Carla J Berg, Laura C Schubel, Darcey M McCready, Sheena Shajan, Palash Bhanot, Campbell Dopke, Afrah Howlader, Pamela S Hinds, Jennifer Levine, Maureen E Lyon, Pavani Chalasani, Hannah Arem
{"title":"美国年轻成年癌症幸存者的生活质量概况及其与潜在的希望和心理灵活性的社会心理干预目标的关系","authors":"Carla J Berg, Laura C Schubel, Darcey M McCready, Sheena Shajan, Palash Bhanot, Campbell Dopke, Afrah Howlader, Pamela S Hinds, Jennifer Levine, Maureen E Lyon, Pavani Chalasani, Hannah Arem","doi":"10.1007/s11136-025-04010-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Given the growing population of young adult (YA) cancer survivors, understanding their different quality of life (QOL) profiles is important for informing interventions to promote QOL, which may target constructs like hope or psychological flexibility. This study assessed YA survivors' QOL profiles and their associations with these 2 constructs.</p><p><strong>Methods: </strong>Latent class analysis (LCA) was conducted on PROMIS QOL measures (physical functioning, social functioning, fatigue, sleep disturbance, pain interference, anxiety, depression) among 155 YA survivors (ages 18-39; M<sub>age</sub> = 32.89, 87.7% female, 8.4% Hispanic, 22.6% racial minority) within 3 years post-treatment. Multivariable regressions assessed sociodemographic and cancer-related factors in relation to class (multinomial logistic), and class in relation to scores on Snyder's Hope Scale and the Acceptance and Action Questionnaire-II assessing psychological inflexibility (linear).</p><p><strong>Results: </strong>LCA identified 4 classes: (1) low physical/social functioning with high symptoms (i.e., fatigue, sleep disturbance, pain interference, anxiety, depression; 43.2%); (2) high physical/social functioning with high symptoms (23.9%); (3) high physical/social functioning with low symptoms (17.4%); and (4) low physical functioning, moderate social functioning and physical symptoms, and low mental health symptoms (15.5%). Compared to class 3 (referent), classes 1 and 4 more likely had chemotherapy (aOR = 6.54, CI 1.22-34.48; aOR = 12.82, CI 1.05-28.67), and class 2 had higher monthly income (≥ vs. < $4,200: aOR = 1.16, CI 1.02-1.54). Additionally, classes 1 and 2 had lower hope (B = -10.95, CI -14.42, -7.48; B = -5.50, CI -9.28, -1.71) and higher psychological inflexibility (B = 12.41, CI 9.06, 15.76; B = 8.21, CI 4.57, 11.86).</p><p><strong>Conclusions: </strong>YA survivors demonstrated varied QOL profiles, often with considerable symptoms. Interventions targeting hope and/or psychological flexibility may promote QOL.</p><p><strong>Trial registration: </strong>NCT05905250.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":"2677-2688"},"PeriodicalIF":2.7000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Profiles of quality of life among US young adult cancer survivors and their associations with potential psychosocial intervention targets of hope and psychological flexibility.\",\"authors\":\"Carla J Berg, Laura C Schubel, Darcey M McCready, Sheena Shajan, Palash Bhanot, Campbell Dopke, Afrah Howlader, Pamela S Hinds, Jennifer Levine, Maureen E Lyon, Pavani Chalasani, Hannah Arem\",\"doi\":\"10.1007/s11136-025-04010-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Given the growing population of young adult (YA) cancer survivors, understanding their different quality of life (QOL) profiles is important for informing interventions to promote QOL, which may target constructs like hope or psychological flexibility. This study assessed YA survivors' QOL profiles and their associations with these 2 constructs.</p><p><strong>Methods: </strong>Latent class analysis (LCA) was conducted on PROMIS QOL measures (physical functioning, social functioning, fatigue, sleep disturbance, pain interference, anxiety, depression) among 155 YA survivors (ages 18-39; M<sub>age</sub> = 32.89, 87.7% female, 8.4% Hispanic, 22.6% racial minority) within 3 years post-treatment. Multivariable regressions assessed sociodemographic and cancer-related factors in relation to class (multinomial logistic), and class in relation to scores on Snyder's Hope Scale and the Acceptance and Action Questionnaire-II assessing psychological inflexibility (linear).</p><p><strong>Results: </strong>LCA identified 4 classes: (1) low physical/social functioning with high symptoms (i.e., fatigue, sleep disturbance, pain interference, anxiety, depression; 43.2%); (2) high physical/social functioning with high symptoms (23.9%); (3) high physical/social functioning with low symptoms (17.4%); and (4) low physical functioning, moderate social functioning and physical symptoms, and low mental health symptoms (15.5%). Compared to class 3 (referent), classes 1 and 4 more likely had chemotherapy (aOR = 6.54, CI 1.22-34.48; aOR = 12.82, CI 1.05-28.67), and class 2 had higher monthly income (≥ vs. < $4,200: aOR = 1.16, CI 1.02-1.54). Additionally, classes 1 and 2 had lower hope (B = -10.95, CI -14.42, -7.48; B = -5.50, CI -9.28, -1.71) and higher psychological inflexibility (B = 12.41, CI 9.06, 15.76; B = 8.21, CI 4.57, 11.86).</p><p><strong>Conclusions: </strong>YA survivors demonstrated varied QOL profiles, often with considerable symptoms. 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引用次数: 0
摘要
目的：鉴于年轻成人（YA）癌症幸存者的数量不断增长，了解他们不同的生活质量（QOL）状况对于告知干预措施以提高生活质量非常重要，这些干预措施可能针对希望或心理灵活性等结构。本研究评估了YA幸存者的生活质量概况及其与这两种结构的关系。方法：采用潜类分析（LCA）对155例YA幸存者(18-39岁；治疗后3年内，法师= 32.89，女性87.7%，西班牙裔8.4%，少数族裔22.6%。多变量回归评估了社会人口学和癌症相关因素与阶级的关系（多项逻辑），以及阶级与斯奈德希望量表和评估心理不灵活性的接受和行动问卷- ii得分的关系（线性）。结果：LCA确定了4个类别：(1)低身体/社会功能伴高症状（即疲劳、睡眠障碍、疼痛干扰、焦虑、抑郁）；43.2%);(2)伴有高症状的高身体/社会功能（23.9%）；(3)低症状、高身体/社会功能（17.4%）；(4)低躯体功能、中度社会功能和躯体症状、低心理健康症状（15.5%）。与3级（参照组）相比，1级和4级患者更可能接受化疗(aOR = 6.54, CI 1.22-34.48；aOR = 12.82, CI 1.05-28.67)， 2级患者月收入较高(≥vs.；结论：YA幸存者表现出不同的生活质量，通常有相当的症状。以希望和/或心理灵活性为目标的干预措施可能会提高生活质量。试验注册：NCT05905250。
Profiles of quality of life among US young adult cancer survivors and their associations with potential psychosocial intervention targets of hope and psychological flexibility.
Purpose: Given the growing population of young adult (YA) cancer survivors, understanding their different quality of life (QOL) profiles is important for informing interventions to promote QOL, which may target constructs like hope or psychological flexibility. This study assessed YA survivors' QOL profiles and their associations with these 2 constructs.
Methods: Latent class analysis (LCA) was conducted on PROMIS QOL measures (physical functioning, social functioning, fatigue, sleep disturbance, pain interference, anxiety, depression) among 155 YA survivors (ages 18-39; Mage = 32.89, 87.7% female, 8.4% Hispanic, 22.6% racial minority) within 3 years post-treatment. Multivariable regressions assessed sociodemographic and cancer-related factors in relation to class (multinomial logistic), and class in relation to scores on Snyder's Hope Scale and the Acceptance and Action Questionnaire-II assessing psychological inflexibility (linear).
Results: LCA identified 4 classes: (1) low physical/social functioning with high symptoms (i.e., fatigue, sleep disturbance, pain interference, anxiety, depression; 43.2%); (2) high physical/social functioning with high symptoms (23.9%); (3) high physical/social functioning with low symptoms (17.4%); and (4) low physical functioning, moderate social functioning and physical symptoms, and low mental health symptoms (15.5%). Compared to class 3 (referent), classes 1 and 4 more likely had chemotherapy (aOR = 6.54, CI 1.22-34.48; aOR = 12.82, CI 1.05-28.67), and class 2 had higher monthly income (≥ vs. < $4,200: aOR = 1.16, CI 1.02-1.54). Additionally, classes 1 and 2 had lower hope (B = -10.95, CI -14.42, -7.48; B = -5.50, CI -9.28, -1.71) and higher psychological inflexibility (B = 12.41, CI 9.06, 15.76; B = 8.21, CI 4.57, 11.86).
Conclusions: YA survivors demonstrated varied QOL profiles, often with considerable symptoms. Interventions targeting hope and/or psychological flexibility may promote QOL.
期刊介绍：
Quality of Life Research is an international, multidisciplinary journal devoted to the rapid communication of original research, theoretical articles and methodological reports related to the field of quality of life, in all the health sciences. The journal also offers editorials, literature, book and software reviews, correspondence and abstracts of conferences.
Quality of life has become a prominent issue in biometry, philosophy, social science, clinical medicine, health services and outcomes research. The journal''s scope reflects the wide application of quality of life assessment and research in the biological and social sciences. All original work is subject to peer review for originality, scientific quality and relevance to a broad readership.
This is an official journal of the International Society of Quality of Life Research.
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