Quality of Life Research最新文献

{"title":"Living with a new kidney from the perspective of adolescents: A mandala-supported qualitative study.","authors":"Büşra Nur Temür, Mustafa Volkan Düzgün, Nilgün Aksoy, Ayşegül Işler, Elif Çetinkaya","doi":"10.1007/s11136-024-03879-7","DOIUrl":"https://doi.org/10.1007/s11136-024-03879-7","url":null,"abstract":"<p><strong>Background: </strong>Despite advances in transplant procedures, children and adolescents still face some challenges post-transplant and are at high risk for psychiatric, academic, and social problems. This study aims to explore the lived experiences of adolescent kidney transplant recipients through interviews and the use of mandala art therapy.</p><p><strong>Methods: </strong>This study adopted a descriptive phenomenological design and thematic analysis approach based on Husserl's philosophy. The sample included kidney transplant recipients aged 12-18 years admitted to the pediatric nephrology polyclinic of a university hospital in southern Türkiye. Data were collected through in-depth interviews conducted during a mandala art activity with 14 adolescent kidney transplant recipients. The qualitative data were analyzed using Colaizzi's seven-stage qualitative analysis method, which is suitable to the descriptive phenomenological design employed in the present study.</p><p><strong>Results: </strong>Four themes and seven subthemes emerged from the data related to the problems and experiences of adolescents with kidney transplantation and growing up with a new kidney. (1) Education, (2) Ideas about the kidney; including the sub-themes \"What the kidney transplant process gave them, Feelings about their kidneys\", (3) Family; including the sub-themes \"Relationship with the donor, Relationship with siblings\", (4) Social environment; including the sub-themes \"Experiences with hospital, Relationship with friends and Desire for friendship with a transplanted Peer\".</p><p><strong>Conclusion: </strong>Mandala art therapy-assisted interviews are an effective communication method for adolescent kidney transplant recipients to express their feelings and thoughts and to look at life from a broader perspective. Understanding the life experiences of adolescents with kidney transplantation and the difficulties they face may enable better and more systematic planning of the care to be given to them.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142897116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying thresholds for defining levels of physical function and pain interference using bookmarking in orthopaedics.","authors":"Nan E Rothrock, Anastasiya Drandarov, Aaron J Kaat, Hannah Mosher, Juliano Prado, Marilyn Heng","doi":"10.1007/s11136-024-03881-z","DOIUrl":"https://doi.org/10.1007/s11136-024-03881-z","url":null,"abstract":"<p><strong>Purpose: </strong>Bookmarking is a qualitative method used to assign descriptive labels to ranges of patient-reported outcome (PROM) scores. We aimed to evaluate variability between bookmarking samples and test score ranges where there was variability in expert opinion in previous studies.</p><p><strong>Methods: </strong>We conducted two bookmarking sessions with patients who experienced orthopaedic fractures (n = 11) and one session with orthopaedic clinicians (n = 10). Participants reviewed vignettes comprised of PROM items and responses that represented hypothetical patients with a range of severity. Vignettes were constructed for PROMIS Upper Extremity Function, Physical Function, and Pain Interference measures. Participants placed bookmarks between vignettes that reflected different levels of severity (e.g., mild, moderate). The score reflecting the midpoint between vignettes was used as the recommended threshold between categories. We evaluated the variability in thresholds across participants, bookmarking panels, and previous studies.</p><p><strong>Results: </strong>Although patients and clinicians were not unanimous, the majority agreed on thresholds separating levels of severity for PROMIS Upper Extremity (≥ 40 = within normal limits, 30-39 = mild, 23-29 = moderate, < 23 = severe), PROMIS Physical Function (≥ 46 = within normal limits, 38-45 = mild, 26-37 = moderate, < 26 = severe), and PROMIS Pain Interference (≤ 50 = within normal limits, 51-60 = mild, 61-68 = moderate, > 68 = severe).</p><p><strong>Conclusion: </strong>Testing new vignette scores within the same patient population enables more nuanced testing of score ranges without clear consensus and provides additional evidence for recommending thresholds for severity categories. These thresholds can be utilized to help interpret PROMIS scores from patients receiving orthopaedic care.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life measures for people following stroke: a structured content review.","authors":"Catherine Mariam George, Armaghan Dabbagh, Janelle Unger, Folarin Babatunde, Joy C MacDermid","doi":"10.1007/s11136-024-03877-9","DOIUrl":"https://doi.org/10.1007/s11136-024-03877-9","url":null,"abstract":"<p><strong>Introduction: </strong>Patient Reported Outcome Measures (PROMs) are used widely to collect patient perspectives on their Health-Related Quality of Life (HRQoL) after stroke. Existing reviews on PROMs typically report the psychometric properties but rarely focus on the content validity. We performed a structured review of the content of items of stroke-specific HRQoL outcomes.</p><p><strong>Methods: </strong>We searched four databases using a combination of terms (Stroke, HRQoL, PROMs) to choose the three most frequently used stroke-specific HRQoL-related PROMs. Two raters independently linked the items of the Stroke Impact Scale, Stroke Specific Quality of Life and the Stroke and Aphasia Quality of Life to the International Classification of Functioning, Disability and Health (ICF) and Item Perspective Classification (IPC). We compared the ICF codes to the ICF Core Sets for Stroke and calculated ICF linkage indicators.</p><p><strong>Results: </strong>More than 75% of the content for all three PROMs is represented in the Comprehensive Stroke Core Set, indicating the universality and validity of the content of these PROMs. All three PROMs represent the content of the ICF Core Sets for Stroke to a similar extent. Most items use an Intensity response option and have a Descriptive perspective. On the IPC framework, most items have a Rational appraisal type and represent the Biological domain.</p><p><strong>Conclusion: </strong>Clinicians and researchers should use patient goals as a reference to choose the appropriate PROM. A deeper understanding of the content of PROMs can help clinicians and researchers make informed decisions on which HRQoL outcomes to use among people following stroke.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative evidence on EQ-5D-5L skin irritation and self-confidence bolt-ons in Darier's disease and Hailey-Hailey disease.","authors":"Dóra Plázár, Zseraldin Metyovinyi, Márta Medvecz, Fanni Rencz","doi":"10.1007/s11136-024-03871-1","DOIUrl":"https://doi.org/10.1007/s11136-024-03871-1","url":null,"abstract":"<p><strong>Objectives: </strong>Limited evidence is available about the content validity of the EQ-5D-5L in rare skin fragility disorders. Previous research has demonstrated that the skin irritation and self-confidence additional dimensions (bolt-ons) improve the content validity of the EQ-5D-5L in psoriasis and atopic dermatitis. Our aim was to investigate the content validity of the EQ-5D-5L and the two bolt-ons in Darier's disease and Hailey-Hailey disease.</p><p><strong>Methods: </strong>In 2023, we conducted qualitative, semi-structured interviews with 15 adult patients at a university dermatology clinic. Patients completed the EQ-5D-5L with two bolt-ons using a think-aloud technique. We used probing questions to explore the relevance, comprehensiveness and comprehensibility. Thematic analysis was applied to analyze the transcripts from the interviews.</p><p><strong>Results: </strong>Most patients found both the EQ-5D-5L and the two bolt-ons comprehensible and relevant to their disease. All patients preferred the EQ-5D-5L with the two bolt-ons over the EQ-5D-5L alone. Twelve potential missing concepts were identified after the EQ-5D-5L + bolt-ons, but only financial impact and sex life were identified by more than one patient. Only one patient reported a conceptual overlap between the skin irritation bolt-on and the pain/discomfort dimension.</p><p><strong>Conclusions: </strong>Our findings suggest that there is no actionable evidence indicating gaps in the content validity of the EQ-5D-5L with two bolt-ons in Darier's and Hailey-Hailey disease. Future studies are encouraged to conduct quantitative psychometric testing of the bolt-ons in this and other chronic dermatological patient populations.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping and comparing the quality of life outcomes in childhood and adolescent and young adult cancer survivors: an umbrella review and future directions.","authors":"Céline Bolliger, Kirsty Way, Gisela Michel, Samantha C Sodergren, Anne-Sophie Darlington","doi":"10.1007/s11136-024-03825-7","DOIUrl":"https://doi.org/10.1007/s11136-024-03825-7","url":null,"abstract":"<p><strong>Background: </strong>A cancer diagnosis early in life can leave a legacy in terms of compromised Quality of Life (QoL). There is a lack of clarity regarding the impact on QoL according to age at diagnosis, with childhood cancer survivors (CCS) and adolescents and young adult cancer survivors (AYACS) often combined. As part of an EORTC Quality of Life Group study, this umbrella review aims to (1) identify the QoL outcomes reported in the literature for both CCS and AYACS, and (2) investigate the similarities and differences in QoL challenges between both groups.</p><p><strong>Methods: </strong>A systematic literature search of systematic reviews and meta-analyses was conducted in December 2023 using PubMed, PsychInfo, and CINAHL. Methodological quality was evaluated using the AMSTAR tool.</p><p><strong>Results: </strong>Overall, 1457 articles were assessed, and 39 systematic reviews and meta-analyses met the inclusion criteria. QoL outcomes were categorized into eight QoL domains, all of which were reported in both groups of young survivors. However, reviews on CCS often focused on outcomes relating to emotional functioning, cognitive difficulties, social challenges, school functioning, body image and overall happiness, whereas AYACS reviews had a greater focus on depressive symptoms, outcomes related to sexual health and reproductive health, employment, financial difficulties, self-image and identity and the impact of cancer.</p><p><strong>Conclusion: </strong>This umbrella review comprehensively explores QoL outcomes among CCS and AYACS, revealing both shared and distinct challenges. Future research should focus on developing tailored questionnaires, emphasizing transition periods and incorporating a life perspective to capture unique developmental tasks of young survivors.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Content and face validity of preference-based quality of life instruments in indigenous youth experiencing mental health problems: a qualitative study.","authors":"Thao Thai, Lidia Engel, Sandra Eades, Lena Sanci, Robyn William, Pippa Gregory, Justine Whitby, Cathrine Mihalopoulos","doi":"10.1007/s11136-024-03870-2","DOIUrl":"https://doi.org/10.1007/s11136-024-03870-2","url":null,"abstract":"<p><strong>Background: </strong>Mainstream preference-based quality of life (QoL) measures have been traditionally based on Western principles of health. It is critical to examine whether existing preference-based QoL measures capture what is important to Indigenous people while being comprehensive and culturally acceptable. This study aims to assess the content and face validity of the EuroQol-5 dimensions 5-levels (EQ-5D-5 L), 12-item short form survey (SF-12), assessment of quality of life-6 dimensions (AQoL-6D), and recovering quality of life 10-item (ReQoL-10) within the context of indigenous youth mental health.</p><p><strong>Methods: </strong>Eight individual yarns and five yarning circles were conducted with 20 indigenous young people aged 15-25 years, with a history of at least 1 mental health problem in the Perth and Bunbury regions of Western Australia. The measures were explored in random order using the yarning approach, and then ranked by relevance by participants. Data were analysed using thematic and constant comparative approaches.</p><p><strong>Results: </strong>The face and content validity of each preference-based QoL instrument was summarised into four themes: (1) appropriateness, (2) comprehensiveness, (3) comprehensibility, and (4) layout and format. The ReQoL-10 emerged as a more suitable measure due to its mental health focus, clear response options, and well-designed layout and format. While some positive comments were made about the other measures, there were critical issues around their content and face validity. Our data revealed a clear preference for the ReQoL.</p><p><strong>Conclusion: </strong>The ReQoL-10 appears to be a promising measure in the context of indigenous youth mental health, and was explicitly preferred by indigenous youth.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between cardiovascular health and perceived quality of life in ethnically diverse adults: insights from the Community of Mine study using the American Heart Association's Life's Simple 7.","authors":"E J Ambeba, D D Sears, T Benmarhnia, L Natarajan, S Zamora, S Alismail, C P Tribby, M M Jankowska","doi":"10.1007/s11136-024-03853-3","DOIUrl":"https://doi.org/10.1007/s11136-024-03853-3","url":null,"abstract":"<p><strong>Purpose: </strong>The association between cardiovascular health (CVH) with perceived quality of life (PQoL) and variations by sex and Hispanic ethnicity is not well understood.</p><p><strong>Methods: </strong>This study included 583 participants (42% Hispanic, 56% female, mean age 59 years). Linear regression modeled the covariate-adjusted associations between CVH, using the combined 7 components of Life's Simple 7 (LS7; ideal and intermediate, compared to poor), and PQoL (total and physical, social, and cognitive health domains). For individual LS7 components, we assessed effect modification by sex and Hispanic ethnicity.</p><p><strong>Results: </strong>Compared to individuals with poor CVH, those with intermediate (β [95% CI] = 0.22 [0.09, 0.35]) and ideal (β [95% CI] = 0.22 [0.08, 0.36]) CVH had higher overall PQoL. This effect was dominated by the physical PQoL domain. Of LS7 components, ideal body mass index (BMI) (β [95% CI] = 0.17 [0.03, 0.31]) and physical activity (β [95% CI] = 0.26 [0.12, 0.40]) were associated with overall PQoL. Ideal diet (β [95% CI] = 0.32 [0.08, 0.56]) and fasting plasma glucose (β [95% CI] = 0.32 [0.06, 0.58]) were associated with the physical PQoL domain. A higher PQoL score was associated with intermediate BMI in women, and physical PQoL was associated with smoking for women. A BMI*Hispanic interaction resulted in larger associations between intermediate/ideal BMI and physical PQoL in non-Hispanics.</p><p><strong>Conclusion: </strong>Ideal or intermediate CVH health factors and health behaviors were associated with higher PQoL. Sex and ethnicity differences suggest that perceived quality of life is associated with BMI for women and non-Hispanics.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential item functioning between English, German, and Spanish PROMIS® physical function ceiling items.","authors":"Constantin Yves Plessen, Felix Fischer, Claudia Hartmann, Gregor Liegl, Ben Schalet, Aaron J Kaat, Rodrigo Pesantez, Alexander Joeris, Marilyn Heng, Matthias Rose","doi":"10.1007/s11136-024-03866-y","DOIUrl":"https://doi.org/10.1007/s11136-024-03866-y","url":null,"abstract":"<p><strong>Purpose: </strong>We investigated the validity of the German and Spanish translations of 35 new high functioning items added to the Patient Reported Outcomes Measurement Information System (PROMIS®) Physical Function item bank 2.0. We assessed differential item functioning (DIF) between three general population samples from Argentina, Germany, and the United States.</p><p><strong>Methods: </strong>PROMIS Physical Function data was collected in online panels from 3601 individuals (mean age, 41.6 years old; range, 18-88 years; 53.7% female). Of these, 1001 participants completed the Spanish version, 1000 completed the German version, and 1600 completed the English version. DIF was assessed by a multiverse analysis that systematically varied analytic choices across the entire range of plausible options within the logistic ordinal regression framework.</p><p><strong>Results: </strong>Translated items generally met the assumptions of unidimensionality, monotonicity, and local independence. The 272 different analyses suggest consistent DIF between languages in four items. Test characteristic curves suggested that the magnitude and impact of DIF on the test scores were negligible for all items at the test level. After correcting for potential DIF, we observed greater scoring for physical functioning in Argentina compared to the US, Cohen's d = 0.25, [0.17, 0.33], and Argentina compared to Germany, Cohen's d = 0.23, [0.15, 0.32].</p><p><strong>Conclusions: </strong>Our findings support the universal applicability of PROMIS Physical Function items across general populations in Argentina, Germany, and the U.S. The sensitivity analyses indicate that the identification of DIF items was robust for different data analytic decisions. Multiverse analysis is a promising approach to address lack of clear cutoffs in DIF identification.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression in patients with anorectal fistulas and anal fissures: a propensity score-matched cohort study.","authors":"Andreas Krieg, Ernst W Kolbe, Michael Kaspari, Sarah Krieg, Sven H Loosen, Christoph Roderburg, Karel Kostev","doi":"10.1007/s11136-024-03863-1","DOIUrl":"https://doi.org/10.1007/s11136-024-03863-1","url":null,"abstract":"<p><strong>Purpose: </strong>Anal fissures and anorectal fistulas are diseases often associated with significant pain and prolonged discomfort, resulting in a significantly reduced quality of life (QoL). They are not only a surgical problem but also have a profound psychosocial impact and influence on QoL. The aim of this study was to investigate the incidence of depression in patients with these pathologies and to highlight the need to address the psychosocial aspects of these diseases.</p><p><strong>Methods: </strong>Data from the Disease Analyzer database of approximately 3,000 general practitioners in Germany were retrospectively analyzed. The retrospective cohort study included patients aged ≥ 18 years diagnosed with anal fissure (n = 15,467) or anorectal fistula (n = 3,520) between January 2005 and December 2022 and propensity score matched individuals without these disorders (n = 94,935). The primary outcome was a diagnosis of depression within five years of the index date. Kaplan-Meier curves and Cox regression analyses were used to analyze the association between the two anorectal diseases and depression.</p><p><strong>Results: </strong>After 5 years of follow-up, 13.0% of patients with anal fissure and 12.3% of patients with anorectal fistula were diagnosed with depression, compared with 9.7-10.3% in the control group (p < 0.001). Cox regression analysis showed a significant association between both diseases and depression (anal fissure: HR: 1.31; 95% CI: 1.25-1.38; anorectal fistula: HR: 1.30; 95% CI: 1.17-1.44).</p><p><strong>Conclusion: </strong>The results suggest that anal fissures or anorectal fistulas are significantly associated with a subsequent depression. This highlights the importance of multidisciplinary management that addresses both physical and psychosocial aspects to improve patient outcomes.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the content validity of the EQ-5D-5L and four bolt-ons (skin irritation, self-confidence, sleep, social relationships) in atopic dermatitis and chronic urticaria.","authors":"Anna-Katrine Sussex, Fanni Rencz, Millie Gaydon, Andrew Lloyd, Katy Gallop","doi":"10.1007/s11136-024-03875-x","DOIUrl":"https://doi.org/10.1007/s11136-024-03875-x","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to assess the content validity of the EQ-5D-5L and four bolt-ons: skin irritation, self-confidence, social relationships and sleep, for people with atopic dermatitis (AD) and chronic urticaria (CU).</p><p><strong>Methods: </strong>Adults with AD or CU in the United Kingdom, with varying levels of severity, participated in either online or in-person semi-structured interviews. During the interviews, participants were first asked about the symptoms and impacts of their condition. They were then asked to complete the EQ-5D-5L and four bolt-ons using 'think-aloud' and retrospective probing. Interviews were recorded, transcribed, then analysed using content and thematic analysis.</p><p><strong>Results: </strong>Thirty participants (N = 15 with AD; N = 15 with CU) were interviewed. Participants spontaneously reported itch (AD: 100%; CU: 93%), self-confidence (AD: 100%, CU: 47%), sleep (AD: 53%; CU: 53%), and social relationships (AD: 27%; CU: 60%). The skin irritation bolt-on was the most important or relevant dimension for 60% of AD and 73% of CU participants. For all participants, skin irritation and self-confidence bolt-ons improved the EQ-5D-5L's comprehensiveness. Social relationships was more frequently ranked as the least relevant among the other bolt-ons.</p><p><strong>Conclusions: </strong>This study assessed the content validity of four EQ-5D-5L bolt-ons within two patient populations. Skin irritation, self-confidence and sleep bolt-ons showed good evidence of content validity for people with AD and CU, providing support for their application in other skin conditions. The value of a social relationships bolt-on was less clear. Quantitative psychometric research is recommended to further support the use of bolt-ons in CU and AD.</p>","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}