Prostaglandins, leukotrienes, and medicine最新文献_第4页

Stability of leukotrienes C4 and D4 in human urine 白三烯C4和D4在人尿中的稳定性

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-10-01 DOI: 10.1016/0262-1746(87)90012-6

G. Beyer, C.O. Meese, U. Klotz

引用次数: 11

Effect of effervescent buffered aspirin on prostaglandin synthesis by human gingival fibroblasts 泡腾缓冲阿司匹林对人牙龈成纤维细胞合成前列腺素的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-10-01 DOI: 10.1016/0262-1746(87)90013-8

T.M.A. Elattar, H.S. Lin, R.D. Platt

引用次数: 3

Mode of action of chlorpromazine (CPZ) blockage on 13,14-dihydroprostaglandin F2-alpha formation in rat ovary 氯丙嗪(CPZ)阻断对大鼠卵巢13,14-二氢前列腺素f2 - α形成的作用模式

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-10-01 DOI: 10.1016/0262-1746(87)90004-7

Hiroshi Kogo , Hiroyuki Iida , Kazuyoshi Taya , Shuji Sasamoto , Norihisa Inazu , Tetsuo Satoh

{"title":"Mode of action of chlorpromazine (CPZ) blockage on 13,14-dihydroprostaglandin F2-alpha formation in rat ovary","authors":"Hiroshi Kogo , Hiroyuki Iida , Kazuyoshi Taya , Shuji Sasamoto , Norihisa Inazu , Tetsuo Satoh","doi":"10.1016/0262-1746(87)90004-7","DOIUrl":"10.1016/0262-1746(87)90004-7","url":null,"abstract":"<div>The mode of action of the inhibitory effect of CPZ on 13,14-dihydroprostaglandin F2-alpha (13, 14H2-PGF2-alpha) formation in rat ovary was examined. The inhibition of 13, 14H2-PGF2-alpha formation and of ovulation induced by a proestrus were completely recovered by an injection of hCG (25 IU/rat) or LH-RH (500 ng/rat) at 15:00 on the same day. 13,14H2-PGF2-alpha formation and ovulation were not inhibited by a single injection of prolactin (PRL:6 IU/rat) at 13:00 on the day of proestrus. Repeated injection of PRL inhibited cyclic ovulation and 13,14H2-PGF2-alpha formation. The estrus cycle of PRL treated animals showed a continuous state of diestrus. Although 13,14H2-PGF2-alpha formation and ovulation were inhibited by the repeated injection of CPZ, the repeated-simultaneous injection of CPZ and bromocriptine at 10:00 once a day for 3 days from the first day of diestrus partly restored both and entirely reversed the suppression of the cyclic-changes in the in the vaginal smear pattern.These results indicate that the inhibition of 13,14H2-PGF2-alpha formation induced by a single injection of CPZ probably occurs via the suppression of LH-RH release from the hypothalamus, whereas PRL secretion may participate in the inhibitory effects of repeated injections of CPZ.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90004-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14555532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Effects of calmodulin inhibitors on rabbit synoviocyte phospholipase A2 钙调素抑制剂对兔滑膜细胞磷脂酶A2的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-09-01 DOI: 10.1016/0262-1746(87)90097-7

Ralph J. Rothenberg

{"title":"Effects of calmodulin inhibitors on rabbit synoviocyte phospholipase A2","authors":"Ralph J. Rothenberg","doi":"10.1016/0262-1746(87)90097-7","DOIUrl":"10.1016/0262-1746(87)90097-7","url":null,"abstract":"<div>The effect of calmodulin inhibitors on synoviocyte phospholipase A2 activity was evaluated. Cells were incubated with [3H]arachidonic acid for 24 hours to label phospholipids. [3H]prostaglandin E2 synthesis was stimulated by <math><mtext>Salmonella minnesota</mtext></math> lipopolysaccharide (100 μg/ml). Trifluoperazine, 35 μM, reduced lipopolysaccharide-stimulated [3H]prostaglandin E2 synthesis by 50%. In sonicated suspensions of cells, calcium-dependent phospholipase A2 activity was inhibited by trifluoperazine 3–100 pM and by compound <math><mtext>48</mtext><mtext>80</mtext></math> (3 μg/ml). These agents inhibit calmodulin-dependent enzyme activity. The addition of calmodulin, 1 or 2.5 μM, to compound <math><mtext>48</mtext><mtext>80</mtext><mtext>-</mtext><mtext>treated</mtext></math> suspensions reversed this inhibition in a dose-dependent manner. Agents which inhibit calmodulin-dependent enzymes can reversibly inhibit synoviocyte phospholipase A2 and thus prostaglandin E2 production.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90097-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14250039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Twice monthly bibliography on prostaglandins— late April prepared by Sheffield University, biomedical information service 4月下旬，谢菲尔德大学生物医学信息服务处准备的前列腺素参考书目，每月两次

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-09-01 DOI: 10.1016/0262-1746(87)90103-X

引用次数: 0

Effects of halothane and enflurane on prostanoid concentrations in operation patients 氟烷和安氟醚对手术患者前列腺素浓度的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-09-01 DOI: 10.1016/0262-1746(87)90100-4

S. Kaukinen , E. Seppala , L. Kaukinen , R. Ojanen , H. Vapaatalo

{"title":"Effects of halothane and enflurane on prostanoid concentrations in operation patients","authors":"S. Kaukinen , E. Seppala , L. Kaukinen , R. Ojanen , H. Vapaatalo","doi":"10.1016/0262-1746(87)90100-4","DOIUrl":"10.1016/0262-1746(87)90100-4","url":null,"abstract":"<div>Prostanoid formation may be stimulated by different events associated with anaesthesia and operation, such as positive pressure ventilation and tissue trauma. We investigated the effects of halothane and enflurane on plasma and serum prostanoid concentrations in 19 patients scheduled for minor operations. In 9 abdominal surgery patients, thromboxane B2 concentrations were followed up to the fifth postoperative day. Prostanoid determinations were carried out with RIA. In general, the changes in prostanoid concentrations in patients anaesthetised with halothane or enflurane were similar. During spontaneous breathing there was a decrease in plasma PGE2 and TxB2 concentrations. During intermittent positive pressure ventilation and operation, PGE2 and TxB2 concentrations rose but 6-keto-PGF1α did not. After operation, TxB2 concentrations remained elevated but the other prostanoids returned to preoperative values. TxB2 concentrations decreased to the preoperative level on the first postoperative day. The elevated TxB2 concentrations during and after surgery can be regarded, in some patients, as a potential risk factor for cardiovascular and thromboembolic complications.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90100-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14603347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Interference with the distribution and release of arachidonic acid in human keratinocytes by bradykinin, histamine and phosphatidic acid 缓激肽、组胺和磷脂酸对花生四烯酸在人角质形成细胞中的分布和释放的干扰

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-09-01 DOI: 10.1016/0262-1746(87)90093-X

Kari Punnonen , Tapio Puustinen

引用次数: 2

Increased aortic thromboxane production in experimental atherosclerosis 实验性动脉粥样硬化中主动脉血栓素产生增加

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-09-01 DOI: 10.1016/0262-1746(87)90098-9

Peter Henriksson , Monika Stamberger , Ulf Diczfalusy

引用次数: 24

Effects of progesterone withdrawal on uterine prostaglandin levels in the ovariectomized pregnant rat 黄体酮停用对去卵巢妊娠大鼠子宫前列腺素水平的影响

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-09-01 DOI: 10.1016/0262-1746(87)90101-6

Laird Wilson Jr. , Russell Lindsey

{"title":"Effects of progesterone withdrawal on uterine prostaglandin levels in the ovariectomized pregnant rat","authors":"Laird Wilson Jr. , Russell Lindsey","doi":"10.1016/0262-1746(87)90101-6","DOIUrl":"10.1016/0262-1746(87)90101-6","url":null,"abstract":"<div>Prostaglandin (PG) levels increase dramatically just before parturition in the rat. Coincident with this dramatic increase in uterine PGs is a precipitous decrease in plasma progesterone and enhanced plasma estradiol levels. The purpose of the present study was to mimic the progesterone withdrawal phenomenon in the presence and absence of estradiol in ovariectomized pregnant rats and determine the effects on uterine PGF, PGE, thromboxane B2 (TxB2) and 6-keto-PGF1a (6KF) levels. Rats were ovariectomized on gay 16 of pregnan4 and silastic inserts containing progesterone and estradiol placed s.c. in two groups of rats (I and II) while the third group (III) received progesterone only. On day 19 of pregnancy progesterone was withdrawn from groups II and III and rats sacrificed 0, 6, 12 and 24 hours later. Uterine tissue was assayed for PGs by radioimmunoassay. Progesterone withdrawal in the absence of estradiol (III) administration significantly (p< .05) elevated PGE, TxB2 and 6KF, but not PGF, at the 24 hour period compared to controls (I). When progesterone was withdrawn in the presence of exogenously administered estradiol (II) only PGF showed enhancement (p < .05) over III at the 24 hour period thus indicating a specific effect of estradiol on the PGF metabolic pathway. In conclusion, these data indicate that: (1) progesterone withdrawal is a potent stimulus for uterine PG production and is probably a major contributor to the augmented uterine PGE, TxB2 and 6KF levels at term in the pregnant rat; and (2) progesterone withdrawal in the presence of exogenously administered estradiol enhances uterine PGF production thus indicating a specific effect of estradiol on PGF production.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90101-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14603348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Platelet function and prostaglandins in patients with peripheral vascular disease treated with calcium dobesilate 多贝酸钙治疗外周血管疾病患者血小板功能和前列腺素的变化

Prostaglandins, leukotrienes, and medicine Pub Date : 1987-09-01 DOI: 10.1016/0262-1746(87)90091-6

H. Sinzinger , F. Rauscha , H. Vinazzer

{"title":"Platelet function and prostaglandins in patients with peripheral vascular disease treated with calcium dobesilate","authors":"H. Sinzinger , F. Rauscha , H. Vinazzer","doi":"10.1016/0262-1746(87)90091-6","DOIUrl":"10.1016/0262-1746(87)90091-6","url":null,"abstract":"<div>In a double-blind placebo controlled study, 25 male patients (age range: 48–67 years) suffering from peripheral vascular disease were treated daily for 4 weeks with either 2 g of calcium dobesilate (n=13) or placebo (n=12). Different platelet and prostaglandin parameters were examined before and at the end of therapy. The number of circulating endothelial cells decreased significantly (4.9 ± 2.9 to 2.0 ± 1.9; p<0,0004). In addition, a decrease in serum TXB2 was noted (p<0,0001), but no significant change in plasma TXB2. The fibrinogen half-life was shortened (p<0,0001) and the platelet half-life was prolonged (p<0,04). The level of βTG was decreased (p<0,006), but PF4 was unchanged. No alteration in the conversion of exogenous 14C-arachidonic acid by platelets to eicosanoids was observed. These observations indicate that calcium dobesilate is able to exert a favourable effect on some parameters of platelet function and prostaglandin synthesis which are important in the regulation of the hemostatic process. It is suggested that these pharmacological actions might explain, at least in part, the beneficial clinical effect of the drug.</div>","PeriodicalId":20720,"journal":{"name":"Prostaglandins, leukotrienes, and medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1987-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0262-1746(87)90091-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14094639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16