多贝酸钙治疗外周血管疾病患者血小板功能和前列腺素的变化

H. Sinzinger , F. Rauscha , H. Vinazzer
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引用次数: 16

摘要

在一项双盲安慰剂对照研究中,25名患有外周血管疾病的男性患者(年龄范围:48-67岁)每天接受2 g多贝酸钙(n=13)或安慰剂(n=12)治疗,持续4周。在治疗前和治疗结束时检测血小板和前列腺素的不同参数。循环内皮细胞数明显减少(4.9±2.9 ~ 2.0±1.9);术;0,0004)。此外,血清TXB2下降(p< 0.0001),但血浆TXB2无显著变化。纤维蛋白原半衰期缩短(p<0,0001),血小板半衰期延长(p<0,04)。βTG水平降低(p< 0.006),但PF4不变。未观察到血小板对外源性14c -花生四烯酸转化为类二十烷酸的改变。这些观察结果表明,多苯磺酸钙能够对血小板功能和前列腺素合成的一些参数产生有利影响,这些参数在止血过程的调节中是重要的。这表明,这些药理作用可能解释,至少部分,药物的有益临床效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Platelet function and prostaglandins in patients with peripheral vascular disease treated with calcium dobesilate

In a double-blind placebo controlled study, 25 male patients (age range: 48–67 years) suffering from peripheral vascular disease were treated daily for 4 weeks with either 2 g of calcium dobesilate (n=13) or placebo (n=12). Different platelet and prostaglandin parameters were examined before and at the end of therapy. The number of circulating endothelial cells decreased significantly (4.9 ± 2.9 to 2.0 ± 1.9; p<0,0004). In addition, a decrease in serum TXB2 was noted (p<0,0001), but no significant change in plasma TXB2. The fibrinogen half-life was shortened (p<0,0001) and the platelet half-life was prolonged (p<0,04). The level of βTG was decreased (p<0,006), but PF4 was unchanged. No alteration in the conversion of exogenous 14C-arachidonic acid by platelets to eicosanoids was observed. These observations indicate that calcium dobesilate is able to exert a favourable effect on some parameters of platelet function and prostaglandin synthesis which are important in the regulation of the hemostatic process. It is suggested that these pharmacological actions might explain, at least in part, the beneficial clinical effect of the drug.

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