRQOL outcomes into global, physical, emotional, social, and breast cancer-specific domains. Risk of bias was assessed, and findings from observational studies were compared with those from clinical trials.</p><p><strong>Results: </strong>The search identified 5831 sources, with 11 studies meeting inclusion criteria. For most domains, studies reported positive associations between aerobic activity and HRQOL. Meeting aerobic activity guidelines was found to have clinically meaningful positive associations with global HRQOL (Five studies), physical HRQOL (Two studies), and breast cancer-specific HRQOL (One study). Fewer studies reported on emotional/social domains of HRQOL or the association between muscle-strengthening activity and HRQOL. Overall, observational findings were consistent with clinical trial findings.</p><p><strong>Conclusions: </strong>Observational evidence suggests that aerobic activity guideline adherence may be associated with increased global and physical HRQOL. These findings indicate that benefits observed in trials may extend to real-world recreational aerobic activity. Further research is needed on muscle-strengthening activity and activity dosage.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2513-2529"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' experiences of responding to a Patient-Reported Outcome Measure for palliative care: a mixed method study.","authors":"Jahan Shabnam, Mette Raunkiær, Maiken Bang Hansen, Mogens Grønvold, Anders Løkke, Edina Nikolett Barna, Camilla Lykke, Tina Broby Mikkelsen, Cecilie Lindstöm Egholm","doi":"10.1007/s11136-025-04006-w","DOIUrl":"10.1007/s11136-025-04006-w","url":null,"abstract":"<p><strong>Background: </strong>Worldwide, there is growing interest in using Patient-Reported Outcome Measures (PROM) in palliative care. The Danish Health Data Authority has developed a new PROM called PRO-Pall, which was launched for nationwide use in patients with heart, lung, and kidney diseases, as well as cancer.</p><p><strong>Aim: </strong>To explore patients' experiences of responding to the PRO-Pall and using it in a consultation about palliative care needs in non-specialised palliative care settings.</p><p><strong>Methods: </strong>This is a multicentre, mixed-methods study combining a quantitative approach using structured questionnaires (n = 270) and a qualitative analysis based on semi-structured interviews (n = 17). The quantitative survey included items assessing relevance, ease of use, and perceived benefits of PRO-Pall in preparing for consultations. Qualitative data collection involved interviews focusing on patients' experiences with PRO-Pall and its integration into clinical discussions. Quantitative data were analysed descriptively as numbers (n) and proportions (%), while qualitative data were analysed using thematically using to identify key themes.</p><p><strong>Results: </strong>A total of 270 patients completed the survey, and 17 patients participated in interviews. The analysis revealed that the patients evaluated the PRO-Pall positively. The patients strongly agreed or agreed that the PRO-Pall was relevant (85%), easy to fill out (85%), helped to become aware of symptoms (61%) and a good way to prepare for the consultation (70%). The qualitative findings further supported these results, highlighting that patients found PRO-Pall relevant, appropriate, and convenient. Participants emphasized that PRO-Pall responses should be actively discussed during consultations with healthcare professionals to enhance its impact. Additionally, they noted that the timing of completing PRO-Pall was crucial, as patients' conditions fluctuate over time, potentially influencing their responses.</p><p><strong>Conclusion: </strong>Most patients found the PRO-Pall relevant, appropriate, and easy to fill out. However, its effectiveness depends on healthcare professionals actively integrating patient responses into consultations. Otherwise, it would serve merely as documentation rather than an avenue for patients to discuss their concerns.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2651-2662"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the ecological momentary well-being instrument (EMOWI) in Canadian adolescents.","authors":"Marie Buzzi, Karen A Patte, Yan Kestens, Grégory Moullec, Laetitia Minary, Jennifer O'Loughlin, Scott T Leatherdale, Nelly Agrinier, Jonathan Epstein","doi":"10.1007/s11136-025-04001-1","DOIUrl":"10.1007/s11136-025-04001-1","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2605-2616"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lived experiences of the sexual and reproductive health consequences of parkinson's disease and their impact on health-related quality of life in Ethiopia.","authors":"Arefayne Alenko, Morankar Sudhakar, Legese Chelkeba, Ines Keygnaert","doi":"10.1007/s11136-025-04013-x","DOIUrl":"10.1007/s11136-025-04013-x","url":null,"abstract":"","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2719-2730"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of the adult social care outcomes toolkit (ASCOT) in research studies: an international scoping review.","authors":"Stacey Rand, Nick Smith, Elizabeth Welch, Stephen Allan, James Caiels, Ann-Marie Towers","doi":"10.1007/s11136-025-03958-3","DOIUrl":"10.1007/s11136-025-03958-3","url":null,"abstract":"<p><strong>Purpose: </strong>Since the launch of Adult Social Care Outcomes Toolkit (ASCOT) in 2012, there has been increasing interest in use of ASCOT measures in social care research and evaluation, internationally. This scoping review seeks to understand ASCOT use and the methodologies within which the measures have been applied.</p><p><strong>Methods: </strong>An international scoping review of studies published between January 2012 and July 2024 that utilized ASCOT, excluding measure development and psychometric studies.</p><p><strong>Results: </strong>Fifty-five articles (11 protocols) reported use of ASCOT. Most reported cross-sectional studies (n = 19) or randomized controlled trials (n = 15) that explored the effectiveness of policy, interventions or systems. ASCOT measures were also applied in mixed methods and other study designs, including qualitative studies. A few studies applied ASCOT to develop theory or conceptual frameworks that relate to care, including how to understand unmet need.</p><p><strong>Conclusion: </strong>ASCOT measures have been applied, internationally, in a range of ways, with a focus on evaluation studies. Further research is required to explore how ASCOT is used in practice, including care planning. Focus is also needed on ensuring users select the appropriate measure for their study, and widen awareness of adapted versions to support data collection, like ASCOT easy read (ASCOT-ER).</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2437-2450"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric analysis of the Neuro-QoL Fatigue in generalized Myasthenia Gravis (gMG) using data from a phase 3 trial.","authors":"Anthony Raborn, Andrea Savord, Carrie R Houts, Sheryl Pease, Kayla Scippa, Sindhu Ramchandren","doi":"10.1007/s11136-025-03998-9","DOIUrl":"10.1007/s11136-025-03998-9","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the psychometric properties of the Neuro-QoL Fatigue patient-reported outcome measure and its short form when used to assess fatigue in adults living with generalized Myasthenia Gravis (gMG).</p><p><strong>Methods: </strong>Data from Vivacity-MG3 (ClinicalTrials.gov Identifier: NCT04951622), a double-blind placebo-controlled phase 3 study of nipocalimab enrolled 196 participants living with gMG were analyzed. Psychometric analyses of Neuro-QoL Fatigue scores (19-item version and short-form version) focused on data from Baseline and the 24-week double-blind interventional phase of the trial. Factor analytic and classical test theory (CTT) analyses were performed to investigate support for intended Neuro-QoL Fatigue score use, along with convergent and discriminant relationships, known groups analyses, and sensitivity to change analyses. Thresholds to define meaningful within-person change (improvement) over time were also investigated.</p><p><strong>Results: </strong>The full form factor analytic analyses showed evidence that a unidimensional model adequately fits the data (TLI = 0.99, RMSEA = 0.07), CTT analyses showed high internal consistency (alpha = 0.95), and high test-retest reliability for stable participants (r = 0.92); similar results were observed for the short form. Both versions' scores were correlated with a variety of reference variables at expected levels, demonstrated the ability to differentiate between clinically meaningfully distinct groups, and were significantly correlated with changes in other reference variables. Analyses suggested 19-item and short-form score changes of 6.7 and 7.6, respectively, as showing meaningful improvement over time.</p><p><strong>Conclusions: </strong>Results provided robust psychometric evidence that supports the use of Neuro-QoL Fatigue scores for assessing fatigue in adults living with gMG.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2577-2589"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144294816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}